LOCUS       NM_022175                794 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus Rhox homeobox family member 5 (Rhox5), mRNA.
ACCESSION   NM_022175 XM_039099478
VERSION     NM_022175.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 794)
  AUTHORS   MacLean,J.A. 2nd, Hayashi,K., Turner,T.T. and Wilkinson,M.F.
  TITLE     The Rhox5 homeobox gene regulates the region-specific expression of
            its paralogs in the rodent epididymis
  JOURNAL   Biol Reprod 86 (6), 189 (2012)
   PUBMED   22423045
  REMARK    GeneRIF: regulates the expression of other Rhox genes in the
            epididymis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 794)
  AUTHORS   Bhardwaj,A., Song,H.W., Beildeck,M., Kerkhofs,S., Castoro,R.,
            Shanker,S., De Gendt,K., Suzuki,K., Claessens,F., Issa,J.P.,
            Orgebin-Crist,M.C. and Wilkinson,M.F.
  TITLE     DNA demethylation-dependent AR recruitment and GATA factors drive
            Rhox5 homeobox gene transcription in the epididymis
  JOURNAL   Mol Endocrinol 26 (4), 538-549 (2012)
   PUBMED   22322598
  REMARK    GeneRIF: GATA factors collaborate to dictate the unique
            developmental and region-specific expression pattern of the RHOX5
            homeobox transcription factor in the caput epididymis.
REFERENCE   3  (bases 1 to 794)
  AUTHORS   MacLean,J.A. 2nd, Rao,M.K., Doyle,K.M., Richards,J.S. and
            Wilkinson,M.F.
  TITLE     Regulation of the Rhox5 homeobox gene in primary granulosa cells:
            preovulatory expression and dependence on SP1/SP3 and GABP
  JOURNAL   Biol Reprod 73 (6), 1126-1134 (2005)
   PUBMED   16093360
  REMARK    GeneRIF: expression in the ovary is governed by the distal promoter
            and is expressed at least as early as Day 5 postpartum. mRNA levels
            are regulated during the ovarian cycle, peaking before ovulation
REFERENCE   4  (bases 1 to 794)
  AUTHORS   Rao,M.K., Maiti,S., Ananthaswamy,H.N. and Wilkinson,M.F.
  TITLE     A highly active homeobox gene promoter regulated by Ets and Sp1
            family members in normal granulosa cells and diverse tumor cell
            types
  JOURNAL   J Biol Chem 277 (29), 26036-26045 (2002)
   PUBMED   11986330
  REMARK    GeneRIF: Pem promoter may be a useful model system to understand
            the molecular mechanism by which a tissue-specific promoter can be
            corrupted in tumor cells
REFERENCE   5  (bases 1 to 794)
  AUTHORS   Maiti,S., Doskow,J., Li,S., Nhim,R.P., Lindsey,J.S. and
            Wilkinson,M.F.
  TITLE     The Pem homeobox gene. Androgen-dependent and -independent
            promoters and tissue-specific alternative RNA splicing
  JOURNAL   J Biol Chem 271 (29), 17536-17546 (1996)
   PUBMED   8663309
REFERENCE   6  (bases 1 to 794)
  AUTHORS   Maiti,S., Doskow,J., Sutton,K., Nhim,R.P., Lawlor,D.A., Levan,K.,
            Lindsey,J.S. and Wilkinson,M.F.
  TITLE     The Pem homeobox gene: rapid evolution of the homeodomain, X
            chromosomal localization, and expression in reproductive tissue
  JOURNAL   Genomics 34 (3), 304-316 (1996)
   PUBMED   8786129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before May 21, 2021 this sequence version replaced
            XM_039099478.1, NM_022175.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000021.1  121402049-121402080
            33-93               JAXUCZ010000021.1  121403020-121403080
            94-175              JAXUCZ010000021.1  121403724-121403805
            176-527             JAXUCZ010000021.1  121403973-121404324
            528-573             JAXUCZ010000021.1  121404932-121404977
            574-794             JAXUCZ010000021.1  121407423-121407643
FEATURES             Location/Qualifiers
     source          1..794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..794
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /note="Rhox homeobox family member 5"
                     /db_xref="GeneID:24631"
                     /db_xref="RGD:3295"
     exon            1..32
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
     exon            33..93
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
     exon            94..175
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..723
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /note="homeobox protein Pem; reproductive homeobox on
                     chromosome X 5; placenta and embryonic expression protein;
                     placentae and embryos oncofetal; Homeobox gene Pem;
                     reproductive homeobox 5"
                     /codon_start=1
                     /product="homeobox protein Rhox5"
                     /protein_id="NP_071511.2"
                     /db_xref="GeneID:24631"
                     /db_xref="RGD:3295"
                     /translation="MEAQGSSHDISRLLCLGVKEDSEEQHDVKAEAFFQAGEGRDEKG
                     AQGQPGEGAVGTEGEGEELNGGEGHFGPGVPGPVGEGDKDGGTRASGMEEEQHEPVAE
                     GTESVKSEDKQMPLRRPGSTQRRLAELERILLSSGSSSGPTWEELDRWMDISVSRVQN
                     WFKIRRAAYRRNRRRRTPIPEHFRATSGCPACLGARWGVRCPFATPRF"
     exon            176..527
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
     exon            528..573
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
     exon            574..794
                     /gene="Rhox5"
                     /gene_synonym="Pem"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atattttgga gagagaaaag ccaagcagcc atccttcaag atcacctcct gtattcctag
       61 ctggacaaga ggaaacacaa agagaaccat ccagatatgg aggctcaagg ctctagccat
      121 gatatcagcc gcttactctg cctgggagtc aaggaagact cggaagaaca gcatgatgtg
      181 aaagcagagg ctttctttca ggctggagag gggagagacg agaaaggtgc acagggtcag
      241 cctggagagg gagcagtggg aacagaaggc gaaggagaag aattaaatgg aggagaaggc
      301 cactttggtc ctggtgttcc aggtcctgtg ggtgaggggg acaaggatgg tggcaccaga
      361 gctagtggca tggaggagga gcaacatgag cccgttgccg agggcactga gagtgtcaag
      421 tctgaggata agcagatgcc actccgccgc cctgggtcca cccagcggcg gctggcggaa
      481 ttggagcgca ttttgctaag cagtggttcc tccagtggcc caacatggga ggagcttgat
      541 agatggatgg atatcagtgt gtccagagtg cagaattggt ttaagattag gagggctgca
      601 tacagaagaa ataggaggcg gagaacacca atccctgaac attttagagc aacatctggg
      661 tgccctgctt gtcttggagc aagatgggga gtaagatgtc cttttgcaac accgagattt
      721 tgatcacata tgccagccat gacaactctt gcctttcaac aattctgtca gcaataaaga
      781 aatgattctc agta
//
