LOCUS       NM_001395071            4587 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus RNA sensor RIG-1 (Rig1), mRNA.
ACCESSION   NM_001395071 XM_039109438
VERSION     NM_001395071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Cadena,C., Ahmad,S., Xavier,A., Willemsen,J., Park,S., Park,J.W.,
            Oh,S.W., Fujita,T., Hou,F., Binder,M. and Hur,S.
  TITLE     Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in
            Innate Immunity
  JOURNAL   Cell 177 (5), 1187-1200 (2019)
   PUBMED   31006531
REFERENCE   2  (bases 1 to 4587)
  AUTHORS   Shi,Y., Yuan,B., Zhu,W., Zhang,R., Li,L., Hao,X., Chen,S. and
            Hou,F.
  TITLE     Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation
            in antiviral innate immunity
  JOURNAL   Nat Commun 8, 15138 (2017)
   PUBMED   28469175
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4587)
  AUTHORS   Hao,Q., Jiao,S., Shi,Z., Li,C., Meng,X., Zhang,Z., Wang,Y.,
            Song,X., Wang,W., Zhang,R., Zhao,Y., Wong,C.C. and Zhou,Z.
  TITLE     A non-canonical role of the p97 complex in RIG-I antiviral
            signaling
  JOURNAL   EMBO J 34 (23), 2903-2920 (2015)
   PUBMED   26471729
REFERENCE   4  (bases 1 to 4587)
  AUTHORS   Peisley,A., Wu,B., Xu,H., Chen,Z.J. and Hur,S.
  TITLE     Structural basis for ubiquitin-mediated antiviral signal activation
            by RIG-I
  JOURNAL   Nature 509 (7498), 110-114 (2014)
   PUBMED   24590070
REFERENCE   5  (bases 1 to 4587)
  AUTHORS   Sathe,A. and Reddy,K.V.
  TITLE     TLR9 and RIG-I signaling in human endocervical epithelial cells
            modulates inflammatory responses of macrophages and dendritic cells
            in vitro
  JOURNAL   PLoS One 9 (1), e83882 (2014)
   PUBMED   24409285
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4587)
  AUTHORS   Mukherjee,A., Morosky,S.A., Shen,L., Weber,C.R., Turner,J.R.,
            Kim,K.S., Wang,T. and Coyne,C.B.
  TITLE     Retinoic acid-induced gene-1 (RIG-I) associates with the actin
            cytoskeleton via caspase activation and recruitment
            domain-dependent interactions
  JOURNAL   J Biol Chem 284 (10), 6486-6494 (2009)
   PUBMED   19122199
REFERENCE   7  (bases 1 to 4587)
  AUTHORS   Cui,S., Eisenacher,K., Kirchhofer,A., Brzozka,K., Lammens,A.,
            Lammens,K., Fujita,T., Conzelmann,K.K., Krug,A. and Hopfner,K.P.
  TITLE     The C-terminal regulatory domain is the RNA 5'-triphosphate sensor
            of RIG-I
  JOURNAL   Mol Cell 29 (2), 169-179 (2008)
   PUBMED   18243112
REFERENCE   8  (bases 1 to 4587)
  AUTHORS   Loo,Y.M., Fornek,J., Crochet,N., Bajwa,G., Perwitasari,O.,
            Martinez-Sobrido,L., Akira,S., Gill,M.A., Garcia-Sastre,A.,
            Katze,M.G. and Gale,M. Jr.
  TITLE     Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
  JOURNAL   J Virol 82 (1), 335-345 (2008)
   PUBMED   17942531
REFERENCE   9  (bases 1 to 4587)
  AUTHORS   Saito,T., Hirai,R., Loo,Y.M., Owen,D., Johnson,C.L., Sinha,S.C.,
            Akira,S., Fujita,T. and Gale,M. Jr.
  TITLE     Regulation of innate antiviral defenses through a shared repressor
            domain in RIG-I and LGP2
  JOURNAL   Proc Natl Acad Sci U S A 104 (2), 582-587 (2007)
   PUBMED   17190814
REFERENCE   10 (bases 1 to 4587)
  AUTHORS   Mibayashi,M., Martinez-Sobrido,L., Loo,Y.M., Cardenas,W.B., Gale,M.
            Jr. and Garcia-Sastre,A.
  TITLE     Inhibition of retinoic acid-inducible gene I-mediated induction of
            beta interferon by the NS1 protein of influenza A virus
  JOURNAL   J Virol 81 (2), 514-524 (2007)
   PUBMED   17079289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 3, 2021 this sequence version replaced XM_039109438.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12979.1,
                                           SRR26643299.22292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000005.1  60165759-60165995   c
            238-372             JAXUCZ010000005.1  60163583-60163717   c
            373-554             JAXUCZ010000005.1  60153488-60153669   c
            555-702             JAXUCZ010000005.1  60152414-60152561   c
            703-825             JAXUCZ010000005.1  60150907-60151029   c
            826-933             JAXUCZ010000005.1  60149177-60149284   c
            934-1087            JAXUCZ010000005.1  60148650-60148803   c
            1088-1346           JAXUCZ010000005.1  60147129-60147387   c
            1347-1509           JAXUCZ010000005.1  60145181-60145343   c
            1510-1614           JAXUCZ010000005.1  60143641-60143745   c
            1615-1772           JAXUCZ010000005.1  60140849-60141006   c
            1773-1908           JAXUCZ010000005.1  60139834-60139969   c
            1909-2057           JAXUCZ010000005.1  60137126-60137274   c
            2058-2148           JAXUCZ010000005.1  60131264-60131354   c
            2149-2319           JAXUCZ010000005.1  60129183-60129353   c
            2320-2471           JAXUCZ010000005.1  60128059-60128210   c
            2472-2615           JAXUCZ010000005.1  60121313-60121456   c
            2616-4587           JAXUCZ010000005.1  60117398-60119369   c
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4587
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /note="RNA sensor RIG-1"
                     /db_xref="GeneID:297989"
                     /db_xref="RGD:1309460"
     exon            1..237
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2912
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DDX58; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 58; DEXD/H-box helicase
                     58"
                     /codon_start=1
                     /product="antiviral innate immune response receptor RIG-I"
                     /protein_id="NP_001382000.1"
                     /db_xref="GeneID:297989"
                     /db_xref="RGD:1309460"
                     /translation="MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLRDDEVQCIQAE
                     KNNKGPIEAASLFLRYLLELQTEGWFRAFLDALYHAGYCGLYEAIETWDFQKLEKLEE
                     HRLLLRRLEPEFKATVSPTDILSEISECLINQECEEIRQICFTKGRMAGAEKMVQCLL
                     RSDKENWPKVLQFALEKDNSKFSELWLVDKGVRRVDCKAVEDDGTEMASIQIFIQEEP
                     ECQNLSQNPGPPSEASPNNSHSPLKPRNYQLELALPAKKGKNTVICAPTGCGKTFVSL
                     LICEHHLKNFPHGQKGKVVFFANQIPVYEQQATVFSRYFERFGYNVAGISGATADNVS
                     VQHIIENNDIVILTPQILVNSLNNGAIPSLSVFTLMIFDECHNTSKHHPYNQIMFRYL
                     DHKLGGSPDPLPQVIGLTASVGVGDAKTVEEAMLHICKLCAALDASVIATVRDNVEEL
                     EQVVYKPQKISRKVESRASNTFKCIISQLMREAERLAKNVSEELGKFFQIQNREFGTQ
                     KYEQWIVAVHKACTVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEDAQMKDALN
                     YLKAFFHDVREAAFDETEQDLTRRFEEKLEELENVSRDPSNENPKLRDLYLILQEEYH
                     LKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNQATGMTLPAQKCV
                     LEAFRANADNNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARDSKCF
                     LLTSSADVIEKEKANMVKEKIMNESILRLQTWDEVKFQKTVHRIQLDEKLLRDSQHKP
                     QPVPDRENKKLLCGKCKTFACYTADIRVVEKSHYTVLGDAFKERFVCKPHPKPKIYDS
                     FEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIESGVQNRHSKWKDFHF
                     ERKQFNPEEMST"
     exon            238..372
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            373..554
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            555..702
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            703..825
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            826..933
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1087
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1346
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1509
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1614
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1772
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1908
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2057
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2148
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2319
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2471
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2615
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..4587
                     /gene="Rig1"
                     /gene_synonym="Ddx58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcagttt cggtttcctt gcgcccgccg gtgctgcttc agctgctgga ctctctggaa
       61 agtcctcacc gcgttcatcc cgggcggatt tgggggagcc agggcgctca tagatcgcgg
      121 ggagccacag aatgaccgca gagcagcggc agaatctgca agcattcaga gactatatca
      181 agaagattct ggaccccacc tacatcctca gctatatgag ttcctggctc cgggatgatg
      241 aggtgcagtg cattcaggcc gagaagaaca acaagggccc aatagaggcc gcctcactgt
      301 tcctccggta cctgttggag ctgcagacag agggctggtt ccgggccttt ttggatgccc
      361 tgtaccatgc aggttactgt ggactttatg aagccatcga aacttgggac tttcaaaaac
      421 ttgaaaagtt agaggaacac agattacttt taagacgttt agagccggaa tttaaggcca
      481 cagttagccc gacagatatc ctttctgaaa tatctgaatg tttgattaat caggaatgtg
      541 aagaaatcag acagatctgc ttcactaaag ggaggatggc gggtgcggag aagatggtcc
      601 aatgtcttct cagatccgat aaggagaact ggccaaaggt tttgcagttt gctttggaga
      661 aagacaacag caagtttagt gaactgtggc tcgtcgataa aggtgtcaga agggttgact
      721 gtaaggctgt tgaggatgac ggaacagaga tggccagcat acagattttc attcaggaag
      781 aaccggagtg tcagaatctc agtcagaatc ccggccctcc ttcagaagcg tctcctaata
      841 attcacacag cccattgaaa ccaagaaatt accaactgga gcttgccctg cctgccaaga
      901 aagggaaaaa tacagtaata tgtgctccta ctggttgtgg aaaaaccttt gtgtcgcttc
      961 tcatatgcga acatcatctt aaaaactttc cgcacggaca gaaagggaaa gtggtctttt
     1021 ttgctaacca gatccctgtg tatgaacagc aggccactgt gttctcacga tatttcgaaa
     1081 gatttgggta caatgtcgcc ggcatttcgg gggcaacggc tgataatgtg tcagtgcagc
     1141 acatcattga aaacaatgac atcgtcatcc tgacacccca gattcttgtg aacagtctca
     1201 acaatggagc catcccctcg ctgtctgtct tcactctgat gatattcgac gagtgtcata
     1261 acaccagcaa acaccacccg tacaaccaga tcatgttcag atacctagat cacaaactcg
     1321 gagggtcacc cgacccactg cctcaggtca ttgggctgac tgcttccgtt ggtgttggag
     1381 atgctaaaac cgtggaggaa gccatgctgc acatctgcaa actctgtgcc gccctcgatg
     1441 cctcagtgat tgccacagtc agagacaacg tggaagaact ggagcaggtt gtttataagc
     1501 ctcagaaaat ttccaggaaa gtggaatcac gggcttcgaa cacgtttaaa tgcatcatat
     1561 ctcagctgat gagggaggca gagaggctgg cgaagaacgt ctctgaggaa cttggaaagt
     1621 tctttcaaat tcaaaatcga gaatttggca cccagaaata tgagcagtgg attgtcgccg
     1681 ttcacaaagc atgcacggtg tttcagatgc ctgacaaaga tgaggagagc aggatctgca
     1741 aggcgctctt tctgtacacc tcccacttgc ggaaatacaa cgacgccctc atcatcagcg
     1801 aggatgcaca gatgaaagac gctctaaatt acctcaaagc cttcttccat gatgtccgag
     1861 aagcagcatt tgatgagact gagcaagatc ttacgcggag gtttgaagaa aaactggagg
     1921 aactagaaaa cgtttccagg gatcccagca acgagaatcc taaactaaga gacctctact
     1981 tgatcttaca agaagaatac cacttaaagc cggagaccaa gaccattctc ttcgtgaaga
     2041 ccagagcact tgtggatgct ttgaagaaat ggattgaaga aaatcctgca ctgagttttc
     2101 taaaacctgg catactgact ggacgtggca gaacaaacca ggcaacaggg atgacgctcc
     2161 ctgcacagaa gtgtgtgttg gaggcattca gagccaatgc ggataacaat attctgattg
     2221 ctacctcggt cgctgatgaa ggcattgaca ttgctcagtg caatctcgtc atcctgtatg
     2281 agtacgtggg caacgtcatc aagatgatcc aaaccagagg cagaggaaga gcacgagata
     2341 gcaagtgctt cctcctgacc agcagtgctg atgtgattga aaaagaaaag gcgaacatgg
     2401 tcaaggaaaa aataatgaat gagtccatct taagactgca gacatgggat gaagtgaaat
     2461 ttcaaaagac ggttcaccgc atacagctgg atgaaaaact cctcagggac agtcaacaca
     2521 aaccacagcc cgtccccgac agagaaaaca agaaactgct gtgtggaaag tgcaagactt
     2581 ttgcgtgcta cacagctgac attcgagtgg tcgagaaatc ccactacact gtgcttggag
     2641 atgcttttaa ggagcgcttt gtgtgtaagc cacaccctaa accaaagatc tatgatagtt
     2701 ttgagaagaa agcaaaaata ttctgtgcca aacagaactg cagccatgac tgggggattt
     2761 ttgtgagata caagacgttt gagattccag tcataaaaat cgaaagcttc gttgttgaag
     2821 atattgagag tggagttcag aaccggcact caaagtggaa ggactttcat tttgaaagaa
     2881 aacagttcaa tcccgaagaa atgtccacat gatcttgggc ttctcagtct cacgctatag
     2941 ggagccatgc cttaagtgtg gaagtgacca gccaatgcgt tcttacccaa gcttgcacaa
     3001 tcctttctta cacaaccttg cactgtgttg agtgccaggt aacctgacct gtttgctcta
     3061 agctgtttct gtccacacaa agtgcaaact gaagctccga atgctttgtt caccaataac
     3121 tcttagcact cggcgatggt ggggagggtt gaaagttttc ccttttacat ttttcagaac
     3181 tgcccaccag agaatgcaca gctactcggt acatcgagac gcgtgatgac tggcgctagg
     3241 tttcccatac tctctctttg ctctacctgc cgtaagctgc ctttcgccct taacaatcca
     3301 ctgacttagt tcttttccag gccaccacac tcacagatcc agccgtactc tactctgtcc
     3361 cttgcgttga ctcctttctg aatttggccc tgccaccctg ccaccctctg cagattctcc
     3421 tggtttccgt cccttcccag tctttcccac tgatttcttt gctgacacaa atttggtgat
     3481 ttcaaggttc aatatgcaca acatgtgttt taaaaagaca tacttttaag atgtgaaaga
     3541 ctttagttaa tagcttacta cgcttactga gaaggtattt ctgttctgtt catttactat
     3601 acatcttact gtaatctgtt ctttgaattt gggccattta ccctccttga atagactctt
     3661 agaccatctc atctgttatg tctgtcctcc cacctgtttg agacaggatc tctctataga
     3721 ccagaaacat gatatgtgga ccatgctggc cttaaactca cagattcccc ccacctcata
     3781 agtgctgaaa ttaacatttt tcaccaggcc tggctctggc tattttcaat aaaggctgat
     3841 attaacaatt gaatatttcc agttcatccc ctaacatggc ttgttgttgt tctttttgag
     3901 acactgttcc tacgtgtagc cctgggtctg tagaccaggc tgcccttgat cacagagggc
     3961 tgtcagctcc tgcctcctgg gcgctgagac tgaaggcctg catcaccatg cctggctttc
     4021 ttcttaagcc ttatgtattc aaacggcaat tccatgtgtc ttcacagagt ttgttaatgc
     4081 ttcaaagagc ttagtttctt cagatcaaga gacaggtgtc tgaagggctg ttactgctaa
     4141 cagaccaagg cgctccagtt cagggaagga atcgtactgg ttttgaaggc cgtaaagtgg
     4201 ttttaacact ttcctaaaac ttacaattca ctagggccat caatggccta aacaaaactg
     4261 cagagattac atggccacat agcccttttt acatggcatt tacatctgaa gactatccca
     4321 agaccaccca gagcagaggg gtcacccaaa ctacccagat caaccctgga ggtcaacaga
     4381 atgaccactt cccacatatg cctagagaaa ataaccggca actaactttt ttggggaaaa
     4441 aaacctatag ggattaggct tttaattgat aggtggaaaa gatgatacat agtagttctt
     4501 gataatggtt attgataaac ttcttagtaa gtgcaataaa atggactaga tgaatttgct
     4561 gggagctgac tttcatttat gtctttt
//
