LOCUS       NM_001013060            1930 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus Ras-like without CAAX 2 (Rit2), mRNA.
ACCESSION   NM_001013060 XM_214590
VERSION     NM_001013060.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Ren,Y.S., Li,H.H., Yao,J.C., Tan,Y.J., Pan,L.H., Peng,T.,
            Zhao,L.L., Zhang,G.M., Yue,J., Hu,X.M., Liu,Z. and Li,J.
  TITLE     Application quantitative proteomics approach to identify
            differentially expressed proteins associated with cardiac
            protection mediated by cycloastragenol in acute myocardial
            infarction rats
  JOURNAL   J Proteomics 222, 103691 (2020)
   PUBMED   32068187
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   Zhang,L., Wahlin,K., Li,Y., Masuda,T., Yang,Z., Zack,D.J. and
            Esumi,N.
  TITLE     RIT2, a neuron-specific small guanosine triphosphatase, is
            expressed in retinal neuronal cells and its promoter is modulated
            by the POU4 transcription factors
  JOURNAL   Mol Vis 19, 1371-1386 (2013)
   PUBMED   23805044
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Navaroli,D.M., Stevens,Z.H., Uzelac,Z., Gabriel,L., King,M.J.,
            Lifshitz,L.M., Sitte,H.H. and Melikian,H.E.
  TITLE     The plasma membrane-associated GTPase Rin interacts with the
            dopamine transporter and is required for protein kinase C-regulated
            dopamine transporter trafficking
  JOURNAL   J Neurosci 31 (39), 13758-13770 (2011)
   PUBMED   21957239
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Shi,G.X., Jin,L. and Andres,D.A.
  TITLE     Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin
            activation requires Src and contributes to the regulation of HSP27
            signaling during neuronal differentiation
  JOURNAL   Mol Cell Biol 28 (16), 4940-4951 (2008)
   PUBMED   18541665
  REMARK    GeneRIF: These observations identify an unsuspected role for Rin in
            neuronal PACAP signaling and establish a novel Galpha-Src-Rin-HSP27
            signal transduction pathway as a critical element in
            PACAP38-mediated neuronal differentiation signaling.
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Lein,P.J., Guo,X., Shi,G.X., Moholt-Siebert,M., Bruun,D. and
            Andres,D.A.
  TITLE     The novel GTPase Rit differentially regulates axonal and dendritic
            growth
  JOURNAL   J Neurosci 27 (17), 4725-4736 (2007)
   PUBMED   17460085
  REMARK    GeneRIF: Rit is a convergence point for multiple signaling pathways
            and it functions to promote axonal growth but inhibit dendritic
            growth via activation of ERK1/2
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Shi,G.X., Han,J. and Andres,D.A.
  TITLE     Rin GTPase couples nerve growth factor signaling to p38 and
            b-Raf/ERK pathways to promote neuronal differentiation
  JOURNAL   J Biol Chem 280 (45), 37599-37609 (2005)
   PUBMED   16157584
  REMARK    GeneRIF: observations establish Rin as a neuronal specific
            regulator of neurotrophin signaling, required to couple NGF
            stimulation to sustain activation of p38 MAP kinase and b-Raf
            signaling cascades required for neuronal development [rin]
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Spencer,M.L., Shao,H., Tucker,H.M. and Andres,D.A.
  TITLE     Nerve growth factor-dependent activation of the small GTPase Rin
  JOURNAL   J Biol Chem 277 (20), 17605-17615 (2002)
   PUBMED   11877426
REFERENCE   8  (bases 1 to 1930)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
REFERENCE   9  (bases 1 to 1930)
  AUTHORS   Wes,P.D., Yu,M. and Montell,C.
  TITLE     RIC, a calmodulin-binding Ras-like GTPase
  JOURNAL   EMBO J 15 (21), 5839-5848 (1996)
   PUBMED   8918462
REFERENCE   10 (bases 1 to 1930)
  AUTHORS   Lee,C.H., Della,N.G., Chew,C.E. and Zack,D.J.
  TITLE     Rin, a neuron-specific and calmodulin-binding small G-protein, and
            Rit define a novel subfamily of ras proteins
  JOURNAL   J Neurosci 16 (21), 6784-6794 (1996)
   PUBMED   8824319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091382.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214590.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091382.1, FQ213009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840127
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1930
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /note="Ras-like without CAAX 2"
                     /db_xref="GeneID:291713"
                     /db_xref="RGD:1307654"
     exon            1..412
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..963
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /EC_number="3.6.5.2"
                     /note="Ras-like without CAAX 1"
                     /codon_start=1
                     /product="GTP-binding protein Rit2"
                     /protein_id="NP_001013078.1"
                     /db_xref="GeneID:291713"
                     /db_xref="RGD:1307654"
                     /translation="MEAENEAHCCPGSSSGGSREYKVVMLGAGGVGKSAVTMQFISHQ
                     FPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVT
                     DRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGMTLARDYNCAFF
                     ETSAALRFGIDDAFQGLVREIRRKESMLSLVERKLKRKDSLWKKIKASLKKKRENMI"
     exon            413..469
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..543
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..735
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1900
                     /gene="Rit2"
                     /gene_synonym="Rin; Rit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaatggaga aataaaacgc agagggaagg ggaaaaaatc agaatgagca agtgagatca
       61 gtggagatgt gaaacagtga aggatcagag ggagggggag gcaaagccag atttttattg
      121 gaagcaattg aagtggttgc tatgagaccc gctccagcag aggaccagca ggcagcctgt
      181 cgctgatggt tcttgtcgtg caccaaagct ttcctttgac acagttttag agttgtttac
      241 tgtctgagca agcacctgac acggtgactt ttttcttcct ttttttcctc ctcgggtccc
      301 ccgagaaaaa tggaagcaga aaacgaagcc cactgctgcc ctggcagctc atcaggcggg
      361 tccagagagt acaaggtggt aatgctgggc gcagggggcg ttggtaaaag cgcagtcaca
      421 atgcagttta taagccacca gttcccggac tatcatgacc ccacaatcga agatgcttat
      481 aaaacccagg tgaggattga caacgagcct gcttacttag acatcttgga cactgccggt
      541 caggcagagt tcacagccat gagggagcag tacatgcgtg ggggagaggg cttcatcatc
      601 tgctattctg tcactgaccg ccagtcattc caggaggctg ccaagttcaa ggagctgatt
      661 ttccaggtcc gtcacaccta tgaaattccc ctcgtgctag tgggtaacaa gattgacttg
      721 gagcagttcc gtcaggtttc tacagaagaa ggcatgactc ttgctcgaga ctacaactgt
      781 gccttctttg agacctctgc agcccttcga ttcggtattg atgatgcttt tcaaggctta
      841 gtgagagaaa tacgcaggaa ggaatccatg ctgtccttgg tggaaaggaa attaaagagg
      901 aaggacagcc tgtggaagaa gataaaagcc tcgctgaaga agaagcgaga aaacatgata
      961 tgaggccttg cttctgcatc cttcgtgtct gtctttgtgg gctttatcat ccagacaact
     1021 gttcatatct ccatcttctc tctctaccca cctctccctg tctttctgtc tgtctgtctc
     1081 tcaacatcta actgcaggca gaaattagac ttctttaact gtatgtcttg aggtagtttt
     1141 attttgcctt taacagctgg gtagattttg tcaatcagct ggatagtgct ttacagattt
     1201 cacaatatat taccaaataa aattaacatt ccaattgcct cattttcctg taaagagtag
     1261 cttcattttg tatgctgtct ggctataaag aaaatatgca aacttgtaac tgggatgata
     1321 aaaggcttag gggatctgct ttcgcctgat aaccctggtt gtttgcattt cacaaatctg
     1381 taaataatga agaggctgaa atagtttaaa ggaaaaaaga aaacagtcct gtgtcttctc
     1441 ttaagtggaa gagtcttgct atttcttctc gagtcctcta cagatgagca ttagagaaat
     1501 tattgataat aagaacttag tttgtgttgt aacaaaaatt acgtgtccat attcacagtg
     1561 cgcagccttt catacacttc tatagaagta tcacagtgga gttactgtgc tgaaagtatg
     1621 ttatctgttg tagagagaag caatgctatg aacttggtgg tatgtatgcc caagaaagga
     1681 ccctttgccc ctctctgtga atctttctta gaattgcttc acctgcacag tggccgtctg
     1741 tctgcaggga tgcggcctcc acatactaaa tgttctcttt atattagtaa attccctgtc
     1801 tctatttcaa tgaagtatta caagaagctg acatcagaga tgttgttgtt atttgtctta
     1861 taatggttca ttgtgtaaaa taaaacctct cgttcagcca aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa
//
