LOCUS       NM_001396548            3374 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Ras-like without CAAX 1 (Rit1), transcript
            variant 3, mRNA.
ACCESSION   NM_001396548 NM_001109185 XM_039102890
VERSION     NM_001396548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3374)
  AUTHORS   Song,Z., Liu,T., Chen,J., Ge,C., Zhao,F., Zhu,M., Chen,T., Cui,Y.,
            Tian,H., Yao,M., Li,J. and Li,H.
  TITLE     HIF-1alpha-induced RIT1 promotes liver cancer growth and metastasis
            and its deficiency increases sensitivity to sorafenib
  JOURNAL   Cancer Lett 460, 96-107 (2019)
   PUBMED   31247273
REFERENCE   2  (bases 1 to 3374)
  AUTHORS   Takahara,S., Inoue,S.I., Miyagawa-Tomita,S., Matsuura,K.,
            Nakashima,Y., Niihori,T., Matsubara,Y., Saiki,Y. and Aoki,Y.
  TITLE     New Noonan syndrome model mice with RIT1 mutation exhibit cardiac
            hypertrophy and susceptibility to beta-adrenergic
            stimulation-induced cardiac fibrosis
  JOURNAL   EBioMedicine 42, 43-53 (2019)
   PUBMED   30898653
REFERENCE   3  (bases 1 to 3374)
  AUTHORS   Castel,P., Cheng,A., Cuevas-Navarro,A., Everman,D.B.,
            Papageorge,A.G., Simanshu,D.K., Tankka,A., Galeas,J., Urisman,A.
            and McCormick,F.
  TITLE     RIT1 oncoproteins escape LZTR1-mediated proteolysis
  JOURNAL   Science 363 (6432), 1226-1230 (2019)
   PUBMED   30872527
REFERENCE   4  (bases 1 to 3374)
  AUTHORS   Feng,Y.F., Lei,Y.Y., Lu,J.B., Xi,S.Y., Zhang,Y., Huang,Q.T.,
            Wu,Q.L. and Wang,F.
  TITLE     RIT1 suppresses esophageal squamous cell carcinoma growth and
            metastasis and predicts good prognosis
  JOURNAL   Cell Death Dis 9 (11), 1085 (2018)
   PUBMED   30348939
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3374)
  AUTHORS   Cave,H., Caye,A., Ghedira,N., Capri,Y., Pouvreau,N., Fillot,N.,
            Trimouille,A., Vignal,C., Fenneteau,O., Alembik,Y.,
            Alessandri,J.L., Blanchet,P., Boute,O., Bouvagnet,P., David,A.,
            Dieux Coeslier,A., Doray,B., Dulac,O., Drouin-Garraud,V.,
            Gerard,M., Heron,D., Isidor,B., Lacombe,D., Lyonnet,S., Perrin,L.,
            Rio,M., Roume,J., Sauvion,S., Toutain,A., Vincent-Delorme,C.,
            Willems,M., Baumann,C. and Verloes,A.
  TITLE     Mutations in RIT1 cause Noonan syndrome with possible juvenile
            myelomonocytic leukemia but are not involved in acute lymphoblastic
            leukemia
  JOURNAL   Eur J Hum Genet 24 (8), 1124-1131 (2016)
   PUBMED   26757980
REFERENCE   6  (bases 1 to 3374)
  AUTHORS   Yaoita,M., Niihori,T., Mizuno,S., Okamoto,N., Hayashi,S.,
            Watanabe,A., Yokozawa,M., Suzumura,H., Nakahara,A., Nakano,Y.,
            Hokosaki,T., Ohmori,A., Sawada,H., Migita,O., Mima,A.,
            Lapunzina,P., Santos-Simarro,F., Garcia-Minaur,S., Ogata,T.,
            Kawame,H., Kurosawa,K., Ohashi,H., Inoue,S., Matsubara,Y., Kure,S.
            and Aoki,Y.
  TITLE     Spectrum of mutations and genotype-phenotype analysis in Noonan
            syndrome patients with RIT1 mutations
  JOURNAL   Hum Genet 135 (2), 209-222 (2016)
   PUBMED   26714497
REFERENCE   7  (bases 1 to 3374)
  AUTHORS   Chen,P.C., Yin,J., Yu,H.W., Yuan,T., Fernandez,M., Yung,C.K.,
            Trinh,Q.M., Peltekova,V.D., Reid,J.G., Tworog-Dube,E., Morgan,M.B.,
            Muzny,D.M., Stein,L., McPherson,J.D., Roberts,A.E., Gibbs,R.A.,
            Neel,B.G. and Kucherlapati,R.
  TITLE     Next-generation sequencing identifies rare variants associated with
            Noonan syndrome
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11473-11478 (2014)
   PUBMED   25049390
REFERENCE   8  (bases 1 to 3374)
  AUTHORS   Aoki,Y., Niihori,T., Banjo,T., Okamoto,N., Mizuno,S., Kurosawa,K.,
            Ogata,T., Takada,F., Yano,M., Ando,T., Hoshika,T., Barnett,C.,
            Ohashi,H., Kawame,H., Hasegawa,T., Okutani,T., Nagashima,T.,
            Hasegawa,S., Funayama,R., Nagashima,T., Nakayama,K., Inoue,S.,
            Watanabe,Y., Ogura,T. and Matsubara,Y.
  TITLE     Gain-of-function mutations in RIT1 cause Noonan syndrome, a
            RAS/MAPK pathway syndrome
  JOURNAL   Am J Hum Genet 93 (1), 173-180 (2013)
   PUBMED   23791108
REFERENCE   9  (bases 1 to 3374)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
REFERENCE   10 (bases 1 to 3374)
  AUTHORS   Lee,C.H., Della,N.G., Chew,C.E. and Zack,D.J.
  TITLE     Rin, a neuron-specific and calmodulin-binding small G-protein, and
            Rit define a novel subfamily of ras proteins
  JOURNAL   J Neurosci 16 (21), 6784-6794 (1996)
   PUBMED   8824319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 20, 2021 this sequence version replaced
            NM_001109185.1, XM_039102890.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.148712.1,
                                           SRR26360176.1085812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000002.1  176478616-176478718
            104-248             JAXUCZ010000002.1  176479074-176479218
            249-305             JAXUCZ010000002.1  176479354-176479410
            306-379             JAXUCZ010000002.1  176487527-176487600
            380-571             JAXUCZ010000002.1  176487813-176488004
            572-3374            JAXUCZ010000002.1  176490467-176493269
FEATURES             Location/Qualifiers
     source          1..3374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3374
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /note="Ras-like without CAAX 1"
                     /db_xref="GeneID:499652"
                     /db_xref="RGD:1559874"
     exon            1..103
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
     exon            104..248
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..802
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     GTP-binding protein Rit1"
                     /codon_start=1
                     /product="GTP-binding protein Rit1 isoform 1"
                     /protein_id="NP_001383477.1"
                     /db_xref="GeneID:499652"
                     /db_xref="RGD:1559874"
                     /translation="MESGARPVGSSCSSPAALSREYKLVMLGAGGVGKSAMTMQFISH
                     RFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSI
                     TDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVSKEEGLSLAREFNCPF
                     FETSAAYRYYIDDVFHALVREIRKKEKELVLAMEKKAKPKSSVWKRLKSPFRRKKDSV
                     T"
     exon            249..305
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
     exon            306..379
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
     exon            380..571
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
     exon            572..3374
                     /gene="Rit1"
                     /gene_synonym="RGD1559874"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccaccgg cgccatcttc caggacccgg gcggggccct gggctgtggg gcgcagctgg
       61 gaacgaacgc gggttacagc ccggatcgga actcgtttca gaggaggcct ttcccagggg
      121 cccaggactg cccaagagga caatggagtc tggagctcgc ccagttggta gcagctgtag
      181 cagccctgca gcactctcaa gggaatacaa actagtgatg ctgggtgccg gtggagttgg
      241 gaagagtgcc atgacaatgc agttcatcag ccaccgattc ccagaagatc atgaccccac
      301 cattgaagat gcctataaga tccggatccg cattgacgac gaacccgcca atctggacat
      361 cctggacaca gcaggacagg cagagtttac agccatgcgg gatcagtata tgagagcagg
      421 agaaggattt atcatttgtt actccatcac ggatcgtcga agtttccatg aagttcggga
      481 gtttaaacaa ctgatttacc gagtccgccg caccgatgac acaccggtgg ttcttgtggg
      541 aaacaagtct gacctaaagc agctgaggca ggtctccaag gaagagggat tgtctctggc
      601 tcgagaattc aattgtccct tttttgagac ctctgctgcc tatcgttact acattgatga
      661 cgttttccat gctctcgtac gggagattcg taagaaagaa aaggagttag tactggccat
      721 ggagaaaaag gctaagccca aaagcagcgt gtggaagagg ctgaagtcac cgttcaggag
      781 gaagaaggac tcagtgacct gagtgaagtg ggcagcagcg ctgtgagctg cagtgctccc
      841 ccacgcagtc agtactctgc actagtgagc atgctgtttg ctctcctgct atgtgcttat
      901 tctaaatgcc actggcgagg ggacttgcct actgggagtt gtcactgact tactgtctaa
      961 agccctgtgc taggtgactc tgactcatga actcatcagg gcactgtcca ctccttagtt
     1021 gtcacattag aatttggttg gccattgttt tggttatgtt gctgatgtaa atttattcgt
     1081 gtaaattgtt tatacccagg agagtatgtg aaccgtgtgc acttgactga gtttacaaag
     1141 gaactctgtg ttgtattctt cccaccaccc ttcaacttga gcctcctggt accgtctcac
     1201 agaagaacct ctgccttgtt tagccacact gtgcatccta gagacagcaa aggttgagga
     1261 gcgaaactgg cactaaaggt gagtaggtgt ctgctgagtg gactcctgtc atggactgtg
     1321 gagtgccgag gtttaagctc acacaagaag acgaggccag aaacatgcag ggtcagaaca
     1381 gtgctcctac agtgagcgag agaagtgcac atttgaccct gctgctcagg tggtaaggag
     1441 acaggagcac atttctccct ggacatgctt ggttccccct tccctctctg ccctctttac
     1501 ctgggcaacc tgattctggg tctgggacca ctgctaatca ctcaaatctt ctttaaatcc
     1561 ttttttgggc taggcatcac ttctgtactc ctcctaagtc tgaagcagga ggactaccgt
     1621 gagtttaccg tagattacag aatgagagcc tgtctcagaa aaacaaaacc acaagtaaat
     1681 aaaaacaaat tctttcttag gaccatttta ccacagacct tgtccagttt tctatcccct
     1741 ttgaaaaatt aggtaaggcc tgatggtttt taggcctttc actagactga tgttattgtc
     1801 caaacagaag agccatcagg ggctcttcaa acacaaaatt gttgtgttcc cataacctca
     1861 gcagtcctta gatagactcg gggctggaca gtgtgtggtg tctgtccgat ggagcagtct
     1921 tgaagcttta ggactcacat gtgtgaattg gcttcacaat cagaagattt cctcagagta
     1981 gtcagagcag cctcagagaa ctcctgaagc agctccgtac gtgattgaga ctagtcctgc
     2041 acggagcagc ttgaactgtt agtggtcaac tctctgtcat ggggtcagga ttatcttgtg
     2101 gttcgaatgt gctgtgtgtg gcacattcag gagagtcggg gtcacttcag gctcaggtgc
     2161 catgggcagc ccctcttgaa agctgccact caacttcttg ctcctcatta tcagaagaat
     2221 ggcagatctg gatccagatc ccagaaggag tctctgctgg gatttttaaa ttctggttag
     2281 ttgtcttttg aaaagcctgg tacctttttg ctactatgca aattgcattt taatactgaa
     2341 gccatcaaaa aaaaagaaag acccaggagc tagtgagatg gctcaggggt taagagcact
     2401 gactgctctt ccagaggttc tgagttcaat tcccagcaac tacatggtgg ctcacaacca
     2461 tctgtaatgg gatctgaagc cctcttctgg tgtctgaaga cagttacagt gtactcatac
     2521 ataaagacaa taaataattt aaaaaaatga aagacccaag tccaagcctg tgtaacagaa
     2581 gcacttggga gaagcagcaa agtatgaaga aagtgcagca gccatcgctt aacaatatct
     2641 cactgcataa ggactgctag actgaacaat atctcactgc ataaggaccg ccagactgaa
     2701 caatatctca ctgcataagg actgccagac tgaacagtat ctcactgcat aaggactgct
     2761 agactgaaca gtatctcact gcataaggac cgccagactg aacgctttca ctgcccagtt
     2821 ctcccagtct gtgggattgt cagcagtacc aagcactgat agccacagcg attgatggtt
     2881 gtcaagcaat aggaagccac tgctaggaag acctgtaaga aaaggattca ttctgtagga
     2941 ggaaaactgc agtgagtgtt ttaaggctat ccctgtccca cgttggatcc tggacaagct
     3001 agtcccttaa tctgcattga gaattgtatt catggtgctg ggtagcttca agtgcagtgt
     3061 gtgagccgta ggcctcctca gtggtccagt agctaactta caagctttag gtcatcagta
     3121 ttggccaacc tgaaggcatg aaaatcaagt gttccctgga attttgaaga gaagactcag
     3181 gacaagttga aaggcactga acccgtttgt gttgaagcag attagtaatt acaaataatt
     3241 acaattggtg gggagatatg ttttaacctt gatatattaa aaagtattgt gtgtcacctg
     3301 ggaagaagtt cttcactagt ccactcacat atgaagacaa tctgtgcagc ataatacacg
     3361 aggtttaaac acga
//
