LOCUS       NM_057132                585 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), mRNA.
ACCESSION   NM_057132
VERSION     NM_057132.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 585)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 585)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 585)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 585)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 585)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 585)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 585)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 585)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 585)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY026068.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_057132.4.
            
            On Jun 10, 2007 this sequence version replaced NM_057132.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY026068.1, AY026069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKY"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..585
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     CDS             1..582
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_476473.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     exon            1..156
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..277
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            278..408
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..585
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctgcca tcaggaagaa actggtgatt gttggtgatg gagcttgtgg taagacatgc
       61 ttgctcatag tcttcagcaa ggaccagttc ccagaggttt atgtgcccac ggtgtttgaa
      121 aactatgtgg cagatattga agtggacggg aagcaggtag agttggcttt atgggacaca
      181 gctggacagg aagattatga ccgtctgagg cctctctcct acccagacac tgatgttata
      241 ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaaatggact
      301 ccagaagtca agcatttctg tccaaatgtg cccatcatcc tagttgggaa caagaaggat
      361 cttcggaatg atgagcacac aaggcgggag ttagccaaaa tgaagcagga gccggtaaaa
      421 cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca
      481 gcaaagacca aagacggagt gagagaggtt tttgagatgg ccacgagagc tgctctgcaa
      541 gctagacgcg ggaagaaaaa gtcggggtgc ctcatcttgt gaagc
//
