LOCUS       NM_001100511            2085 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus RIO kinase 1 (Riok1), mRNA.
ACCESSION   NM_001100511 XM_001063945 XM_214454
VERSION     NM_001100511.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C and
            Kutay U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Widmann B, Wandrey F, Badertscher L, Wyler E, Pfannstiel J, Zemp I
            and Kutay U.
  TITLE     The kinase activity of human Rio1 is required for final steps of
            cytoplasmic maturation of 40S subunits
  JOURNAL   Mol Biol Cell 23 (1), 22-35 (2012)
   PUBMED   22072790
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K,
            Fischer U and Grimmler M.
  TITLE     RioK1, a new interactor of protein arginine methyltransferase 5
            (PRMT5), competes with pICln for binding and modulates PRMT5
            complex composition and substrate specificity
  JOURNAL   J Biol Chem 286 (3), 1976-1986 (2011)
   PUBMED   21081503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079173.1 and CO565410.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_214454.3, XM_001063945.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079173.1, FQ209749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1844              BC079173.1         1-1844
            1845-2085           CO565410.1         461-701
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2085
                     /gene="Riok1"
                     /note="RIO kinase 1"
                     /db_xref="GeneID:291061"
                     /db_xref="RGD:1306086"
     exon            1..252
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1882
                     /gene="Riok1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO1"
                     /protein_id="NP_001093981.1"
                     /db_xref="GeneID:291061"
                     /db_xref="RGD:1306086"
                     /translation="MDCSLDRMATVVPGQFDDADSSDSEDKEVQSIQAKDDILLKNLQ
                     NDAAEVKGEDEIEEEDSYDYDSDWYLDDSTGKLTKGWTWNGSSNHQANRQTSNYNSAK
                     MSTPIDKSLRKFENKINLSKLNVTDSVINKVTVKLRQKEAESYRIKDKADRATVEQVL
                     DPRTRMILFKLLHKEHISEIHGCISTGKEANVYYASTPSGESRAIKIYKTSILMFKDR
                     DKYVTGEFRFRRGYCKGNPRKMVKTWAEKEMRNLSRLRTANIPCPEPIRLRSHVLLMS
                     FIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGGD
                     VYIIDVSQSVEHDHPHALEFLRKDCANVNDFFFKHAVAVMTVKELFEFVTDPSITLEN
                     IDAYLEKAMEIASQRTMEEKTSQDHVDEEVFKQAYIPRTLNEVKNYERDVDIMMRLKE
                     EDMALNTQQDNILYQTVTGLKKDLSGVQKVPALLESEVKEETCFDSDDAGSSECSDTD
                     PEEQGDQAGCQNHTADPDVDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKAKKGK
                     "
     exon            253..451
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..542
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..612
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..655
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..748
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..861
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..942
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1029
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1167
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1271
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1378
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1444
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1564
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1618
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1771
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2085
                     /gene="Riok1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgccttt gctgaaaccc ggcatcctgg cacctcgtgg cccctggtcc ttgctttggg
       61 cctgggggtt gcctagggat ttgagaggcc gggatctcgg agacgcggtt gggttctcta
      121 ggtggaaagt cgtctcttcc actcgcggcc tgcggggctc cgagggctta ccccactagt
      181 catggactgc agtctggata ggatggccac ggtggtcccc gggcaatttg acgacgcgga
      241 ttcctcagac agtgaagaca aagaagtgca gtcaatccaa gcaaaagacg acattctact
      301 taaaaacctt cagaatgatg cagcagaggt gaagggcgaa gatgagattg aggaggaaga
      361 cagctatgat tatgacagtg actggtactt ggacgactcg actggaaaac tcaccaaggg
      421 ttggacctgg aatggcagca gtaaccatca ggcaaatcga cagacttcta actacaattc
      481 agccaaaatg tctactccaa ttgacaagtc tttgcgaaaa tttgaaaata agatcaatct
      541 aagtaagctg aatgttactg attctgtcat aaataaagtc accgtaaaat tgagacaaaa
      601 agaagcagaa tcgtatcgca ttaaagacaa ggccgacaga gcaactgtag aacaggtttt
      661 ggatcccaga acaaggatga ttttattcaa gttgttgcat aaagagcaca tatcagagat
      721 acatggctgc atcagtactg gaaaagaagc taatgtatac tatgctagca cacccagtgg
      781 agagagcaga gcaatcaaaa tatacaaaac ttctattttg atgttcaaag atcgtgataa
      841 gtatgtgact ggggagttca ggttccgccg tggctattgc aaaggaaacc ctagaaaaat
      901 ggtgaagacg tgggcagaga aggagatgag gaatttgtcc aggttaagaa cagcaaacat
      961 accatgccca gaaccaatca ggctaagaag tcatgttctc ctcatgagct tcattggcaa
     1021 ggatgacatg cctgcaccac ttttgaaaaa tgtccagttg tcagaatcca aggcacggga
     1081 gctgtacctg caggtcattc agtacatgag gaaaatgtat caggatgcca gacttgtcca
     1141 tgcagatctc agtgaattca acatgctgta ccatggtgga gatgtatata tcattgatgt
     1201 ttctcagtct gtggagcatg accacccaca tgcattggag ttcttgagaa aagactgtgc
     1261 caatgtcaat gatttctttt tcaagcatgc tgttgctgtg atgactgtga aggagctctt
     1321 cgagttcgtc acggatccct ccatcaccct tgagaacata gatgcttatt tggaaaaggc
     1381 tatggaaata gcatctcaga ggaccatgga agaaaagact agccaagatc atgtggatga
     1441 agaggtgttc aaacaagcat atattcccag aaccttaaat gaagtaaaga attatgagag
     1501 agatgtggac ataatgatga ggttaaagga agaggacatg gctttgaaca ctcagcagga
     1561 caatattcta taccagactg tcacaggact gaaaaaagat ttgtcaggag tccagaaggt
     1621 ccctgcgctc ctagaaagtg aagttaagga agagacttgt tttgattcag acgatgctgg
     1681 gagctctgag tgctctgaca cagaccctga agagcaggga gatcaagccg gatgccaaaa
     1741 ccatactgct gaccctgacg ttgataaaaa ggaaagaaaa aagatggtca aggaagccca
     1801 gagagagaag agaaaaaata aaatccctaa acacgtgaaa aaaagaaagg aaaaaacagc
     1861 caaggccaaa aagggcaaat agagtggagc cagctctcag ctacttggaa cccggaagta
     1921 gaagtagttg gaggggcttc ttcaccatct cactgtcagg aggctggggt gtggtcatgt
     1981 ggttgcttca aaaggcccaa gcctggggtt ggggatttag ctcagtggta gagcgcttgc
     2041 ctaggaagcg caaggccctg ggttcggtct ccagctctga aaaaa
//
