LOCUS       NP_001101893             519 aa            linear   ROD 23-MAR-2023
DEFINITION  serine/threonine-protein kinase RIO3 [Rattus norvegicus].
ACCESSION   NP_001101893 XP_001072670 XP_341579
VERSION     NP_001101893.1
DBSOURCE    REFSEQ: accession NM_001108423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Takashima,K., Oshiumi,H., Takaki,H., Matsumoto,M. and Seya,T.
  TITLE     RIOK3-mediated phosphorylation of MDA5 interferes with its assembly
            and attenuates the innate immune response
  JOURNAL   Cell Rep 11 (2), 192-200 (2015)
   PUBMED   25865883
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Feng J, De Jesus PD, Su V, Han S, Gong D, Wu NC, Tian Y, Li X, Wu
            TT, Chanda SK and Sun R.
  TITLE     RIOK3 is an adaptor protein required for IRF3-mediated antiviral
            type I interferon production
  JOURNAL   J Virol 88 (14), 7987-7997 (2014)
   PUBMED   24807708
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C and
            Kutay U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Baumas K, Soudet J, Caizergues-Ferrer M, Faubladier M, Henry Y and
            Mougin A.
  TITLE     Human RioK3 is a novel component of cytoplasmic pre-40S
            pre-ribosomal particles
  JOURNAL   RNA Biol 9 (2), 162-174 (2012)
   PUBMED   22418843
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Widmann B, Wandrey F, Badertscher L, Wyler E, Pfannstiel J, Zemp I
            and Kutay U.
  TITLE     The kinase activity of human Rio1 is required for final steps of
            cytoplasmic maturation of 40S subunits
  JOURNAL   Mol Biol Cell 23 (1), 22-35 (2012)
   PUBMED   22072790
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Shan J, Wang P, Zhou J, Wu D, Shi H and Huo K.
  TITLE     RIOK3 interacts with caspase-10 and negatively regulates the
            NF-kappaB signaling pathway
  JOURNAL   Mol Cell Biochem 332 (1-2), 113-120 (2009)
   PUBMED   19557502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474073.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_341579.3, XP_001072670.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     Protein         1..519
                     /product="serine/threonine-protein kinase RIO3"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=58673
     Region          253..453
                     /region_name="RIO3_euk"
                     /note="Catalytic domain of the atypical protein serine
                     kinase, RIO3 kinase; cd05146"
                     /db_xref="CDD:270697"
     Site            order(257,262..263,265,288,290,347,359..362,371,411,413,
                     422..423)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270697"
     CDS             1..519
                     /gene="Riok3"
                     /coded_by="NM_001108423.1:915..2474"
                     /db_xref="GeneID:361293"
                     /db_xref="RGD:1310833"
ORIGIN      
        1 mdlvgvsspe pgpaaawgps kcpwatpqnt vscslaevms eelakelqle eeaaafpeav
       61 vaegpfisge nmdtssdlml aqmlqmefdr eydaqlrree kkfngdskvs isfenyrkvh
      121 pfedsdssed evdwqdtrdd pyrpakpvpt pkkgfigkgk dittkhdevv cgrkntarme
      181 nfapgfqvgd gigmdlklsn hvfnalkqha yseerrsarl hekkehstae kavdpktrll
      241 mykmvnsgml etitgcistg kesvvfhayg gsledekedg kviptecaik vfkttlnefk
      301 nrdkyikddf rfkdrfskln prkiirmwae kemhnltrmq kagipcptvv llkkhilvms
      361 fighdqvpap klkevklsee emkdayhqtl hlmqqlykec tlvhadlsey nmlwhagkvw
      421 lidvsqsvep thphgleflf rdcrnvsqff qkggvkealn erelfnavsg lsisadnead
      481 flaeiealek mnedhvqkng rkaasflkde gsppmlyae
//
