LOCUS       NM_001013430            1556 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ras homolog family member H (Rhoh), mRNA.
ACCESSION   NM_001013430 XM_223404
VERSION     NM_001013430.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1556)
  AUTHORS   Crequer A, Troeger A, Patin E, Ma CS, Picard C, Pedergnana V,
            Fieschi C, Lim A, Abhyankar A, Gineau L, Mueller-Fleckenstein I,
            Schmidt M, Taieb A, Krueger J, Abel L, Tangye SG, Orth G, Williams
            DA, Casanova JL and Jouanguy E.
  TITLE     Human RHOH deficiency causes T cell defects and susceptibility to
            EV-HPV infections
  JOURNAL   J Clin Invest 122 (9), 3239-3247 (2012)
   PUBMED   22850876
REFERENCE   2  (bases 1 to 1556)
  AUTHORS   Oda H, Fujimoto M, Patrick MS, Chida D, Sato Y, Azuma Y, Aoki H,
            Abe T, Suzuki H and Shirai M.
  TITLE     RhoH plays critical roles in Fc epsilon RI-dependent signal
            transduction in mast cells
  JOURNAL   J Immunol 182 (2), 957-962 (2009)
   PUBMED   19124738
REFERENCE   3  (bases 1 to 1556)
  AUTHORS   Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters
            T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B,
            Klinkert WE, Straten PT, Kollgaard T, Sixt M and Brakebusch C.
  TITLE     RhoH is important for positive thymocyte selection and T-cell
            receptor signaling
  JOURNAL   Blood 109 (6), 2346-2355 (2007)
   PUBMED   17119112
REFERENCE   4  (bases 1 to 1556)
  AUTHORS   Gu Y, Chae HD, Siefring JE, Jasti AC, Hildeman DA and Williams DA.
  TITLE     RhoH GTPase recruits and activates Zap70 required for T cell
            receptor signaling and thymocyte development
  JOURNAL   Nat Immunol 7 (11), 1182-1190 (2006)
   PUBMED   17028588
REFERENCE   5  (bases 1 to 1556)
  AUTHORS   Li X, Bu X, Lu B, Avraham H, Flavell RA and Lim B.
  TITLE     The hematopoiesis-specific GTP-binding protein RhoH is GTPase
            deficient and modulates activities of other Rho GTPases by an
            inhibitory function
  JOURNAL   Mol Cell Biol 22 (4), 1158-1171 (2002)
   PUBMED   11809807
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091269.1.
            
            On Apr 20, 2005 this sequence version replaced XM_223404.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091269.1, FQ232983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06621351,
                                           SAMN06680429 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1556
                     /gene="Rhoh"
                     /note="ras homolog family member H"
                     /db_xref="GeneID:305341"
                     /db_xref="RGD:1307623"
     exon            1..244
                     /gene="Rhoh"
                     /inference="alignment:Splign:2.1.0"
     exon            245..366
                     /gene="Rhoh"
                     /inference="alignment:Splign:2.1.0"
     exon            367..1492
                     /gene="Rhoh"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..1143
                     /gene="Rhoh"
                     /note="ras homolog gene family, member H"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoH"
                     /protein_id="NP_001013448.1"
                     /db_xref="GeneID:305341"
                     /db_xref="RGD:1307623"
                     /translation="MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVD
                     VFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHSSFLNLKNKWISEV
                     RSNLPCTPVLVVATQTDQREMGPHRASCINAIEGKRLAQDVRAKGYLECSALSNRGVQ
                     QVFECAVRTAVNQARRRNRRKLFSINECKIF"
ORIGIN      
        1 gttcctgctg tcggtcacct cggacaccaa gagccaccac ctctggtgga ctctgccagt
       61 ccagtgttac aaattttccg acagtgattc actgggagcc ttgagaggta gcttagctcc
      121 caggaggaac tctcagcagt gataggtttt agctacccta gattttacat ggcgtcgaga
      181 gctacttaga cttccggagt cagtggtttt ggtgttgaga ccttcatttg gcattctaca
      241 acagttccca aagtgactga gatctactag aaccctgagg ccacaaacac gcagctgcct
      301 ttgcctgggt tcttttctgc ttcttggcca gtcaacagct gttcacgagt gtcattcaca
      361 catcagttgg cagccacgcg tcagaggttt cccactgctt ctcacctggc cagactggag
      421 acgcaacatc tgtaaccgat gtctgagatt ctacgaacat aagccccagt tgttgtctcc
      481 tcactctatg gaacctgtta tagaaaccca ttgagggttc ttccccttga gatcctagac
      541 tcttagatac aacttcagac gaggaagatg ctgagctcta tcaagtgtgt gctggtcggc
      601 gacagtgctg tgggaaaaac ctcactgttg gtgcgcttca cctctgagac cttccccgag
      661 gcctacaaac ccactgtgta tgagaataca ggtgtagacg tcttcatgga tggcatccag
      721 atcagcctgg gtctctggga cactgcaggc aatgatgcct tcagaagcat ccgccccctg
      781 tcctaccagc aggcagatgt ggtactaatg tgttactcgg tggccaacca tagctcgttc
      841 ctgaacttga agaacaaatg gattagtgag gtcaggagca acctaccctg taccccggtg
      901 ctggtggtgg ccactcagac tgaccagaga gagatgggac ctcacagggc ttcctgcatc
      961 aatgccatag aagggaagag acttgcccag gatgtgcgag ccaagggcta cctggagtgc
     1021 tcagccctta gcaaccgggg agtccagcag gtatttgaat gtgctgtccg aacagctgtc
     1081 aaccaggcca ggagacgaaa tagaaggaag ctgttttcca tcaacgaatg caagatcttc
     1141 taaccccgag gtcctgtacc caacattcat gaacatacct caaagactca tgggagaggg
     1201 gaagggggca agccacgagg accgatcttg accgatcttg gcacatctga acaatctttc
     1261 agttatgggg aagtctgcca ctgatgcttt cacaaactgt actctgcaga tgaactctgt
     1321 gccaacacaa cctgagagat tccttgggga gccatgtgag aagtccgtct tcaatgagag
     1381 attaaaacga ccatcctaat ttagacaatg aagtgcattt cccaagtatg ctgtatttaa
     1441 acccacatct tatttaaata atgaccaaat atagagctct tgttttcctg tgaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
