LOCUS       NP_001094130            1217 aa            linear   ROD 27-APR-2025
DEFINITION  rho family-interacting cell polarization regulator 1 [Rattus
            norvegicus].
ACCESSION   NP_001094130 XP_001075785 XP_214666
VERSION     NP_001094130.1
DBSOURCE    REFSEQ: accession NM_001100660.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1217)
  AUTHORS   Mardakheh,F.K., Self,A. and Marshall,C.J.
  TITLE     RHO binding to FAM65A regulates Golgi reorientation during cell
            migration
  JOURNAL   J Cell Sci 129 (24), 4466-4479 (2016)
   PUBMED   27807006
REFERENCE   2  (residues 1 to 1217)
  AUTHORS   Gao,K., Tang,W., Li,Y., Zhang,P., Wang,D., Yu,L., Wang,C. and Wu,D.
  TITLE     Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at
            leading edges polarizes neutrophils
  JOURNAL   J Cell Sci 128 (5), 992-1000 (2015)
   PUBMED   25588844
REFERENCE   3  (residues 1 to 1217)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (residues 1 to 1217)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 1217)
  AUTHORS   Patrakka,J., Xiao,Z., Nukui,M., Takemoto,M., He,L., Oddsson,A.,
            Perisic,L., Kaukinen,A., Szigyarto,C.A., Uhlen,M., Jalanko,H.,
            Betsholtz,C. and Tryggvason,K.
  TITLE     Expression and subcellular distribution of novel
            glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and
            2310066E14Rik
  JOURNAL   J Am Soc Nephrol 18 (3), 689-697 (2007)
   PUBMED   17251388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ147070.1, BF524907.1 and AY724537.1.
            
            On or before Aug 29, 2012 this sequence version replaced
            XP_001075785.3, XP_214666.6.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..1217
                     /product="rho family-interacting cell polarization
                     regulator 1"
                     /note="protein FAM65A; family with sequence similarity 65,
                     member A"
                     /calculated_mol_wt=131601
     Region          17..365
                     /region_name="PL48"
                     /note="Filopodia upregulated, FAM65; pfam15903"
                     /db_xref="CDD:464930"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Region          138..205
                     /region_name="HR1"
                     /note="Protein kinase C-related kinase homology region 1
                     (HR1) domain that binds Rho family small GTPases; cl00087"
                     /db_xref="CDD:469609"
     Site            order(140,143,146..147,150..151,153..154,157..158,
                     160..161,184..185,188,191..192,195)
                     /site_type="other"
                     /note="Rho binding site 1 [polypeptide binding]"
                     /db_xref="CDD:212026"
     Site            order(148..149,151..152,155..156,158..159,162..163,
                     179..180,182)
                     /site_type="other"
                     /note="putative Rho binding site 2 [polypeptide binding]"
                     /db_xref="CDD:212026"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6ZS17; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            351
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6ZS17; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Region          371..413
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            455
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Region          <497..>747
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          565..762
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Region          850..874
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            868
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68FE6; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Site            869
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68FE6; propagated from
                     UniProtKB/Swiss-Prot (Q4FZU8.2)"
     Region          1063..1184
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          1091..1121
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1127..1153
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1217
                     /gene="Ripor1"
                     /gene_synonym="Fam65a; RGD1307772"
                     /coded_by="NM_001100660.1:128..3781"
                     /db_xref="GeneID:291974"
                     /db_xref="RGD:1307772"
ORIGIN      
        1 mmslsvrpqr rllsarvsrs qsfagvlgsq ergprnftvf sppgpqrkpl vlsrvsrmfs
       61 vahpapkvpq perldlvyaa lkrgltayle vhqqeqeklq rqikeskrns rlgflydldk
      121 qvksierflr rlefhaskid elyeaycvqr rlrdgaynmv raystgspgs reardslaea
      181 trghreytes mcllenelea qlgefhlrmk glagfarlcv gdqyeicmky grqrwklrgr
      241 iessgkqvwd seetvflpll teflsikvte lkglanhvvv gsvscetkdl faalpqvvav
      301 dindlgtikl sleviwspfd kddqpsaast vnkastvtkr fstysqsppd tpslreqafy
      361 nmlrrqeele ngtawslsse ssddssspql sgtarysstp kplvqqpepl pvqvtfrrpe
      421 slssgsmdee ppltpalvng hapysrtlsh iseasvdaal teameavdlk cpapgpsplv
      481 ypesthvehv ssvppvadng rsatspalst agpaptfidp asstqldlvh katdsgssel
      541 psithtmass tysavspins vpgltsttvg sthkpmpspl tstgsipsvt dsiqtttspt
      601 httpspthtt vspthstpsp thttvspsna alspsnatps lshsttsptq katmsthtts
      661 avgpvqttts pisttvspsp svdtaiisss savpsvpgpe arpcshptst pytkadptaa
      721 ctsspslass gpkpltspap dsleqilksp ssspssivpe pqrselslal vaqapvpeat
      781 ggagdrrlee alrtlmaald dyrgqfpelq gleqevtrle sllmqrqglt rsrasslsit
      841 vehalesfsf lnddedednd spgdrptssp evvaeerlds snaqclstgc saldatlvqh
      901 lyhcsclllk lgtfgplrcq eawalerllr earvlqevce hsklwgnavt saqevvqfsa
      961 srpgfltfwd qcteglnpfl cpveqvlltf csqygarlsl rqpglaeavc vkfledalgq
     1021 klprrphsgp geqltifqfw syvevldsps meayvtetae evllvqnlns ddqavvlkal
     1081 rlapegrlrk dglralssll vhgnskvmaa vstqlrslsl gpvfrerall cfldqleded
     1141 vqtrvagcla lgcikapegi eplvylcqtd teavreaarq slqqcgeegq sahrqleesl
     1201 dalpclfgps smastaf
//
