LOCUS       NM_001191865            2582 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus receptor-interacting serine-threonine kinase 2
            (Ripk2), mRNA.
ACCESSION   NM_001191865 XM_342810
VERSION     NM_001191865.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Xia,Z. and Sun,G.
  TITLE     Blocking RIPK2 Function Alleviates Myocardial Ischemia/Reperfusion
            Injury by Regulating the AKT and NF-kappaB Pathways
  JOURNAL   Immunol Invest 52 (5), 529-545 (2023)
   PUBMED   37128885
  REMARK    GeneRIF: Blocking RIPK2 Function Alleviates Myocardial
            Ischemia/Reperfusion Injury by Regulating the AKT and NF-kappaB
            Pathways.
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Goncharuk,S.A., Artemieva,L.E., Tabakmakher,V.M., Arseniev,A.S. and
            Mineev,K.S.
  TITLE     CARD domain of rat RIP2 kinase: Refolding, solution structure,
            pH-dependent behavior and protein-protein interactions
  JOURNAL   PLoS One 13 (10), e0206244 (2018)
   PUBMED   30352081
  REMARK    GeneRIF: Receptor-interacting serine-threonine kinase 2 (RIP2)
            tends to form high-order oligomers at physiological pH while being
            monomeric under acidic conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Huang,W., Gou,F., Long,Y., Li,Y., Feng,H., Zhang,Q., Gao,C.,
            Chen,G. and Xu,Y.
  TITLE     High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-kappaB
            Inflammatory Signaling in Mesangial Cells
  JOURNAL   Exp Clin Endocrinol Diabetes 124 (8), 512-517 (2016)
   PUBMED   27169686
  REMARK    GeneRIF: combined results support the hypothesis that high glucose
            and LPS can activate the NOD1-RICK-NF-kappaB inflammatory signaling
            pathway via the NOD1 receptor, and may participate in the
            development of diabetic nephropathy.
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Ma,G., Shi,B., Liu,J., Zhang,H., YinTao,Z., Lou,X., Liang,D.,
            Hou,Y., Wan,S. and Yang,W.
  TITLE     Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by
            Muramyl Dipeptide Via Oligopeptide Transporter in Rats
  JOURNAL   Dig Dis Sci 60 (11), 3264-3270 (2015)
   PUBMED   26138652
  REMARK    GeneRIF: Nod2-Rip2-NFkappaB signaling involved in the small
            intestinal inflammatory injury caused by muramyl dipeptide which is
            transported through PepT1.
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Razmara,M., Srinivasula,S.M., Wang,L., Poyet,J.L., Geddes,B.J.,
            DiStefano,P.S., Bertin,J. and Alnemri,E.S.
  TITLE     CARD-8 protein, a new CARD family member that regulates caspase-1
            activation and apoptosis
  JOURNAL   J Biol Chem 277 (16), 13952-13958 (2002)
   PUBMED   11821383
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Lee,S.H., Stehlik,C. and Reed,J.C.
  TITLE     Cop, a caspase recruitment domain-containing protein and inhibitor
            of caspase-1 activation processing
  JOURNAL   J Biol Chem 276 (37), 34495-34500 (2001)
   PUBMED   11432859
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Druilhe,A., Srinivasula,S.M., Razmara,M., Ahmad,M. and Alnemri,E.S.
  TITLE     Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two
            dominant negative caspase recruitment domain proteins
  JOURNAL   Cell Death Differ 8 (6), 649-657 (2001)
   PUBMED   11536016
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Ogura,Y., Inohara,N., Benito,A., Chen,F.F., Yamaoka,S. and Nunez,G.
  TITLE     Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes
            and activates NF-kappaB
  JOURNAL   J Biol Chem 276 (7), 4812-4818 (2001)
   PUBMED   11087742
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
            Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 17, 2010 this sequence version replaced XM_342810.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.21073.1,
                                           SRR26643285.18755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000005.1  34459357-34459663   c
            308-461             JAXUCZ010000005.1  34454461-34454614   c
            462-617             JAXUCZ010000005.1  34451970-34452125   c
            618-775             JAXUCZ010000005.1  34446188-34446345   c
            776-825             JAXUCZ010000005.1  34441836-34441885   c
            826-987             JAXUCZ010000005.1  34440697-34440858   c
            988-1073            JAXUCZ010000005.1  34437569-34437654   c
            1074-1160           JAXUCZ010000005.1  34433841-34433927   c
            1161-1254           JAXUCZ010000005.1  34432585-34432678   c
            1255-1416           JAXUCZ010000005.1  34430211-34430372   c
            1417-2582           JAXUCZ010000005.1  34428573-34429738   c
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2582
                     /gene="Ripk2"
                     /note="receptor-interacting serine-threonine kinase 2"
                     /db_xref="GeneID:362491"
                     /db_xref="RGD:1309167"
     exon            1..307
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1754
                     /gene="Ripk2"
                     /EC_number="2.7.11.1"
                     /note="receptor (TNFRSF)-interacting serine-threonine
                     kinase 2"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 2"
                     /protein_id="NP_001178794.1"
                     /db_xref="GeneID:362491"
                     /db_xref="RGD:1309167"
                     /translation="MNGDAICSALPHIPYHKLADLHYLSRGASGTVSSARHADWRVRV
                     AVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS
                     LNELLHRKTEYPEIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHV
                     KIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVI
                     MWEVLSRKQPFEEVTNPLQIMYSVSQGHRPNTSEENLPFDIPHRGLMISLIQSGWAQN
                     PDERPSFLKCLIELEPVLRTFEDITFLEAVIQLKKSKIQSASSTIHLCDKKMDLSLNI
                     PASHPPQEESCGSSLLSRNAGSPGTSRSLSAPQDKGFFHGGPQDCSSSKAYHCPGNHS
                     WDGIISVSQEAAFCDRRASSCSLTVIRPLLVEKSSERPQPGIAQQWIQSKREAIVSQM
                     TEACLNQSLDALLSRDLIMKEDYELISTKPTRTAKVRQLLDTSDIQGEEFARVIVQKL
                     KDNKQMGLQPYPEVLLVSRTPSSNVLQNKTL"
     exon            308..461
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..617
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..775
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..825
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..987
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1073
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1160
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1254
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1416
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..2582
                     /gene="Ripk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcaga cccgacgggc tcccagggac agccggccgg gccggaactg cagagaatgg
       61 gccgccccgg gacctagcgc accgcagcac gggccgcggc cagggtcggg cggagccgct
      121 gcgcagctgg agccatgaac ggggacgcca tctgcagcgc gctgccccac atcccctacc
      181 acaagctcgc cgacctgcac tacctcagcc gcggcgcctc aggcaccgtc tcgtcggcaa
      241 gacacgcgga ctggcgggtg cgggtggcag tgaagcacct gcacattcac acgccgctgc
      301 tcgacagtga aagaaatgat atcttacgag aagccgaaat attacataaa gcaagattta
      361 gttacattct tccaatattg ggaatttgca atgagcctga atttttgggc atagttactg
      421 aatacatgcc aaacggatca ttaaatgagc ttctacacag aaaaactgaa tatcctgaga
      481 ttgcatggcc attgagattc cgcatcctgc atgaaattgc tcttggtgta aattacctgc
      541 acaatatgaa cccccctctg cttcatcatg acttaaagac tcagaatatc ttgttggata
      601 atgaatttca tgttaagatt gcagatttcg gtttatcaaa atggcgcatg atgtcactct
      661 cccaatcacg gagctacaaa tctgcacccg aagggggaac gatcatctat atgccacctg
      721 agaactatga accgggacag aaatcaaggg ccagcgtgaa gcatgatata tacagctatg
      781 cggttatcat gtgggaagtg ttgtccagaa aacagccttt tgaagaggtc accaatcctt
      841 tgcagatcat gtacagtgtg tcccagggac atcggcctaa caccagtgag gaaaatttgc
      901 catttgatat acctcatcga ggtctcatga tctctctaat acaaagtgga tgggcacaaa
      961 acccagatga gagaccatcc ttcttgaaat gcttaataga acttgaacca gttctgagaa
     1021 catttgaaga cataactttt cttgaagctg ttattcagct aaaaaaatca aagatacaga
     1081 gtgcatcgag tacaattcac ttatgtgata agaaaatgga tttatcactg aacatacctg
     1141 caagccatcc tccacaggag gaatcatgtg gatcctctct gctctctaga aacgctggtt
     1201 ctcctggaac ctccaggtct ctgtcagctc ctcaagacaa aggttttttc catggaggac
     1261 ctcaagactg ttcttcgtcg aaggcgtacc attgtcctgg aaatcacagc tgggatggta
     1321 tcatttctgt gtcacaagag gcagccttct gtgatcgcag agccagctcg tgctccttga
     1381 ctgtgataag gccactgttg gttgagaaaa gttcagagcg cccacaaccc gggatagcac
     1441 aacagtggat ccagagtaag agggaagcca ttgtgagcca gatgactgaa gcctgcctga
     1501 accaatccct ggacgccctt ctgtctcggg acctgatcat gaaggaggac tatgaactca
     1561 ttagcaccaa acctacaagg accgcaaaag tcagacagct gctagatacc tctgacatcc
     1621 aaggagaaga gtttgccaga gttatagtac agaagttgaa agacaacaag cagatggggc
     1681 ttcagcctta cccggaagta cttttggttt ccagaacacc atcttcaaat gtccttcaaa
     1741 ataaaacctt ataagggggc cttctttgag gggaaagtcg gtttacaaat gattatttat
     1801 atttctgtta cctgtataat atttgtataa aaacatgaga gtattagatg cttcagtgaa
     1861 ggtttttgga agagtctctt cccatgacgt tgcagtattt ttttttaaat taatataagt
     1921 aaaaagtttg cattatgctg tgtagttcag tttttatgtc agcttcacta cttgaacttt
     1981 tttttaatgt gataatcaca tttttcttat atgtaacaag ccttcgtttc tgatggaaga
     2041 cattttccca ctcacctgac ctgtggattc ctcattattc ctctaaagtg cggtttgaca
     2101 ttacatagca gtgatatggt gttgcccctc tgcaacccca agttcagatc tccagagagt
     2161 tactcatttt taaatttgat ttacaaattc tttagaaggt ggtttcaagg aatacaaagt
     2221 gtataaagaa gaaaaaaaag agagagagag agaatctttt actaacactg gccgtccgtg
     2281 tacctctgct tgacctttgc ctcctgtctt tctccagagc aagcagccca ttgtgtatcc
     2341 tgctgcagcc tgcttccggc tcctatttta agaatatgct ggttgggtag aggccggcct
     2401 ttgcttcgct atttcctttg taacacacca tggtttttga actgaagggt acatccggtg
     2461 tctcccccag ctcacctaac taactccgtt caattaccgc acagcggcca tgcctctctg
     2521 tgtttgcttt tccaagcgtg ttctcaactt cacgacaaac aataaaaagg caatacagtg
     2581 tg
//
