LOCUS       NM_001107622            5009 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus Rho-related BTB domain containing 1 (Rhobtb1),
            mRNA.
ACCESSION   NM_001107622 XM_001074130 XM_001074156 XM_039098738 XM_228131
VERSION     NM_001107622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5009)
  AUTHORS   Xiao,J., Liu,H., Cretoiu,D., Toader,D.O., Suciu,N., Shi,J.,
            Shen,S., Bei,Y., Sluijter,J.P., Das,S., Kong,X. and Li,X.
  TITLE     miR-31a-5p promotes postnatal cardiomyocyte proliferation by
            targeting RhoBTB1
  JOURNAL   Exp Mol Med 49 (10), e386 (2017)
   PUBMED   29053138
  REMARK    GeneRIF: miR-31a-5p controls postnatal cardiomyocyte proliferation
            by targeting RhoBTB1, and increasing miR-31a-5p level might be a
            novel therapeutic strategy for enhancing cardiac reparative
            processes.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Aug 4, 2021 this sequence version replaced
            XM_039098738.1, NM_001107622.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.57610.1,
                                           SRR21887620.1491122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-742               JAXUCZ010000020.1  19401316-19402057   c
            743-792             JAXUCZ010000020.1  19399220-19399269   c
            793-994             JAXUCZ010000020.1  19369084-19369285   c
            995-1098            JAXUCZ010000020.1  19368363-19368466   c
            1099-1284           JAXUCZ010000020.1  19351105-19351290   c
            1285-2255           JAXUCZ010000020.1  19346651-19347621   c
            2256-2374           JAXUCZ010000020.1  19344597-19344715   c
            2375-2525           JAXUCZ010000020.1  19337844-19337994   c
            2526-2614           JAXUCZ010000020.1  19331826-19331914   c
            2615-2720           JAXUCZ010000020.1  19328963-19329068   c
            2721-5009           JAXUCZ010000020.1  19326197-19328485   c
FEATURES             Location/Qualifiers
     source          1..5009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..5009
                     /gene="Rhobtb1"
                     /note="Rho-related BTB domain containing 1"
                     /db_xref="GeneID:309722"
                     /db_xref="RGD:1306871"
     exon            1..742
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..792
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..994
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             803..2890
                     /gene="Rhobtb1"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 1"
                     /protein_id="NP_001101092.1"
                     /db_xref="GeneID:309722"
                     /db_xref="RGD:1306871"
                     /translation="MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQ
                     LLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDV
                     VVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLA
                     RPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWK
                     SHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTSDAACLLDNPLCADVLFILHDQE
                     HIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGEEVPCRDFQGRTQSLGAAEEGQE
                     GSQRTPQADPGASSGQDLLESLASQTDASVSEAHALTGWSKGFVSMHREVRVNPISKR
                     VGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVEN
                     IMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEW
                     MAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFC
                     LTHLVALVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYN
                     SVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSR
                     RKWCFWHPSPAVA"
     exon            995..1098
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1284
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..2255
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2374
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2525
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2614
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2720
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..5009
                     /gene="Rhobtb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctgggc tcggttttga aacaaaagcc aatgtcctcc ctcggagtcc gcgaccggtc
       61 agttcctagg gggaagaaag ctatgctgcc cagccggtta gtggcccaac ttacttttcc
      121 tgagcccagg attgagggcc agcggatgtt cgggagtggg tgggatgctg cggggagggg
      181 gcgcgggaca gctcgcacac accctgccct gctctgttct ccgcttggcc caaggccgga
      241 tccccaggat gcgggacaca cgctggtccc aaccaagcgc cctggagccc aggcccctcc
      301 ggtgtgcgtg cagccgcggc accttcgcca cctcgcgtcc cacagttcag acacacaagg
      361 ccctggtttc atgaatgaaa tccaatcgtg tggttataaa tagccgccaa ggctgctcac
      421 gtcacggtgg agagagaggg agcgatcgga ggccgccacc gcgttgcttg ctccgtgctg
      481 gggcgcaggg ttccgcccgg tgccccgcct ggcgggggaa gggggcggga ggagggcagg
      541 gctggcggca atagcgacct ggggacgagt cccgtggcct gcgccgggac gcggacgcgg
      601 ccgggcgcgg ctgggccatg ctgcctttgt gccacgccgg gcgggtggcg cgcggtgcgc
      661 agggtcccgg cgtccccgcg agcgcgcgcg gcgggggccg ctgctgagcg gcggagggag
      721 ccgggtctcg ctcggctgca gggtaaggcc agctgtgcta ggaactcctg ttcttcactt
      781 ccagcgagcc agagctttat aaatggactc tgacatggac tacgaaagac ccaacgttga
      841 aaccatcaag tgcgtggttg tgggtgacaa cgccgtgggg aagactcgcc tgatctgtgc
      901 ccgggcgtgc aataccaccc tgacacagta ccagctgctg gccacccatg tgcccaccgt
      961 gtgggccatt gaccagtacc gcgtctgcca agaggtcctg gagcggtcca gggatgttgt
     1021 tgatgaagtg agcatctccc tcaggctttg ggacactttt ggagatcacc ataaagacag
     1081 gcgtttcgca tacggcaggt ccgatgttgt ggttctctgc tttagcatcg cgaatcccaa
     1141 ctccctaaat catgtgaaaa ccatgtggta tcaagaaatc aagcactttt gccctcgaac
     1201 acctgtcgtt ctggttggct gccagctaga cctccgctac gccgacctgg aggctgttaa
     1261 ccgggccaga cgccccttag caaggcccat aaagagaggt gatattttgc ccccagaaaa
     1321 aggccgcgag gtggcgaagg aacttggcat cccgtactat gagaccagcg tgtttgacca
     1381 gtttggcatc aaggacgtgt tcgacaatgc catccgggca gccctcatct cccgccggca
     1441 cctgcagttc tggaaatccc acttgaaaaa agtccagaag cctctgcttc aggcgccctt
     1501 cctacctccg aaagctcctc ccccggtcat caaagtcccc gagtgtccgt ccaccgggac
     1561 gagcgacgca gcctgtttac tggacaatcc cctatgcgcc gacgtcctct ttatcctcca
     1621 cgaccaggag cacatctttg cgcaccgcat ttacctcgct acctcttctt ccaaattcta
     1681 cgaccttttt ttaatggagt gtgaagattc cccgggttgg agtggaggag ctggtgagga
     1741 ggtgccatgc agggattttc aggggcggac gcagagtctt ggagcagccg aggaagggca
     1801 ggagggctcc cagaggaccc ctcaggctga cccaggagca tcttcaggcc aggacctctt
     1861 ggagagtctg gcttcgcaga ccgatgcctc ggtttccgag gcgcacgccc taaccggctg
     1921 gagcaagggg tttgtcagca tgcacaggga ggtgcgggtc aaccccattt ccaagcgggt
     1981 gggcccagtg accgtggtca ggctggactc ttcgatgcag tcaggccctt tccggaccct
     2041 actgagattc ctctactctg ggcagctgga cgaaaaggag aaagatctcc tggggctagc
     2101 tcagatggcc gaggtcttgg agatgtttga tctgaggatg atggtggaga atatcatgaa
     2161 caaggaggcc tttatgaacc aggagatcac gaaagccttc cacgtcagga aagccaatcg
     2221 gatcaaagaa tgtctcagta agggcacctt ctcagatgtg acattcacct tggatgacgg
     2281 agccatcagt gcccacaagc cgctgctgat ctgtagttgc gagtggatgg ccgccatgtt
     2341 cgggggctcc tttgtggaaa gcaccaacag tgaggttcac cttccaaaca taaacaagat
     2401 gtccatgcag gccgtgttgg aatacctcta caccaagcag ttgtcgccca acttggacct
     2461 ggaccctctg gagctaatcg ccttagctaa cagattttgc ctgacacact tggttgcact
     2521 cgtagaacag catgccgtcc aggagctcac taaggccgct gtgagtggtg tgagcattga
     2581 tggtgaagta ctctcctact tggagttggc gcagtttcac aatgccaacc agctagccgc
     2641 ctggtgttta catcacatct gcaccaacta caacagcgtc tgttccaagt tccgcaagga
     2701 aatcaaatcc aagtcagcag acaaccagga gtactttgaa cgccaccgct ggccccctgt
     2761 gtggtacctt aaggaggaag accactacca gcgtgtgaag agggaacgag agaaagagga
     2821 cctggcgctg aacaagcacc attcgaggag aaagtggtgt ttctggcatc cgtccccagc
     2881 cgtggcctga ggaggaggga gaggggaccg tcatccgctg aggccacctc caccgttgac
     2941 agctctactg ttaaaaacca gcctccttag ccgtccgcgc agttagggtt tgaggcactg
     3001 gcttttccac tcgtgtgcat ttatctccac caggatcaaa gagaaagctt tgatgccatc
     3061 aacagggcat aaaaggaaaa ctgactgact ttcctctgaa cccttcagac ccataatgtc
     3121 ctcccttttc tttctttttt tttttttttc cttgttagga agctttaata cactttagtc
     3181 cgttattttg ttccttttta tacaaagaca aaacaaagcc cagctttcct gtccccagat
     3241 tccagattgg agaatatttt tataaggact cttgtctgtc gctgaagtga caatactgtg
     3301 tattcctctc ttttacaggc cacacattga ccatgaagtt gctccccacc cccacccacg
     3361 agtctctcgg cccatgtgcc cgccgagcgt tactcataat tacagagtta tccttttgtt
     3421 gcgaggtaaa ggggtggggc tgaaatcacc cgaactataa gctagaagcg cctaatcttt
     3481 gctctgatga gccactggtg taagttccta ttcacacgat ttcctctgta agtgcttgta
     3541 attataaggt tatctgtgcc atataaacta tggtgagggc agatatccta ccatttaaaa
     3601 tgtctagatt taaagaggct aagccttata atcattagaa gggcttattc aaccccagtc
     3661 ctgtcagggg caaggctgac tgccaggcct gcgtacctac aacaacggcc agccaagtcc
     3721 taccgttgga taaccgtgtc agagtcggtg gctttcgatg gtctctgatt tcgctgtgct
     3781 cccaccagca aaccctcctg gggcctgaag agaggtaagg gaaggggaaa agactcatcc
     3841 cactggctac aggtcagtca cctcggcctc acggcctcac acctacagcc aacttcactt
     3901 tgtaagacaa gtatttgtat tttttttttt ttaattttaa ctcttcccag ggaaaattca
     3961 ggtcaccact gaagtaggcc aaggcagggc acctgcttct tagagaggtc tcaccaggga
     4021 gcctgtgaaa gcacaaagct gggggttggg tcctgccttc tccagcaggg aaaggagtca
     4081 gttactaaga gcatagggaa tggtgctatt ccgaggtagt tctgaccccg tgccccttgg
     4141 gaaggtcagt gttagaacag aacttgcaaa gcaggggagg tctcaagagg catcaatatc
     4201 attgcctctc cgcagattaa aatgttacag tatacacact tgcacacaca cacacacaca
     4261 cacacaacca tcagagagtc acaactccac acctgccaca ggatgtcgtg tgctagacac
     4321 tggggcccat cctgttggga ggtcacctta ctgatgctaa gggctattga tttttttgtt
     4381 tgtttgcttt ttggttttgg gtttattttg ttttttgttt tgttttgttt tgttttgttt
     4441 tctctgaaga tgggaaagag acagttgagt ccaaactcca aatgccatat ggatttggaa
     4501 atctgtgtag accacaggca ggtgtttgtt tctggcatgg ccacattcca gatacaagaa
     4561 cgtagagaga cccagcaagg caccacaccc tctcatggca gagagggagc agtggggcag
     4621 ggtgagggcc agctaataaa gcctcccctc ccccccttaa ctttgttcat agggcaaatg
     4681 gctgacggaa ggagaaggtg ggtaggttga gagggtatgc gtcaagactt ggggagaggt
     4741 agcagatagc cgtcttgagg ctctgttttc aatgagtagt cctagtcgac cttaaccaaa
     4801 gctccatccg attgtattct tgccaaaaca caacagacac atgcacgaac atggggcgta
     4861 agcaataatg tcctctcgtg ttctccacgg ctgctcgaac caagtggctg gttcatttgg
     4921 ttgacactga ttcgccttta accatgacgg ttcctgtttt ttatttcaca gaaagccaat
     4981 aaaattgttt agctataaaa aaaaaaaaa
//
