LOCUS       NM_170666               5259 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus regulating synaptic membrane exocytosis 4
            (Rims4), mRNA.
ACCESSION   NM_170666
VERSION     NM_170666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5259)
  AUTHORS   Alvarez-Baron,E., Michel,K., Mittelstaedt,T., Opitz,T., Schmitz,F.,
            Beck,H., Dietrich,D., Becker,A.J. and Schoch,S.
  TITLE     RIM3gamma and RIM4gamma are key regulators of neuronal arborization
  JOURNAL   J Neurosci 33 (2), 824-839 (2013)
   PUBMED   23303958
  REMARK    GeneRIF: gamma-RIMs are involved in cell biological functions
            distinct from the regulation of synaptic vesicle exocytosis and
            play a role in the molecular mechanisms controlling the
            establishment of dendritic complexity and axonal outgrowth
REFERENCE   2  (bases 1 to 5259)
  AUTHORS   Uriu,Y., Kiyonaka,S., Miki,T., Yagi,M., Akiyama,S., Mori,E.,
            Nakao,A., Beedle,A.M., Campbell,K.P., Wakamori,M. and Mori,Y.
  TITLE     Rab3-interacting molecule gamma isoforms lacking the Rab3-binding
            domain induce long lasting currents but block neurotransmitter
            vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels
  JOURNAL   J Biol Chem 285 (28), 21750-21767 (2010)
   PUBMED   20452978
REFERENCE   3  (bases 1 to 5259)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000120.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_170666.3.
            
            On Oct 27, 2022 this sequence version replaced NM_170666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF548739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JACYVU010000120.1  7156919-7157305     c
            388-526             JACYVU010000120.1  7114393-7114531     c
            527-639             JACYVU010000120.1  7100606-7100718     c
            640-741             JACYVU010000120.1  7100272-7100373     c
            742-881             JACYVU010000120.1  7099707-7099846     c
            882-5259            JACYVU010000120.1  7093217-7097594     c
FEATURES             Location/Qualifiers
     source          1..5259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5259
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /note="regulating synaptic membrane exocytosis 4"
                     /db_xref="GeneID:266976"
                     /db_xref="RGD:628695"
     exon            1..387
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1100
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /note="synaptic regulatory protein RIM4gamma;
                     rab3-interacting molecule 4"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     4"
                     /protein_id="NP_733766.2"
                     /db_xref="GeneID:266976"
                     /db_xref="RGD:628695"
                     /translation="MERSQSRLSLSASFEALAIYFPCMNSFDDEDAADSRRLKGAIQR
                     STETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGP
                     AQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLE
                     NGVCIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARV
                     LLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS"
     exon            388..526
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            527..639
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            640..741
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            742..881
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            882..5259
                     /gene="Rims4"
                     /gene_synonym="RIM 4; Rim4gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgcgct gcgccgccgc caccaccacc accgccgccg ccgccgccgc cgccgccgcc
       61 gccaccaccg ccaccaccgc cgccaccgcc gcgagcaccg cgcgtctccc gctccaagcg
      121 ccgccagtgt ccggccctct gcgcccaggc gccagccccg ccgcccgccc gcggagcccc
      181 gggccgccgc caccacgccg cgcgccgtac tccgcgtcaa gaatggggcg gccaagctgc
      241 ccaagccgcc cgccgccgcg gcggccgagg ctcctggagc gggcgcgggc atggagcgct
      301 cgcagagccg cctcagcctg tccgcctcct tcgaggcgct cgccatctac ttcccgtgca
      361 tgaactcctt cgatgatgag gacgcagcag acagccggag gctgaagggt gccatccaga
      421 gaagcacaga gacagggctg gccgtggaga tgcccagccg gacgttacgc caagccagcc
      481 atgagtccat cgaggacagc atgaatagct atggctcaga gggcaacctg aactatggag
      541 gagtttgtct agcttcggat gcccagttca gtgacttcct ggggagcatg gggccagcac
      601 agtttgtggg ccgccagacc ctggctacca cacccatggg ggatgtggag atcggtttac
      661 aggagcggaa cggtcagctg gaggtggaca tcatccaggc acgcgggctg actgccaagc
      721 caggctcgaa gacactgcca gctgcctata tcaaggccta tctgctggaa aatggtgtct
      781 gcattgccaa gaagaagacc aaagtggccc gcaagtcact ggacccgttg tacaaccagg
      841 tgcttctgtt tcctgagagt ccccagggca aagtcctgca ggtaattgtg tggggaaact
      901 acggacgaat ggagcggaag cagttcatgg gcgtggctcg agtgctgctg gaggaactgg
      961 acttgaccac cctggccgtg ggttggtaca agctcttccc cacctcctcc atggtggacc
     1021 cagccacagg tcccctgctt cggcaggcat cccagctgtc cctcgagagc accgtggggc
     1081 cctgtggcga gcgatcttaa tgccagggat ggggaggggc tccccgagat ggcctggaga
     1141 ccacccagcc ctgacctggg accccaggcc caggggcaca ttggacattg gaggatgggg
     1201 ttcttcccca cagtggggaa gcagaatggg gagacctgcc ccccatgggc ccctcctcac
     1261 tccttcacct cctacccctg agaccttccc tttcccagtg ggttggctac acttttgact
     1321 tggccggttt tgacctggtg gatgcggcta caatcggaga aagactgaag tggcagagca
     1381 aaccactctt ccgccctacc ctaccctacc ccaccccacc cattccccct ttgcctcctt
     1441 ggaagctcgc tgcccagagc caagtccaga accaagccgg ccatctccat ggtgccaatt
     1501 accagcaagt gtctttcctg cggcaccggg ttccggcagc tactcctgcc ccagagctga
     1561 cggggcagtt tgcaaggatc cggagccagc tcccaaaggg ggtgcccaga gctccccact
     1621 tgaaggggag cgtgggtctc cctctgcctg cccgtggaag gagctttgcc gcagcctgtc
     1681 tgagtccatc catccatccc ctcctgcctg tccctctgct gtaagctcta ggaattgggg
     1741 gccagcagag accaaaggaa aggaggaggt acccaaggct tggcaggatc cccaagggtc
     1801 cttgctccat gggattgcaa caagctggtc tggagctctt ggtggactgg aaaggacatt
     1861 gtcatctgtg atatggtgga gggactaagg ggaacctgag tttccagaac cttgtacgca
     1921 gggaacagct ctcctgtggg agagtggtag gagcggagcg ttgaagaagc tggagttagg
     1981 tatatgtggc accaaggtga gggttttcca aacaggagat cccttcttgt tggatgagat
     2041 caaaggtcat cttgttatcc ctctgcctct gggctagggt cttggagagg cattagagcc
     2101 actcacattt tagtctgttt aaataaacca tcccgtagga agggcaaaag ccactgccca
     2161 gcctcatcac cttggctcaa ggagagatgg cgttccagga ggagggatat agagctaaaa
     2221 gtttgagaat tgaggctcca atgaggcctg agtagctgcc ttcctgtggc cctccctggg
     2281 gcctgcagga gcccttttgc atgcgaggga ggacacagtc tggcccctat agaagcacat
     2341 ttctatcacc cactcctggg aggcgcccag cagccagtcc tcctcaggta gtccctgctg
     2401 tgtagggtgt agtccaggtt agctgggtaa ttagtgttca cacctgaggc ctgttagctc
     2461 agatgtagtc tttttttcaa gccccaggct gtgagtagag gggaggcccc ccagtacatt
     2521 ccagaagatt atagactctc tctctagcct gggctggatg ggctgcctgg ctccccggag
     2581 gccagccctt ccacctcctc cctgccttcc tctctcctcc cttctaaggt tgtagcccta
     2641 actgtccatc actctcagca ctctggtgta atagaccctc ggccttgatt ttctttacca
     2701 cgcactcccg agggttgctg ggccttgcag agagaggcct ggactacatt tagacagaat
     2761 catttcccgc caaggacgcc aggactctgt tgaatccctc cttgttcctg gttcattcac
     2821 caagggattc cttcaacttg gaaattctca ttcccagcct ggctaagcct ggggtgccct
     2881 ttagggttct gtccagttct ggcccctccc catgcagctg ttgacgctac acggggaggg
     2941 gctgtgaaca ggcccctctt ctccaattgg tcttcagcgt gtctttggga gtgtccttgg
     3001 tcaggcctcc tggacaaggg agcagggctc tcgatgggct gtcttcgagg cccacagtta
     3061 gccatcaccc catttttcca gtgtgatatc cttgctgtta ggttattact cgccgtttgg
     3121 gagtattttg agccaggaga gcacctccct ctccagctgt catcgctgtg gtcgttcagg
     3181 gtcggatgga gcctggctgt cacagccagc agggagaggc tcagctccaa tgtggagaga
     3241 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gcgagcgcga
     3301 gagcacgagc gcacgaggga gcactgactc caaagcaata acaacaccct gaggtggtca
     3361 gcaaggcccc tcagagactt tcttgtttgt tctgtgaaat cacactcacc tcctggaggg
     3421 gtagagtggg ggggctggag ccccatttct ttgtaccatt gtaagcgtgt gcccgagggg
     3481 ctgtgaccac tgggtgtggg acccatttct gtcctcacca aaggactgga cggggcttgg
     3541 ggacggggag tgattttttt catccttagc ctcggggacc aacaagccca gcctgttccc
     3601 actgctgtct gaccctctgt caactcaaac tctaccatct ggaggggagt cgagagggtg
     3661 gagtgggggg agcctttctg gtgctgtgtc tctaagggtg tttctttctt ccctctggac
     3721 aaaggtcatg tgtaggattg tcgtgtaaag agccatctcc attttcctta cccagaatgc
     3781 ctctgcattc tgaagggaca ggcctgtggc tctctagtcc atttgcatta aaaaaaaaaa
     3841 acaaaaggat accaaggccc tgcctgagga gagccatcgt ggggtcactg gaaggtccag
     3901 tggcatttcc acccaggtct ccccttcatg tctcatgctg agctggtgcc agggaaggct
     3961 gaaggaggac agcatttctc atcctttcta ttgcttctct ttggagcctc ctagtggctc
     4021 ccagctgtgg caggacaaac ggtagcccat ctgagaggtt aggaaactca ggccatagca
     4081 agcaggaagg gccctcagca atatgcactg gggggacaaa gctgggagac caccactcag
     4141 gggtgccacc atcatcattt ctgtccttta ggcacaggtg gcattgtcct gcttggctct
     4201 ctttcctggg ctagtgcctt ttctgggctt gagttgggag aagagggcgg ctggtgggag
     4261 gggtaccggg ttggcctgga tgtcctgggc tatctcccca gggatcatga gctgaagggt
     4321 tttattctgg gtcattacct cttcaggtct agctgcgagt gggtggggtg agaaaaaaaa
     4381 aaaaacaagt tcccttctgg gttcatagag cgggggctca aggaagtcct ctctaacctt
     4441 cagaagcacc tcatcccata acacctccca cggcgcgtcc cccgtgattt cactctgacc
     4501 cccatcagag ccccgaatag ccagggaagg gatgcttgca attgtcagcc ttgttttcag
     4561 gagggagcga aggtcctgaa agagaaaggt gcttgctcac gttatggctt tgacagagct
     4621 agctcgctct ccagtggtcc atagcacagg catgcaagca tgtaacagag gcagttaagc
     4681 agttcacctc caggttcctt caggcaggag cttcttgagt actttggggt tcacgaacag
     4741 cacaggggct cccacattct cccaaggcag agctgttgca ccaggcaagg tcacctgcat
     4801 ttatttattg agcagcagca ctacactagg cccagagcct tagacccctt tcccgtcccc
     4861 tgcaatggtt ctcttggcct tccaagaggg cctgtgtctg cagaacagga ccttggtgga
     4921 tagagagttt ctataggctt acctagcaag ccccaagggt tttttgtttc atcaagagat
     4981 cctgtgtggg ctgggccgga ggctggaagt agacgtaggt gttacttctg agtcctttgt
     5041 gccgtcctgt aaggtgacag gaaggtggga ccccagaatc ctggggctgg gagcctccct
     5101 tcatctaccc acctttccct gtttcctctt ggggggcagg aacagcctgg tcctccaggg
     5161 agggagggat ttgggggcgt ctgagttgga gcgggtcaca tggcattgta ttcatgacta
     5221 tatagctcat gttggaaatt aaagtttttg gcttttcta
//
