LOCUS       NM_053945               5639 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus regulating synaptic membrane exocytosis 2
            (Rims2), transcript variant 1, mRNA.
ACCESSION   NM_053945
VERSION     NM_053945.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5639)
  AUTHORS   Wang,S.S.H., Held,R.G., Wong,M.Y., Liu,C., Karakhanyan,A. and
            Kaeser,P.S.
  TITLE     Fusion Competent Synaptic Vesicles Persist upon Active Zone
            Disruption and Loss of Vesicle Docking
  JOURNAL   Neuron 91 (4), 777-791 (2016)
   PUBMED   27537483
REFERENCE   2  (bases 1 to 5639)
  AUTHORS   Shen,Y., Ge,W.P., Li,Y., Hirano,A., Lee,H.Y., Rohlmann,A.,
            Missler,M., Tsien,R.W., Jan,L.Y., Fu,Y.H. and Ptacek,L.J.
  TITLE     Protein mutated in paroxysmal dyskinesia interacts with the active
            zone protein RIM and suppresses synaptic vesicle exocytosis
  JOURNAL   Proc Natl Acad Sci U S A 112 (10), 2935-2941 (2015)
   PUBMED   25730884
REFERENCE   3  (bases 1 to 5639)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   4  (bases 1 to 5639)
  AUTHORS   Kaeser,P.S., Deng,L., Fan,M. and Sudhof,T.C.
  TITLE     RIM genes differentially contribute to organizing presynaptic
            release sites
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11830-11835 (2012)
   PUBMED   22753485
REFERENCE   5  (bases 1 to 5639)
  AUTHORS   Deng,L., Kaeser,P.S., Xu,W. and Sudhof,T.C.
  TITLE     RIM proteins activate vesicle priming by reversing autoinhibitory
            homodimerization of Munc13
  JOURNAL   Neuron 69 (2), 317-331 (2011)
   PUBMED   21262469
REFERENCE   6  (bases 1 to 5639)
  AUTHORS   Schoch,S., Castillo,P.E., Jo,T., Mukherjee,K., Geppert,M., Wang,Y.,
            Schmitz,F., Malenka,R.C. and Sudhof,T.C.
  TITLE     RIM1alpha forms a protein scaffold for regulating neurotransmitter
            release at the active zone
  JOURNAL   Nature 415 (6869), 321-326 (2002)
   PUBMED   11797009
REFERENCE   7  (bases 1 to 5639)
  AUTHORS   Kashima,Y., Miki,T., Shibasaki,T., Ozaki,N., Miyazaki,M., Yano,H.
            and Seino,S.
  TITLE     Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated
            insulin secretion
  JOURNAL   J Biol Chem 276 (49), 46046-46053 (2001)
   PUBMED   11598134
REFERENCE   8  (bases 1 to 5639)
  AUTHORS   Ozaki,N., Shibasaki,T., Kashima,Y., Miki,T., Takahashi,K., Ueno,H.,
            Sunaga,Y., Yano,H., Matsuura,Y., Iwanaga,T., Takai,Y. and Seino,S.
  TITLE     cAMP-GEFII is a direct target of cAMP in regulated exocytosis
  JOURNAL   Nat Cell Biol 2 (11), 805-811 (2000)
   PUBMED   11056535
REFERENCE   9  (bases 1 to 5639)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
REFERENCE   10 (bases 1 to 5639)
  AUTHORS   Wang,Y., Okamoto,M., Schmitz,F., Hofmann,K. and Sudhof,T.C.
  TITLE     Rim is a putative Rab3 effector in regulating synaptic-vesicle
            fusion
  JOURNAL   Nature 388 (6642), 593-598 (1997)
   PUBMED   9252191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF199322.1.
            
            On Aug 31, 2012 this sequence version replaced NM_053945.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF199322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5639              AF199322.1         1-5639
FEATURES             Location/Qualifiers
     source          1..5639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..5639
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /note="regulating synaptic membrane exocytosis 2"
                     /db_xref="GeneID:116839"
                     /db_xref="RGD:620001"
     exon            1..227
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..4719
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulating synaptic membrane exocytosis protein 2; RIM 2;
                     rab3-interacting molecule 2; rab-3-interacting molecule 2;
                     regulating synaptic membrane exocytosis protein 2-like"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     2 isoform 1"
                     /protein_id="NP_446397.1"
                     /db_xref="GeneID:116839"
                     /db_xref="RGD:620001"
                     /translation="MSAPLGPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIIQAVM
                     DRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFAD
                     GCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQ
                     QPDQKALRGLRSEEAPQEKKAKLHEQTQFQGPPGDSSVPAVERGRAHGLTRQDSIKNG
                     SGMKHQIASDMPSDRKRSPSVSRDQNRRYDQSEEREEYSQYVPSDSTMPRSPSDYADR
                     RSQREPQFYEEPDHLNYRDSNRRGHRHSKEYIVDDEDVESRDEYERQRREEEYQARYR
                     SDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANAELEDSRISLLRMDRPS
                     RQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRTTNHSPPTPRRSPIPLDRPELRR
                     ADSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPRPHKSKKGGKMR
                     QVSLSSSEEELASTPEYTSCDDVEIESESVGEKGDMEYSWLEHASWHSSEASPMSLHP
                     VTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVK
                     KGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDMP
                     RIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRT
                     TPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRR
                     TKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELET
                     ALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYD
                     CEDGVGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVP
                     PPQRNVEQGLRGTRATGHYNTISRMDRHRVMDDHYSSERDSHFLTLPRSRHRQTSEHH
                     HRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSSERADTNLMRSMPSLMTGRSAP
                     PSPALSRSHPRTGSVQTSPSSTPVTGRRGRQLPQLPPKGTLERMITEDMDSTRKRNSG
                     AMDIEERNRQMKLNKYKQVAGSDPRLEQDYHSKYRSGWDPHRGADTVSTKSSDSDVSD
                     VSAVSRTSSASRFSSTSYMSVQSERPRGNRKISVFTSKMQSRQMGVSGKSMAKSTSIS
                     GDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLSQTEGG
                     GKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQ
                     FSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP
                     APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMD
                     HKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSY
                     SRS"
     exon            228..438
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..749
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1675
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1743
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1863
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1963
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2087
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2134
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2247
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2295
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2426
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2598
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2752
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2821
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2978
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3089
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3155
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3335
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3445
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3487
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3588
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3761
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..4003
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4145
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4258
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4360
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4500
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..5639
                     /gene="Rims2"
                     /gene_synonym="Nim2; Rim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtggag ttgcctccct gcttccctag ggtggttcgg ctccaccaaa catgtcggct
       61 ccactcgggc cccggggccg cccggctccc accccggcgg cctctcagcc tcctccgcag
      121 cccgagatgc cggacctcag ccacctcacg gaagaggaga ggaaaatcat ccaggctgtc
      181 atggatcgtc agaagaaaga agaggagaag gagcagtccg tgctcaaaaa gctgcatcaa
      241 caatttgaaa tgtataagga gcaagtcaag aaaatgggag aggaatcaca acagcagcaa
      301 gagcagaagg gcgacgcccc gacctgcggc atctgccaca agacaaaatt tgcagatgga
      361 tgcggccata actgttcata ttgccaaacc aagttctgtg ctcgttgtgg aggtcgagtg
      421 tcattacgct caaacaaggt tatgtgggtg tgtaatttgt gccgaaaaca acaagaaatc
      481 ctcactaagt cgggcgcgtg gttttacaat agtgggtcta atacaccgca gcagcctgat
      541 caaaaggctc ttcgagggct tcgcagtgag gaagcccctc aggagaagaa ggcaaaactg
      601 catgagcaga cgcagttcca gggacccccc ggtgactcat cagtacctgc agttgagaga
      661 ggtcgagctc atgggctcac aagacaggat tctattaaga atggctcagg aatgaagcac
      721 cagatcgcca gtgacatgcc ttcagacaga aaaagaagtc cgtcagtgtc cagggatcaa
      781 aatcgaagat acgaccaaag tgaagaaaga gaggaatatt cacagtatgt tccttcagat
      841 agcacaatgc ctagatctcc atcagattat gctgatagac gatctcaacg tgaacctcaa
      901 ttttatgaag aacctgatca tttaaattat agggattcta acaggagagg ccatagacat
      961 tccaaagagt atattgtaga cgacgaagat gtggagagca gagatgaata tgaaagacaa
     1021 aggagagagg aggagtacca ggcacgctac agaagtgatc caaatttggc ccggtatccg
     1081 gtaaagccac aaccctatga agagcaaatg cggatccacg ctgaagtgtc ccgggcacga
     1141 cacgagagaa ggcacagtga tgtttctttg gcaaatgctg aactagaaga ttccaggatt
     1201 tctctgctaa ggatggatag accatcaagg caaagatctg tatctgaacg tagagctgca
     1261 atggaaaacc agcgatcgta ttcaatggaa agaactcgag aagctcaggg acaaagttct
     1321 tatccacaaa ggaccacaaa tcatagtcct cctacccctc gcaggagccc tataccgctc
     1381 gatagaccag agctgaggcg tgccgactcc ctacggaaac aacaccactt agatcccagc
     1441 tctgctgtaa ggaaaacgaa gcgagaaaaa atggaaacaa tgttgaggaa tgattctttg
     1501 agttcagacc agtctgagtc agtgaggccg cccccaccaa ggcctcataa atccaagaaa
     1561 ggaggtaaaa tgcgccaggt ttcactgagc agctcagagg aggagttggc atccacgcct
     1621 gagtatacaa gctgtgatga cgtggagatt gaaagcgaga gcgtaggtga gaaaggagac
     1681 atggagtaca gctggttgga gcatgcgtct tggcatagca gtgaggcatc cccaatgtct
     1741 ttgcaccctg tgacctggca gccatccaaa gatggagatc gcctaattgg tcgtatttta
     1801 ttaaataagc gtttaaaaga tgggagtgta cctcgagatt caggagcaat gctgggctta
     1861 aaggttgtag gaggaaagat gactgaatca ggtcgacttt gtgcatttat taccaaagtg
     1921 aaaaaaggaa gtttagctga tactgtagga catcttagac caggtgatga agtcttggaa
     1981 tggaatggaa ggctattgca aggagccaca tttgaggaag tttacaacat tattctagaa
     2041 tccaagcctg aaccacaagt tgagcttgtt gtttcaaggc cgattggaga tatgcctaga
     2101 atacctgata gcactcatgc acaactggaa tccagttcta gctcatttga atctcaaaaa
     2161 atggatcgtc cgtctatatc ggttacctct cccatgagtc ctggcatgct gagggatgtc
     2221 ccacagttct tatctggaca gctttcaagc caaagcctta gtagaagaac aacgcctttt
     2281 gttcctaggg ttcagataaa actatggttt gacaaggttg gtcaccagtt aatagttaca
     2341 attttgggag caaaggatct cccttccagg gaagatggga ggccaaggaa tccttatgtt
     2401 aaaatttact tccttccaga cagaagtgat aaaaacaaga gaagaacaaa aacagtcaag
     2461 aaaactttgg aacccaaatg gaaccagact ttcatttatt ctcctgttca ccgaagagaa
     2521 ttccgggaac gaatgctcga aatcaccctt tgggatcaag ctcgagttcg agaggaagaa
     2581 agtgaattcc taggagagat tttaattgaa ttggaaacag ctctgttaga tgatgaacca
     2641 cactggtaca aacttcagac ccatgatgtc tcctcattgc cactccctca cccttctcca
     2701 tatatgccac ggagacagct gcatggagag agcccaacac gcaggttgca aaggtcgaag
     2761 agaataagtg acagcgaagt atccgactat gactgcgagg acggcgtggg agtcgtgtca
     2821 gattaccgac acgatggccg tgatcttcaa agctccacat tatcagtgcc agaacaagtc
     2881 atgtcatcaa accattgctc accatcaggc tctcctcatc gagtagatgt tataggaagg
     2941 actaggtcat ggtcgcctag tgtccctcct cctcaaagga atgtggaaca ggggcttcga
     3001 gggacacgtg ctactggcca ttacaataca attagccgga tggacagaca ccgtgtcatg
     3061 gacgaccatt actcttcaga gagagacagt cattttctca ctctacctcg ctctcgacac
     3121 aggcagacca gtgagcatca ccacagggat ggaagggatt gtgaagcagc agatagacag
     3181 ccatatcaca gatccagatc aacagaacaa cggcctctcc tagagcggac caccacccgc
     3241 tccagatcct ctgaacgtgc tgatacaaac ctcatgaggt cgatgccttc attaatgact
     3301 ggaagatctg cccctccttc acctgcctta tcgaggtctc accctcgcac tggctctgtc
     3361 cagaccagtc cgtcaagtac tcccgtaaca ggacgaaggg gccggcagct tcctcagctc
     3421 ccaccaaagg gaacactgga aagaatgatc acagaagaca tggactccac aaggaagaga
     3481 aactcaggtg ctatggatat agaggagaga aatcgccaaa tgaaacttaa caaatacaaa
     3541 caggtagccg gatcagatcc cagactggaa caagattacc attcgaagta tcgctcagga
     3601 tgggatccac atagaggggc agatactgtt tctactaaat cctcggacag tgatgtaagt
     3661 gatgtatctg cggtttcaag gactagtagt gcttctcgtt tcagcagcac aagctacatg
     3721 tccgtccaat cagaacggcc gagaggaaac aggaaaatca gtgtctttac gtccaaaatg
     3781 caaagcagac agatgggtgt gtcggggaag agcatggcca aaagcaccag catcagtgga
     3841 gacatgtgct cactggagaa gaatgatggc agccagtcgg acactgcagt gggcgccctg
     3901 ggcaccagtg gcaagaagcg gcgatctagc attggggcca aaatggtagc tattgttggt
     3961 ctctcacgga aaagtcgcag tgcctcccaa ctcagccaaa ccgaaggagg aggtaaaaag
     4021 ctacgcagca ctgtccagag aagcacggag accgggctag cagtggagat gaggaactgg
     4081 atgacaagac aggccagccg ggaatccacg gatggcagca tgaacagtta cagctcagaa
     4141 ggaaatctga tctttcctgg ggtccgcctg gcctctgaca gccagttcag cgatttcctt
     4201 gatggtctgg gccctgctca gctagtggga cgccagaccc tggcgactcc tgcaatgggt
     4261 gacattcagg tggggatgat ggataagaag ggacagctgg aggtagagat catccgggct
     4321 cgaggccttg tagtaaaacc aggttccaag acactgccag caccatatgt caaggtgtac
     4381 ctgttagaca acggagtctg catagccaaa aagaaaacca aggtggcgag aaagacgctg
     4441 gagcccctgt atcagcagct gttatctttc gaagagagcc cccaggggaa ggtgttacag
     4501 atcattgtct ggggagatta tggccgcatg gatcacaaat cctttatggg agtggcccag
     4561 atactcttag atgaactgga actatccaac atggtaattg gatggttcaa actcttccct
     4621 ccttcctccc tagtagatcc aaccttggca cctctgacaa gaagagcttc ccaatcgtct
     4681 ctggaaagtt ctactggacc ttcttactct cgttcatagc aactataaaa ctgttgtcac
     4741 aacaaccagc gttacaaaaa ccagaagaaa ccacccaggt ggggaccctg gtcccactgc
     4801 atgcttgatg ttgtgtctcc ggagcccacg tctagggata aagagccatc ctgtgctctc
     4861 agaggaagcc atccgtgcac agtgtgccct agcaaaggcc ctcgggtgaa cgagcagagc
     4921 ctcgaggaac tgtcaggttt ggagttcaat gacactgagt gttggtccaa tctgaagcca
     4981 tggagtaatc tcagaatcag tcagcccttt tcaatggcac ctttatattg ttattgtttc
     5041 tcttcattta tctgacccca aagccctgtt atgccacaga aatggagctc tacagccatt
     5101 aagccacatt acaggccaag gagcaaagac ctaggaagca tcaggtgaaa agcaagagac
     5161 caaagaagtg gtcaggagca gagtcggcca ccgttcctgg aggggctcca gcagggagag
     5221 cggtcgactg ggctgctctg ggaggcaatg tcattcacta atgccaagat gtgttggact
     5281 ctgaaaatca aaattctgtg actgcactgt actgaatgaa attaaagaaa ctctttttgc
     5341 atggacacag attagctgaa tatttaaatt cttttctcgg ggctgcaact tgcaaaaaaa
     5401 taaataaaaa tcagccattt tcaacaattt atattatttt taaaaataaa tttcactagt
     5461 gcatggtttt aaaatgggag agaatgcaac agggtgatac aaagacacac caagtttatt
     5521 ctttaatcat agtctgtgtt ttggcagaca ttacaaatga aaatactttc tagcagatac
     5581 aattctcttt atgtgacaat aagtataata tattcagttt atttccatgt taaatatac
//
