LOCUS       NM_181823               2781 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ras homolog family member T2 (Rhot2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_181823
VERSION     NM_181823.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Li,Y., Lim,S., Hoffman,D., Aspenstrom,P., Federoff,H.J. and
            Rempe,D.A.
  TITLE     HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters
            mitochondrial distribution and transport
  JOURNAL   J Cell Biol 185 (6), 1065-1081 (2009)
   PUBMED   19528298
REFERENCE   4  (bases 1 to 2781)
  AUTHORS   Saotome,M., Safiulina,D., Szabadkai,G., Das,S., Fransson,A.,
            Aspenstrom,P., Rizzuto,R. and Hajnoczky,G.
  TITLE     Bidirectional Ca2+-dependent control of mitochondrial dynamics by
            the Miro GTPase
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20728-20733 (2008)
   PUBMED   19098100
  REMARK    GeneRIF: Miro proteins serve as a [Ca(2+)](c)-sensitive switch and
            bifunctional regulator for both the motility and fusion-fission
            dynamics of the mitochondria.
REFERENCE   5  (bases 1 to 2781)
  AUTHORS   Fransson,S., Ruusala,A. and Aspenstrom,P.
  TITLE     The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in
            mitochondrial trafficking
  JOURNAL   Biochem Biophys Res Commun 344 (2), 500-510 (2006)
   PUBMED   16630562
REFERENCE   6  (bases 1 to 2781)
  AUTHORS   Shan,Y., Hexige,S., Guo,Z., Wan,B., Chen,K., Chen,X., Ma,L.,
            Huang,C., Zhao,S. and Yu,L.
  TITLE     Cloning and characterization of the mouse Arht2 gene which encodes
            a putative atypical GTPase
  JOURNAL   Cytogenet Genome Res 106 (1), 91-97 (2004)
   PUBMED   15218247
REFERENCE   7  (bases 1 to 2781)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 2781)
  AUTHORS   Fransson,A., Ruusala,A. and Aspenstrom,P.
  TITLE     Atypical Rho GTPases have roles in mitochondrial homeostasis and
            apoptosis
  JOURNAL   J Biol Chem 278 (8), 6495-6502 (2003)
   PUBMED   12482879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY303973.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY303973.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMD00132261,
                                           SAMD00132262 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2781
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /note="ras homolog family member T2"
                     /db_xref="GeneID:287156"
                     /db_xref="RGD:727970"
     exon            1..160
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            161..404
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..2236
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /EC_number="3.6.5.-"
                     /note="MIRO-2; ras homolog gene family, member T2"
                     /codon_start=1
                     /product="mitochondrial Rho GTPase 2"
                     /protein_id="NP_861544.1"
                     /db_xref="GeneID:287156"
                     /db_xref="RGD:727970"
                     /translation="MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPA
                     DVTPEKVPTHIVDYSEAEQTEEELQEEIHKANVVCVVYDVSEEATIEKIRTKWIPLVN
                     GRTATGPRLPIILVGNKSDLRPGSTIEAVLPIMSQFPEIETCVECSAKHLRNISELFY
                     YAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDHALSDKELNAFQKSCFG
                     HPLAPQALEDVKRVVCKNVAGGVQDDRLTLEGFLFLNTLFIQRGRHETTWTILRRFGY
                     SDSLELTPDYLCPPLYVPPGCSTELNHRGYQFVQRVFEKHDQDHDGVLSPTELESLFS
                     VFSVAPWGPELLHTVPTEAGCLSLRGYLCQWTLVTYLDVQHCLAHLGYLGYPTLCEQD
                     SQAQAITVTREKRLDQEKGQTQRSVLMCKVLGARGVGKSAFLQAFLGHSLGEARDRDA
                     PEKLPTHTINTVRVSGQEKYLILCEVNADSLLDTSLDTTCDVACLMFDSSDPETFVQC
                     ATIYKRYYMDGQTPCLFISSKADLPEGVAPPGLSPAEFCRRHRLPAPASFSCLGPAQS
                     SIDVFTQLATMATFPHLAHTELHPTPFWLRGVLVAVGTAVAAVLSFSLYRVLVKSR"
     exon            405..463
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..545
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..589
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..696
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..805
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..907
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1006
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1115
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1236
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1321
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1464
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1565
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1696
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1783
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1906
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2109
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2762
                     /gene="Rhot2"
                     /gene_synonym="Miro2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgtttttca catgaaggtt gttttattgt ttttattttg tacagtttaa gtaaataaaa
       61 actggtattt atcatatcga tacattgttt tattgttcca taaattgtat ctctacatca
      121 cttggggcct gagcgcaccc ttgcccctac ccacaatcca cactcaactg gcaggcgctg
      181 tcccttagct caaccactag ctggtgctgt gtgggcggga ccggaagttt ggatgagggc
      241 ggtactgaag acaggaagtg cgcggtcctg cgcgggttga aggagagggt tggggttggg
      301 attgggtcta cttggtccgt tctgggccag gaggggtggt tttggggtgc tgctgcgggc
      361 agcagtcatg aggcgcgacg tgcgcatcct gctgctgggc gaggcccagg tggggaagac
      421 ttctctgatc ctgtcgctgg tcggcgagga gtttcccgag gaggtccctg cccgcgcgga
      481 ggagataacc atccccgccg acgtcacccc agagaaggtg cccacccata tcgtggatta
      541 ctcagaagcg gagcagacag aggaggaact tcaggaggag atccacaagg caaacgtggt
      601 gtgtgtggtg tacgatgtgt ctgaggaagc caccattgag aagatccgaa ccaagtggat
      661 tcccctcgtg aatggcagga cggcaacagg gcccaggttg cccatcatcc tggtaggcaa
      721 taagtcagac ctgcggccag ggagtaccat agaggctgtg ttgcccatta tgagccagtt
      781 tcctgagata gagacctgtg tggagtgttc tgccaagcac ttgaggaata tctcagagct
      841 gttctactat gcccagaagg ctgttctgca tcccaccgct cccctttatg accctgaggc
      901 caaacagtta aggcctgcct gcgcccaggc actcacacgc atcttcaggc tgtcggatca
      961 ggacctagac cacgcactca gcgacaagga gctcaatgcc ttccagaagt cctgctttgg
     1021 ccatcctctg gccccacaag ccctggagga tgtaaagagg gtagtgtgca agaatgtggc
     1081 aggtggtgtg caggatgacc gactgaccct ggaaggcttc ctcttcctga acacactttt
     1141 catccagcgt ggccggcatg agactacgtg gaccatccta cggcgctttg gttacagtga
     1201 ctcgctggag ctgactcctg actacctctg tccaccgctc tacgtacccc ctggctgcag
     1261 caccgagctc aaccatcgtg gctaccagtt tgtgcagcgg gtgtttgaga agcatgatca
     1321 ggaccatgat ggtgtcctct cacccacgga actagagagt ctcttcagcg tgttctcagt
     1381 tgctccgtgg ggccctgaac tcttacacac agtccccact gaggctggct gtctgtcctt
     1441 gcgtggatat ctctgccagt ggaccctggt gacctacttg gatgtccagc actgccttgc
     1501 ccatcttggc tacctgggtt accctaccct ctgtgagcag gactcacagg cacaggctat
     1561 cacagttacc cgcgagaaga gactggacca ggagaaaggg caaacacagc gcagcgtcct
     1621 catgtgtaag gtgttgggag cccgaggagt gggcaagtcg gccttcttgc aggccttcct
     1681 cggccacagc cttggggaag ccagggacag ggacgcccct gagaaattgc ccacgcatac
     1741 catcaataca gtgcgggtca gcggacagga aaagtacctg attctgtgtg aagtgaatgc
     1801 tgacagcctg ctggacacct ctctagacac tacctgtgat gtcgcctgct taatgtttga
     1861 cagcagtgac cccgagacct tcgtgcagtg tgctaccatc tacaagcgtt attacatgga
     1921 tgggcagaca ccctgcctct ttatctcctc caaagctgat ctccctgaag gtgttgcccc
     1981 accaggccta tcaccagctg agttctgccg taggcaccgg ctgccagccc cggcctcatt
     2041 ctcctgcttg ggaccagcac agtccagcat agatgtcttt acccaacttg ctactatggc
     2101 cactttccca cacctggcgc acacagagct gcaccccacc cccttctggc tccgaggcgt
     2161 gctggtggct gttgggaccg cggtggctgc tgtccttagc ttctcactat atagggtcct
     2221 agtgaagagc cgatgacaaa ggactcgtga cctctcctgc ccccaggcac agcacactgt
     2281 ggtgtctcgt gtgagcccac gcggcagagg agtatggtct tttagcctgg tggtgtaatg
     2341 tctgtgtggc cagctacagg gtccctggga ctgatgtggg tacctgctca gggacttggt
     2401 atctaaatcg tggcttccaa aaccctgctg ccctgttaca ggcctgtcct gctgagccca
     2461 agagtacggg tggcaggtgc gagccctcag cctttcaggg agcatcgtgt gttagagaga
     2521 ggctgggctg tgagtaggaa atcagtgacc agaactgaag ttctcagggt gcttcctcct
     2581 tcctggttct gtgtggccag tggtcttgat tgggggcagg aggcaatggt caaatcaggg
     2641 agggacctga tagtcaaaga gttcccacca ttctgtcaga tgtggagcct tacccacaca
     2701 gtgccagctg cagagcaagt ggaattgggt ttcctgatta aagttgtctt ttccatctct
     2761 tgaaaaaaaa aaaaaaaaaa a
//
