LOCUS       NM_001106461            1267 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ras homolog family member C (Rhoc), mRNA.
ACCESSION   NM_001106461 XM_001068816 XM_215659
VERSION     NM_001106461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Zhao,B., Wu,Z. and Muller,U.
  TITLE     Murine Fam65b forms ring-like structures at the base of stereocilia
            critical for mechanosensory hair cell function
  JOURNAL   Elife 5, e14222 (2016)
   PUBMED   27269051
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Hsu,S.P., Chen,T.H., Chou,Y.P., Chen,L.C., Kuo,C.T., Lee,T.S.,
            Lin,J.J., Chang,N.C. and Lee,W.S.
  TITLE     Extra-nuclear activation of progesterone receptor in regulating
            arterial smooth muscle cell migration
  JOURNAL   Atherosclerosis 217 (1), 83-89 (2011)
   PUBMED   21440892
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Bravo-Cordero,J.J., Oser,M., Chen,X., Eddy,R., Hodgson,L. and
            Condeelis,J.
  TITLE     A novel spatiotemporal RhoC activation pathway locally regulates
            cofilin activity at invadopodia
  JOURNAL   Curr Biol 21 (8), 635-644 (2011)
   PUBMED   21474314
  REMARK    GeneRIF: RhoC activity is spatially confined to areas surrounding
            invadopodia; it is controlled by 'spatially distinct regulatory
            elements' that confine RhoC activation within this compartment.
            RhoC activation enhances cofilin phosphorylation outside
            invadopodia.
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Wallace,S.W., Magalhaes,A. and Hall,A.
  TITLE     The Rho target PRK2 regulates apical junction formation in human
            bronchial epithelial cells
  JOURNAL   Mol Cell Biol 31 (1), 81-91 (2011)
   PUBMED   20974804
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Jiang,L., Liu,X., Kolokythas,A., Yu,J., Wang,A., Heidbreder,C.E.,
            Shi,F. and Zhou,X.
  TITLE     Downregulation of the Rho GTPase signaling pathway is involved in
            the microRNA-138-mediated inhibition of cell migration and invasion
            in tongue squamous cell carcinoma
  JOURNAL   Int J Cancer 127 (3), 505-512 (2010)
   PUBMED   20232393
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Kamijo,K., Ohara,N., Abe,M., Uchimura,T., Hosoya,H., Lee,J.S. and
            Miki,T.
  TITLE     Dissecting the role of Rho-mediated signaling in contractile ring
            formation
  JOURNAL   Mol Biol Cell 17 (1), 43-55 (2006)
   PUBMED   16236794
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Yonemura,S., Hirao-Minakuchi,K. and Nishimura,Y.
  TITLE     Rho localization in cells and tissues
  JOURNAL   Exp Cell Res 295 (2), 300-314 (2004)
   PUBMED   15093731
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Horiuchi,A., Imai,T., Wang,C., Ohira,S., Feng,Y., Nikaido,T. and
            Konishi,I.
  TITLE     Up-regulation of small GTPases, RhoA and RhoC, is associated with
            tumor progression in ovarian carcinoma
  JOURNAL   Lab Invest 83 (6), 861-870 (2003)
   PUBMED   12808121
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 1267)
  AUTHORS   Fritz,G., Brachetti,C., Bahlmann,F., Schmidt,M. and Kaina,B.
  TITLE     Rho GTPases in human breast tumours: expression and mutation
            analyses and correlation with clinical parameters
  JOURNAL   Br J Cancer 87 (6), 635-644 (2002)
   PUBMED   12237774
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215659.4, XM_001068816.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166849.1, SRR8487231.16016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1267
                     /gene="Rhoc"
                     /note="ras homolog family member C"
                     /db_xref="GeneID:295342"
                     /db_xref="RGD:1304965"
     exon            1..256
                     /gene="Rhoc"
                     /inference="alignment:Splign:2.1.0"
     exon            257..420
                     /gene="Rhoc"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..846
                     /gene="Rhoc"
                     /note="ras homolog gene family, member C"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoC"
                     /protein_id="NP_001099931.1"
                     /db_xref="GeneID:295342"
                     /db_xref="RGD:1304965"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECS
                     AKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL"
     exon            421..541
                     /gene="Rhoc"
                     /inference="alignment:Splign:2.1.0"
     exon            542..672
                     /gene="Rhoc"
                     /inference="alignment:Splign:2.1.0"
     exon            673..1267
                     /gene="Rhoc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaactgacc tcggaggaga gcactttcct gcttcccgga tcgctcgggg aacggctcag
       61 gagggggttc cgggcggggt atgggagagc gtcctgtgcc gcggggcagg cgctctcgcc
      121 tcctgagctc tcgaaccaca gcccagagcc ccttcccttt ctgagtcttg cctctccgga
      181 cctccctagc tgggccagga acacacttgg atctccctga gcgactctac ccagaagctc
      241 cagttccggg cggggatttc agtcatggcc gcaatccgaa agaagctggt aattgtgggt
      301 gatggcgcct gcgggaagac ctgcctcctc atcgtcttca gcaaggatca gtttccggag
      361 gtctacgtcc ctactgtctt tgagaactac atagcagaca tcgaagtgga tggcaagcag
      421 gtggagctgg ctctgtggga cacagcaggg caagaagact acgatcgcct gcggcctctc
      481 tcctacccgg acactgacgt catccttatg tgtttctcca ttgacagtcc tgacagcctg
      541 gaaaacattc ctgagaagtg gaccccggag gtgaagcact tctgtcccaa tgtgcccatc
      601 atcctagtgg ggaataagaa ggacctgagg caagatgagc ataccaggag agagctggcc
      661 aaaatgaaac aggagccggt tcgatctgag gaaggccggg acatggcaaa caggatcagc
      721 gccttcggct accttgagtg ctcagccaag actaaggaag gggtgcggga ggtatttgag
      781 atggccactc gggctggcct acaggtccgg aagaataagc gccggagggg ctgtcccatt
      841 ctctgaattc cccaaagcct ccttaaccct cccactcttc ccttcacagg ggtacagacc
      901 cccctccccc catttcatcc ttgtaggatt tcatgctgcc agtttctttt ttggttcctt
      961 tctgccctgg actgcatgag tttccccagc cccaagtggg ggctgctagg ccccttctcc
     1021 ctgcctctgg gaactaggtt ggtgccctgc ccttcttttg cagggctcct cctcctgatg
     1081 aggtccaggg gtggggttct tagtccgttt ggccttcccc atattacaca ccagcacttt
     1141 atatattttt ggctcacagg aggagtctag gatagggact ggggtttctg ctttgggtag
     1201 tagccttgta tttgacttta cttggtggga gggcaggaca tgaataaagg tcaaaggttg
     1261 caccatg
//
