LOCUS       NM_001107103            3586 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus receptor-interacting serine-threonine kinase 4
            (Ripk4), mRNA.
ACCESSION   NM_001107103 XM_001055952 XM_221619
VERSION     NM_001107103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Mitchell K, O'Sullivan J, Missero C, Blair E, Richardson R,
            Anderson B, Antonini D, Murray JC, Shanske AL, Schutte BC, Romano
            RA, Sinha S, Bhaskar SS, Black GC, Dixon J and Dixon MJ.
  TITLE     Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome
            locus
  JOURNAL   Am J Hum Genet 90 (1), 69-75 (2012)
   PUBMED   22197488
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Bertrand MJ, Lippens S, Staes A, Gilbert B, Roelandt R, De Medts J,
            Gevaert K, Declercq W and Vandenabeele P.
  TITLE     cIAP1/2 are direct E3 ligases conjugating diverse types of
            ubiquitin chains to receptor interacting proteins kinases 1 to 4
            (RIP1-4)
  JOURNAL   PLoS One 6 (9), e22356 (2011)
   PUBMED   21931591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473967.1.
            
            [WARNING] On Oct 11, 2024 this sequence was replaced by
            NM_001107103.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221619.4, XM_001055952.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..3586
                     /gene="Ripk4"
                     /note="receptor-interacting serine-threonine kinase 4"
                     /db_xref="GeneID:304053"
                     /db_xref="RGD:1311691"
     exon            1..228
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2407
                     /gene="Ripk4"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 4"
                     /protein_id="NP_001100573.1"
                     /db_xref="GeneID:304053"
                     /db_xref="RGD:1311691"
                     /translation="MEGEGRGRWALGLLRTFDAGEFAGWEKVGSDGFGQVYKVRHVHW
                     KTWLAIKCSPSLHVDDRERTELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETG
                     SLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKIS
                     DFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLT
                     QKKPFSDEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTF
                     QEITSETEDLCEKPDEEVKDLAHEPGEKSSPEPRSEARPESSRLKRASAPPFDNDCSL
                     SELLSQLDSGISQTLEGPEELSRSSSECKLPSSSSGKRLSGVSSVDSAFSSRGSLSLS
                     FEREASTGDLGPTDIQKKKLVDAIVSGDTNKLMKILQPQDVDLVLDSSASLLHLAVEA
                     GQEECVKWLLLNNANPNLTNKKGSTPLHMAVERRGRGIVELLLARKTSVNAKDEDQWT
                     ALHFAAQNGDEASTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRTLLRRGVDVG
                     LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI
                     LIDLSSDINICSLQAQTPLHVAAETGHTSTARLLLHRGAGKEALTSEGYTALHLAARN
                     GHLATVKLLIEEKADVLARGPLNQTALHLAAARGHSEVVEELVSADLIDLSDEQGLSA
                     LHLAAQGRHSQTVEILLKHGAHINLQSLKFQGGQSSTATLLRRSKT"
     exon            229..520
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..669
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            670..719
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..878
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            879..982
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1247
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..3586
                     /gene="Ripk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacctgggcg gtcacggttg agccaggctg cggcaatacg cacgcgatgg agggcgaggg
       61 ccggggccgg tgggcgctgg ggctgttgcg caccttcgat gcgggcgaat tcgcaggctg
      121 ggagaaggtg ggctcggacg gcttcggaca ggtgtacaag gtgcgccacg tgcactggaa
      181 gacatggctc gcgatcaagt gctcgcccag tctgcacgtc gacgacaggg aacgcacgga
      241 gctgctggag gaagctaaga agatggagat ggccaagttc cgctacattc tccccgtgta
      301 tggcatatgc caggaacctg ttggcttggt catggagtac atggagacag gctccctgga
      361 gaagctgctg gcctcagagc cattgccttg ggacctgcgc ttccgcattg tgcatgagac
      421 agccgtgggc atgaacttcc tgcattgcat gtccccgcca ctgctgcacc tagacctgaa
      481 accagcaaac atcctgctgg atgcccacta ccatgtcaag atttctgact ttgggctggc
      541 caagtgcaat ggcatgtccc actctcatga cctcagcatg gatggcctgt ttggcacaat
      601 cgcctacctc cctccagagc gaattcgtga gaagagccgg ttgtttgaca ccaaacatga
      661 tgtatacagt tttgccatcg tgatctgggg cgtgcttaca cagaagaagc cattttcaga
      721 tgagaagaac atcctacaca tcatgatgaa agtggtgaag ggccaccgcc cagagctgcc
      781 acccatctgc agaccccggc cgcgcgcctg tgccagcctg atagggctca tgcaacggtg
      841 ctggcatgca gacccacagg tgcggcccac cttccaagaa attacctcag aaaccgaaga
      901 cctctgtgaa aaacctgacg aggaggtgaa agacctggct catgagccgg gtgagaaaag
      961 ttctccagag cccaggagtg aggccaggcc tgagtcctca cgcctcaagc gcgcctctgc
     1021 tccccccttc gataatgact gcagtctctc cgagctgctg tcacagctgg actctgggat
     1081 ctcccagact cttgaaggcc ccgaggagct cagccggagc tcctcagaat gcaagctccc
     1141 atcgtccagt agtggcaaga ggctctcggg ggtgtcctcc gtggactccg ccttttcctc
     1201 cagaggatca ctgtcactgt catttgagcg ggaagcctcg acgggcgatc tgggccccac
     1261 agacatccag aaaaagaagc tagtggatgc catcgtgtca ggagacacta acaagctgat
     1321 gaagatccta cagccccaag acgtggactt ggttctggac agcagcgcca gcctgctgca
     1381 cctggctgta gaggctggac aggaggagtg tgtcaagtgg ctgctgctta acaatgccaa
     1441 ccccaacctg accaacaaga agggctctac accgctacat atggctgtgg agaggagggg
     1501 gcgtggaatt gtggagctac tgctggcccg gaagaccagc gtcaatgcca aggatgaaga
     1561 ccagtggacc gccctgcact ttgcagccca aaatggggat gaggccagca caaggctgct
     1621 actagagaag aatgcttctg tcaatgaggt tgacttcgag ggccgaacgc ccatgcatgt
     1681 agcctgccag catggacagg aaaacattgt tcgcaccctg ctccgccgtg gtgtggacgt
     1741 gggattgcag ggaaaggatg cctggttgcc tctgcactat gctgcctggc agggccacct
     1801 gcccattgtt aagctgctag ccaagcagcc tggggtgagt gtgaatgccc agacactaga
     1861 tggtaggaca cccctgcacc tggctgctca gagggggcac taccgtgtgg ctcgcatcct
     1921 catagacctg agctctgaca ttaacatctg cagcctgcag gcacagacac ctctgcatgt
     1981 tgccgcagag actggacaca ctagtactgc caggctactc ttgcatcgtg gtgctggcaa
     2041 ggaggctttg acctcagagg gctacactgc cctgcacctg gcagcccgga atggacacct
     2101 agctactgtc aagctgctca tagaggagaa ggctgacgtg ctggctcggg ggcccctgaa
     2161 tcaaacagca ctgcacctgg ctgctgcccg tggacactca gaggtggtag aagagctggt
     2221 cagtgctgac ctcattgacc tgtctgatga gcagggcctc agtgcactac acctggctgc
     2281 tcagggcagg cattcacaga ctgtggagat actgctcaaa catggagcac acattaactt
     2341 gcagagtctc aagttccaag gaggccagag ctctactgcc acactgctcc gacgcagcaa
     2401 gacctagctt gccagccaca gaaccagggc tccatgtagg cttctggtcc atccttgttc
     2461 cctcatgggg acgggatggt cctgggacac tgctcaccct gttggtggcc tgcccataca
     2521 ccgaccaagc agaggctaat ggacaaggca gtagtagcag agtcaggaca gaggctgcct
     2581 accaccaact gctgacctgc atagccagta tctgatatca gatgggatta ggttggtgtc
     2641 atgtcactgt ggtattgaat ggccgctgat gcaggccttt tatgacaaag cctatacaag
     2701 aatgtgccct ctgtcccaga gcgagccact tctgcttgct tggcgcatgg cgtcttcagg
     2761 agagatgtgg gaagggcagt gtcctttgtc ttctcgttgc gatgggcaga gtatctgtct
     2821 ctgaagccat agtgggttct ttatacatga gtgacatgat agctttgctt gagacctctg
     2881 aggatctgat tgatggagtc tagaaaggga atgattataa aaccacaggg ctggtcctaa
     2941 cgctgaacaa ccttaccagc gtgaaaacaa tgtttcattt gggttgtttt tttgtttctg
     3001 tttttagttt tgatgtctag gtcaccacgc ctctttcccc cactttccct gctgagttct
     3061 cacctaaaac atcagagcca tatatatata tatatatgtt acaggaaaat tctttgtaaa
     3121 tgggttttat actaaaaatt gtttagtcaa acagttcact ttttcaggct cttttggtga
     3181 agtgatggtt tgtgccaagg gcattgctga cttgccctgg ggcaactcat gccgtgttcc
     3241 agccacagat gaatgtggct cagggtggcc tttagagatg gtcatgctct gagaagtcag
     3301 atttgatagc ctttgttgta ccttctgtgt tctgaacact tcaccgtaga agtgacccgt
     3361 gtgcagacac atgctgtagc atggcgtgtg gcacagaatg gtattaatgt actgtgtact
     3421 ttgatatgaa tcgtggacag gatgcctttt catgacggga cgtagtggag ctggctatgt
     3481 tttagtatgc ctcagttcgt cttcactgcc tccccgctct tgtgtaaaaa aaaaaacaga
     3541 gaccatggga gatgtcgatt gattgatgtc aataaaggac tcacct
//
