LOCUS       NM_212549               1741 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 1 (Ring1), mRNA.
ACCESSION   NM_212549 XM_228012
VERSION     NM_212549.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Liu,H., Ji,W., Gong,P., Liu,C., Duan,C., Gao,Y., Liu,X., Zhang,D.,
            Zhu,S. and Gong,L.
  TITLE     Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord
            Injury
  JOURNAL   Neurochem Res 42 (4), 1191-1201 (2017)
   PUBMED   28032293
  REMARK    GeneRIF: RING1 protein levels were increased at day 3 after spinal
            cord injury and then decreased gradually.
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Gil,J. and O'Loghlen,A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Simon,J.A. and Kingston,R.E.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Takahashi,M. and Osumi,N.
  TITLE     Pax6 regulates boundary-cell specification in the rat hindbrain
  JOURNAL   Mech Dev 128 (5-6), 289-302 (2011)
   PUBMED   21501682
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   del Mar Lorente,M., Marcos-Gutierrez,C., Perez,C., Schoorlemmer,J.,
            Ramirez,A., Magin,T. and Vidal,M.
  TITLE     Loss- and gain-of-function mutations show a polycomb group function
            for Ring1A in mice
  JOURNAL   Development 127 (23), 5093-5100 (2000)
   PUBMED   11060235
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Walter,L. and Gunther,E.
  TITLE     Physical mapping and evolution of the centromeric class I
            gene-containing region of the rat MHC
  JOURNAL   Immunogenetics 51 (10), 829-837 (2000)
   PUBMED   10970097
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Schoorlemmer,J., Marcos-Gutierrez,C., Were,F., Martinez,R.,
            Garcia,E., Satijn,D.P., Otte,A.P. and Vidal,M.
  TITLE     Ring1A is a transcriptional repressor that interacts with the
            Polycomb-M33 protein and is expressed at rhombomere boundaries in
            the mouse hindbrain
  JOURNAL   EMBO J 16 (19), 5930-5942 (1997)
   PUBMED   9312051
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Walter,L., Fischer,K. and Gunther,E.
  TITLE     Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and
            RT1.Hb genes in the rat major histocompatibility complex
  JOURNAL   Immunogenetics 44 (3), 218-221 (1996)
   PUBMED   8662089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1 and BC098635.1.
            
            On Aug 31, 2012 this sequence version replaced NM_212549.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098635.1, SRR22582424.1901320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000020.1  4832013-4832068
            57-1741             BC098635.1         1-1685
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1741
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /note="ring finger protein 1"
                     /db_xref="GeneID:309626"
                     /db_xref="RGD:3576"
     exon            1..148
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            149..274
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1417
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /EC_number="2.3.2.27"
                     /note="polycomb complex protein RING1; RING-type E3
                     ubiquitin transferase RING1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RING1"
                     /protein_id="NP_997714.2"
                     /db_xref="GeneID:309626"
                     /db_xref="RGD:3576"
                     /translation="MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHS
                     ELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPN
                     FDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPM
                     PGSDQTTTMSGGEGEPGEGEGDGEDISSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGG
                     AAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKG
                     EYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETVEPGGPGGGASDTGGPDGGGG
                     ERGVSGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVS
                     RPLELCYAPTKDPK"
     exon            275..435
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            436..651
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1041
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1315
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1713
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcctcag cgcccgggcc atggcggcgg cggtggcagc aagggttgcg gcgtgagtgg
       61 cagctacgga ccgagcagac cagggcggcg gagccccggg gtccccgggg agaggcccgc
      121 agtggggcag cgcgaaggcc ggagccggac ctctctcagc ggagccctgc ttggaggggg
      181 tcggtgcccc gtcgccatga cgacgccggc gaatgcacag aatgccagca aaacgtggga
      241 actgagtctc tatgagctgc accggacccc gcaggaagcc atcatggacg ggacggagat
      301 tgctgtttcg ccccggtcac tgcattcgga gctcatgtgc cccatctgcc tggacatgct
      361 gaaaaacaca atgaccacca aggaatgctt gcacaggttc tgctcggact gcatcgtcac
      421 tgccctgcgg agcgggaaca aagagtgccc cacctgccgg aaaaagctgg tatccaagcg
      481 gtccctacgg cccgacccca acttcgacgc cctgatctcc aaaatctatc ctagccggga
      541 ggagtacgag gcccatcaag accgggtgct catccgcctc agccgcctgc acaaccagca
      601 ggcgctgagc tccagtatcg aggaggggct tcggatgcag gccatgcaca gggcccagcg
      661 tgtgaggcgg ccgatgccag gatctgatca gaccaccaca atgagtgggg gggaaggaga
      721 gcctggggag ggagaagggg atggggagga cataagctcc gactccgccc cagactctgc
      781 tccgggcccc gctcccaagc gaccccgtgg agggggtgca gggggcagca gtgtagggac
      841 agggggtggt gctgctggtg gggcttgcgg gggtgctggt tctgaagact ctggtgatcg
      901 gggcggcacc ctgggagggg gaaccctagg ccccccaagc cctcctgggg ctcccagtcc
      961 tccagagcca ggtggagaga tcgagcttgt gttccggccc catcccctgc ttgtggagaa
     1021 aggagaatac tgccagacta ggtatgtgaa gactactggg aatgccacag tggatcacct
     1081 ctccaagtac ttggccctgc gcattgccct ggagaggagg cagcagcagg aaaccgtaga
     1141 gcccggaggg cctggcgggg gtgcctcgga cacaggcgga cctgacgggg gtggtgggga
     1201 gagaggggtt tctggaggag gcgaaggtcc tgaggagcct gccctgccca gcctggaagg
     1261 tgtcagcgaa aaacagtaca ccatctacat agctcctggg ggcggagcat tcacgacgct
     1321 gaatggctcc ctgaccttgg agcttgtgaa cgagaagttc tggaaggtct ccaggccgtt
     1381 agagctatgc tatgccccga cgaaggaccc aaaatgacgt cacagggaca gccagaagat
     1441 ggggaccatg gggtgtctct gtgtcccagc tcagcctgac agcttcatct cccaaagccc
     1501 cccagccaga cagcaagagg acagacaagg gcagacggct tttatacaaa gtatctatat
     1561 tgaactagtc tatattgtac agcacgggac ccgcgcccac tactgccttt tctatgggcc
     1621 cccactgccc accgagccgg tgacccggcg gtcgaacaag gccccctccc cgccctcctc
     1681 ccaacaacaa atttgcttat ttcttctttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 a
//
