LOCUS       NM_001009687            1814 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus RIO kinase 2 (Riok2), mRNA.
ACCESSION   NM_001009687 XM_217975
VERSION     NM_001009687.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C and
            Kutay U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Liu T, Deng M, Li J, Tong X, Wei Q and Ye X.
  TITLE     Phosphorylation of right open reading frame 2 (Rio2) protein kinase
            by polo-like kinase 1 regulates mitotic progression
  JOURNAL   J Biol Chem 286 (42), 36352-36360 (2011)
   PUBMED   21880710
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE and
            Kutay U.
  TITLE     Distinct cytoplasmic maturation steps of 40S ribosomal subunit
            precursors require hRio2
  JOURNAL   J Cell Biol 185 (7), 1167-1180 (2009)
   PUBMED   19564402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088297.1.
            
            On Jan 13, 2005 this sequence version replaced XM_217975.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088297.1, SRR8487230.111089.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1814
                     /gene="Riok2"
                     /note="RIO kinase 2"
                     /db_xref="GeneID:308201"
                     /db_xref="RGD:1311588"
     exon            1..77
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1667
                     /gene="Riok2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO2"
                     /protein_id="NP_001009687.1"
                     /db_xref="GeneID:308201"
                     /db_xref="RGD:1311588"
                     /translation="MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPCSLVASIASL
                     KHGGCNKILRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVDSVGNQIG
                     VGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWIYLSRLSAMK
                     EFAYMKALHERKFPVPKPVDYNRHAVIMELINGYPLCQIHHVEDPASVYDEAMELIVK
                     LGNHGLIHGDFNEFNLMLDKDDHITMIDFPQMVSTSHPNAEWYFDRDVKCIREFFLKR
                     FNYESELYPTFSDIRREDSLDVEVSASGYTKEMQADDELLHPVGPDDKITETEEESDL
                     SLSDEEMLERAKVQRSELENEPNPADESGSSCCFSSADSKQMKEDGLPEESADVSSFE
                     VTKLHQAVEEVGRQVLTHKSVAEVSEESTRTEDDPRHDGQPGQSSPAGCAEGEDELPD
                     LIALSSLNKEFRPFRDEDSVSSVTQHRTRTLSVTSTGSVLSCSTIPPELVKQKVKRQL
                     TRQQKAAARRRLQKGEANIFTKQRRENMQNIKSSLEADSFWGD"
     exon            78..216
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..333
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..509
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..598
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..790
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..883
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1405
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1502
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1790
                     /gene="Riok2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggcaag catggggaag gtgaatgtgg ccaagctaag gtacatgagt cgagatgact
       61 tcagagttct gactgcggtt gaaatgggca tgaaaaacca tgagatcgtt ccctgcagtt
      121 tggttgcttc tatagccagc ctgaaacacg gtggctgtaa taaaatctta agagaattgg
      181 tgaagcataa acttatagca tgggaacgta ctaaaactgt ccagggctat cggttgacaa
      241 atgctggcta tgattaccta gctttgaaaa ccctgtcttc cagacaggta gttgattctg
      301 ttggaaacca gataggtgtc ggcaaagagt cagatattta cattgttgca aatgaagaag
      361 ggcagcagtt tgcactgaag ctgcaccgac tggggagaac ctcctttcga aatctgaaaa
      421 acaagcgtga ttaccataag cacagacata atgtttcttg gatttattta tctcgtctct
      481 ctgccatgaa ggaatttgcc tatatgaagg cattacatga gcggaaattc ccagttccaa
      541 agccagttga ctacaatcgc cacgcagtga tcatggagct tatcaatggc taccccctgt
      601 gtcagataca tcatgttgaa gaccctgcat cagtgtatga cgaagctatg gaactgatag
      661 tcaaactggg aaaccatggg ctgattcatg gagatttcaa tgaattcaac ctcatgttgg
      721 acaaagatga ccacatcacc atgattgatt ttccacagat ggtttccact tcccacccga
      781 acgctgaatg gtattttgac agagatgtta aatgcattcg agagttcttc ctgaaacgtt
      841 ttaactatga aagtgagctc tacccaacct tcagtgatat caggagagag gattctctcg
      901 atgttgaggt ctctgccagt ggttacacga aggaaatgca ggcagatgat gaactgctac
      961 atccagtagg tccggatgat aaaattactg aaacagaaga ggaatctgac ttgtcactct
     1021 ctgatgaaga aatgttagaa agagccaaag ttcagaggtc agaactggaa aatgaaccaa
     1081 acccagcgga tgaatcaggt agctcctgtt gcttctcatc tgcagacagc aaacagatga
     1141 aggaagacgg cttacctgag gagagtgctg atgtgtccag ttttgaagta actaagttac
     1201 atcaagctgt agaagaagtg ggaaggcagg ttcttaccca caagtctgtt gctgaggttt
     1261 ctgaggagag cactagaact gaggatgatc ccaggcatga tggccagccg ggtcagagca
     1321 gccctgctgg ctgtgcagag ggggaggatg aactccccga tctcattgcc ctgtcatcat
     1381 tgaacaagga gttcaggcct ttcagagatg aagacagtgt gagcagtgtt actcagcata
     1441 gaacaagaac cttgagtgtt acgtctaccg gcagtgtcct gagctgctcc acaatccctc
     1501 cagaactggt gaagcagaag gtgaagcgtc agctgacgag gcagcagaag gcagctgcca
     1561 gacgccggct gcagaaagga gaagccaata tatttaccaa gcagcggagg gaaaacatgc
     1621 agaatatcaa atcaagtttg gaagcagaca gcttttgggg agactaataa atttttgatc
     1681 tgtatatttt tttagatact gtaattctat ttttagccag tatattggtc tttttaagac
     1741 caaagccaat atttatggaa attatggaaa taaaccctta ttagactcaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaa
//
