LOCUS       NM_139038               2549 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Ras and Rab interactor 1 (Rin1), mRNA.
ACCESSION   NM_139038
VERSION     NM_139038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Ma,L., Chen,X., Zhao,B., Shi,Y. and Han,F.
  TITLE     Enhanced apoptosis and decreased ampa receptors are involved in
            deficit in fear memory in rin1 knockout rats
  JOURNAL   J Affect Disord 268, 173-182 (2020)
   PUBMED   32174475
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Dhaka,A., Costa,R.M., Hu,H., Irvin,D.K., Patel,A., Kornblum,H.I.,
            Silva,A.J., O'Dell,T.J. and Colicelli,J.
  TITLE     The RAS effector RIN1 modulates the formation of aversive memories
  JOURNAL   J Neurosci 23 (3), 748-757 (2003)
   PUBMED   12574403
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Han,L., Wong,D., Dhaka,A., Afar,D., White,M., Xie,W., Herschman,H.,
            Witte,O. and Colicelli,J.
  TITLE     Protein binding and signaling properties of RIN1 suggest a unique
            effector function
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4954-4959 (1997)
   PUBMED   9144171
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Han,L. and Colicelli,J.
  TITLE     A human protein selected for interference with Ras function
            interacts directly with Ras and competes with Raf1
  JOURNAL   Mol Cell Biol 15 (3), 1318-1323 (1995)
   PUBMED   7862125
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139038.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U80076.1, SRR26643299.5547.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               JAXUCZ010000001.1  211785107-211785397
            292-472             JAXUCZ010000001.1  211785542-211785722
            473-587             JAXUCZ010000001.1  211785822-211785936
            588-660             JAXUCZ010000001.1  211786026-211786098
            661-752             JAXUCZ010000001.1  211786209-211786300
            753-1493            JAXUCZ010000001.1  211786437-211787177
            1494-1799           JAXUCZ010000001.1  211787426-211787731
            1800-1931           JAXUCZ010000001.1  211788044-211788175
            1932-2083           JAXUCZ010000001.1  211788310-211788461
            2084-2549           JAXUCZ010000001.1  211789290-211789755
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2549
                     /gene="Rin1"
                     /note="Ras and Rab interactor 1"
                     /db_xref="GeneID:207119"
                     /db_xref="RGD:620006"
     exon            1..291
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2533
                     /gene="Rin1"
                     /note="ras interaction/interference protein 1; ras
                     inhibitor"
                     /codon_start=1
                     /product="ras and Rab interactor 1"
                     /protein_id="NP_620607.2"
                     /db_xref="GeneID:207119"
                     /db_xref="RGD:620006"
                     /translation="MCTPVPWGLDSLPESQEKLKELPAMEDPGETEAHPLGATSLNFV
                     PGYQQEEKPSPDPLYDTPDARGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAA
                     LHVLRTEPPGTFLVRKSNTRQCQTLCVRLPEASGPSFVSSHYLQESPGGISLEGSELT
                     FPDLVQLICAYCHTRDILLLPLRLPRAIHQAATHKELEAISHLGMEFWSSSLNTKNQQ
                     RPSEAPQIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTET
                     SSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSASGPSLPPLPS
                     LQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAA
                     TMLMHNRYTAVGQLVQDLLTQVRVGPESRELQGIRQALSRARAMLSAELGPEKLLPPE
                     RLELVLEKSLHRSVLKPLRPILAARLRRRLSTDGSLGRLAEGFRLARTQGPGAFGSHL
                     NLSSPVEIEPVRQKLLQLLRAYSPSAQIKWLLQACKLLYTALKTQAGENAGADEFLPL
                     LSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQAHALPL
                     SPAQELQRSLALWEQRRLPATHNFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQL
                     CATKFRVTQPDAFGLFLYKDQGYHRLPPEALVHRLPTTGYLIYRRAERPETQRAATEK
                     TKTGNERPEAGAWEEEKGGLNGEGKSEIAVDQEGKDQARGGHMQLEEQKAEGCPALEE
                     "
     exon            292..472
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..587
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..660
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..752
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1493
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1799
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1931
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2083
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2549
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaagcctc tgccattcaa gactgggcca agagcaaaag aagtggacac tggctacatg
       61 gagtggacat acaagagtta actggcgggg tgtgaccggg cgaaccgcct tcaggaagtg
      121 ttactcaccg ccaggaatgt gcacgcctgt gccttggggg ttggattctc ttcctgagtc
      181 ccaggagaag ctgaaggagc tcccagccat ggaagaccct ggtgagaccg aagcacaccc
      241 tctgggagcc accagcctga actttgtacc tgggtaccaa caggaagaaa agccatctcc
      301 agacccactg tatgacacac ctgatgccag aggggttcag gcaggcgggt cccaacaacc
      361 agcacgcaca gtgagcttgc gggagcggct gctgatcacc cggcctgtgt ggttacagct
      421 gcgggccaac gctgcagccg cactgcacgt gctgaggaca gagcctccgg ggaccttcct
      481 ggtgcggaaa tctaacactc gccagtgcca gactctatgt gtgcggctgc cagaagctag
      541 tggcccctct tttgtctcca gccactatct ccaagagagt cctggcggca tctctttgga
      601 gggctcagag ctcacattcc cggacctggt ccagctcatc tgtgcatact gtcataccag
      661 ggacattctt ctcctccctc tccgactccc cagagccatt catcaggcag ccacccacaa
      721 agagctggag gccatctccc atctgggcat ggagttctgg agttcctctc tcaacaccaa
      781 gaaccaacag agaccttcag aagctccgca gataccccgg ctgaaggctc gctcccctca
      841 agagctggat cagggcactg gtgcagccct ctgcttcttc aaccccctct tccccgggga
      901 tctgggcccc accaaacgtg agaaattcaa gaggagtttc aaagtgcgtg tatccacaga
      961 gacctccagc cctctgtctc cacctgctgt gccgcctcct ccagtccccg ttctgccagg
     1021 gacatcttcc agccaaacgg aaagactgcc ccctcgacag ctgctgcaga gggagagctc
     1081 agtgggatac cgtgtgccag gaagtgcttc tggtcctagt cttcctcccc taccttcact
     1141 tcaggaggtg gactgctgct cccccagcag ctcagaggag gagggttctt caggaagccc
     1201 tacaacctcc ccacgcctaa gccgcccaag gcaccggcgg cctctgcttc ggtccatgag
     1261 ttctgctttc tgctctctgc tggcaccaga gaggcaggtg ggccgggcag ctacaatgct
     1321 aatgcacaac cgatacacag ctgtgggtca gctagtgcag gacctattga cccaggttcg
     1381 tgttggtcct gagtcccggg agttgcaggg catccgacag gccctgagtc gggcacgggc
     1441 catgctgagt gcagagctgg gccctgagaa actgctacca ccagagcggc tggaattggt
     1501 cctggagaaa tccctgcatc gctctgttct caagcctctt cgacccattc tagctgcccg
     1561 cctgcggcgc cgactttcca cagacggttc ccttggccgc ctagctgagg gcttccgcct
     1621 ggcccggacc caggggcctg gagccttcgg gtcccacctg aacctttctt ccccagtgga
     1681 gatagaacca gtgcgtcaga agctgctgca gctccttcgt gcctactcgc ctagtgccca
     1741 gatcaagtgg ctcctgcagg cctgcaagtt gctatacaca gccctgaaaa cccaggcagg
     1801 ggagaatgca ggtgctgatg agttcctgcc tctcttgagc cttgtcttgg cccagtgcga
     1861 ccttcctgac ctcctgttag aagctgagta tatgtcagag ctactggaac ccacattgct
     1921 cactggggag ggcggctact acctgaccag cctctcagcc agcctggcct tgttgagtgg
     1981 cctaagccag gcccacgcac tgccactcag ccctgcccag gagctccaac gttctctggc
     2041 cctctgggaa cagcgccgcc tgccggccac ccacaacttc cagcacctcc tccgagtagc
     2101 ctaccaggac cccagcacag gttgcacctc caagaccttg gctgtgcccc cggggtcttc
     2161 gattgccacc ctgagtcaac tctgtgccac caagttccga gtgacccaac cggatgcatt
     2221 tggcctcttt ctctacaagg accagggcta ccatcgcctg ccccctgaag ccctagtcca
     2281 caggcttccc acaactggtt acctcatcta ccgccgggca gagcgccccg agacccagag
     2341 ggctgcaaca gagaagacca agacaggaaa tgagaggcca gaggcaggag catgggagga
     2401 ggagaaaggg ggtctaaatg gtgaagggaa atctgagata gctgttgacc aagaaggcaa
     2461 ggatcaggcc agaggaggtc acatgcagct agaggaacaa aaggcagagg gatgcccggc
     2521 tttagaagag tagccaggaa cagctaaaa
//
