LOCUS       NM_001107026            2941 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus ras homolog family member T1 (Rhot1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001107026
VERSION     NM_001107026.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2941)
  AUTHORS   Man,G., Yang,H., Shen,K., Zhang,D., Zhang,J., Wu,H., Zhang,H. and
            Wang,J.
  TITLE     Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in
            Chondrocyte Autophagy and Proliferation in Osteoarthritis
  JOURNAL   J Immunol Res 2022, 4370873 (2022)
   PUBMED   35300071
  REMARK    GeneRIF: Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to
            Participate in Chondrocyte Autophagy and Proliferation in
            Osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2941)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2941)
  AUTHORS   Kalinski,A.L., Kar,A.N., Craver,J., Tosolini,A.P., Sleigh,J.N.,
            Lee,S.J., Hawthorne,A., Brito-Vargas,P., Miller-Randolph,S.,
            Passino,R., Shi,L., Wong,V.S.C., Picci,C., Smith,D.S., Willis,D.E.,
            Havton,L.A., Schiavo,G., Giger,R.J., Langley,B. and Twiss,J.L.
  TITLE     Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and
            mediates axon growth inhibition
  JOURNAL   J Cell Biol 218 (6), 1871-1890 (2019)
   PUBMED   31068376
  REMARK    GeneRIF: The data point to HDAC6-dependent deacetylation of Miro1
            as a mediator of axon growth inhibition through decreased
            mitochondrial transport.
REFERENCE   4  (bases 1 to 2941)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   5  (bases 1 to 2941)
  AUTHORS   Su,B., Ji,Y.S., Sun,X.L., Liu,X.H. and Chen,Z.Y.
  TITLE     Brain-derived neurotrophic factor (BDNF)-induced mitochondrial
            motility arrest and presynaptic docking contribute to BDNF-enhanced
            synaptic transmission
  JOURNAL   J Biol Chem 289 (3), 1213-1226 (2014)
   PUBMED   24302729
REFERENCE   6  (bases 1 to 2941)
  AUTHORS   MacAskill,A.F., Brickley,K., Stephenson,F.A. and Kittler,J.T.
  TITLE     GTPase dependent recruitment of Grif-1 by Miro1 regulates
            mitochondrial trafficking in hippocampal neurons
  JOURNAL   Mol Cell Neurosci 40 (3), 301-312 (2009)
   PUBMED   19103291
  REMARK    GeneRIF: These data suggest that Miro1 and the kinesin adaptor
            Grif-1 play an important role in regulating mitochondrial transport
            in neurons.
REFERENCE   7  (bases 1 to 2941)
  AUTHORS   Saotome,M., Safiulina,D., Szabadkai,G., Das,S., Fransson,A.,
            Aspenstrom,P., Rizzuto,R. and Hajnoczky,G.
  TITLE     Bidirectional Ca2+-dependent control of mitochondrial dynamics by
            the Miro GTPase
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20728-20733 (2008)
   PUBMED   19098100
  REMARK    GeneRIF: Miro proteins serve as a [Ca(2+)](c)-sensitive switch and
            bifunctional regulator for both the motility and fusion-fission
            dynamics of the mitochondria.
REFERENCE   8  (bases 1 to 2941)
  AUTHORS   Fransson,S., Ruusala,A. and Aspenstrom,P.
  TITLE     The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in
            mitochondrial trafficking
  JOURNAL   Biochem Biophys Res Commun 344 (2), 500-510 (2006)
   PUBMED   16630562
REFERENCE   9  (bases 1 to 2941)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2941)
  AUTHORS   Fransson,A., Ruusala,A. and Aspenstrom,P.
  TITLE     Atypical Rho GTPases have roles in mitochondrial homeostasis and
            apoptosis
  JOURNAL   J Biol Chem 278 (8), 6495-6502 (2003)
   PUBMED   12482879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129123.1.
            
            On Oct 7, 2007 this sequence version replaced NM_001107026.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129123.1, SRR8487231.86838.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25-q26"
     gene            1..2941
                     /gene="Rhot1"
                     /note="ras homolog family member T1"
                     /db_xref="GeneID:303351"
                     /db_xref="RGD:1307023"
     exon            1..222
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2042
                     /gene="Rhot1"
                     /note="ras homolog gene family, member T1"
                     /codon_start=1
                     /product="mitochondrial Rho GTPase 1"
                     /protein_id="NP_001100496.1"
                     /db_xref="GeneID:303351"
                     /db_xref="RGD:1307023"
                     /translation="MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPE
                     EVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHS
                     IDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVEC
                     SAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLN
                     DAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGR
                     HETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRD
                     CALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLE
                     YLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQS
                     LLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLV
                     YDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPP
                     PQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMY
                     RALLKQR"
     exon            223..281
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            282..363
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..407
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..461
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..514
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..623
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..725
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..824
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..933
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1054
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1139
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1285
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1386
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1517
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1601
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1721
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1924
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2917
                     /gene="Rhot1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggagcgt cagcggagga gtcggtgccg caggtcctgg cggccgagat tccggcgcag
       61 aggcctgaga ggctggcagg aggcggcagt agcgcgggga gagcggcgcc acgggctggg
      121 cgctcccggc gtgaggcgtg cgctccatgc gtgcgggccg agtgcggccc ctgcgagcct
      181 ccgacatgaa gaaagacgtg cggatcctgc tggtgggaga acctagagtt gggaagacat
      241 cactgattat gtctctggtc agtgaagaat ttccggaaga ggttcctcct cgggcagaag
      301 aaatcaccat tccagctgat gtcacccctg aaagagttcc aacacacatt gttgattatt
      361 cagaggcaga acagagtgat gaacaacttc atcaagaaat atcacaggct aatgtcatct
      421 gcatagttta tgctgttaac aacaaacatt ctattgataa ggtaacaagc cgatggattc
      481 ctctcataaa tgaaagaaca gacaaagaca gcaggctgcc tttgatattg gttgggaaca
      541 aatctgacct ggtggagtat agtagtatgg agaccatcct tccaattatg aaccaatata
      601 cagaaataga aacctgtgtg gagtgttcag caaaaaacct aaagaatata tcagaactgt
      661 tctattatgc acagaaagct gttcttcatc ctacagggcc tttgtactgc ccagaggaga
      721 aagagatgaa accagcttgt ataaaagccc tcactcgtat atttaaaata tctgaccaag
      781 ataatgatgg cactctgaat gatgctgagc tcaacttctt tcagagaatt tgtttcaaca
      841 ctcctttagc tccccaagct ctggaagatg tcaagaatgt ggttagaaag cacttaagtg
      901 acggtgtggc tgacagtggg ctgacactca gaggttttct ctttttacat acacttttta
      961 tccagagggg gaggcatgag accacttgga ctgtgcttcg acgatttggt tatgatgatg
     1021 atctggatct gacgcccgag tacttattcc ccctgctaaa aatacctcct gattgcacta
     1081 ctgaactaaa tcatcatgca tatttgtttc ttcaaagcac ctttgacaaa catgatctgg
     1141 acagagactg tgctttgtca cctgatgaac tcaaagattt atttcaagtt ttcccttaca
     1201 taccttgggg accagatgta aataacacag tttgtacaaa tgaaagcggc tggataacct
     1261 accagggatt cctttcccag tggacgctca caacctactt agatgtacag cgttgtctgg
     1321 agtatctggg ctatctaggc tattccatac tgacggaaca agagtctcaa gcttcagcca
     1381 tcacagtaac aagagataaa aagattgacc tgcagaaaaa acagactcag agaaatgtgt
     1441 tcagatgtaa tgtgattgga gtgaaaggct gtggaaaaac tggagttctt cagtctctcc
     1501 ttggaagaaa cctaatgagg cagaagaaaa ttcgtgatga tcataaatcc tattatgcaa
     1561 ttaacactgt ctatgtatac ggacaagaga aatacttgtt gctacatgat atctcagagt
     1621 cggagtttct tactgaggct gagatcgttt gtgatgttgt atgcctggta tatgatgtca
     1681 ccaatcccaa gtcatttgaa tactgcgcca ggatttttaa gcaacatttt atggacagca
     1741 gaattccctg cttaattgta gctgcaaagt cagacctgca tgaagtcaag caagaacaca
     1801 gtgtctcacc tactgatttc tgcaggaaac acaaaatgcc tccgcctcaa gccttcactt
     1861 gtaacactgc tgatgcgccc agtaaggata tctttgttaa gctgacaacg atggccatgt
     1921 acccgcacgt gacacaagct gacctcaaga gctcaacatt ctggcttcga gcaagctttg
     1981 gtgctactgt ctttgcagtc gtgggctttg ctatgtacag agcactattg aaacagcgat
     2041 gattaagatc aagaaccggc ctcccacaca cacacttcta tgtacatcct gaatgcttta
     2101 agttctgcta gagacactga gatatttata catgcagagt tactttatta atattagtaa
     2161 ttcatgcata agagtatttt actcatagta atgactgcag tattggctgg catgtggaaa
     2221 gaaaacatct tagtagccaa atataaatgg ctaagtttca aaggccaaaa gggaatattc
     2281 tgtaaataat gtaaatattc aagcaagata tggtctcctg aaccgacttc tagaaatggt
     2341 atttccagac atttctccag tagtgttgtg tggcccacct gctaggttca gtcccagggg
     2401 ttgtgtttac tcaggtatca cacgttattt caaggggact cagaatgagc ctttggcttc
     2461 tatagccatt tctctccact tttaagatca cacaggagtc aaggtcagct ttccaaaacc
     2521 actctgtttc cgtcactgtg gtaggccggc attaaagcca tcatgaaacc tagaaagttg
     2581 tggagctgag tatgtggctg aggacctgag gcagaaacag gtagcggagg ttacccgtgt
     2641 caccacattg cttctttgtc agagtgtgga ttttatagcc ctttcagtca aatggggaaa
     2701 acaatttgta tattatcaat gtttttagtt ctattaaaga agccaccctg accaccgctg
     2761 actcacccag agtgaaaacc gtcctatcat ggctgtgtct gtgtagtata ttgccgtagc
     2821 tgcatgtgtc atgaactgtt ctatatctgg ccaggataac ctagaggcaa cattttttta
     2881 atggtaaaat aaatctaatg aatataaact ctcacaaaaa aaaaaaaaaa aaaaaaaaaa
     2941 a
//
