LOCUS       NM_001107645            4858 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho-related BTB domain containing 3 (Rhobtb3),
            mRNA.
ACCESSION   NM_001107645 XM_001058672 XM_226604
VERSION     NM_001107645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4858)
  AUTHORS   Lutz J, Grimm-Gunter EM, Joshi P and Rivero F.
  TITLE     Expression analysis of mouse Rhobtb3 using a LacZ reporter and
            preliminary characterization of a knockout strain
  JOURNAL   Histochem Cell Biol 142 (5), 511-528 (2014)
   PUBMED   24923387
REFERENCE   2  (bases 1 to 4858)
  AUTHORS   Schenkova K, Lutz J, Kopp M, Ramos S and Rivero F.
  TITLE     MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of
            RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a
            predominantly nuclear dimeric protein
  JOURNAL   J Mol Biol 422 (5), 659-673 (2012)
   PUBMED   22709582
REFERENCE   3  (bases 1 to 4858)
  AUTHORS   Espinosa EJ, Calero M, Sridevi K and Pfeffer SR.
  TITLE     RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi
            transport
  JOURNAL   Cell 137 (5), 938-948 (2009)
   PUBMED   19490898
REFERENCE   4  (bases 1 to 4858)
  AUTHORS   Kang D, Oh S, Ahn SM, Lee BH and Moon MH.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226604.4, XM_001058672.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..4858
                     /gene="Rhobtb3"
                     /note="Rho-related BTB domain containing 3"
                     /db_xref="GeneID:309922"
                     /db_xref="RGD:1311683"
     exon            1..420
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..2254
                     /gene="Rhobtb3"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 3"
                     /protein_id="NP_001101115.1"
                     /db_xref="GeneID:309922"
                     /db_xref="RGD:1311683"
                     /translation="MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLL
                     NAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNV
                     NDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTE
                     GIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKASEKMKKRKMTGSFHG
                     IRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVMGVVEAHKIVLCS
                     VSHVFMLLFNVKSPNDIQDSSIIRTTQDLFAINRDAVLPGASQESSSNPPLRVIVKDA
                     LFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLR
                     NCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFN
                     GNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQH
                     ICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQK
                     PEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM"
     exon            421..646
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            647..833
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..988
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1100
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1466
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1579
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1700
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1874
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2041
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2138
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..4858
                     /gene="Rhobtb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagcaaact tgctgcaggc ggattggcag cgagcagctc ccgggctccg tgtcgtcccc
       61 gcgcccgccg ctcctttgtg tccagcggcc gccgcctggg cgcggggggc ctcggcgggc
      121 agccagcttc ctcgcgcgcc ggactctaag ggcgacacgt gcgggccccg ggtcccggag
      181 gagcagaggc ggagccgggg cggaggcgcg gcggccagga gcagtgacca gggatccgca
      241 gcgctgcccg cgcccggcgg cagttcattc cgggcccgct ctgttctgca gtggcagcgc
      301 cgcggtacag gcgcgcgagg gccacggctg ggggatgagc tgactgcagt gaaagcgtcg
      361 ctccggcccc ctccaggcct ccggccgcag tctcccggcc gccttgccag ccgcaatcat
      421 gtctatccac atcgtggcgc tggggaacga gggcgacact ttccaccagg acaaccggcc
      481 gtcggggctc atccgcacgt acctggggag aagcccgctg gtgtcggggg acgagagtag
      541 cttgttgctg aacgccgcca gcacagttgc gcgcccggtc ttcaccgagt accaggccag
      601 tgcgttcggg aacgtcaagc tggtagtgca cgactgtccc gtctgggaca tttttgacag
      661 tgattggtac acctcccgaa atctaattgg gggtgccgac atcattgtga tcaaatacaa
      721 tgtcaatgac aagttttcat tccatgaagt aaaggataat tatattcccg tgattaaaag
      781 agcatcgaac tcagttccag tcatcattgc ggctgttggt acgagacaaa atgaagaatt
      841 accttgtaca tgcccactgt gtacttcaga ccgagggagc tgtgttacca ccacagaagg
      901 gatccaactt gccaaagaac tgggagctac ctatctggaa ctccacagcc ttgatgattt
      961 ctacatcgga aagtactttg gaggagtgtt ggagtatttt atgattcaag ccttaaatca
     1021 gaaggcaagt gaaaaaatga agaaaaggaa gatgacgggc tccttccatg gaattcgacc
     1081 tcctcagctg gaacagccag aaaagatgcc tgtcttgaaa gctgaagcat cacactatca
     1141 ctccgacttg aataacttgc tgctctgctg ccagtgtgtt gatgtggtct tttaccaccc
     1201 ggaagtgatg ggtgtcgtgg aagcccacaa gatcgttctc tgctctgtaa gccatgtttt
     1261 catgctgctt ttcaatgtga agagccctaa cgacattcag gattccagta tcatccgaac
     1321 cacccaggat ctctttgcca taaacagaga tgctgtgctt ccaggtgcta gccaagaatc
     1381 ctccagcaac ccgccattgc gcgtcattgt taaggatgcc ctcttctgct cgtgtttgtc
     1441 agacattctg cgcttcattt attcaggtgc ttttcagtgg gaagaacttg aagaagatgt
     1501 caggaggaag ttgaaagatt caggggatgt ttctgatata atcgagaaag ttaaatgcat
     1561 tttaaaaaca ccaggaaaga ttaattgcct gaggaattgc aagacatacc aagccaggaa
     1621 gcctctgtgg ttttataata catctctcaa gtttttcctt aacaaaccaa tgcttgccga
     1681 tgttgtcttt gaaatacaag gagcaactgt gccagcccac agggccatct tggtggctcg
     1741 atgtgaagta atggccgcca tgtttaatgg taattatatg gaagccaaga gtgtactgat
     1801 tccagtttat ggcgtttcca aagagacatt cttgtcattt ttagaatact tatacacaga
     1861 ctcttgttgc ccagctggca tttttcaggc catgtgcctc ctgatctgtg ccgagatgta
     1921 ccaagtctcc agactgcagc acatctgtga gctgttcatc atcacccagc tgcagagcat
     1981 gcccagcagg gagctggcct ccatgaacct tgacattgtg gacttgctca aaaaggccaa
     2041 gtttcaccac tcggactgcc tttccacctg gctgcttcat ttcattgcca ctaactacct
     2101 catattcagc caaaagcccg aattccagga cctttcagtg gaagaacgaa gttttgttga
     2161 aaagcacaga tggccatcaa acatgtactt gaagcagctg gcagaataca ggaaatatat
     2221 ccactcccgg aaatgtcgct gtttagtcat gtgacctgag cttttgcata cttacacttt
     2281 tttattatta tgaagaatgg gtacttctgg attccagtaa aattcttata actaaaatca
     2341 atgtttttta aaaatcacta tatagcttct tactagttac cttttaaaga ctatggtggt
     2401 cttaaaaggg aacaaaagct accacagact taattaatgc ttcatctaga atataaaact
     2461 gttggacatt gggtctcctt taagtttccc tattgcttta ataacatcaa gacctctcct
     2521 agttaaaaga tatttaattt aaaaaatcta ggataaatac aaaaatttca tcatgtctga
     2581 gtgattgctc tgctaaaata aggagcattt aaaagccaag cggaaccatg gaattcagag
     2641 gagctctaac cagtgcagca tgaaattgta gaaatagaaa tttgcccatg tctttgatag
     2701 tcatgtgtca tctggcttcc agtccattaa gagtatttgg atcaatatga tagccccatc
     2761 tgtaccatcc acccacatct gcttgtcaat caggctgcaa acctaagtag gctggtagtt
     2821 atctctgtgt aaccttctag agtttatcga cttccaaact tagaagggtc tggcatttgg
     2881 tttagtgctc tgctagtaca gttgttaaat tcttaaaaat gtttgatgaa gggcccatgt
     2941 tttcactttg caccggttcc ccaaaattgt gtgtatttcc taacaagaaa aaaatgctga
     3001 gatactgttt tcttttcctt tttttttgtt tttgtttttg tttttgtttt gttttgtttt
     3061 gttttttcat tttttgtttg ctttgttttg ttttttgttt tcattttttg tttgttttgt
     3121 tttgtttttt cagagggggt ttctctgtgt aacatcccta gctgttctgg aacttgcttt
     3181 atagaccagg ctggcctcaa attcacaaag ttctgctggg ataaaggatg tgtgccacca
     3241 tgcctagctt aaaatgtttt ttttttcttg ctcaaacctt ctctctatgg aagcagaaac
     3301 gttgctgata gccaggaaag gacagtagct tttggccaga agagcagagt ggagactccc
     3361 atctttggga aaggacatat gcccatgcgc ctccacaaag atctttcctg gcaataagaa
     3421 atgctgaaat gctttttgtt ggttttgaaa cactccccca gttatagctg taccccagaa
     3481 aagcaaatac tttcttgatc aatatgtaaa gtcaggaagt tgttaagact gatagagtaa
     3541 cctgactata atacacagag tgataagcca caggaaaaga tgtcttctaa agacttgggc
     3601 ctaaaaactt aaatatcctt tcttttaact gttaagaata agatgccaat tgcatgaatt
     3661 gagttctttt caaggactga tagactattt ggtatgaagt agcaaagcca cctgggaagg
     3721 taaaaaagga tgtaaatcaa agacatcctt ttttgtcgat gtagagacaa tggtgtctgg
     3781 gattgaaggc agagttagta tcactcatag catatatttg cagaaatgat tctgcaagat
     3841 gctcaacggc atggaaaaac atattactct tttttgttaa tatcatggtc atgggatata
     3901 tttttctaat ttctagtgat ttttagtatg catatttttc aaacttttca aaaatttgat
     3961 tcaataatct tatcctgtag tgttaggatt ccatacagaa agccctatta tacataccaa
     4021 actatcagaa taaaggggaa agaatcccaa gagagcttat tttaattttg ctgtgtcaat
     4081 gaagattact gaaatgaatt ttgtccttta tattttaatc acttgagtga atcaacattg
     4141 gcaaatccca tttggtggct tagcattaga aagaacagct gatgccagaa gttcctctgc
     4201 tttttcagat cagtggtggc ctttgatact ctaaagtaat tatgttcacc ctctgtacta
     4261 atgacattta aaattctaaa attttatgat attgacatga aaaataggag ctgagaaaaa
     4321 aacattttct tggaaatatt attttaacat ttaggtggat cataactaat tttactaggg
     4381 tgtttttcct gagtaggagt tgagtttgga actggtagtc ttgcatgtta aacataaagt
     4441 gtgactgaga cagccatgag tcagaatata gatgaattct taaatgtttg aatacaaagg
     4501 cctcggtatt gttactcaac aattccaatc cactcagttg gaagtaatag gagattttga
     4561 atctttataa atgatcttgt gtaaattact gctggttgta agggttgttt cccaatcaaa
     4621 ggttatttct agacagtgat atgcttgttg caatttcttg cttctattgg ccaagcattt
     4681 tacttagaaa ggatactatg tagttgaact aaggctactt ctagtctggg cttgcatctt
     4741 gttgtgcatt ccttgtatgc tgttgaccac atccctgttc cttctgcaga ggactagatt
     4801 tctaacagaa cattggccta gtagctgaaa cccacccctg tgcaagccag aatggagc
//
