LOCUS       NM_001108423            3843 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RIO kinase 3 (Riok3), mRNA.
ACCESSION   NM_001108423 XM_001072670 XM_341578
VERSION     NM_001108423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3843)
  AUTHORS   Takashima,K., Oshiumi,H., Takaki,H., Matsumoto,M. and Seya,T.
  TITLE     RIOK3-mediated phosphorylation of MDA5 interferes with its assembly
            and attenuates the innate immune response
  JOURNAL   Cell Rep 11 (2), 192-200 (2015)
   PUBMED   25865883
REFERENCE   2  (bases 1 to 3843)
  AUTHORS   Feng J, De Jesus PD, Su V, Han S, Gong D, Wu NC, Tian Y, Li X, Wu
            TT, Chanda SK and Sun R.
  TITLE     RIOK3 is an adaptor protein required for IRF3-mediated antiviral
            type I interferon production
  JOURNAL   J Virol 88 (14), 7987-7997 (2014)
   PUBMED   24807708
REFERENCE   3  (bases 1 to 3843)
  AUTHORS   Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C and
            Kutay U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   4  (bases 1 to 3843)
  AUTHORS   Baumas K, Soudet J, Caizergues-Ferrer M, Faubladier M, Henry Y and
            Mougin A.
  TITLE     Human RioK3 is a novel component of cytoplasmic pre-40S
            pre-ribosomal particles
  JOURNAL   RNA Biol 9 (2), 162-174 (2012)
   PUBMED   22418843
REFERENCE   5  (bases 1 to 3843)
  AUTHORS   Widmann B, Wandrey F, Badertscher L, Wyler E, Pfannstiel J, Zemp I
            and Kutay U.
  TITLE     The kinase activity of human Rio1 is required for final steps of
            cytoplasmic maturation of 40S subunits
  JOURNAL   Mol Biol Cell 23 (1), 22-35 (2012)
   PUBMED   22072790
REFERENCE   6  (bases 1 to 3843)
  AUTHORS   Shan J, Wang P, Zhou J, Wu D, Shi H and Huo K.
  TITLE     RIOK3 interacts with caspase-10 and negatively regulates the
            NF-kappaB signaling pathway
  JOURNAL   Mol Cell Biochem 332 (1-2), 113-120 (2009)
   PUBMED   19557502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474073.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341578.3, XM_001072670.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3843
                     /gene="Riok3"
                     /note="RIO kinase 3"
                     /db_xref="GeneID:361293"
                     /db_xref="RGD:1310833"
     exon            1..977
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     CDS             915..2474
                     /gene="Riok3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO3"
                     /protein_id="NP_001101893.1"
                     /db_xref="GeneID:361293"
                     /db_xref="RGD:1310833"
                     /translation="MDLVGVSSPEPGPAAAWGPSKCPWATPQNTVSCSLAEVMSEELA
                     KELQLEEEAAAFPEAVVAEGPFISGENMDTSSDLMLAQMLQMEFDREYDAQLRREEKK
                     FNGDSKVSISFENYRKVHPFEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGK
                     DITTKHDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSA
                     RLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDE
                     KEDGKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMH
                     NLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSEEEMKDAYHQTLHL
                     MQQLYKECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFF
                     QKGGVKEALNERELFNAVSGLSISADNEADFLAEIEALEKMNEDHVQKNGRKAASFLK
                     DEGSPPMLYAE"
     exon            978..1093
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1239
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1347
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1457
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1601
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1729
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1927
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2087
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2168
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2258
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2366
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..3843
                     /gene="Riok3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtcaaaaca accagcctca aggtcttttt aatcttagct cttgtgattt gaatctcaac
       61 aactcccagc aaagctcatg tgttaaaatg ctaggcgacc agctggaggg gtcatttaat
      121 ttccaaattg agttacttta ttctatgtgc ctgtttcatt ttcaggtacg gatagaatct
      181 tctcaacatc gtttttgaga ttaaaaccct gactagtgct tggatatagt gatgtataat
      241 gcttctgctt ttccagtcac tttgtgaatt tctcaacaaa acagagaatc acaaatttta
      301 ttgtgccgtc ttattttttg ctcagcatta tgccacactt tctcattcta cacttgccct
      361 caaatgacac tagtaaccac cgcaatccgt atcactttcc cctctgggaa cctgccggtt
      421 ccgccccgct tctcctcgaa ttcggtccag tttcgaatta ccccgggaaa taatgatcag
      481 agtcagcctg gctcgagcat tcggaggcca cactggttgg gttcatgaga ttcggtgact
      541 gggaggaagg aaccggaagg cggtggccgc acagggagta ccagctgaga ggaagtcaaa
      601 cccacgtctg ccgtgccagg agtgggtcaa caccaaccct agccagacgt actttgagcc
      661 ggaggggcag aggccggaag aacagccctc ccgggttagg agcagccaat cagaagtgag
      721 aacactagca tataggacgg aagagaagca gcccagttcc ggacgcggcc gccgcggccg
      781 ccatctgtca cctcatctcc ggcaccggca gccggttgcc cgtgtcccgc ccgtgtcccg
      841 cccgtgtctt cgtcggagcc cgccctcctc ctgtcacctc tcggctccgt tgtcgtctct
      901 gccttcttcc ccgaatggat ctggtcggag tgtcttcacc tgaacccggg cccgcagcag
      961 cttggggacc cagtaagtgc ccatgggcta cccctcaaaa cacagtatcc tgttcactgg
     1021 cggaggtgat gagtgaagaa ctggccaaag agctgcagtt ggaagaagaa gcagctgctt
     1081 tccctgaagc tgtcgttgct gaaggaccgt ttatttctgg agaaaacatg gacacttcca
     1141 gtgacctgat gctggctcag atgctacaga tggaatttga cagagaatac gatgcacagc
     1201 ttaggcgtga agaaaagaag ttcaacggtg acagcaaagt ttccatttca tttgaaaact
     1261 atcggaaagt tcatcccttt gaagacagtg acagctctga ggacgaggtt gactggcagg
     1321 acactcgcga cgatccctac agaccagcaa agccagttcc tactcccaaa aagggtttta
     1381 ttggaaaagg aaaagacatc acaactaagc atgatgaagt agtatgtgga agaaagaaca
     1441 cagcaagaat ggaaaacttt gcacctggct ttcaggttgg agatggaatt ggaatggatt
     1501 taaaactatc caaccacgtt tttaatgctt taaaacaaca tgcctactcg gaagaacgtc
     1561 gaagtgcccg tctccatgag aagaaggaac attccaccgc tgaaaaagca gttgatccta
     1621 agacacgctt acttatgtat aaaatggtca actctggaat gttggagaca atcactggct
     1681 gtattagtac aggaaaggaa tctgttgtct ttcatgcata tggagggagc ctggaggatg
     1741 aaaaggagga tggtaaagtt ataccaacag aatgtgccat caaggtattt aaaacaactc
     1801 ttaatgagtt caagaatcgt gacaaataca ttaaagatga tttcaggttt aaagatcgct
     1861 tcagtaaact aaatccacgt aagatcatcc gcatgtgggc agagaaggag atgcacaatc
     1921 tcacaagaat gcagaaggct ggaattcctt gtccaacagt tgtactgctt aagaagcaca
     1981 ttttagttat gtctttcatt ggccacgatc aagttccagc ccctaaatta aaggaagtaa
     2041 agcttagtga agaagaaatg aaagatgcct accaccagac tctccacttg atgcagcagt
     2101 tgtacaagga atgcaccctt gtgcacgccg acctcagcga gtacaacatg ctgtggcatg
     2161 ctgggaaggt ctggttgatt gatgtcagtc agtcggtaga accgacccat cctcatggcc
     2221 tggagttctt attccgtgac tgtaggaacg tttcacagtt cttccagaag ggaggagtaa
     2281 aggaagccct taacgagcgg gagctgttca atgctgtttc tggcctgagc atctcagcag
     2341 acaatgaagc tgacttctta gctgagatag aagctttgga gaaaatgaac gaagatcatg
     2401 ttcagaagaa tggaaggaaa gcagcctcgt ttctgaaaga tgaaggaagt ccacccatgc
     2461 tgtatgcaga gtagtccagc agagatggcc agctgccaca gccagcgagt gggtgacctg
     2521 acagaccaaa gcaggagtgg acagcgctgc ttctgtgctc ctcactctga cccacgtgcc
     2581 agatgtgtgc aatttttaac tcggcattga aagaataaaa tgtcactacc tctcatctta
     2641 caaaaaggat aatagaattc tttaacacat acagatgtgt agccaaagga gtctggattt
     2701 tacacaactc atgatctgaa atgtcttgat gaggattttc acataggcag tgtttccaaa
     2761 cgtgggaggt ggggactgag gtttttgcag gggaggctcg atggctgcac tgctccacgc
     2821 cacttgcctc ttgctttccc tggcatctat gggtgaatgc taccatttta aatcagcctt
     2881 ctcaactgct ggactgtgag cctggagacc ccggtgggtc tagaagtggg catttggctt
     2941 cagagtggat ggcggaagta gacagaagca gtgtgcctgg tggtagacct cggatgtgtg
     3001 ggagtctaca tttctatctc acccaggaaa gacaacgtgg gtttctgaaa gataaataga
     3061 gaaggatttc ttaactaaat tttaaaactt tcaggttttc ttcatttagg ttaaatggtt
     3121 gggatgtaat tcatctacat ttataatgaa atataaagta tctggaaggg cagaatgtaa
     3181 gaattgtatc tgatacagtt taagaaggca atgaaacatt tcagtttaca tttccctaaa
     3241 attgttcaca tattgattgc taatcatttg gagagaaata gaacaaagta actagagaac
     3301 ttaaataagt ggaagacaaa gtaatgaatt aaccagcaac tcagctgttg gcctctttgc
     3361 ccgtcttcac cctggctgga ctcagcttga gaaggggagg gagccttgtt ctgaagacca
     3421 gtggctgctt gctctcacct cattacccca ttccaggagt cacagtggat ccactaaaca
     3481 cctaactttc tgtccggtta taaagagtaa atgtaattta tatttgaaag gttttaacat
     3541 tatttaaatg gccagctatg ttctttctag actatttatc tttgtttctg ttatactgct
     3601 ttcaattgca ttccagagga gtgggaattt aggtgactcc tccacttacg cgatgtttgc
     3661 cactccacac agagttaaat gatgactaag tattggctgg acggaaatcc cagaaaactc
     3721 atttggaaca atcatttaaa actttgtttg ctttcttgac atattctttc tcaaaccatt
     3781 gcctggagtg tgctatgaac ttgcctttca agaaattaaa aatgaagaga tcattttaga
     3841 att
//
