LOCUS       NM_138902                711 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ribonuclease A family member 3 (Rnase3), mRNA.
ACCESSION   NM_138902
VERSION     NM_138902.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Pulido,D., Moussaoui,M., Nogues,M.V., Torrent,M. and Boix,E.
  TITLE     Towards the rational design of antimicrobial proteins: single point
            mutations can switch on bactericidal and agglutinating activities
            on the RNase A superfamily lineage
  JOURNAL   FEBS J 280 (22), 5841-5852 (2013)
   PUBMED   23992292
REFERENCE   2  (bases 1 to 711)
  AUTHORS   O'Reilly,M.A., Yee,M., Buczynski,B.W., Vitiello,P.F., Keng,P.C.,
            Welle,S.L., Finkelstein,J.N., Dean,D.A. and Lawrence,B.P.
  TITLE     Neonatal oxygen increases sensitivity to influenza A virus
            infection in adult mice by suppressing epithelial expression of
            Ear1
  JOURNAL   Am J Pathol 181 (2), 441-451 (2012)
   PUBMED   22677423
REFERENCE   3  (bases 1 to 711)
  AUTHORS   Navarro,S., Boix,E., Cuchillo,C.M. and Nogues,M.V.
  TITLE     Eosinophil-induced neurotoxicity: the role of eosinophil cationic
            protein/RNase 3
  JOURNAL   J Neuroimmunol 227 (1-2), 60-70 (2010)
   PUBMED   20619905
  REMARK    GeneRIF: ECP induces dose-dependent cell death in both cerebellar
            granule cells and astrocytes; the effect of ECP action on cell
            morphology is consistent with apoptosis for both cell types.
REFERENCE   4  (bases 1 to 711)
  AUTHORS   Gu,Q., Wiggers,M.E., Gleich,G.J. and Lee,L.Y.
  TITLE     Sensitization of isolated rat vagal pulmonary sensory neurons by
            eosinophil-derived cationic proteins
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 294 (3), L544-L552 (2008)
   PUBMED   18178677
  REMARK    GeneRIF: results demonstrate direct, charge-dependent, &
            long-lasting sensitizing effect of cationic proteins on pulmonary
            sensory neurons, may contribute to hyperresponsiveness associated
            with airway infiltration of eosinophils under pathophysiological
            conditions
REFERENCE   5  (bases 1 to 711)
  AUTHORS   Tollin,M., Bergman,P., Svenberg,T., Jornvall,H., Gudmundsson,G.H.
            and Agerberth,B.
  TITLE     Antimicrobial peptides in the first line defence of human colon
            mucosa
  JOURNAL   Peptides 24 (4), 523-530 (2003)
   PUBMED   12860195
REFERENCE   6  (bases 1 to 711)
  AUTHORS   Singhania,N.A., Dyer,K.D., Zhang,J., Deming,M.S., Bonville,C.A.,
            Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Rapid evolution of the ribonuclease A superfamily: adaptive
            expansion of independent gene clusters in rats and mice
  JOURNAL   J Mol Evol 49 (6), 721-728 (1999)
   PUBMED   10594173
REFERENCE   7  (bases 1 to 711)
  AUTHORS   Nittoh,T., Hirakata,M., Mue,S. and Ohuchi,K.
  TITLE     Identification of cDNA encoding rat eosinophil cationic
            protein/eosinophil-associated ribonuclease
  JOURNAL   Biochim Biophys Acta 1351 (1-2), 42-46 (1997)
   PUBMED   9116043
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D88586.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88586.1, CF109810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..711
                     /gene="Rnase3"
                     /gene_synonym="EAR; Ear11; ECP; R1; R7"
                     /note="ribonuclease A family member 3"
                     /db_xref="GeneID:192264"
                     /db_xref="RGD:621580"
     exon            1..58
                     /gene="Rnase3"
                     /gene_synonym="EAR; Ear11; ECP; R1; R7"
                     /inference="alignment:Splign:2.1.0"
     exon            59..711
                     /gene="Rnase3"
                     /gene_synonym="EAR; Ear11; ECP; R1; R7"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..531
                     /gene="Rnase3"
                     /gene_synonym="EAR; Ear11; ECP; R1; R7"
                     /note="ribonuclease 1; ribonuclease 7; EAR-11; RNase 3;
                     ribonuclease 3; eosinophil secondary granule ribonuclease
                     11; eosinophil-associated ribonuclease; eosinophil
                     cationic protein; eosinophil-associated, ribonuclease A
                     family, member 11; ribonuclease, RNase A family, 3"
                     /codon_start=1
                     /product="eosinophil cationic protein precursor"
                     /protein_id="NP_620257.1"
                     /db_xref="GeneID:192264"
                     /db_xref="RGD:621580"
                     /translation="MGLKLLESRLCLLLSLGLVLMLASCQPPTPSQWFEIQHIYNRAY
                     PRCNDAMRHRNRFTGHCKDINTFLHTSFASVVGVCGNRNIPCGNRTYRNCHNSRYRVS
                     ITFCNLTTPARIYTQCRYQTTRSRKFYTVGCDPRTPRDSPMYPVVPVHLDRIF"
     polyA_site      711
                     /gene="Rnase3"
                     /gene_synonym="EAR; Ear11; ECP; R1; R7"
                     /note="8 A nucleotides"
ORIGIN      
        1 acctctgatt tccaggacag ccagcactca gttccacagg agccacaacg cacactggga
       61 aacatgggtc tgaagctgct cgagtccaga ctttgtctcc ttctgtcgct gggacttgtc
      121 ttgatgcttg cctcatgcca gccaccaacc ccttcccagt ggtttgaaat ccagcacatc
      181 tataataggg cttatccccg atgtaatgat gcaatgcgac acagaaacag attcacagga
      241 cattgtaagg acataaatac ttttcttcat acaagttttg ctagtgttgt tggtgtgtgt
      301 ggcaatagaa acatcccctg tggaaacagg acatatagaa attgtcataa cagtcgatat
      361 cgggtatcta taactttctg taacctcaca actccggcaa ggatttatac ccaatgtaga
      421 taccaaacta caagatccag gaagttctac acagttggct gtgacccgag gactccacgg
      481 gacagtccca tgtatccagt ggttccggtt cacttggata ggatatttta gctccggtgc
      541 cagcactttg tacctgagct catcggctcc tgccaagatc acagtagtga agatccagtt
      601 cctctgtctg cactgcatat cagctcctgt cctcatgaaa cctgtccctg actcctttta
      661 gtatagctta acagattttt gtaatcaata aacacctttg catatgcatc t
//
