LOCUS       NM_170667                470 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus relaxin 3 (Rln3), mRNA.
ACCESSION   NM_170667
VERSION     NM_170667.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Golyszny,M., Zielinski,M. and Obuchowicz,E.
  TITLE     Acute Stress Affects the Relaxin/Insulin-Like Family Peptide
            Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats
  JOURNAL   Dev Psychobiol 66 (6), e22523 (2024)
   PUBMED   38970242
  REMARK    GeneRIF: Acute Stress Affects the Relaxin/Insulin-Like Family
            Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar
            Rats.
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Sinaei,M., Alaei,H., Nazem,F., Kargarfard,M., Feizi,A., Talebi,A.,
            Esmaeili,A., Nobari,H. and Perez-Gomez,J.
  TITLE     Endurance exercise improves avoidance learning and spatial memory,
            through changes in genes of GABA and relaxin-3, in rats
  JOURNAL   Biochem Biophys Res Commun 566, 204-210 (2021)
   PUBMED   34214757
  REMARK    GeneRIF: Endurance exercise improves avoidance learning and spatial
            memory, through changes in genes of GABA and relaxin-3, in rats.
REFERENCE   3  (bases 1 to 470)
  AUTHORS   Kania,A., Szlaga,A., Sambak,P., Gugula,A., Blasiak,E., Micioni Di
            Bonaventura,M.V., Hossain,M.A., Cifani,C., Hess,G., Gundlach,A.L.
            and Blasiak,A.
  TITLE     RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via
            M-like Current Activation and Contributes to Binge Eating Behavior
  JOURNAL   J Neurosci 40 (28), 5362-5375 (2020)
   PUBMED   32532885
  REMARK    GeneRIF: RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular
            Neurons via M-like Current Activation and Contributes to Binge
            Eating Behavior.
REFERENCE   4  (bases 1 to 470)
  AUTHORS   de Avila,C., Chometton,S., Ma,S., Pedersen,L.T., Timofeeva,E.,
            Cifani,C. and Gundlach,A.L.
  TITLE     Effects of chronic silencing of relaxin-3 production in nucleus
            incertus neurons on food intake, body weight, anxiety-like
            behaviour and limbic brain activity in female rats
  JOURNAL   Psychopharmacology (Berl) 237 (4), 1091-1106 (2020)
   PUBMED   31897576
  REMARK    GeneRIF: Effects of chronic silencing of relaxin-3 production in
            nucleus incertus neurons on food intake, body weight, anxiety-like
            behaviour and limbic brain activity in female rats.
REFERENCE   5  (bases 1 to 470)
  AUTHORS   Yagi,H., Kageyama,K., Kinoshita,N., Niioka,K., Yamagata,S., Ito,E.
            and Daimon,M.
  TITLE     Relaxin-3 regulates corticotropin-releasing factor gene expression
            in cultured rat hypothalamic 4B cells
  JOURNAL   Neurosci Lett 692, 137-142 (2019)
   PUBMED   30412752
  REMARK    GeneRIF: Study shows that relaxin-3 regulates
            corticotropin-releasing factor gene expression in cultured rat
            hypothalamic 4B cells. Results suggest that the action of relaxin-3
            in cultured hypothalamic 4B cells may be regulated through both
            RXFP1 and RXFP3.
REFERENCE   6  (bases 1 to 470)
  AUTHORS   Tanaka,M., Iijima,N., Miyamoto,Y., Fukusumi,S., Itoh,Y., Ozawa,H.
            and Ibata,Y.
  TITLE     Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond
            to stress
  JOURNAL   Eur J Neurosci 21 (6), 1659-1670 (2005)
   PUBMED   15845093
  REMARK    GeneRIF: Relaxin 3 produced in the nucleus incertus is released
            from nerve endings and is involved in the regulation of the stress
            response.
REFERENCE   7  (bases 1 to 470)
  AUTHORS   Samuel,C.S., Unemori,E.N., Mookerjee,I., Bathgate,R.A.,
            Layfield,S.L., Mak,J., Tregear,G.W. and Du,X.J.
  TITLE     Relaxin modulates cardiac fibroblast proliferation,
            differentiation, and collagen production and reverses cardiac
            fibrosis in vivo
  JOURNAL   Endocrinology 145 (9), 4125-4133 (2004)
   PUBMED   15155573
  REMARK    GeneRIF: relaxin regulates fibroblast proliferation,
            differentiation, and collagen deposition and may have therapeutic
            potential in diseased states characterized by cardiac fibrosis.
REFERENCE   8  (bases 1 to 470)
  AUTHORS   Liu,C., Eriste,E., Sutton,S., Chen,J., Roland,B., Kuei,C.,
            Farmer,N., Jornvall,H., Sillard,R. and Lovenberg,T.W.
  TITLE     Identification of relaxin-3/INSL7 as an endogenous ligand for the
            orphan G-protein-coupled receptor GPCR135
  JOURNAL   J Biol Chem 278 (50), 50754-50764 (2003)
   PUBMED   14522968
  REMARK    GeneRIF: GPCR135 (SALPR) is the receptor for relaxin-3 Rln3 is the
            only member of the insulin/relaxin superfamily that can activate
            GPCR135. In situ hybridization showed that relaxin-3 mRNA is
            predominantly expressed in the dorsomedial ventral tegmental
            nucleus of
REFERENCE   9  (bases 1 to 470)
  AUTHORS   Kizawa,H., Nishi,K., Ishibashi,Y., Harada,M., Asano,T., Ito,Y.,
            Suzuki,N., Hinuma,S., Fujisawa,Y., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Production of recombinant human relaxin 3 in AtT20 cells
  JOURNAL   Regul Pept 113 (1-3), 79-84 (2003)
   PUBMED   12686464
REFERENCE   10 (bases 1 to 470)
  AUTHORS   Burazin,T.C., Bathgate,R.A., Macris,M., Layfield,S., Gundlach,A.L.
            and Tregear,G.W.
  TITLE     Restricted, but abundant, expression of the novel rat gene-3 (R3)
            relaxin in the dorsal tegmental region of brain
  JOURNAL   J Neurochem 82 (6), 1553-1557 (2002)
   PUBMED   12354304
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB076564.1.
            
            On Jun 10, 2007 this sequence version replaced NM_170667.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076564.1, AY112741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..470
                     /gene="Rln3"
                     /gene_synonym="Insl7"
                     /note="relaxin 3"
                     /db_xref="GeneID:266997"
                     /db_xref="RGD:628745"
     exon            1..207
                     /gene="Rln3"
                     /gene_synonym="Insl7"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..446
                     /gene="Rln3"
                     /gene_synonym="Insl7"
                     /note="prorelaxin R3; insulin-like peptide 7; insulin-like
                     peptide INSL7; insulin-like 7"
                     /codon_start=1
                     /product="relaxin-3 precursor"
                     /protein_id="NP_733767.1"
                     /db_xref="GeneID:266997"
                     /db_xref="RGD:628745"
                     /translation="MATRGLLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFT
                     CGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVGSSEWLALTKSPQVFYGGR
                     SSWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC"
     exon            208..470
                     /gene="Rln3"
                     /gene_synonym="Insl7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgcaggc atctcagctg atcatggcaa ctcgggggct gctgctggct tcctgggctc
       61 tcctcggggc tctggtgctg caggccgagg cgaggcccgc gccctatggg gtgaagctct
      121 gcggtcggga gttcatccgc gcggtcatct tcacctgcgg gggctcacga tggcgccggg
      181 cggacatctt ggcccacgac cctctggggg aattcttcgc tgatggagaa gccaatacag
      241 accacctggc cagcgaactg gacgaagctg tgggctccag cgagtggctg gccctgacca
      301 aatcccccca ggtcttctat gggggtcgat ccagctggca agggtctccc ggagtggttc
      361 ggggcagcag agatgtgctg gctggccttt ccagcagctg ttgcgagtgg ggctgtagta
      421 agagccaaat tagcagcttg tgctaggatc tgggctgagc gattgggaag
//
