LOCUS       NP_113902                137 aa            linear   ROD 08-APR-2024
DEFINITION  2-iminobutanoate/2-iminopropanoate deaminase [Rattus norvegicus].
ACCESSION   NP_113902
VERSION     NP_113902.2
DBSOURCE    REFSEQ: accession NM_031714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 137)
  AUTHORS   Park,O.H., Ha,H., Lee,Y., Boo,S.H., Kwon,D.H., Song,H.K. and
            Kim,Y.K.
  TITLE     Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP
            Complex
  JOURNAL   Mol Cell 74 (3), 494-507 (2019)
   PUBMED   30930054
REFERENCE   2  (residues 1 to 137)
  AUTHORS   Wang,H., Wu,G., Park,H.J., Jiang,P.P., Sit,W.H., van Griensven,L.J.
            and Wan,J.M.
  TITLE     Protective effect of Phellinus linteus polysaccharide extracts
            against thioacetamide-induced liver fibrosis in rats: a proteomics
            analysis
  JOURNAL   Chin Med 7 (1), 23 (2012)
   PUBMED   23075396
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 137)
  AUTHORS   Dhawan,L., Liu,B., Pytlak,A., Kulshrestha,S., Blaxall,B.C. and
            Taubman,M.B.
  TITLE     Y-box binding protein 1 and RNase UK114 mediate monocyte
            chemoattractant protein 1 mRNA stability in vascular smooth muscle
            cells
  JOURNAL   Mol Cell Biol 32 (18), 3768-3775 (2012)
   PUBMED   22801372
  REMARK    GeneRIF: These studies define new roles for glucocorticoid
            receptor, Y-box binding protein 1, and RNase UK114 in the formation
            of a molecular complex that degrades MCP-1 mRNA.
REFERENCE   4  (residues 1 to 137)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 137)
  AUTHORS   Lambrecht,J.A., Flynn,J.M. and Downs,D.M.
  TITLE     Conserved YjgF protein family deaminates reactive enamine/imine
            intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme
            reactions
  JOURNAL   J Biol Chem 287 (5), 3454-3461 (2012)
   PUBMED   22094463
REFERENCE   6  (residues 1 to 137)
  AUTHORS   Asagi,K., Oka,T., Arao,K., Suzuki,I., Thakur,M.K., Izumi,K. and
            Natori,Y.
  TITLE     Purification, characterization and differentiation-dependent
            expression of a perchloric acid soluble protein from rat kidney
  JOURNAL   Nephron 79 (1), 80-90 (1998)
   PUBMED   9609467
REFERENCE   7  (residues 1 to 137)
  AUTHORS   Schmiedeknecht,G., Kerkhoff,C., Orso,E., Stohr,J., Aslanidis,C.,
            Nagy,G.M., Knuechel,R. and Schmitz,G.
  TITLE     Isolation and characterization of a 14.5-kDa
            trichloroacetic-acid-soluble translational inhibitor protein from
            human monocytes that is upregulated upon cellular differentiation
  JOURNAL   Eur J Biochem 242 (2), 339-351 (1996)
   PUBMED   8973653
REFERENCE   8  (residues 1 to 137)
  AUTHORS   Oka,T., Tsuji,H., Noda,C., Sakai,K., Hong,Y.M., Suzuki,I., Munoz,S.
            and Natori,Y.
  TITLE     Isolation and characterization of a novel perchloric acid-soluble
            protein inhibiting cell-free protein synthesis
  JOURNAL   J Biol Chem 270 (50), 30060-30067 (1995)
   PUBMED   8530410
REFERENCE   9  (residues 1 to 137)
  AUTHORS   Levy-Favatier,F., Cuisset,L., Nedelec,B., Tichonicky,L., Kruh,J.
            and Delpech,M.
  TITLE     Characterization, purification and cDNA cloning of a rat
            perchloric-acid-soluble 23-kDa protein present only in liver and
            kidney
  JOURNAL   Eur J Biochem 212 (3), 665-673 (1993)
   PUBMED   8385007
REFERENCE   10 (residues 1 to 137)
  AUTHORS   Critz,S.D., Wible,B.A., Lopez,H.S. and Brown,A.M.
  TITLE     Stable expression and regulation of a rat brain K+ channel
  JOURNAL   J Neurochem 60 (3), 1175-1178 (1993)
   PUBMED   8436968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 24, 2020 this sequence version replaced NP_113902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231669.1, X70825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..137
                     /product="2-iminobutanoate/2-iminopropanoate deaminase"
                     /EC_number="3.5.99.10"
                     /note="perchloric acid-soluble protein; ribonuclease
                     UK114; perchrolic acid soluble protein; heat-responsive
                     protein 12; 14.5 kDa translational inhibitor protein;
                     UK114 antigen homolog; liver perchloric acid-soluble
                     protein; translation inhibitor L-PSP ribonuclease"
                     /calculated_mol_wt=14172
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000269|PubMed:8530410; propagated from
                     UniProtKB/Swiss-Prot (P52759.3)"
     Region          6..129
                     /region_name="TIGR00004"
                     /note="reactive intermediate/imine deaminase"
                     /db_xref="CDD:129116"
     Site            order(21..22,25,27,30,32,34..35,75,77..78,80,82,93,96,
                     105..112,122,124,126)
                     /site_type="other"
                     /note="homotrimer interaction site [polypeptide binding]"
                     /db_xref="CDD:100004"
     Site            order(21,89,93,107,122)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:100004"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52758; propagated from
                     UniProtKB/Swiss-Prot (P52759.3)"
     CDS             1..137
                     /gene="Rida"
                     /gene_synonym="Hrsp12; L-PSP; Psp; PSP1; rp14.5"
                     /coded_by="NM_031714.2:72..485"
                     /db_xref="GeneID:65151"
                     /db_xref="RGD:70940"
ORIGIN      
        1 mssiirkvis tskapaaiga ysqavlvdrt iyvsgqigmd pssgqlvpgg vaeeakqalk
       61 nlgeilkaag cdftnvvktt vlladindfg tvneiyktyf qgnlparaay qvaalpkgsr
      121 ieieaiavqg pfttagl
//
