LOCUS       NM_001008320            1855 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ras homolog family member J (Rhoj), mRNA.
ACCESSION   NM_001008320 XM_216737
VERSION     NM_001008320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Eelen G, Dubois C, Cantelmo AR, Goveia J, Bruning U, DeRan M,
            Jarugumilli G, van Rijssel J, Saladino G, Comitani F, Zecchin A,
            Rocha S, Chen R, Huang H, Vandekeere S, Kalucka J, Lange C,
            Morales-Rodriguez F, Cruys B, Treps L, Ramer L, Vinckier S,
            Brepoels K, Wyns S, Souffreau J, Schoonjans L, Lamers WH, Wu Y,
            Haustraete J, Hofkens J, Liekens S, Cubbon R, Ghesquiere B,
            Dewerchin M, Gervasio FL, Li X, van Buul JD, Wu X and Carmeliet P.
  TITLE     Role of glutamine synthetase in angiogenesis beyond glutamine
            synthesis
  JOURNAL   Nature 561 (7721), 63-69 (2018)
   PUBMED   30158707
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Chang TY, Tsai WC, Huang TS, Su SH, Chang CY, Ma HY, Wu CH, Yang
            CY, Lin CH, Huang PH, Cheng CC, Cheng SM and Wang HW.
  TITLE     Dysregulation of endothelial colony-forming cell function by a
            negative feedback loop of circulating miR-146a and -146b in
            cardiovascular disease patients
  JOURNAL   PLoS One 12 (7), e0181562 (2017)
   PUBMED   28727754
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Ackermann KL, Florke RR, Reyes SS, Tader BR and Hamann MJ.
  TITLE     TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is
            Coordinately Regulated by Amino Acids within the N Terminus and a
            Distal Loop Region
  JOURNAL   J Biol Chem 291 (45), 23604-23617 (2016)
   PUBMED   27660391
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R,
            Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S
            and Ema M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K,
            Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE and Oettgen
            P.
  TITLE     RhoJ is an endothelial cell-restricted Rho GTPase that mediates
            vascular morphogenesis and is regulated by the transcription factor
            ERG
  JOURNAL   Blood 118 (4), 1145-1153 (2011)
   PUBMED   21628409
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Jun HS, Hwang K, Kim Y and Park T.
  TITLE     High-fat diet alters PP2A, TC10, and CIP4 expression in visceral
            adipose tissue of rats
  JOURNAL   Obesity (Silver Spring) 16 (6), 1226-1231 (2008)
   PUBMED   18388891
  REMARK    GeneRIF: High-fat diet might have a relevance to insulin resistance
            by increasing the expression of PP2A and suppressing the expression
            of TC10 and CIP4 in the insulin-signaling cascade in the visceral
            adipose tissue.
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere
            C, Blangy A and Fort P.
  TITLE     Characterization of TCL, a new GTPase of the rho family related to
            TC10 andCcdc42
  JOURNAL   J Biol Chem 275 (46), 36457-36464 (2000)
   PUBMED   10967094
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086525.1.
            
            On Dec 16, 2004 this sequence version replaced XM_216737.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086525.1, BI289636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1855
                     /gene="Rhoj"
                     /note="ras homolog family member J"
                     /db_xref="GeneID:299145"
                     /db_xref="RGD:1310528"
     exon            1..442
                     /gene="Rhoj"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..900
                     /gene="Rhoj"
                     /note="ras homolog gene family, member J; TC10-like Rho
                     GTPase"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoJ"
                     /protein_id="NP_001008321.1"
                     /db_xref="GeneID:299145"
                     /db_xref="RGD:1310528"
                     /translation="MSCREGTDSSCGCGGRDENRILKCVVVGDGAVGKTCLLMSYAND
                     AFPEEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSV
                     VNPASYHNVQEEWVPELKDCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHG
                     VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKKKKKGCHGCCVII"
     exon            443..501
                     /gene="Rhoj"
                     /inference="alignment:Splign:2.1.0"
     exon            502..666
                     /gene="Rhoj"
                     /inference="alignment:Splign:2.1.0"
     exon            667..762
                     /gene="Rhoj"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1853
                     /gene="Rhoj"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgagagttc ctcaactcca gctctactcc aactcctctt ctccgttggg attgggagaa
       61 aggaacggac ccttttcatc cctcctccca agagtgcgtt gcctttcttc tgcagcatgg
      121 tgagcggcgg ggctcgcgtg tgtctgggct gtgcctggga gagccgggcc agccacagtc
      181 aggccgcctg agctccagcc ccgggcccgt gccaccgctc catgcactac agaagcccca
      241 gcagctgctg cgggagccac caacatgagc tgcagagagg ggactgacag cagctgcggc
      301 tgcggtgggc gcgatgaaaa caggatcctg aagtgcgtgg tggtcgggga cggcgcggtg
      361 gggaagactt gcctgctgat gagctacgcc aacgacgcct tcccggagga atacgtgccc
      421 actgtgtttg accactacgc agttaccgtg acagtgggag gcaagcagca cctgcttgga
      481 ctgtacgaca ccgcgggaca ggaggactac aaccagctgc ggcccctctc ttaccccaac
      541 accgacgtgt ttctcatctg cttctctgtc gtgaaccctg cctcttacca caacgttcag
      601 gaggagtggg tcccggagct gaaggactgc atgcctcacg tgccttacgt gctcattggg
      661 acccagattg atctccgaga tgaccccaaa accttggcgc gtctgctgta catgaaggag
      721 aagcccctca cctatgagca cggcgtgaaa ctggcgaaag cgataggagc tcagtgctac
      781 ttggaatgct ctgccctgac tcagaagggt ctcaaagctg tttttgatga agccatcctc
      841 accattttcc accccaagaa aaaaaagaaa ggctgccacg gctgctgtgt aatcatctga
      901 agttgcctga gacccgtctc tccgccatgc aaagagggaa gccagtctct gagaaccaac
      961 gctagccgaa aggagggcgt gaccagaaag gaattcctgc atcctcaaag cctgtcccca
     1021 caccctgcca attccccagc tcagtatcct gtaagccact gccacagccc caagccagcc
     1081 agacatccac actgcgcatg gagaaagcag aggctcgttc aaaccgcagg ctggcgaggt
     1141 gttggaagcc gagtgaagat ccgtccagta tttcacatct tctctctcac ggttatgaac
     1201 caaccggaag tcatgacggg caaaccaagt actctctgtc ctgaaccaat ggccttagtt
     1261 catgtcttca ccaaccttgg gaatacgaca actttttttt ttctgagtct tttactcaag
     1321 ccccttgccg ttcatttatt tctactgcag tttcctgttg tccaatcact tgagccttac
     1381 aaatccacat caaaataacc gaaagacaag ctggattgtg tttatgccaa ctgacagtgg
     1441 ctctctgcca atgttcttag agctgccatg tacctctgaa tgcctaatta caaaaaaaaa
     1501 attacaactt ttataaactg acagacccat aatgttttta acctttttaa aagaaagcat
     1561 cctgtgaatt attacagctc cccgagtttg gccaaagatc aacctacaaa tgctgcaggt
     1621 gatagggggt ctgctcttgc aaagccttac tgtcattcaa aaacggactg tcgtggaaga
     1681 aaccgttttc tactcctcct ctaaactggt caggacaata atagagcaaa gctatcttcc
     1741 cactgcagga gagtgagcct gacccaccct gttcatgtag tatcttcact ttttctcctg
     1801 tgcccactgt gttcccagtc aaagcttgcc aaaaaaaaaa aaaaaaaaaa aaaaa
//
