LOCUS       NM_022931               6506 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus regulating synaptic membrane exocytosis 3
            (Rims3), mRNA.
ACCESSION   NM_022931
VERSION     NM_022931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6506)
  AUTHORS   Alvarez-Baron,E., Michel,K., Mittelstaedt,T., Opitz,T., Schmitz,F.,
            Beck,H., Dietrich,D., Becker,A.J. and Schoch,S.
  TITLE     RIM3gamma and RIM4gamma are key regulators of neuronal arborization
  JOURNAL   J Neurosci 33 (2), 824-839 (2013)
   PUBMED   23303958
  REMARK    GeneRIF: gamma-RIMs are involved in cell biological functions
            distinct from the regulation of synaptic vesicle exocytosis and
            play a role in the molecular mechanisms controlling the
            establishment of dendritic complexity and axonal outgrowth
REFERENCE   2  (bases 1 to 6506)
  AUTHORS   Uriu,Y., Kiyonaka,S., Miki,T., Yagi,M., Akiyama,S., Mori,E.,
            Nakao,A., Beedle,A.M., Campbell,K.P., Wakamori,M. and Mori,Y.
  TITLE     Rab3-interacting molecule gamma isoforms lacking the Rab3-binding
            domain induce long lasting currents but block neurotransmitter
            vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels
  JOURNAL   J Biol Chem 285 (28), 21750-21767 (2010)
   PUBMED   20452978
REFERENCE   3  (bases 1 to 6506)
  AUTHORS   Liang,F., Zhang,B., Tang,J., Guo,J., Li,W., Ling,E.A., Chu,H.,
            Wu,Y., Chan,Y.G. and Cao,Q.
  TITLE     RIM3gamma is a postsynaptic protein in the rat central nervous
            system
  JOURNAL   J Comp Neurol 503 (4), 501-510 (2007)
   PUBMED   17534942
REFERENCE   4  (bases 1 to 6506)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
REFERENCE   5  (bases 1 to 6506)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_022931.3.
            
            On Nov 30, 2020 this sequence version replaced NM_022931.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28698.1,
                                           SRR26360176.2394353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               JAXUCZ010000005.1  139714320-139714643
            325-495             JAXUCZ010000005.1  139731306-139731476
            496-743             JAXUCZ010000005.1  139736265-139736512
            744-885             JAXUCZ010000005.1  139741453-139741594
            886-995             JAXUCZ010000005.1  139744822-139744931
            996-1097            JAXUCZ010000005.1  139746626-139746727
            1098-1237           JAXUCZ010000005.1  139746988-139747127
            1238-6506           JAXUCZ010000005.1  139748877-139754145
FEATURES             Location/Qualifiers
     source          1..6506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6506
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /note="regulating synaptic membrane exocytosis 3"
                     /db_xref="GeneID:65025"
                     /db_xref="RGD:628762"
     exon            1..324
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            325..495
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..743
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..1450
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /note="RIM 3; RIM3 gamma; rab-3-interacting molecule 3"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     3"
                     /protein_id="NP_075220.2"
                     /db_xref="GeneID:65025"
                     /db_xref="RGD:628762"
                     /translation="MFNGEPGPASAGASRNVVRSSSISGEICGSQQAGGGAGTTTAKK
                     RRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQ
                     GSRESTDGSTNSNSSEGTFIFPTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVH
                     IAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKAYLLENGACVAKKKTKVAKKTCD
                     PLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAVVTGWYKLF
                     PTSSVADSTLGSLTRRLSQSSLESATSPSCS"
     exon            744..885
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..995
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1097
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1237
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..6506
                     /gene="Rims3"
                     /gene_synonym="Nim2; Nim3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcccgct tcctcccgcc agtcgtggct ccggctttgc acccggcggc gactgagaac
       61 tgtgtggcga ctgcggagcc agcagcgcag gcgggcggag cggagctgtc cggcccggtg
      121 gcgggcgatg cccccgtgag tctctgtcgc tgcccctccc cgccccgcgt ccctacccct
      181 tcggagtccg cgcccgtccg gggccgggcc gcgcctaccg ctgggtccgc ggggcggggt
      241 cccggggcag cacctgcctt gccttgcggc gccactctgc cagcggaacc ccgctccagg
      301 cgtggacccc ggccccacct cgggatcctg tcatcacatt gcttccccct ggaagcctgc
      361 cctgattgcc tttaccttct tctctgaaaa tcggtgtctc aacagaagtg aagctctgtg
      421 cagacttggg gctgtgctgt tgagagagca cagccccttg tgatgcggag cgtcacacgc
      481 agactcagca actcgaattg cctgaagccc tgccatcctg gggaccatgt ttaacgggga
      541 gcctggtcca gcctcggctg gggcctccag gaatgtagtg aggagctcca gcatcagcgg
      601 tgagatctgt ggatcccagc aagccggagg cggggccggg accaccacag ccaagaaacg
      661 gcgcagcagc ctgggcgcca agatggtggc tattgtcggc ttgacccagt ggagcaaaag
      721 cacactgcag ctcccccagc ctgaaggggc caccaagaag ctgcgcagca acattcgacg
      781 gagcacagag acgggcattg ccgtggagat gcggagccgt gtaacccgcc agggcagccg
      841 ggagtctacc gatgggagca ccaacagcaa cagctccgag ggcacgttta ttttccccac
      901 acggcttgga gctgaaagcc agttcagtga ctttctggat ggcctgggac cagcccagat
      961 agtgggacga cagacactgg ccacaccccc catgggagat gtgcacattg ccatcatgga
     1021 ccggagtggc cagctggagg tagaagtgat tgaagctcgg ggcctgaccc ccaaaccagg
     1081 ctccaaatcc ctcccagcca cctatatcaa ggcttacctg ctggagaacg gggcatgtgt
     1141 ggccaagaaa aagacaaagg tggccaagaa gacttgtgat cccttgtacc agcaagcttt
     1201 gctctttgat gaggggcccc aaggcaaggt tctacaggtg atcgtctggg gagactatgg
     1261 ccgtatggac cacaagtgct tcatgggtat ggcccagatc atgctggacg agctggacct
     1321 gagtgctgtg gtcactggct ggtacaaact cttccccaca tcctctgtgg ccgactccac
     1381 acttggatcc ctcaccaggc gcctgtctca gtcctccttg gagagtgcca ccagcccctc
     1441 gtgctcctaa ggacctcgat gaagacaaga ggccaggggc tattggggga agggagcctg
     1501 ctggacccac caccccctgt acatagtctc catgaccttc tggacccctt accctgctgc
     1561 atgcctgtgg ccactgggct tgtcccagct ggcagtggag actgtagtgt gtgtctgtgt
     1621 gtctctctct gtgtatgtgt gtgtgtgtcc atatatctgt ccatttgtct gtgtacaatc
     1681 agtcctggtg atctcatgga ctatatagtc cacatctctg tatcttgctg gaaagaaccc
     1741 aaaggagcat cattcggaca cttcttgccc atggagtctc caggggtggc aataggggat
     1801 gtggccacca gtgggcctcg cttagtccct gccttgttgt cttatggtct ccacttgctt
     1861 ttctgtcctg tctttttctt tgcctctccc agcattgctg ctcttttttg aggaatgtag
     1921 catccattgc ggctgaccac acctggttcc gtctaggaac ctacgtctct cctccctacc
     1981 acggccacga tggtggtcaa cccattgaac gcactccaca gcatgtagca tgctcaccca
     2041 gtgccctaac cagggccccg ggaagacaga gaagggtgtc tggggaggag gatgctggcc
     2101 agacacacta gaggatgtgc tgggacctct cctccctgga gtgttcccac ataccaaagg
     2161 agctgcccag tggacccagg aggttgcaaa tagctggcct tctcaggcat caagggtggc
     2221 cctgtcccct tctggggtta ttcctgaggg aacatggcgt ggtaagaggt gccacagaat
     2281 tggctccttg ctggaggaag gaaggctaag gttaatttgt tttgagccac agtcaggaat
     2341 cctgtcttac ctgggattag ctacatgaag ctgttctttc agggttcagc tttctttgct
     2401 catctgtaga caccagaccc catctggagt ccggacacac cggggctcca gcctccagct
     2461 ctgtgggcag cctggctctg cagtcaaggg tgcctctgtc accagctctg taccagcaat
     2521 actcacccct cctccacctc cctgactttc ttgagtgggt ccctgctccc ctaggcagtg
     2581 gtctgctcta ggcatctcag ctgcctctgc tttactcccc cttcccttgt ctgcctgggg
     2641 ctcctaccaa ccactgagaa cactgttgga gggactagtg cctggaccag atcccaaaat
     2701 gaccgttgtg aatactaaag gctggctctg gactgctgca tctgttcctt ccctccttag
     2761 ctatggggtg gaattggagg ctgcctggga gatggcaaag cagccctggt ccatgtctac
     2821 tgggaggaag gaggcagggg atgggtaggg gatagggaag actcttctgt ctgcctcttt
     2881 cccagcccat gcctctagta taagtgccta ggcagagaga gctacaaggg taactgaaga
     2941 gccttggcct gtatgcgaat cccatttgca ccaaagctgg ggtgcacaaa gccatcccag
     3001 cccgacaggc ctccctggag tcagagtcct gcactcacct ttcaaagaaa ggcagtgaag
     3061 aggcctccat gtcaactcgg gggaggagga ggatattgaa cgggactgag gatgtgtcct
     3121 tgcaggcagg agagtgaggt gggggccagc gaagttctct tgccagcctt tctggctgga
     3181 gagtatatat gtatctccca tgtcactaga tatggggcaa agtgctcttg gcctccaagc
     3241 cttaatgggt tggggggcaa ggaggaaact agcttgcaaa aggctgtttt catcttgctc
     3301 gaggtatgtg cgcctttaaa gcagttaccc tccggatggt gtgaaagcca tttggagtgg
     3361 aggagtgtca gtgacaatac agacctttgt ggatatggca ttgagtcgct cccagatgtg
     3421 ggagctgcca gcagagtgtc cctcacctct taggagggtc agcacagggg atgctgtagc
     3481 cagaggaggg gctgatgtgc tgggaactca cgctgacctg cctacagtcc gaggctgtaa
     3541 actacctaag agatgggcac ttggctgtcc cccacctcca tggaagataa tccccctccc
     3601 caatcgattt tggggaattc actcttctta acagtaagta atcccatcta gatgtttgct
     3661 cacttgtgtg ggttgtgtaa ggctagtgtg tacatgtgac ggggaggctg tgcttaaagc
     3721 tctgcttctc agcatgctgg atgccattcc ggaagcaggt gtacccaagt gtgactcttg
     3781 cctgggctgg aagcgatctg ccctttgagg gaaggacatt gggtcaaaaa gtaactggat
     3841 ccttgtgaat tcccttacca gctggccacc tcacataacc ccttgctgca ggtggcagtg
     3901 gctgcaggaa tgggatttgg tcatcctgtc tctatggtgg gccagattca tcagtgatgt
     3961 ggctgggaca ggggcggccc tgcagcgatg ctgggatgtg ggcaggggca gtgataaatg
     4021 actcagagca tacgtctttg tacctctgcc ctgttcagcc tgtcccactt tttaacagat
     4081 tcctttccta caaggaaagc agagatggga ctctgtgata ggaagcattc tctaggagat
     4141 gggccaagtc ttggtttgac agggacattt gatcctttgg gggaggaact ggctctgaag
     4201 gcgctctcat cccaccgggc tctgaacatc acctcttcag caggtcccgg gcaacgccag
     4261 catgctatgg gaaggaagca gagccgagag aagctccagg gaggtcgggg tggtggtacc
     4321 cggatgggtc tgcccttagg atctcggtgt ccggagcgct ggggtcaagc taactctccc
     4381 aggggctcaa ccctcaaccg gggaagcatg ccagcccttc cttaactgcc agcctgggag
     4441 agaccagcag cctctgtttt tgtttttgtt ttaaagacaa ctgagccctc ctggggcatt
     4501 tctttgaaaa tgaaatgtag cacaatcctc aactgtgttc ccaggagccc tggcataccc
     4561 agagctcccg atacctcact tctccatcgc ccttggccta ggaggcagta gtgccctagc
     4621 aaggctgctt ttccgtgttt ctctgattgc gtccagcact gtgcaaactc taagaagtcg
     4681 ctgcctttgc ccaaggctgc tctccaccgg gtggggagat gcggtacttc atgtggtggc
     4741 ctgaagcttg tccagcagca cgtctgtagc ggccacaggg aagtggacaa gaagaggcct
     4801 gcttcctgcc accacctttc ctctcccgct cctcagttgt ctctaatgcc ccgacacaca
     4861 cagactttct tttgaacaca ccccctctcc tgcgtcgtca ttttctgatg gatgatcaga
     4921 gaggagatgg aaatgctgac tcctcccctg ccttctccct gtggtctgct tctagcccag
     4981 gtcagaattg ttcagaagag gctagggaga tcaaccacca tcagagagca ggggagcccc
     5041 atccgatcag cctggcctgg ctgggaaagg gtcatttgga gagtgcctga gcgtcttgga
     5101 gcaatgtcag tgacgccaaa gagagtgact gggcctccgt gggcagaagc tctgccagtg
     5161 gagctagaga cgaacaccgc tcagatggca gcatgtcccg cggagggtcc ttgttctctg
     5221 acaaagggct taatctttcc atgtagcaaa gcaactcccc tcccccaacc ctgagcatgg
     5281 gcttctgtgg gcccagcacg gctgtgccta caagagaagc cgcataggtg agagatcttg
     5341 tctcctccct gtctgtctta gcaagtgctc cttcaaaagc ctgagtgttg ctgctttgga
     5401 gaaaccagct ctggctggac acccgccagt aaggacaggg ccttgggcct gcaaggaagt
     5461 ccatattgat gccaggaagg gtccctgggc ctgagaattc cagggaccac tgagcatctg
     5521 ccccattagc caatgacctg gacagggatg gctgttctgt accttttttt ttttttttgt
     5581 cccctttttt tctttttgcc agaaactgtg aagaccttgt gtgaggtatc ttgctggacc
     5641 ttagtgtcct catctgtaac aaccagaaca ttcgctggat gctctgtgac cccttccagg
     5701 ctttgtaagt ctatggcttg gagttgctga agtggtgagg gaccagtttc gtccccgttg
     5761 gttctcacgc tgggagccca tcctcatttg gtccatgccc agtcgtggct tcactccttt
     5821 gcggtttgcc ctcctcactc ctctctctgg ttttggtgag aaacaaccaa gggttgctaa
     5881 aggtggacag ctcccaggtg ccgtaatgtc accacctcag ctgaatcctg aataggtccg
     5941 tgtccccacc agcagacagg ctgggccatc gtcattctgc ttctaggtga cagttcagga
     6001 agagtggaca ctcagagcct tttaaaggaa ttctctctga tgggacgaga gagggaacgt
     6061 ccttctaagt gtttagcttt ttaaaaccac ttcttcacca atttcttttc ccaaactttc
     6121 tctcagaagg cagtgtggct gcttcctcag ggaaatcgga cctgagactt ctagcaactc
     6181 ctgtagcaat gagaactcac agaaggcagg aacccctttt ttagaatttc caaatgcatc
     6241 ctgcaaagag agagagagag ctgttaggga ctgacaagca cactgtttag ataagaagca
     6301 attagccttt tatatttgag ctgtctgcag catctttcca aactgtggct cctgggtggc
     6361 aggtggacag ctggaaagga accggctgtc tcatgtgatg tccttgccaa tccccctgag
     6421 gagaaaattc ttcacatggc ttctgcatgt acagtatttg ggcagaaaaa aaaaaaacaa
     6481 aattaaagtc catttgaaat tggttt
//
