LOCUS       NP_001012232             155 aa            linear   ROD 14-APR-2025
DEFINITION  ribonuclease 17 precursor [Rattus norvegicus].
ACCESSION   NP_001012232 XP_008768783
VERSION     NP_001012232.1
DBSOURCE    REFSEQ: accession NM_001012232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 155)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XP_008768783.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1662139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..155
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     Protein         1..155
                     /product="ribonuclease 17 precursor"
                     /note="ribonuclease 1"
                     /calculated_mol_wt=15544
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2717
     Region          29..155
                     /region_name="RNAse_Pc"
                     /note="Pancreatic ribonuclease; smart00092"
                     /db_xref="CDD:128403"
     Site            order(34..43,46,50,52..54,62,65..70,104,124,148)
                     /site_type="active"
                     /note="dimerization with domain swap [active]"
                     /db_xref="CDD:119387"
     Site            order(38,62,66,93,105,150..151)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:119387"
     Site            order(63,96,107,123,125,127..128,130)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119387"
     CDS             1..155
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /coded_by="NM_001012232.2:106..573"
                     /db_xref="GeneID:497195"
                     /db_xref="RGD:1359245"
ORIGIN      
        1 mglkllesrl clllllglvl mlascqpptp sqwfeiqhiy nrayprcnda mrhrnrftrh
       61 ckdkntflht sfasvvgvcg nrnipcrnrr yrnchnspyr vsitfcnltt pariytqcry
      121 qttrsrkfyt vgcdprtprd spmypvvpvh ldrif
//
