LOCUS       NM_013216               1088 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Ras homolog, mTORC1 binding (Rheb), mRNA.
ACCESSION   NM_013216
VERSION     NM_013216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1088)
  AUTHORS   Zou,H., Wang,L., Zhao,J., Yuan,Y., Wang,T., Bian,J. and Liu,Z.
  TITLE     MiR-155 promotes cadmium-induced autophagy in rat hepatocytes by
            suppressing Rheb expression
  JOURNAL   Ecotoxicol Environ Saf 227, 112895 (2021)
   PUBMED   34673407
  REMARK    GeneRIF: MiR-155 promotes cadmium-induced autophagy in rat
            hepatocytes by suppressing Rheb expression.
REFERENCE   2  (bases 1 to 1088)
  AUTHORS   Wang,L., Du,J., Zhao,F., Chen,Z., Chang,J., Qin,F., Wang,Z.,
            Wang,F., Chen,X. and Chen,N.
  TITLE     Trillium tschonoskii maxim saponin mitigates D-galactose-induced
            brain aging of rats through rescuing dysfunctional autophagy
            mediated by Rheb-mTOR signal pathway
  JOURNAL   Biomed Pharmacother 98, 516-522 (2018)
   PUBMED   29287199
  REMARK    GeneRIF: The regulation of Rheb-mTOR signal pathway.
REFERENCE   3  (bases 1 to 1088)
  AUTHORS   Meng,W., Liang,X., Chen,H., Luo,H., Bai,J., Li,G., Zhang,Q.,
            Xiao,T., He,S., Zhang,Y., Xu,Z., Xiao,B., Liu,M., Hu,F. and Liu,F.
  TITLE     Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent
            Downregulation of the cAMP-PKA Signaling Pathway
  JOURNAL   Diabetes 66 (5), 1198-1213 (2017)
   PUBMED   28242620
REFERENCE   4  (bases 1 to 1088)
  AUTHORS   Xing,G., Luo,Z., Zhong,C., Pan,X. and Xu,X.
  TITLE     Influence of miR-155 on Cell Apoptosis in Rats with Ischemic
            Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR
            Pathway
  JOURNAL   Med Sci Monit 22, 5141-5153 (2016)
   PUBMED   28025572
  REMARK    GeneRIF: Inhibition of miR-155 may play protective roles in
            ischemic stroke by phosphorylating S6K through the Rheb/mTOR
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1088)
  AUTHORS   Focking,M., Dicker,P., Lopez,L.M., Hryniewiecka,M., Wynne,K.,
            English,J.A., Cagney,G. and Cotter,D.R.
  TITLE     Proteomic analysis of the postsynaptic density implicates synaptic
            function and energy pathways in bipolar disorder
  JOURNAL   Transl Psychiatry 6 (11), e959 (2016)
   PUBMED   27898073
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1088)
  AUTHORS   Takei,N., Inamura,N., Kawamura,M., Namba,H., Hara,K., Yonezawa,K.
            and Nawa,H.
  TITLE     Brain-derived neurotrophic factor induces mammalian target of
            rapamycin-dependent local activation of translation machinery and
            protein synthesis in neuronal dendrites
  JOURNAL   J Neurosci 24 (44), 9760-9769 (2004)
   PUBMED   15525761
REFERENCE   7  (bases 1 to 1088)
  AUTHORS   Aspuria,P.J. and Tamanoi,F.
  TITLE     The Rheb family of GTP-binding proteins
  JOURNAL   Cell Signal 16 (10), 1105-1112 (2004)
   PUBMED   15240005
  REMARK    Review article
REFERENCE   8  (bases 1 to 1088)
  AUTHORS   Karbowniczek,M., Cash,T., Cheung,M., Robertson,G.P., Astrinidis,A.
            and Henske,E.P.
  TITLE     Regulation of B-Raf kinase activity by tuberin and Rheb is
            mammalian target of rapamycin (mTOR)-independent
  JOURNAL   J Biol Chem 279 (29), 29930-29937 (2004)
   PUBMED   15150271
REFERENCE   9  (bases 1 to 1088)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   10 (bases 1 to 1088)
  AUTHORS   Yamagata,K., Sanders,L.K., Kaufmann,W.E., Yee,W., Barnes,C.A.,
            Nathans,D. and Worley,P.F.
  TITLE     rheb, a growth factor- and synaptic activity-regulated gene,
            encodes a novel Ras-related protein
  JOURNAL   J Biol Chem 269 (23), 16333-16339 (1994)
   PUBMED   8206940
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U08227.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08227.1, BC088857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1088
                     /gene="Rheb"
                     /note="Ras homolog, mTORC1 binding"
                     /db_xref="GeneID:26954"
                     /db_xref="RGD:621840"
     exon            1..175
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..678
                     /gene="Rheb"
                     /EC_number="3.6.5.2"
                     /note="Ras homolog enriched in brain"
                     /codon_start=1
                     /product="GTP-binding protein Rheb"
                     /protein_id="NP_037348.1"
                     /db_xref="GeneID:26954"
                     /db_xref="RGD:621840"
                     /translation="MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFT
                     KLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGK
                     LLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVF
                     RRIILEAEKIDGAASQGKSSCSVM"
     exon            176..247
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            248..315
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            316..398
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            399..455
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            456..503
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            504..585
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
     exon            586..1079
                     /gene="Rheb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcccgccg ccgcgctctg tatgccgcgt tcccccggcg cacccgccgc cgatagtctg
       61 agccggagga gtcgccgccg ctgcggttga tgtggttggg ccggggctga ccaggctacc
      121 aagatgcctc agtccaagtc ccggaagatc gccatcctgg gctatcggtc tgtgggaaag
      181 tcctcattga caattcagtt tgttgaaggt caatttgttg attcctacga tccaaccata
      241 gaaaacacat tcaccaagct gatcacagta aatgggcaag agtatcatct tcagcttgta
      301 gacacagcag ggcaggatga atattccatt tttcctcaga catactccat agatattaat
      361 ggttatattc ttgtgtattc tgttacatca atcaaaagct ttgaagtaat taaagttatc
      421 cacggcaagc tgttggacat ggtggggaaa gtgcagatac cgattatgtt agtcggaaat
      481 aagaaggacc tgcatatgga aagggtgatc agttatgaag aaggaaaggc tttggcagaa
      541 tcttggaatg cagctttttt ggaatcttct gcaaaagaaa atcagactgc tgtggatgtt
      601 tttagaagga taattttgga agcagaaaag attgacggag cggcttcaca agggaagtct
      661 tcgtgctcgg tgatgtgacg cgcctgctgc agagcctgag tgtattccac ctgaggaagc
      721 aagctgcctg tcatccttga agataaaact aggcttctgt tttcttctgt taacctgaac
      781 gatgtcattt gggtcagagg tcctcccctc tcagattatg ttaacgtctg actctgtcca
      841 aatgagttca cttccatttt caaattttaa acaatcatat tttcaattta tatattgtat
      901 ttcttaatat tatgaccaag aattttatcg gcattaattt ttcagtgtag tttgttgttt
      961 aaaataatgt aatcatcaaa atgatacacg ttacactact attagctagg cttcagtcta
     1021 tcagtgttta tctccttgtg ttaaatgtat acttgtaaat aaagtagctg caaaccttaa
     1081 aaaaaaaa
//
