LOCUS       NM_001024892            2156 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ring finger protein, LIM domain interacting
            (Rlim), mRNA.
ACCESSION   NM_001024892 XM_228541
VERSION     NM_001024892.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Magaraki A, Loda A, Gontan C, Merzouk S, Sleddens-Linkels E, Meek
            S, Baarends WM, Burdon T and Gribnau J.
  TITLE     A novel approach to differentiate rat embryonic stem cells in vitro
            reveals a role for RNF12 in activation of X chromosome inactivation
  JOURNAL   Sci Rep 9 (1), 6068 (2019)
   PUBMED   30988473
  REMARK    GeneRIF: A novel approach to differentiate rat embryonic stem cells
            in vitro reveals a role for RNF12 in activation of X chromosome
            inactivation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Barakat TS, Loos F, van Staveren S, Myronova E, Ghazvini M,
            Grootegoed JA and Gribnau J.
  TITLE     The trans-activator RNF12 and cis-acting elements effectuate X
            chromosome inactivation independent of X-pairing
  JOURNAL   Mol Cell 53 (6), 965-978 (2014)
   PUBMED   24613346
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Jonkers I, Barakat TS, Achame EM, Monkhorst K, Kenter A,
            Rentmeester E, Grosveld F, Grootegoed JA and Gribnau J.
  TITLE     RNF12 is an X-Encoded dose-dependent activator of X chromosome
            inactivation
  JOURNAL   Cell 139 (5), 999-1011 (2009)
   PUBMED   19945382
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Tursun B, Schluter A, Peters MA, Viehweger B, Ostendorff HP,
            Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard
            O and Bach I.
  TITLE     The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in
            axonal growth cones
  JOURNAL   Genes Dev 19 (19), 2307-2319 (2005)
   PUBMED   16204183
  REMARK    Erratum:[Genes Dev. 2005 Nov 1;19(21):2643]
REFERENCE   6  (bases 1 to 2156)
  AUTHORS   Ostendorff HP, Peirano RI, Peters MA, Schluter A, Bossenz M,
            Scheffner M and Bach I.
  TITLE     Ubiquitination-dependent cofactor exchange on LIM homeodomain
            transcription factors
  JOURNAL   Nature 416 (6876), 99-103 (2002)
   PUBMED   11882901
REFERENCE   7  (bases 1 to 2156)
  AUTHORS   Bach I, Rodriguez-Esteban C, Carriere C, Bhushan A, Krones A, Rose
            DW, Glass CK, Andersen B, Izpisua Belmonte JC and Rosenfeld MG.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097491.1.
            
            On Jun 17, 2005 this sequence version replaced XM_228541.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097491.1, CV120062.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2156
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /note="ring finger protein, LIM domain interacting"
                     /db_xref="GeneID:317241"
                     /db_xref="RGD:1559832"
     exon            1..121
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            122..184
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            185..373
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2019
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 12; ring finger protein, LIM
                     domain interacting-like 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RLIM"
                     /protein_id="NP_001020063.1"
                     /db_xref="GeneID:317241"
                     /db_xref="RGD:1559832"
                     /translation="MENSDSNDKGSDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYR
                     LMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQSSDENRAGESSDDVSNSDSIIDWLN
                     SVRQSGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQTSENENEPSTR
                     RLSVESMESSSQRQMESHASESTSARPSRAERNSTEALEVPLTRGQRRARSRSPEHRR
                     TRARAERSRSPLHPTIEIPRRAHHNISPQTLEQPLENEPEGSSRTRHHVTLRQQISGP
                     ELLGRGLFAASGSRNPSQGTSSSDTGSNSESSGSGQRPPTIVLDLQVRRVRPGEYRQR
                     DSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGL
                     SETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPSASVSSRNTERAESRNGRGSSGAG
                     NSSASSSSPSPSSNGESSESSSDLFEGTSEGGPSGPSRRDGRHRAPVAFDESGSLPFL
                     SLAQFFLLNEDDEDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLP
                     CSHEYHVHCIDRWLSENSTCPICRRAVLSSGNRESVV"
     exon            374..457
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            458..2131
                     /gene="Rlim"
                     /gene_synonym="Rliml1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagaggcgg gtctctttgc caggttttag aggcgggcga gagcgcggcg gcggcggcgg
       61 tgcggcggag ccccggtagc ggcggcgagc ccagtgagtc cactcctggc cgaaacatcg
      121 aagcggagtg aagaaaacta aaatccagtt tgttggattt tcagtactat gtcataaaag
      181 acagataatt tccacttgtt catcaagatg gagaactcag actctaacga taaaggaagt
      241 gaccagtctg cagctcagcg cagaagccag atggatcgat tggataggga agaggctttc
      301 tatcagtttg taaataatct cagtgaagaa gattatagac ttatgagaga caacaatttg
      361 ctgggcaccc caggcgaaag tactgaggaa gagttgctca gaagactaca gcaaattaaa
      421 gagggtccac caccacagag ctctgatgaa aatagagctg gagagtcttc agatgatgtg
      481 tccaacagtg attctataat agattggctt aattctgtca gacaaagtgg aaatacaaca
      541 agaagtggtc agagaggaaa ccagtcctgg agggcagtga gccggactaa tccaaacagc
      601 ggtgatttca gattcagttt agagataaat gttaaccgta ataatggaag ccaaacctca
      661 gagaatgaaa atgaaccatc cactaggcgt cttagtgtag aaagcatgga aagcagcagc
      721 caaaggcaaa tggaaagtca tgcatctgaa tcaacatctg ccagaccatc tagagcagaa
      781 cgcaattcaa ctgaagcatt agaagtgcca ttgaccaggg gtcagaggag ggcaagaagc
      841 cggagcccag aacatcggag aaccagagca agagctgaaa gaagtaggtc acctctgcat
      901 ccaacaattg aaattccacg aagagctcac cataatatct cacctcagac cttggagcag
      961 cctttggaaa atgagcctga agggagttct agaacccggc accacgtgac tctgagacag
     1021 cagatatctg gaccggagtt gttaggtaga ggtctttttg cagcttctgg atcaagaaat
     1081 ccctctcagg ggacaagttc ttcagacaca ggtagcaata gtgaatcatc aggatccggt
     1141 caaagacctc caaccatagt tcttgatctt caagtaagaa gagttcgtcc aggagaatac
     1201 cgccagagag atagtatagc tagtagaact cgatcaagat ctcagacgcc aaacaacaca
     1261 gttacttatg aaagtgaacg tggaggtttt agacgtacct tttcccgttc tgaacgtgcc
     1321 ggtgtgagaa cctatgtcag cactatcagg attcctattc gtagaatctt aaatactgga
     1381 ttaagtgaaa ctacatctgt ggcaattcaa accatgttaa ggcagataat gacaggtttt
     1441 ggtgagctaa gctactttat gtacagtgac agtgattcag agcctagtgc ctcagtttcc
     1501 agccgaaata cagagagagc agaatcacgg aatggaagag ggagctccgg tgctggtaac
     1561 agctctgctt ccagctcaag ccctagccct agttcaaatg gtgaaagttc agaaagtagc
     1621 tcagatctgt tcgaaggcac tagtgaagga ggcccatctg gcccatccag gagagatggt
     1681 cgacataggg ctccagtcgc atttgatgaa agtggctctc tgccattcct tagtctggct
     1741 cagttttttc ttttaaatga ggatgatgaa gaccaaccta gaggactcac caaagaacag
     1801 atcgataact tggcaatgag aagctttggt gaaaacgacg cattgaaaac atgtagcgtt
     1861 tgcattacag aatatacaga aggcaacaaa ctccgtaaac taccttgctc ccatgagtac
     1921 catgtccact gcatcgaccg ctggttgtca gagaattcca cctgtcccat ctgtcgcagg
     1981 gctgtcttat cttctgggaa cagagagagc gttgtgtaat gaggacagaa ctctcagctg
     2041 tgtagctgga atagtgatgg gcaaacagaa atcacctgct ttatgtccac tttttttgag
     2101 tggtgcttaa aatataaagt cacaacctga aaaaaaaaaa aaaaaaaaaa aaaaaa
//
