LOCUS       NM_013413                796 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus relaxin 1 (Rln1), mRNA.
ACCESSION   NM_013413
VERSION     NM_013413.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 796)
  AUTHORS   Martin,B., Gabris,B., Barakat,A.F., Henry,B.L., Giannini,M.,
            Reddy,R.P., Wang,X., Romero,G. and Salama,G.
  TITLE     Relaxin reverses maladaptive remodeling of the aged heart through
            Wnt-signaling
  JOURNAL   Sci Rep 9 (1), 18545 (2019)
   PUBMED   31811156
  REMARK    GeneRIF: Relaxin reverses maladaptive remodeling of the aged heart
            through Wnt-signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 796)
  AUTHORS   Zhang,X., Pan,L., Yang,K., Fu,Y., Liu,Y., Chen,W., Ma,X. and Yin,X.
  TITLE     Alterations of relaxin and its receptor system components in
            experimental diabetic cardiomyopathy rats
  JOURNAL   Cell Tissue Res 370 (2), 297-304 (2017)
   PUBMED   28776188
  REMARK    GeneRIF: Relaxin-1 mRNA in the hearts of diabetic rats was
            significantly increased and that relaxin-3 mRNA expression at
            different time points was decreased. In addition, significant
            down-regulation of the mRNA expression of RXFP1 and RXFP3 was
            observed at 4 weeks after Streptozocin.
REFERENCE   3  (bases 1 to 796)
  AUTHORS   Garella,R., Squecco,R. and Baccari,M.C.
  TITLE     Site-related Effects of Relaxin in the Gastrointestinal Tract
            Through Nitric Oxide Signalling: An Updated Report
  JOURNAL   Curr Protein Pept Sci 18 (12), 1254-1262 (2017)
   PUBMED   28606038
  REMARK    GeneRIF: The digestive tract has been shown to express relaxin
            receptors; the hormone appears to exert site-specific effects
            acting at the neural or at the smooth muscle level, mainly by a
            nitric oxide-mediated mechanism. (Review)
            Review article
REFERENCE   4  (bases 1 to 796)
  AUTHORS   Pimenta,M.T., Porto,C.S. and Lazari,M.F.
  TITLE     Effects of relaxin in a co-culture of Sertoli and germ cells
  JOURNAL   Ital J Anat Embryol 118 (1 Suppl), 29-31 (2013)
   PUBMED   24640566
  REMARK    GeneRIF: The aim of the present study was to explore a role of
            relaxin at specific stages of spermatogenesis using a co-culture of
            rat Sertoli and germ cells.
REFERENCE   5  (bases 1 to 796)
  AUTHORS   Nascimento,A.R., Pimenta,M.T., Lucas,T.F., Porto,C.S. and
            Lazari,M.F.
  TITLE     Relaxin and Sertoli cell proliferation
  JOURNAL   Ital J Anat Embryol 118 (1 Suppl), 26-28 (2013)
   PUBMED   24640565
  REMARK    GeneRIF: We have shown that relaxin stimulates Sertoli cell
            proliferation through the activation of MEK/ERK1/2 and PI3K/AKT
            pathways.
REFERENCE   6  (bases 1 to 796)
  AUTHORS   Zhao,L., Roche,P.J., Gunnersen,J.M., Hammond,V.E., Tregear,G.W.,
            Wintour,E.M. and Beck,F.
  TITLE     Mice without a functional relaxin gene are unable to deliver milk
            to their pups
  JOURNAL   Endocrinology 140 (1), 445-453 (1999)
   PUBMED   9886856
REFERENCE   7  (bases 1 to 796)
  AUTHORS   Bullesbach,E.E. and Schwabe,C.
  TITLE     Mouse relaxin: synthesis and biological activity of the first
            relaxin with an unusual crosslinking pattern
  JOURNAL   Biochem Biophys Res Commun 196 (1), 311-319 (1993)
   PUBMED   8216305
REFERENCE   8  (bases 1 to 796)
  AUTHORS   Niall,H., Hudson,P., Haley,J., Cronk,M. and Shine,J.
  TITLE     Rat preprorelaxin: complete amino acid sequence derived from cDNA
            analysis
  JOURNAL   Ann N Y Acad Sci 380, 13-21 (1982)
   PUBMED   7044231
REFERENCE   9  (bases 1 to 796)
  AUTHORS   Hudson,P., Haley,J., Cronk,M., Shine,J. and Niall,H.
  TITLE     Molecular cloning and characterization of cDNA sequences coding for
            rat relaxin
  JOURNAL   Nature 291 (5811), 127-131 (1981)
   PUBMED   7231533
REFERENCE   10 (bases 1 to 796)
  AUTHORS   John,M.J., Borjesson,B.W., Walsh,J.R. and Niall,H.D.
  TITLE     Limited sequence homology between porcine and rat relaxins:
            implications for physiological studies
  JOURNAL   Endocrinology 108 (2), 726-729 (1981)
   PUBMED   7004862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013413.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J00780.1, V01264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000001.1  236496187-236496440 c
            255-796             JAXUCZ010000001.1  236493536-236494077 c
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..796
                     /gene="Rln1"
                     /gene_synonym="RELAX"
                     /note="relaxin 1"
                     /db_xref="GeneID:25616"
                     /db_xref="RGD:3579"
     exon            1..254
                     /gene="Rln1"
                     /gene_synonym="RELAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..604
                     /gene="Rln1"
                     /gene_synonym="RELAX"
                     /note="prorelaxin 1; preprorelaxin; Relaxin 1 (H1)"
                     /codon_start=1
                     /product="prorelaxin 1 precursor"
                     /protein_id="NP_038199.1"
                     /db_xref="GeneID:25616"
                     /db_xref="RGD:3579"
                     /translation="MSSRLLLQLLGFWLFLSQPCRARVSEEWMDQVIQVCGRGYARAW
                     IEVCGASVGRLALSQEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAA
                     LSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSDAQSRK
                     KRQSGALLSEQCCHIGCTRRSIAKLC"
     exon            255..796
                     /gene="Rln1"
                     /gene_synonym="RELAX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaaccgcc caggagcacc gcccaggagc agcccagacc ggaatgtcca gcagactctt
       61 gctccagctc ctggggttct ggctgttcct gagccagcct tgcagggcgc gagtctcgga
      121 ggagtggatg gaccaagtca ttcaggtgtg cggccgtgga tatgcccgcg catggatcga
      181 agtctgcggg gcctccgtgg gaagactggc tttgagccag gaggagccag ctccgctagc
      241 caggcaagcc actgcagaag ttgtgccatc cttcatcaac aaagatgcgg agcctttcga
      301 tatgacgttg aaatgccttc caaatttgtc tgaggagcgg aaggcagcac tgtctgaggg
      361 gcgagcaccg ttcccagagc tacaacaaca cgcacccgcg ttgagcgatt ccgttgttag
      421 cttggaagga tttaagaaaa ctttccacaa tcagctgggt gaagcagaag atggcggtcc
      481 tccagagctc aaatacttag gctcagatgc tcagtcacgg aaaaagaggc agtctggcgc
      541 actgctcagt gagcagtgtt gccacatcgg ttgtaccaga agatccattg ctaaactctg
      601 ctgatacgga gctaatggtg cgcaacccgg gcagtgtccg ggtgcgttct tgctacctgg
      661 ctaatgcctc tttctgtccc cttttcttat ttattaggat ctgagaaacc ataattcaca
      721 cttggatttg tcctttgata agagagaaat gttctctgca ttgttgtagt tctgttaata
      781 atatttttat gcaaaa
//
