LOCUS       NM_139342               2011 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus receptor-interacting serine-threonine kinase 3
            (Ripk3), mRNA.
ACCESSION   NM_139342
VERSION     NM_139342.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Bencze,M., Periou,B., Punzon,I., Barthelemy,I., Taglietti,V.,
            Hou,C., Zaidan,L., Kefi,K., Blot,S., Agbulut,O., Gervais,M.,
            Derumeaux,G., Authier,F.J., Tiret,L. and Relaix,F.
  TITLE     Receptor interacting protein kinase-3 mediates both myopathy and
            cardiomyopathy in preclinical animal models of Duchenne muscular
            dystrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (6), 2520-2531 (2023)
   PUBMED   37909859
  REMARK    GeneRIF: Receptor interacting protein kinase-3 mediates both
            myopathy and cardiomyopathy in preclinical animal models of
            Duchenne muscular dystrophy.
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Yuan,G., Cao,C., Cao,D., Li,B., Li,X., Li,H., Shen,H., Wang,Z. and
            Chen,G.
  TITLE     Receptor-interacting protein 3-phosphorylated Ca2+
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis
  JOURNAL   J Neurochem 164 (1), 94-114 (2023)
   PUBMED   36424866
  REMARK    GeneRIF: Receptor-interacting protein 3-phosphorylated Ca[2+]
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis.
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Piao,S.G., Ding,J., Lin,X.J., Nan,Q.Y., Xuan,M.Y., Jiang,Y.J.,
            Zheng,H.L., Jin,J.Z. and Li,C.
  TITLE     Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal
            fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in
            unilateral ureteral obstruction
  JOURNAL   PLoS One 17 (10), e0274116 (2022)
   PUBMED   36223414
  REMARK    GeneRIF: Inhibition of RIP1-RIP3-mediated necroptosis attenuates
            renal fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in
            unilateral ureteral obstruction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Xue,H., Shi,H., Zhang,F., Li,H., Li,C. and Han,Q.
  TITLE     RIP3 Contributes to Cardiac Hypertrophy by Influencing
            MLKL-Mediated Calcium Influx
  JOURNAL   Oxid Med Cell Longev 2022, 5490553 (2022)
   PUBMED   35464769
  REMARK    GeneRIF: RIP3 Contributes to Cardiac Hypertrophy by Influencing
            MLKL-Mediated Calcium Influx.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Qiao,S., Hong,L., Zhu,Y., Zha,J., Wang,A., Qiu,J., Li,W., Wang,C.,
            An,J. and Zhang,H.
  TITLE     RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes
            mellitus by impairing autophagic flux of cardiac fibroblasts
  JOURNAL   Cell Death Dis 13 (2), 147 (2022)
   PUBMED   35165268
  REMARK    GeneRIF: RIPK1-RIPK3 mediates myocardial fibrosis in type 2
            diabetes mellitus by impairing autophagic flux of cardiac
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2011)
  AUTHORS   Zhang,D.W., Shao,J., Lin,J., Zhang,N., Lu,B.J., Lin,S.C., Dong,M.Q.
            and Han,J.
  TITLE     RIP3, an energy metabolism regulator that switches TNF-induced cell
            death from apoptosis to necrosis
  JOURNAL   Science 325 (5938), 332-336 (2009)
   PUBMED   19498109
REFERENCE   7  (bases 1 to 2011)
  AUTHORS   Cho,Y.S., Challa,S., Moquin,D., Genga,R., Ray,T.D., Guildford,M.
            and Chan,F.K.
  TITLE     Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates
            programmed necrosis and virus-induced inflammation
  JOURNAL   Cell 137 (6), 1112-1123 (2009)
   PUBMED   19524513
REFERENCE   8  (bases 1 to 2011)
  AUTHORS   Newton,K., Sun,X. and Dixit,V.M.
  TITLE     Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the
            B-cell and T-cell receptors, tumor necrosis factor receptor 1, and
            Toll-like receptors 2 and 4
  JOURNAL   Mol Cell Biol 24 (4), 1464-1469 (2004)
   PUBMED   14749364
REFERENCE   9  (bases 1 to 2011)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   10 (bases 1 to 2011)
  AUTHORS   Pazdernik,N.J., Donner,D.B., Goebl,M.G. and Harrington,M.A.
  TITLE     Mouse receptor interacting protein 3 does not contain a
            caspase-recruiting or a death domain but induces apoptosis and
            activates NF-kappaB
  JOURNAL   Mol Cell Biol 19 (10), 6500-6508 (1999)
   PUBMED   10490590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 15, 2021 this sequence version replaced NM_139342.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036537.2, SRR21887620.779862.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000015.1  33261770-33262025   c
            257-368             JAXUCZ010000015.1  33259189-33259300   c
            369-473             JAXUCZ010000015.1  33256559-33256663   c
            474-617             JAXUCZ010000015.1  33256189-33256332   c
            618-927             JAXUCZ010000015.1  33255775-33256084   c
            928-1076            JAXUCZ010000015.1  33255239-33255387   c
            1077-1123           JAXUCZ010000015.1  33255070-33255116   c
            1124-1291           JAXUCZ010000015.1  33254710-33254877   c
            1292-1359           JAXUCZ010000015.1  33254545-33254612   c
            1360-1701           JAXUCZ010000015.1  33253990-33254331   c
            1702-1759           JAXUCZ010000015.1  33253830-33253887   c
            1760-2011           JAXUCZ010000015.1  33253071-33253322   c
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2011
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /note="receptor-interacting serine-threonine kinase 3"
                     /db_xref="GeneID:246240"
                     /db_xref="RGD:628899"
     exon            1..256
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..368
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..473
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1890
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /EC_number="2.7.11.1"
                     /note="homocysteine respondent protein HCYP2; RIP-3;
                     RIP-like protein kinase 3; receptor-interacting protein 3"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 3"
                     /protein_id="NP_647558.2"
                     /db_xref="GeneID:246240"
                     /db_xref="RGD:628899"
                     /translation="MSSVKLWLNGASSISLVGSEELENLGFVGKGGFGAVFRARHTAW
                     NLDVAVKIVNSKKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGS
                     LSGLLQPSCPRPWPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLA
                     DFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLA
                     GREAEVVDKTSLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRP
                     SFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSARESSQKGTEVDCPRE
                     TIVYEMLDRLHLEEPSGSVPERLTSLTERRGKEASFGHATPAGTSSDTLAGTPQIPHT
                     LPSRGTTPRPAFTETPGPDPQRNQGDGRNSNPWYTWNAPNPMTGLQSIVLNNCSEVQI
                     GQHNCMSVQPRTAFPKKEPAQFGRGRGW"
     exon            474..617
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..927
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1076
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1123
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1291
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1359
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1701
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1759
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2011
                     /gene="Ripk3"
                     /gene_synonym="Hcyp2; Rip3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacccaa gctgagccta actggccgaa agagtctcca gacttggtca ctgttacctg
       61 aggaaaagta gctgtcccat gcactgtggc tgtcccggcc atgtagggag cagcagctgg
      121 caaggagtca ggggaatcaa gccttagaaa gaggaagagt ctgccaaggg agctgggaga
      181 gcagccctgc cagggctgct gttggctgag ggagaggagg agggccatgc catccagacc
      241 caacaagagg tcaaagacta caaaattcct aacgacagaa actaagactt cagaaactcc
      301 aagctgcatc aagttgagga agtattcaaa ccaaaccact gagcgagcat ccttccaaac
      361 ccatgatgtc taaactctca gccgtagacg ttgtagacgt cggggttcca gctccatctt
      421 tgcacacata atccaggaag ccgctagctc tcgatgtctt ctgtcaagtt atggctcaat
      481 ggtgcgtcat cgatctctct cgtgggctct gaagaactgg agaacctagg atttgtgggc
      541 aaaggcgggt tcggagccgt gttccgggca cgccacacag catggaacct tgatgtagca
      601 gtcaagatcg tgaactcgaa gaagatatcc agggaggtga aggctatggt gaatcttcgt
      661 catgagaacg tgctgctcct gctgggggtc actgagaacc tcgagtggga ctacgtgtac
      721 gggccggctc tggtgacagg attcatggag aacggctccc tctcagggct gctgcaacct
      781 tcatgccctc ggccctggcc tctcctctgt cgcctgctag aggaagtggt gctggggatg
      841 tgctacctac acagcttgaa cccttcgcta ctgcaccggg acctcaagcc ctccaatgtt
      901 ctgctggatc cagagctcca cgccaagtta gcagactttg gcctgtccac atttcaggga
      961 gggtcacagt cagggtcagg gtcaggatcg agagattctg ggggcaccct agcttacttg
     1021 gccccagagc tgttggataa tgacggaaag gcttctaaag caagtgatgt ttacagtttt
     1081 ggggtcctcg tgtggacagt gctggctgga agagaagctg aggtggtaga caagacctca
     1141 ctaattcgtg gagcagtgtg taacaggcag aggcgacctc cattgacaga gctgcctccg
     1201 gacagccctg agactcctgg cttagaagga ctgaaggagt taatgacgca ttgctggagt
     1261 tctgagccta aagacaggcc atccttccaa gactgtgaat caaaaaccaa taatgtttac
     1321 atcctggtac aggacaaggt agatgctgct gtctccaagg taaagcatta tctgtctcag
     1381 tacagaagca gtgacacaaa gttgtctgcc agagagtcca gccaaaaagg tacagaggtg
     1441 gattgcccca gggaaaccat agtttatgaa atgctggacc gcctgcatct ggaggagccc
     1501 tctggatcag ttcctgaaag actcacaagt cttactgaga ggagaggaaa ggaagcatca
     1561 tttgggcatg ccacaccagc agggacatca tctgacacct tggctggcac tccccaaatt
     1621 ccacatactt taccctccag aggcacaaca cctaggccag cctttactga gactccaggt
     1681 cctgaccccc aaaggaatca gggagatgga agaaacagca atccttggta cacctggaac
     1741 gcaccaaatc caatgacagg gctacagtct attgtcttaa acaactgttc tgaagtgcag
     1801 attggacaac acaactgcat gtcagtacaa ccgagaactg cctttcccaa gaaggagcca
     1861 gcacagttcg gcaggggtag gggctggtag cccgtccacg tccacgagta gacttcggag
     1921 aggacctgca agtgcctgaa gcaggaaata caccattcag gcagccagta taaatagagt
     1981 gaaaataaaa gcactttcta agcaacctga a
//
