LOCUS       NM_001037195            1247 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ras homolog family member G (Rhog), mRNA.
ACCESSION   NM_001037195 XM_218977
VERSION     NM_001037195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Ubba V, Soni UK, Chadchan S, Maurya VK, Kumar V, Maurya R,
            Chaturvedi H, Singh R, Dwivedi A and Jha RK.
  TITLE     RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced
            Polycystic Ovary in Rat Model
  JOURNAL   Reprod Sci 24 (5), 738-752 (2017)
   PUBMED   27662902
  REMARK    GeneRIF: RHOG can mediate signaling through downstream effectors
            DOCK1 and RAC1 during ovarian follicular development (theca and
            granulosa cells and oocyte), but dehydroepiandrosterone
            downregulated them in the polycystic ovarian syndrome ovary.
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Schulz J, Franke K, Frick M and Schumacher S.
  TITLE     Different roles of the small GTPases Rac1, Cdc42, and RhoG in
            CALEB/NGC-induced dendritic tree complexity
  JOURNAL   J Neurochem 139 (1), 26-39 (2016)
   PUBMED   27412363
  REMARK    GeneRIF: Rac1, Cdc42, and RhoG perform very specific and
            non-redundant functions at different levels of hierarchy in
            regulating dendritic tree complexity induced by CALEB/NGC
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Samson T, van Buul JD, Kroon J, Welch C, Bakker EN, Matlung HL, van
            den Berg TK, Sharek L, Doerschuk C, Hahn K and Burridge K.
  TITLE     The guanine-nucleotide exchange factor SGEF plays a crucial role in
            the formation of atherosclerosis
  JOURNAL   PLoS One 8 (1), e55202 (2013)
   PUBMED   23372835
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A,
            Harada C and Harada T.
  TITLE     Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by
            forming a ternary complex with Elmo and RhoG
  JOURNAL   Genes Cells 17 (8), 688-697 (2012)
   PUBMED   22734669
  REMARK    GeneRIF: Dock3 forms a complex with Elmo and activated RhoG
            downstream of BDNF-TrkB signaling and induces neurite outgrowth via
            Rac1 activation in PC12 cells.
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Franke K, Otto W, Johannes S, Baumgart J, Nitsch R and Schumacher
            S.
  TITLE     miR-124-regulated RhoG reduces neuronal process complexity via
            ELMO/Dock180/Rac1 and Cdc42 signalling
  JOURNAL   EMBO J 31 (13), 2908-2921 (2012)
   PUBMED   22588079
  REMARK    GeneRIF: RhoG emerges as a cellular conductor of Rac1 and Cdc42
            activity, in turn regulated by miR-124 to control axonal and
            dendritic branching.
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M and Simons
            M.
  TITLE     Suppression of RhoG activity is mediated by a syndecan
            4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1
            activation pathway
  JOURNAL   J Cell Biol 186 (1), 75-83 (2009)
   PUBMED   19581409
  REMARK    GeneRIF: Fibroblast growth factor 2-induced Rac1 activation depends
            on the suppression of RhoG by a previously uncharacterized ternary
            S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Vigorito E, Billadeu DD, Savoy D, McAdam S, Doody G, Fort P and
            Turner M.
  TITLE     RhoG regulates gene expression and the actin cytoskeleton in
            lymphocytes
  JOURNAL   Oncogene 22 (3), 330-342 (2003)
   PUBMED   12545154
REFERENCE   9  (bases 1 to 1247)
  AUTHORS   Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K and Der
            CJ.
  TITLE     RhoG signals in parallel with Rac1 and Cdc42
  JOURNAL   J Biol Chem 277 (49), 47810-47817 (2002)
   PUBMED   12376551
REFERENCE   10 (bases 1 to 1247)
  AUTHORS   Ishikawa Y, Katoh H, Nakamura K, Mori K and Negishi M.
  TITLE     Developmental changes in expression of small GTPase RhoG mRNA in
            the rat brain
  JOURNAL   Brain Res Mol Brain Res 106 (1-2), 145-150 (2002)
   PUBMED   12393274
  REMARK    GeneRIF: results suggest distinct pre- and postnatal roles in the
            development of the central nervous system
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107943.1.
            
            On Nov 23, 2005 this sequence version replaced XM_218977.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107943.1, CV079351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1247
                     /gene="Rhog"
                     /gene_synonym="Arhg"
                     /note="ras homolog family member G"
                     /db_xref="GeneID:308875"
                     /db_xref="RGD:621310"
     exon            1..26
                     /gene="Rhog"
                     /gene_synonym="Arhg"
                     /inference="alignment:Splign:2.1.0"
     exon            27..1223
                     /gene="Rhog"
                     /gene_synonym="Arhg"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..671
                     /gene="Rhog"
                     /gene_synonym="Arhg"
                     /note="ras homolog gene family, member G (rho G)"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoG"
                     /protein_id="NP_001032272.1"
                     /db_xref="GeneID:308875"
                     /db_xref="RGD:621310"
                     /translation="MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQS
                     AVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVC
                     HHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSAL
                     QQDGVKEVFAEAVRAVLNPTPIKRGRSCILL"
ORIGIN      
        1 ctcccccgcc gcggggaggg caccaggtca ctacttccag tggggtccag aagagggagg
       61 aggcactgcc tccacggtag taactttaca acacaatgca gagcatcaag tgtgtggtgg
      121 tgggtgatgg ggccgtaggc aagacgtgcc ttctcatctg ctatacaact aatgccttcc
      181 ccaaggaata catccccact gtgttcgaca attacagcgc ccagagtgcg gttgatgggc
      241 gcaccgtgaa cctaaacctg tgggacactg ccggccagga ggagtacgac cgcctccgca
      301 ccctttccta cccccagacc aacgtcttcg tcatctgttt ctccattgcc agtccaccct
      361 cctatgagaa cgtgaggcac aaatggcacc cagaggtgtg tcaccactgc cctgatgtgc
      421 ccatcctcct ggtgggcacc aagaaggacc tcagagccca gcctgatacc ctacggcgcc
      481 tcaaggagca gggtcaagcg cccatcacac cacagcaggg ccaggcgctg gccaagcaga
      541 tccacgctgt gcgctacctc gagtgctcag cgctgcagca agacggtgtc aaggaggtgt
      601 ttgccgaggc tgtccgggcg gtgctcaacc caacaccgat aaagcgtggg cggtcctgca
      661 tcctcttgtg accctggcac tcagcttgga ggctatccct tgtcccccta ccaattgtgc
      721 cttggcgcct tgtctgcccc cagctgtgcc ttaaggacta attctggcac cccttgcctg
      781 ggaactccct gaatgccttt tattccttaa ggaggtacac agggagaggg gctttgggcc
      841 ccaccccact ctgcttggga ataccaagta ttccatgagt tcacctcaaa cgggttgacc
      901 tttctaagag gctaacccag tgctcccctc catttcctgc tactgaccag ttcatccagc
      961 tttccacaaa gttgttgctg cctgatgtga tgcctcctca agataggggc tctaacctct
     1021 ctctgcctta gctcttggag taagctctcc aagatgttct ctccctctcc caagggagga
     1081 gccacagaat cctcagaaga aaaatgtgcc ctaacctgcc ccatgtgccc aggacttatg
     1141 cgcctgctga ctgactcagg ccccatgctc ctgggggcct ttcctacccc catcagcatc
     1201 aataaaacct cctgtctcca gtgaaaaaaa aaaaaaaaaa aaaaaaa
//
