LOCUS       NM_001115045            3953 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RIC3 acetylcholine receptor chaperone (Ric3),
            transcript variant 1, mRNA.
ACCESSION   NM_001115045 XM_001072861
VERSION     NM_001115045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3953)
  AUTHORS   Koperniak,T.M., Garg,B.K., Boltax,J. and Loring,R.H.
  TITLE     Cell-specific effects on surface alpha7 nicotinic receptor
            expression revealed by over-expression and knockdown of rat RIC3
            protein
  JOURNAL   J Neurochem 124 (3), 300-309 (2013)
   PUBMED   23157401
  REMARK    GeneRIF: These results suggest GH4C1 cells may possess unknown
            chaperone(s) allowing high surface alpha7 expression in the absence
            of known RIC3 splice variants.
            GeneRIF: Two rat RIC-3 isoforms allow surface alpha7 nicotinic
            receptor expression on non-permissive cell lines
REFERENCE   2  (bases 1 to 3953)
  AUTHORS   Wang,Y., Yao,Y., Tang,X.Q. and Wang,Z.Z.
  TITLE     Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly
            of the alpha7 acetylcholine receptor through a cytoplasmic
            coiled-coil domain
  JOURNAL   J Neurosci 29 (40), 12625-12635 (2009)
   PUBMED   19812337
REFERENCE   3  (bases 1 to 3953)
  AUTHORS   Osman,A.A., Schrader,A.D., Hawkes,A.J., Akil,O., Bergeron,A.,
            Lustig,L.R. and Simmons,D.D.
  TITLE     Muscle-like nicotinic receptor accessory molecules in sensory hair
            cells of the inner ear
  JOURNAL   Mol Cell Neurosci 38 (2), 153-169 (2008)
   PUBMED   18420419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 2, 2013 this sequence version replaced NM_001115045.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM422213.1, SRR26643298.4493.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000001.1  172521224-172521349 c
            127-353             JAXUCZ010000001.1  172492539-172492765 c
            354-426             JAXUCZ010000001.1  172491500-172491572 c
            427-520             JAXUCZ010000001.1  172490577-172490670 c
            521-666             JAXUCZ010000001.1  172479085-172479230 c
            667-3953            JAXUCZ010000001.1  172466991-172470277 c
FEATURES             Location/Qualifiers
     source          1..3953
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..3953
                     /gene="Ric3"
                     /note="RIC3 acetylcholine receptor chaperone"
                     /db_xref="GeneID:687147"
                     /db_xref="RGD:1588939"
     exon            1..126
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1106
                     /gene="Ric3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative alpha7-nAChR chaperone; protein RIC-3; resistance
                     to inhibitors of cholinesterase 3 homolog"
                     /codon_start=1
                     /product="protein RIC-3 isoform 1"
                     /protein_id="NP_001108517.1"
                     /db_xref="GeneID:687147"
                     /db_xref="RGD:1588939"
                     /translation="MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRPEPPPGPEGKL
                     GRFPPMMHHHTAPSDGQTPGAHFQRSHLAEAFAKAKGAGGGAGGGGSGRGLMGQIIPI
                     YGFGIFLYILYILFKLSKGKTAEDRNCSTAPPGNTHRKITNFELVQLQEKLKETEEAM
                     EKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDTSPEKEAEEAPYME
                     DWEGYPEETYPIYDLSDGIKRRQETILVDYPDPKEPSAEETAEQMGALDEESSEHLSW
                     DRLPTDPGVQRDNSVTLCDPKPESCSCCFHEDEDPAVLAENAGFSADGYSEQEEATKE
                     NLPQDFTDEGLGTSTDNTHVGGMLRKRSPQGFE"
     exon            127..353
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..426
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
     exon            427..520
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..666
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..3953
                     /gene="Ric3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatggcgta ctccacagta cagagagtgg cgctggcctc tgggctcgtc ctggccgtgt
       61 cgctgctgct gcccaaggcc ttcttgtccc gcgggaagcg gccagagccg ccaccgggcc
      121 cggaaggaaa attgggccgc tttccaccta tgatgcatca ccacacggca ccctcagatg
      181 gtcagacacc aggggctcat ttccagaggt ctcatcttgc agaggccttt gcaaaggcca
      241 agggagcagg aggcggtgct ggaggagggg gtagtggacg aggactgatg ggccagatca
      301 ttccaatcta tggcttcggg atttttttgt acatcctgta cattttgttt aagctttcaa
      361 aggggaaaac tgcagaggac cggaactgct ccactgcccc acccggaaac acccaccgga
      421 agatcaccaa ctttgagctt gttcaactac aagaaaaact aaaagagaca gaggaagcca
      481 tggaaaaatt aatcaacaga gtgggaccta atggtgagag cagagcacag actgtgactt
      541 ctgaccaaga gaaacgatta ctgcatcagc tccgagaaat caccagagtc atgaaagaag
      601 gcaagttcat tgacacatct ccagagaagg aagctgagga agccccgtac atggaggact
      661 gggaaggtta cccagaagag acttatccaa tatatgacct ttcggatggt atcaagcgta
      721 ggcaagaaac tatcctggtg gattacccag atccaaaaga gccctctgct gaagaaacag
      781 ctgaacaaat gggagcgtta gacgaggaga gctcagagca cttgagctgg gatcgtctgc
      841 ccactgaccc cggagtccag agagataatt ctgtgaccct gtgtgaccct aaacccgaat
      901 catgctcctg ctgttttcat gaagacgagg accctgctgt cttggcagag aatgctggtt
      961 tcagtgcaga tggctacagt gagcaagagg aagccaccaa ggaaaacttg ccccaagact
     1021 ttacagacga agggctgggg accagcactg ataacacaca tgtgggcggc atgttgagga
     1081 agcgcagccc ccagggtttt gagtgaaagc agcctgcttg gaaagtatcc attactctgt
     1141 caccatggta cctttcctca gttcatccat ggcctgtgcc atctgcatcc ttctgtgttc
     1201 agaatcacag ttcttgggcc actaccatgg atacagtcta tccttcctgg tgcttgcaca
     1261 cctgtcactt tgtaaagtag cctttagtgt gaacacggga cagaatcacc tctctcttct
     1321 ttcttttccc tgtcagagac gctaacccat tcagtaattg tatttggttg tttgtgcttg
     1381 caggtggcag cacctaggca aacatctgat ccctcctcat aggagcaaca gatgatttac
     1441 ctgtgagtga gttattgaat gggtttgtta gggtaggaca gttgtgaatg aggactgggt
     1501 tcgcagatat tgaggactta agttttaaaa gtgaagattt tagattccca aatgccttat
     1561 tctttgggct ttcagctggt tagtggtctc ctgagaagag tgtgcttgat tctgaggcta
     1621 ggggtccaga gcacagtgaa atagctgagc tacgatctct cctcatggcc ttctaagata
     1681 ccctgactcc tccagagcag caggccatga acacatgggc ccctttggag accatttcac
     1741 ttgcatattc cctccatccc tagcttcctt tgtccttatt ctgttgaaca gaattgccaa
     1801 atctagaagt acctttgaat gtcttctgtg gctagaggga gtttgtgtcc ccagagatga
     1861 agtttgaggt tgcttggata tggtggtcct tccatgaggc gctcaggtag ccaggaagcc
     1921 atgtctttgt gaaacaagat ggaacctaag aatcctaaca agggtgagtc agttcagtta
     1981 catgaattga aagtgaaagg ccgtgtgtct ccaccagcat tcccactcag gaaatgggag
     2041 actcaaaatt taaggaattc tgtgacgctg gatacagtct ttagaattct attgtacctg
     2101 gcgagaatat gatgccagaa ggtagtttgg accactcagg agcatactgc accgcctgtc
     2161 atcagaaggt ctgagaccac actaagatac tgtcagccag tagaaagctt tacatcttag
     2221 ctggggtaga gaagaccctg agtgagtcta aaaccgagct gcactgtatc aatctgtgta
     2281 gaatggttga ttgaacttgt gcagaatgca gttaaacatg gaccgaagat ggtcttggca
     2341 taactaagta taaaaagcag tgtaggcatt cttgtttggg caaattgttt tctggatggt
     2401 tctggcatcc accatgagaa gttgatttag gatagccctg agtcactggt tccagtgttt
     2461 gttcatagga tacagttctg ttatgaggta aggacttgtt tccttctcat tagttagaca
     2521 actgctctgt gctgagtact atggagactg aatttgtacc ttgaagagtt tcagtttaat
     2581 gtatgagtct gacagatgca ctgtggacca caggaaggct tgggattgtg aattcttcag
     2641 gcagatttcc ctgtgcctca ggctgtggaa ttttagatcg gctccttagg cagtctgggc
     2701 ctggtttggg caaagtgagg gtagtaaaaa cacaggtctt tcagggctgt aagctgtaaa
     2761 tgaggtagtc agtgcgcata gggtggcatg cttaattatg ttgttagctc atgcagatca
     2821 tgtggtagct gttttattaa tcacagtgtg gaccataaac cataggagca aaaaagaaca
     2881 ggaatgtttt tgccaaagta ccagaaaatt tcagaagaca ctttatggca agctaagaac
     2941 atggcaagga agagaaggac atttgggcag aaagagtagg ctagcaaaag tggggtgtgt
     3001 agatggataa tcagctggga aaggtttaga gtcgctctgt tactattggg gatgagctat
     3061 ggaaacagtt cccaccaaaa ggaccaatcc ttcgtggttc ttgccactct agatgttagt
     3121 ttgcacatag gaatatattt atttgtatat actggaaact ttgaagtacc tattagtaat
     3181 ttggcatata ggcttttttg tttatttttc agaattgtat cttttggata tgatgatttt
     3241 acatgtatat ccaatccagg gtggccaaca tcaagggact gttttgttgt tgtgatcttt
     3301 atttctcagt attaagggct ttatcaaggc tctgccatta cgtctgcagt gacctctggg
     3361 caccgtagcc actgcacatc acctaggagc atgctcggta agtcaggtgg gtgatcagcc
     3421 agaagatccc ttaactaggt tatacaggaa catgactgtg cctcattatc tcagggacta
     3481 ggcctgggag gtacgctgag atgtagggat ggatttagcc tgtaaaagta ctggcctgcg
     3541 agaactatgt tctttgtatt tagacttagg tgataaaata acatggtcta cactcagaca
     3601 ctctgacaaa aggaacctaa tactcattgc ataattaaat tttctcattg ctatgtcgaa
     3661 caatgcacga ggaacgtata gttgagggca gtccttcagg gcagcaggag tcagaggact
     3721 ggttcacagg gagcagagaa agatgatgga tgatagcact tgacttggtt tgcccctttt
     3781 attcagtctg ggaccccagc taaagggaca gtgctatcca gagtaaggat gggtcttcct
     3841 cctcagctag actttcttgt aaagatcttc atagacaagc atgtttccat ggtgattctg
     3901 agtcccataa agttggcaat aaagtgtaaa caccagaggt aataggtata aaa
//
