LOCUS       NM_001029904             798 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ribonuclease A family member 1, pancreatic
            (Rnase1), mRNA.
ACCESSION   NM_001029904 XM_008770630 XM_344330
VERSION     NM_001029904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 798)
  AUTHORS   Dubois,J.Y., Jekel,P.A., Mulder,P.P., Bussink,A.P., Catzeflis,F.M.,
            Carsana,A. and Beintema,J.J.
  TITLE     Pancreatic-type ribonuclease 1 gene duplications in rat species
  JOURNAL   J Mol Evol 55 (5), 522-533 (2002)
   PUBMED   12399926
  REMARK    GeneRIF: molecular evolution and gene duplication
REFERENCE   2  (bases 1 to 798)
  AUTHORS   Gupta,V., Muyldermans,S., Wyns,L. and Salunke,D.M.
  TITLE     The crystal structure of recombinant rat pancreatic RNase A
  JOURNAL   Proteins 35 (1), 1-12 (1999)
   PUBMED   10090281
REFERENCE   3  (bases 1 to 798)
  AUTHORS   Domachowske,J.B., Bonville,C.A., Dyer,K.D. and Rosenberg,H.F.
  TITLE     Evolution of antiviral activity in the ribonuclease A gene
            superfamily: evidence for a specific interaction between
            eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory
            syncytial virus
  JOURNAL   Nucleic Acids Res 26 (23), 5327-5332 (1998)
   PUBMED   9826755
REFERENCE   4  (bases 1 to 798)
  AUTHORS   Beintema,J.J.
  TITLE     Rat pancreatic ribonuclease: agreement between the corrected amino
            acid sequence and the sequence derived from its messenger RNA
  JOURNAL   FEBS Lett 159 (1-2), 191-195 (1983)
   PUBMED   6873294
REFERENCE   5  (bases 1 to 798)
  AUTHORS   MacDonald,R.J., Stary,S.J. and Swift,G.H.
  TITLE     Rat pancreatic ribonuclease messenger RNA. The nucleotide sequence
            of the entire mRNA and the derived amino acid sequence of the
            pre-enzyme
  JOURNAL   J Biol Chem 257 (24), 14582-14585 (1982)
   PUBMED   7174650
REFERENCE   6  (bases 1 to 798)
  AUTHORS   Beintema,J.J. and Gruber,M.
  TITLE     Rat pancreatic ribonuclease. II. Amino acid sequence
  JOURNAL   Biochim Biophys Acta 310 (1), 161-173 (1973)
   PUBMED   4710592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Mar 5, 2021 this sequence version replaced
            XM_008770630.2, NM_001029904.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227366.1, FQ235014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000015.1  26837094-26837145   c
            53-798              JAXUCZ010000015.1  26835436-26836181   c
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..798
                     /gene="Rnase1"
                     /gene_synonym="Rib1; RL1"
                     /note="ribonuclease A family member 1, pancreatic"
                     /db_xref="GeneID:364304"
                     /db_xref="RGD:3574"
     exon            1..52
                     /gene="Rnase1"
                     /gene_synonym="Rib1; RL1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..798
                     /gene="Rnase1"
                     /gene_synonym="Rib1; RL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..535
                     /gene="Rnase1"
                     /gene_synonym="Rib1; RL1"
                     /EC_number="4.6.1.18"
                     /note="ribonuclease 1 pancreatic; ribonuclease RNase A
                     family 1; ribonuclease pancreatic beta-type; pancreatic
                     ribonuclease; RNase 1 gamma; ribonuclease, RNase A family,
                     1 (pancreatic)"
                     /codon_start=1
                     /product="ribonuclease pancreatic beta-type precursor"
                     /protein_id="NP_001025075.2"
                     /db_xref="GeneID:364304"
                     /db_xref="RGD:3574"
                     /translation="MGLEKSLFLFSLLVLVLGWVQPSLGGESRESSADKFKRQHMDTE
                     GPSKSSPTYCNQMMKRQGMTKGSCKPVNTFVHEPLEDVQAICSQGQVTCKNGRNNCHK
                     SSSTLRITDCRLKGSSKYPNCDYTTTDSQKHIIIACDGNPYVPVHFDASV"
ORIGIN      
        1 actgggactg aagaaactgt cttccaattt gctctggaat tcaaacgttt aggctcctca
       61 gagcagcaaa gccactatgg gtctggagaa gtccctcttt ctgttttcac tgcttgtcct
      121 ggtgcttgga tgggtccagc cttccctggg tggggaatct agggaatcat cggcggataa
      181 gtttaagagg cagcacatgg acacagaggg tccctccaag agcagcccca cctactgtaa
      241 ccagatgatg aagcgccagg ggatgaccaa ggggtcatgc aagccagtga acaccttcgt
      301 gcatgaaccc ttggaggatg tccaggccat ctgctcccag ggacaagtga cctgcaagaa
      361 tgggaggaac aactgccaca agagcagctc caccctgcgc atcactgact gccgcctgaa
      421 gggcagctcc aagtatccca attgcgacta cacaaccact gacagccaga agcacatcat
      481 cattgcttgt gacgggaacc cctacgtccc agtccacttc gatgcttccg tgtagggctt
      541 cacgtaggcc aaaccagtga gatgtccgtg tctcccatca tggcaacacc tgcctcccct
      601 ctcgatcatt ctttccctga gagaaataat tcttgttagg acttccatcc aaccaaacat
      661 tcgttcctgt cccgtgtcct gttcccagac ccctctccag acacagacaa atgaagcaag
      721 atggccctca ccagagcatg tcccttcaac cttagacttt cccgacttag aaccaaataa
      781 aattctgtcc attataaa
//
