LOCUS       NM_001014009            4052 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus RHO family interacting cell polarization
            regulator 2 (Ripor2), mRNA.
ACCESSION   NM_001014009 XM_001053837 XM_001063367 XM_001063486 XM_225319
VERSION     NM_001014009.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4052)
  AUTHORS   Froehlich,J., Versapuech,M., Megrelis,L., Largeteau,Q., Meunier,S.,
            Tanchot,C., Bismuth,G., Delon,J. and Mangeney,M.
  TITLE     FAM65B controls the proliferation of transformed and primary T
            cells
  JOURNAL   Oncotarget 7 (39), 63215-63225 (2016)
   PUBMED   27556504
REFERENCE   2  (bases 1 to 4052)
  AUTHORS   Zhao,B., Wu,Z. and Muller,U.
  TITLE     Murine Fam65b forms ring-like structures at the base of stereocilia
            critical for mechanosensory hair cell function
  JOURNAL   Elife 5, e14222 (2016)
   PUBMED   27269051
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4052)
  AUTHORS   Gao,K., Tang,W., Li,Y., Zhang,P., Wang,D., Yu,L., Wang,C. and Wu,D.
  TITLE     Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at
            leading edges polarizes neutrophils
  JOURNAL   J Cell Sci 128 (5), 992-1000 (2015)
   PUBMED   25588844
REFERENCE   4  (bases 1 to 4052)
  AUTHORS   Diaz-Horta,O., Subasioglu-Uzak,A., Grati,M., DeSmidt,A., Foster,J.
            2nd, Cao,L., Bademci,G., Tokgoz-Yilmaz,S., Duman,D., Cengiz,F.B.,
            Abad,C., Mittal,R., Blanton,S., Liu,X.Z., Farooq,A., Walz,K., Lu,Z.
            and Tekin,M.
  TITLE     FAM65B is a membrane-associated protein of hair cell stereocilia
            required for hearing
  JOURNAL   Proc Natl Acad Sci U S A 111 (27), 9864-9868 (2014)
   PUBMED   24958875
REFERENCE   5  (bases 1 to 4052)
  AUTHORS   Balasubramanian,A., Kawahara,G., Gupta,V.A., Rozkalne,A.,
            Beauvais,A., Kunkel,L.M. and Gussoni,E.
  TITLE     Fam65b is important for formation of the HDAC6-dysferlin protein
            complex during myogenic cell differentiation
  JOURNAL   FASEB J 28 (7), 2955-2969 (2014)
   PUBMED   24687993
REFERENCE   6  (bases 1 to 4052)
  AUTHORS   Rougerie,P., Largeteau,Q., Megrelis,L., Carrette,F., Lejeune,T.,
            Toffali,L., Rossi,B., Zeghouf,M., Cherfils,J., Constantin,G.,
            Laudanna,C., Bismuth,G., Mangeney,M. and Delon,J.
  TITLE     Fam65b is a new transcriptional target of FOXO1 that regulates RhoA
            signaling for T lymphocyte migration
  JOURNAL   J Immunol 190 (2), 748-755 (2013)
   PUBMED   23241886
REFERENCE   7  (bases 1 to 4052)
  AUTHORS   Yoon,S., Molloy,M.J., Wu,M.P., Cowan,D.B. and Gussoni,E.
  TITLE     C6ORF32 is upregulated during muscle cell differentiation and
            induces the formation of cellular filopodia
  JOURNAL   Dev Biol 301 (1), 70-81 (2007)
   PUBMED   17150207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On May 27, 2021 this sequence version replaced NM_001014009.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY325194.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000017.1  40849659-40849714   c
            57-192              JAXUCZ010000017.1  40846797-40846932   c
            193-280             JAXUCZ010000017.1  40841768-40841855   c
            281-432             JAXUCZ010000017.1  40817640-40817791   c
            433-524             JAXUCZ010000017.1  40816074-40816165   c
            525-680             JAXUCZ010000017.1  40815759-40815914   c
            681-759             JAXUCZ010000017.1  40814400-40814478   c
            760-783             JAXUCZ010000017.1  40812790-40812813   c
            784-807             JAXUCZ010000017.1  40812736-40812759   c
            808-957             JAXUCZ010000017.1  40809468-40809617   c
            958-1021            JAXUCZ010000017.1  40806301-40806364   c
            1022-1065           JAXUCZ010000017.1  40798006-40798049   c
            1066-1173           JAXUCZ010000017.1  40796015-40796122   c
            1174-1299           JAXUCZ010000017.1  40795155-40795280   c
            1300-1448           JAXUCZ010000017.1  40794730-40794878   c
            1449-1578           JAXUCZ010000017.1  40793242-40793371   c
            1579-2247           JAXUCZ010000017.1  40786972-40787640   c
            2248-2432           JAXUCZ010000017.1  40782820-40783004   c
            2433-2595           JAXUCZ010000017.1  40779333-40779495   c
            2596-2731           JAXUCZ010000017.1  40776022-40776157   c
            2732-2893           JAXUCZ010000017.1  40774324-40774485   c
            2894-3052           JAXUCZ010000017.1  40772047-40772205   c
            3053-3255           JAXUCZ010000017.1  40768834-40769036   c
            3256-3339           JAXUCZ010000017.1  40767235-40767318   c
            3340-3430           JAXUCZ010000017.1  40765629-40765719   c
            3431-3591           JAXUCZ010000017.1  40752301-40752461   c
            3592-4052           JAXUCZ010000017.1  40751771-40752231   c
FEATURES             Location/Qualifiers
     source          1..4052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..4052
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /note="RHO family interacting cell polarization regulator
                     2"
                     /db_xref="GeneID:306934"
                     /db_xref="RGD:1306939"
     CDS             1..3933
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /note="protein FAM65B; family with sequence similarity 65,
                     member B"
                     /codon_start=1
                     /product="rho family-interacting cell polarization
                     regulator 2"
                     /protein_id="NP_001014031.2"
                     /db_xref="GeneID:306934"
                     /db_xref="RGD:1306939"
                     /translation="MQHCLEQSDITQYQQYYSSWCDARALGPRLSPVALSLLVGRNEH
                     RLSAEPEVHRSQGRCVGVEVPREDINYLSTTCKPEIKSRNLKEDSEDQGRLPTRLPEI
                     MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRQVLGVSPGITRAPSKDVYCKPGYA
                     CRVEFLLCKAFSKQTCNSFIENASALKKPQAKLKKMHNLGHKNTNTPKEPQPKRVEEV
                     YRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKGVLYDLDKVDELYEA
                     YCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCTIEAELESLLGE
                     FSIKMKGLAGFARLCPGDQYESMDGPNPYQRQQGEVYFSLLATRRIGDGSCLSKGARI
                     FMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVT
                     CETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMS
                     MYSQGTPETPTFKDQSFFSNLPDDIFESGNAAEEKRPLSLSFSDLQDGDCVFTSSSTT
                     SPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHSKSDTV
                     EPKKPSVDARSGTESLFLENSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTS
                     AEGPITTNKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKEQYKEFQDLNQE
                     VTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDEVCHVGGGA
                     DSVFSDTETEKSGSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKH
                     LQYCTQLVQQIVFSSKTPFVARSLLEKLSRQVLVLQKLAAVSDENLGNITSVVEAIPE
                     FHKKPSLLSFWTKCCSPSGVYHSSAAHLIKQLEASFARNINKDYPGLAEPVFRTLVSQ
                     ILDRAEPLLCSGLSSEVITVFQYYSFLTSHGVSDLETHLGQLARQVAMVQTLQSLRDE
                     KLLQTMSDLAPSNLPAQQEVLRTLALLLTKDDNEVSEAVTLYLAAASKNEHFREKALL
                     YYCEALTKTNLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLAPY
                     SGSAMTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDPDDVALEGNERGGRA
                     LFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSARTDPHLCDFLESHFL
                     DKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTLKHD"
     exon            1..56
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            57..192
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            193..280
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            281..432
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            433..524
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            525..680
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            681..759
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            760..783
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            784..807
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            808..957
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1021
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1065
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1173
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1299
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1448
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1578
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2247
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2432
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2595
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2731
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2893
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3052
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3255
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3339
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3430
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3591
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..4052
                     /gene="Ripor2"
                     /gene_synonym="Ab2-162; Fam65b; RGD1306939"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaacact gtttggaaca atcagacatc acccagtacc agcaatatta ttcaagctgg
       61 tgcgacgccc gagcgctggg gccacgactg tcacccgtgg ccctttccct gttggttggg
      121 aggaacgagc accggctgtc cgcggagccg gaggtgcacc gcagccaggg gcggtgcgtg
      181 ggtgtcgagg tgccaagaga agacatcaac tacttatcaa caacttgtaa acctgaaatt
      241 aagagcagga acctaaaaga agacagtgag gatcaaggca gactgccaac cagactccca
      301 gaaatcatgc tggtgggatc ccagtccttc tctcctggtg ggcccaatgg catcatccgc
      361 agccagtcct ttgcaggttt tagtgggctg caggaaaggc gatccaggca agtgctgggt
      421 gtttctcctg ggatcacaag agcaccgtca aaagacgtat actgcaagcc aggctatgcc
      481 tgcagagtag agtttctgct ctgcaaagct ttcagcaagc aaacgtgtaa ctccttcatt
      541 gaaaatgcct ctgctctcaa gaagcctcag gccaagctga agaaaatgca taatctagga
      601 cacaaaaata ccaacactcc caaagagcct cagccgaaaa gagtggagga ggtctaccgt
      661 gccttgaaaa acgggcttga tgagtacctg gagtttcacc agaccgagct ggacaaattg
      721 actgctcaat taaaagatat gaaaagaaac tctcgcctgg gtgtgctgta tgacctagac
      781 aagggtgtgc tgtatgacct agacaaggta gatgagctct atgaagccta ttgtatccaa
      841 cggcgtctcc aagatggtgc cagcaaaatg aagcaagcct ttgcgacatc ccctgccagc
      901 aaggctgccc gggagagtct gtctgagatc aaccgcagct acaaggagta cacagagaac
      961 atgtgcacca ttgaagcgga gttggagagt ctgctgggag aattctccat caagatgaaa
     1021 ggtctggctg gctttgcccg cctctgtcct ggagatcaat atgaaagtat ggacggtccc
     1081 aacccttacc agcgtcagca gggggaggtc tatttctctc tgctggctac ccgtagaatt
     1141 ggagatggtt cttgtctctc taaaggagct aggattttca tgaaatatgg ccggcagagg
     1201 tggaaactca agggcaaaat agaagtgaat ggcaaacaga gctgggatgg agaagaaacc
     1261 gtcttcctgc ccctcatagt tgggttcatt tcaatcaagg tcacggaact caaaggactg
     1321 gcaactcaca tcctagtagg cagtgtgacc tgcgagacca aagagctgtt tgcagcccga
     1381 ccccaggtgg tggctgttga catcaatgac cttggtacca tcaaactgaa cctggaaatc
     1441 acctggtatc cctttgacgt ggaggacaca accccatcat caggccctgg gaacaagaca
     1501 gctgctctcc agcggaggat gtccatgtac agccagggta ccccagaaac acccaccttc
     1561 aaagaccagt ccttcttttc aaatctgcca gatgacatct ttgagagtgg aaatgcagca
     1621 gaggagaaaa ggccactgtc tctcagcttc agtgacctgc aagatggaga ctgtgtcttc
     1681 acctccagct caaccacctc tccctccagt tcacactctg cccatccaga gattaccatc
     1741 acccctgctg agcttaccca cagcagcctg tcctcacaaa atgagggcac tgaggacagc
     1801 agctcagcgt cttccaggaa ttccttgggt gaggaccatg agccaaagtc ccactcaaag
     1861 agtgatacgg tagagcccaa gaagcccagt gtggatgcca ggtctggtac tgagagcctt
     1921 tttctagaga atagtgttgc agaggctctc ctgcaggaat cagatgaggc ctctgagctc
     1981 aagcctgtgg aactggacac ttttgaagga aacatcacaa agcaactagt gaagaggctc
     2041 acctcagctg aggggcccat cactaccaac aagcttttct ttgaaggctc tgttggtagt
     2101 gaatctgagg ccggccggtc cttcctcgat ggcagcctgg aagatgcctt caatggactc
     2161 ttccttgcat tagacccaca caaggagcag tacaaagagt tccaggatct gaaccaggaa
     2221 gtcacacatt tggatgatgt cctcaaatgc aagccggctg gcagccgcag caggtcctcc
     2281 agcctaagtc tgacagttga gagtgcttta gaaagctttg atttcctcaa cacctccgac
     2341 tttgatgaag aggaagagga cggtgatgaa gtctgccatg ttggaggagg agcagactcc
     2401 gtgttttcag atactgagac cgagaagagt gggtcagttc acccagaagc caggggccac
     2461 cttagcgaag ctctgactga agacacaggc gttgggacca gtgtggctgg aagcccgctc
     2521 ccactcacca caggaaatga gagcctggat atcaccattg tcaaacattt acaatactgc
     2581 acccagctcg ttcagcaaat cgtcttctct agcaaaaccc cctttgtggc aagaagtctg
     2641 ctggagaagc tgtcgaggca ggtccttgtg ttgcagaagc tggcagcagt gagcgacgag
     2701 aacctcggga acatcacctc tgtggtagaa gccataccag aattccataa aaagccatcc
     2761 ttgctgtcct tctggaccaa gtgctgcagc ccctcggggg tctaccacag ctctgctgcc
     2821 cacctgatca agcagctgga ggccagcttt gccagaaaca tcaacaaaga ctatccaggg
     2881 ctggcagagc cagtgtttag aaccctggtg tcccaaatcc tggaccgcgc tgaacctctc
     2941 ctttgctccg gcctctcctc ggaagtcatc actgtcttcc agtattacag tttcttgacc
     3001 agccacggtg tgagtgacct ggagactcac ctgggtcagc tagccaggca agttgccatg
     3061 gttcagactc tgcagtcact gagagatgag aaactgctgc agactatgag tgaccttgca
     3121 cccagcaacc tccccgctca acaggaagtc ctcaggacac tggctctgct gctcaccaag
     3181 gatgacaatg aggtcagcga ggccgtgaca ctctacttag cagcagcctc caaaaatgaa
     3241 cacttcagag aaaaggcctt gctctattac tgcgaagcac taacgaagac caatctccag
     3301 ctccagaagg cagcatgcct ggccctaaag agcctagagg ccactgaaag cattaaaatg
     3361 ctagtgacat tgtgtcagtc tgacaccgaa gaaatcagaa ccgtggcctc agaaaccctc
     3421 ctgtctcttg ctccatactc cggatcagcc atgacctctc agattcgtca gaattattcc
     3481 accgaagtgg aagctgccgt gaaccgcctg gtcaacttgc acctgcgggc ctcttacacc
     3541 tacctctctc tgggcttctt ttttgatccg gatgatgtgg ctttggaggg caacgaacgc
     3601 gggggccgtg cactcttcca ggatgtgcag aagccatctc aagatgagtg gggtaaaacc
     3661 ctagaggcca tggaagctgc cttggccctg gagaagaacc tgaaccaggc cctcttggat
     3721 ctgcacgccc tgggctctgc ccgcacagac cctcacctct gtgacttctt ggaaagccac
     3781 ttcctggata aggaggtgaa gctcatcaag aagatgggca accacctgac caacctccgt
     3841 agggtggcag ggccacaacc agcgcagact ggcgtggccc aggcatctct gggcgagtat
     3901 ctctttgagc gcctcactct gaagcacgac taggcctctg tgccttccaa ggggctccct
     3961 cctctgctct gcaccgaccg cctcagcacc tccacccgaa tgaacctcta aagccactag
     4021 gcagctttgt aaccgccctg gagcctctcc ca
//
