LOCUS       NM_022542               2175 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ras homolog family member B (Rhob), mRNA.
ACCESSION   NM_022542
VERSION     NM_022542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Wu,F., Wang,F., Yang,Q., Zhang,Y., Cai,K., Zhang,J., Xia,M.,
            Wang,Y., Wang,X., Gui,Y. and Li,Q.
  TITLE     Upregulation of miR-21-5p rescues the inhibition of cardiomyocyte
            proliferation induced by high glucose through negative regulation
            of Rhob
  JOURNAL   J Dev Orig Health Dis 14 (5), 670-677 (2023)
   PUBMED   38073570
  REMARK    GeneRIF: Upregulation of miR-21-5p rescues the inhibition of
            cardiomyocyte proliferation induced by high glucose through
            negative regulation of Rhob.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Sun,G., Song,H. and Wu,S.
  TITLE     miR-19a promotes vascular smooth muscle cell proliferation,
            migration and invasion through regulation of Ras homolog family
            member B
  JOURNAL   Int J Mol Med 44 (6), 1991-2002 (2019)
   PUBMED   31573047
  REMARK    GeneRIF: miR19a promoted proliferation, migration and invasion via
            the MMP/aSMA/SM22a signaling pathway by inhibiting RHOB, suggesting
            that miR19a is a possible regulatory factor of RHOB.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Chen,Z.G., Liu,X., Wang,W., Geng,F., Gao,J., Gan,C.L., Chai,J.R.,
            He,L., Hu,G., Zhou,H. and Liu,J.G.
  TITLE     Dissociative role for dorsal hippocampus in mediating heroin
            self-administration and relapse through CDK5 and RhoB signaling
            revealed by proteomic analysis
  JOURNAL   Addict Biol 22 (6), 1731-1742 (2017)
   PUBMED   27549397
  REMARK    GeneRIF: CDK5 and RhoB are involved in addiction-related signaling
            pathways or protein-protein interaction networks
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Huang,G., Su,J., Zhang,M., Jin,Y., Wang,Y., Zhou,P. and Lu,J.
  TITLE     RhoB regulates the function of macrophages in the hypoxia-induced
            inflammatory response
  JOURNAL   Cell Mol Immunol 14 (3), 265-275 (2017)
   PUBMED   26388235
  REMARK    GeneRIF: these results suggest that RhoB plays an important role in
            the hypoxia-induced activation of macrophages and the inflammatory
            response.
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Hsu,S.P., Chen,T.H., Chou,Y.P., Chen,L.C., Kuo,C.T., Lee,T.S.,
            Lin,J.J., Chang,N.C. and Lee,W.S.
  TITLE     Extra-nuclear activation of progesterone receptor in regulating
            arterial smooth muscle cell migration
  JOURNAL   Atherosclerosis 217 (1), 83-89 (2011)
   PUBMED   21440892
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Gampel,A., Parker,P.J. and Mellor,H.
  TITLE     Regulation of epidermal growth factor receptor traffic by the small
            GTPase rhoB
  JOURNAL   Curr Biol 9 (17), 955-958 (1999)
   PUBMED   10508588
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Leung,T., Chen,X.Q., Manser,E. and Lim,L.
  TITLE     The p160 RhoA-binding kinase ROK alpha is a member of a kinase
            family and is involved in the reorganization of the cytoskeleton
  JOURNAL   Mol Cell Biol 16 (10), 5313-5327 (1996)
   PUBMED   8816443
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
  TITLE     Post-translational modifications of p21rho proteins
  JOURNAL   J Biol Chem 267 (28), 20033-20038 (1992)
   PUBMED   1400319
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Jahner,D. and Hunter,T.
  TITLE     The ras-related gene rhoB is an immediate-early gene inducible by
            v-Fps, epidermal growth factor, and platelet-derived growth factor
            in rat fibroblasts
  JOURNAL   Mol Cell Biol 11 (7), 3682-3690 (1991)
   PUBMED   1710770
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022542.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M74295.1, SRR22582416.1324955.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2175              JAXUCZ010000006.1  37083030-37085204   c
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2175
                     /gene="Rhob"
                     /gene_synonym="Arhb"
                     /note="ras homolog family member B"
                     /db_xref="GeneID:64373"
                     /db_xref="RGD:621309"
     exon            1..2175
                     /gene="Rhob"
                     /gene_synonym="Arhb"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..874
                     /gene="Rhob"
                     /gene_synonym="Arhb"
                     /note="ras homolog gene family, member B"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoB"
                     /protein_id="NP_071987.1"
                     /db_xref="GeneID:64373"
                     /db_xref="RGD:621309"
                     /translation="MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPE
                     VKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECS
                     AKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL"
ORIGIN      
        1 gtccgcaaaa tcagccatcg actcgcacaa agcagcgcga ctccgggaca gccgagaaca
       61 ctacccggca gcagcgcggc gacactccgt gcatcgtatg cccctgcgcc cctgccgcgg
      121 cagccggagc gccccgagag aacgctccac cgcggggtcc aggtgcagtt agcgtgccta
      181 gcccgcatcg cgcggtcgcg ggagagcggg aagcggcaag cagggagcgg gacggcggcg
      241 aggcgctcgc gggcccctcc tgctgcccgc gcccggcgag ctcatggcgg ccatccgcaa
      301 gaagctggtg gtggtgggcg acggcgcgtg cggcaagacg tgcctgctga tcgtgttcag
      361 taaggacgag ttccccgaag tgtacgtgcc caccgtgttc gagaactatg tggcggacat
      421 cgaggtggac ggcaagcagg tggagctggc gctgtgggac acggcgggcc aggaggacta
      481 cgatcgttta cggccgctct cctacccgga caccgacgtc atccttatgt gcttctcggt
      541 agacagcccg gactctctcg agaacatccc cgagaagtgg gtgcccgagg taaagcactt
      601 ctgccccaat gtgcccatca tcttggtggc caacaaaaaa gacctgcgca gcgatgagca
      661 tgtccgcacg gagctggccc gcatgaagca ggagccagtg cgcacggatg acggccgcgc
      721 catggcggtg cgcatccaag cctatgacta cctcgagtgc tcggccaaga ccaaggaggg
      781 cgtgcgcgag gttttcgaga cggccacgcg cgccgcgctg cagaagcgct acggatccca
      841 gaatggctgc atcaactgct gcaaggtgct atgaaggccg cgccctgcct cacgcccttg
      901 ccagcgtggc tccccctcct tggcccggtc gcccactaac cgggagaaag ggagacccgt
      961 gcccccgagg acaccaccag actgcctgac atctgctggt ggctctggct ggtcacgctg
     1021 aatattagcg tgggcaccga gctcccccct tcccagtgtc tgtgtgtgtc cagctgtgtg
     1081 gcacaggcct gggcgccctg ctgagtgcca aggggttcct gagcgtcctt ttctaaagag
     1141 ccaggcctcg aagtgtggtt gtgtgtgtgt acgactccct acacccctac cccactcctg
     1201 ccccaccccc gcctctggtt tccccagggg catgcagagt ggttgagccc cagcagatgt
     1261 tcgcttgtaa ccagcaagcc actactgttg ctccatgtct gtaacataga ccccctggaa
     1321 tcacgggagg ggagggctgg ggaggatggg gatgttacat aaatacagat tttattttcg
     1381 gaggcagaat ggtattgttt agtggtgagt ggtgtgacca gggcccatga gcaactcttc
     1441 ccaggctggg tcaggagccc acccatccaa gcatgaactg gactcggcca tctttccaca
     1501 ccctgggaag acatttgcaa ctgacttgag gttgagagga agcagctccc agacacagtg
     1561 tctcctgggc caagccccag cgaacctcct ttccagccac ctgcagagga tccagggtgt
     1621 gctgtggggt cacttttgcc ataagcgaac tttgtgcctg tcctacaagt gaacattgtt
     1681 cagtcgagag actattgttg ctgaatttat ttaaaggctg aagctttttt tgttgttgat
     1741 gaaagaattc tttgcacaat tgtcccattg tttgacaccc agtgcacttg tcatttgcat
     1801 aaggcagcat tttgaccaca cttgtatgct gtaacctcat ctacttctga tgtttttttt
     1861 ttaaaacaaa ctatgatgac tttaaggaga ttacaaaaaa gattctaatt tttgctttgt
     1921 tttcttgaaa aaaatgtcaa ccatgtgact ttttaaaaat ttgtgtagca tacacacagt
     1981 tttggtaaag gaaggcaaca cgtattgggg tctatttaaa cctccctccc tctccccaca
     2041 agacaagtct cttcatctat gtgaaatttt ctgtacattc tctgtgcaga gcaaagcttc
     2101 ctcttcctta ttccctcctt tcccagccca gtggtacttc tactaaattg tcttgttttg
     2161 tttttgtttt atttt
//
