LOCUS       NM_175598               1760 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Rattus norvegicus RIC8 guanine nucleotide exchange factor B
            (Ric8b), mRNA.
ACCESSION   NM_175598
VERSION     NM_175598.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Lopez-Benito,S., Lillo,C., Hernandez-Hernandez,A., Chao,M.V. and
            Arevalo,J.C.
  TITLE     ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated
            secretion
  JOURNAL   J Cell Sci 129 (9), 1866-1877 (2016)
   PUBMED   26966186
  REMARK    GeneRIF: overexpression of ARMS blocked NGF-mediated secretion,
            without affecting basal secretion, a decrease in ARMS resulted in
            potentiation. Similar effects were observed with synembryn-B, a
            protein that interacts directly with ARMS. Downstream of ARMS and
            synembryn-B are Galphaq and Trio proteins, which modulate the
            activity of Rac1 in response to NGF
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Aguilar,R., Grandy,R., Meza,D., Sepulveda,H., Pihan,P., van
            Wijnen,A.J., Lian,J.B., Stein,G.S., Stein,J.L. and Montecino,M.
  TITLE     A functional N-terminal domain in C/EBPbeta-LAP* is required for
            interacting with SWI/SNF and to repress Ric-8B gene transcription
            in osteoblasts
  JOURNAL   J Cell Physiol 229 (10), 1521-1528 (2014)
   PUBMED   24585571
  REMARK    GeneRIF: Results indicate that a functional N-terminus in
            C/EBPbeta-LAP* is required for interacting with SWI/SNF and for
            Ric-8B gene repression in osteoblasts.
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Chan,P., Gabay,M., Wright,F.A. and Tall,G.G.
  TITLE     Ric-8B is a GTP-dependent G protein alphas guanine nucleotide
            exchange factor
  JOURNAL   J Biol Chem 286 (22), 19932-19942 (2011)
   PUBMED   21467038
  REMARK    GeneRIF: Ric-8BFL-catalyzed nucleotide exchange probably proceeds
            in the forward direction to produce Galpha-GTP in cells.
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Klattenhoff,C., Montecino,M., Soto,X., Guzman,L., Romo,X.,
            Garcia,M.A., Mellstrom,B., Naranjo,J.R., Hinrichs,M.V. and Olate,J.
  TITLE     Human brain synembryn interacts with Gsalpha and Gqalpha and is
            translocated to the plasma membrane in response to isoproterenol
            and carbachol
  JOURNAL   J Cell Physiol 195 (2), 151-157 (2003)
   PUBMED   12652642
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Tall,G.G., Krumins,A.M. and Gilman,A.G.
  TITLE     Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein
            guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 278 (10), 8356-8362 (2003)
   PUBMED   12509430
  REMARK    GeneRIF: two mammalian homologs of the Caenorhabditis elegans
            protein Ric-8 were identified: Ric-8A (Ric-8/synembryn) and Ric-8B
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY177755.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175598.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY177755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1760
                     /gene="Ric8b"
                     /note="RIC8 guanine nucleotide exchange factor B"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
     exon            1..171
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1650
                     /gene="Ric8b"
                     /note="synembryn-B; resistance to inhibitors of
                     cholinesterase 8 homolog B; resistance to inhibitors of
                     cholinesterase 8B; heterotrimeric G protein guanine
                     nucleotide exchange factor-like protein Ric-8B"
                     /codon_start=1
                     /product="chaperone Ric-8B"
                     /protein_id="NP_783188.1"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
                     /translation="MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESADEDKRK
                     KLCEGIFKVLVKGVPTTCQVPCLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESD
                     DSLEKVSEFPVIVESLKCLCNIVFNSQVAQQLSLELNLAAKLCNLLRKCKDRKFINDI
                     KCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHSGPP
                     LSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEE
                     LHSNAVNLLSNVPVSCLDVLICPLTHEETAQEAATLDELPGDKTAEKDTALKSSAMVY
                     NGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPL
                     RDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAG
                     LLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKPMGLKPDGTITPLEEALSQ
                     YSVIEETSSDTD"
     exon            172..219
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            220..828
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..923
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1152
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1538
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1760
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggtag cgggggcgcg aggcgtttac ctgggaggca gcggctgggg cgcgcacagc
       61 ggctgcggct cccccgcacc tgcggccatg gatgaagagc gcgccctcta catcgtccgg
      121 gccggcgagg cgggggctat cgagcgggtc ctgagagatt acagcgacaa gcatagggct
      181 actttcaaat ttgaatcagc agatgaagat aaaagaaaga aactctgtga aggcatattt
      241 aaggtcctgg taaagggtgt cccaacaaca tgccaagtgc cctgcctgga agttctccgc
      301 attctctcca gagacaaaaa gattttagct cctgtaacaa ctgaggaaaa tatgcaaata
      361 ctgctgagac tggccaagct ccatgagtcg gacgattctt tggagaaggt gtcagagttc
      421 ccggtcattg tggagtcatt gaaatgtctt tgtaacatcg tgttcaacag tcaggtggca
      481 cagcagctta gcctggaact gaatctcgct gcaaagctct gtaacctcct gaggaagtgc
      541 aaggaccgga aatttatcaa tgacataaag tgctttgacc tgcgcttgct ctttgtcctg
      601 tcacttttgc acactgacat caggtcacaa ttgcgctatg agctccaggg actgccgctg
      661 ctaacccaga tcttggaaag tgcctttagc atcaagtgga ccgatgagta tgagtcggcc
      721 atagaccata gtggacctcc tctctcacct caggagacag actgtgccat tgaggccctc
      781 aaagctctgt tcaatgtgac ggtagacagt tggaaggtgc ataaagagag cgattctcat
      841 cagttccgtg tcatggccgc tgtccttcgc cactgtttac taattgtagg tccaaccgaa
      901 gacaaaacgg aagagctgca cagtaatgcc gtcaaccttt taagcaatgt tccagtctct
      961 tgtttggatg ttctcatttg tccattaacc catgaagaaa cagcccagga ggcagcaact
     1021 ctagacgaac tgcccggtga taagacagca gagaaagaca cggctttgaa gagcagtgcc
     1081 atggtataca atggcatgaa catggaggcc atccacgttt tactcagttt tatggagaag
     1141 aggattgata agggaagcag ctatagagag ggtctaactc cagttctcag cttattaaca
     1201 gaatgttccc gagcccatcg gaacatccga aaatttctca aagatcaggt gttaccacct
     1261 ttgagggatg tgacaaatcg accagaagtc ggctcaaccg tgagaaataa gctggtgcgc
     1321 ctcatgacac acgttgacct cggagtcaag cagattgctg ctgagttcct cttcgtcctt
     1381 tgcaaagagc gagtggatag tctgctgaag tacactggct atgggaacgc tgcaggactg
     1441 ctggctgcca ggggcctctt ggctggagga agaggagaca attggtactc agaggacgag
     1501 gacacggaca ctgaggaata caaaaacgca aaaccaaaag aggagttgct taaaccaatg
     1561 ggactaaaac ctgacgggac aataacgcct ttggaggaag cgctcagcca gtattctgtc
     1621 atcgaagaga ccagctcgga cacagactga aagcgccgtc acctgctccc tctcaatatg
     1681 gcttttatca gcatcttttc tctgtagctc caggggaatc ttctctagaa cgtttatgcc
     1741 cttgctttgg ctagaaacac
//
