LOCUS       NM_183053               1958 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Rattus norvegicus Rh family, C glycoprotein (Rhcg), mRNA.
ACCESSION   NM_183053 XM_214971
VERSION     NM_183053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Han,K.H., Lee,H.W., Handlogten,M.E., Bishop,J.M., Levi,M., Kim,J.,
            Verlander,J.W. and Weiner,I.D.
  TITLE     Effect of hypokalemia on renal expression of the ammonia
            transporter family members, Rh B Glycoprotein and Rh C
            Glycoprotein, in the rat kidney
  JOURNAL   Am J Physiol Renal Physiol 301 (4), F823-F832 (2011)
   PUBMED   21753075
  REMARK    GeneRIF: Increased plasma membrane Rhcg expression in response to
            hypokalemia in the rat, particularly in the outer medullary
            collecting duct, likely contributes to the increased ammonia
            excretion and thereby to the development of metabolic alkalosis.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Izumi,Y., Hori,K., Nakayama,Y., Kimura,M., Hasuike,Y., Nanami,M.,
            Kohda,Y., Otaki,Y., Kuragano,T., Obinata,M., Kawahara,K.,
            Tanoue,A., Tomita,K., Nakanishi,T. and Nonoguchi,H.
  TITLE     Aldosterone requires vasopressin V1a receptors on intercalated
            cells to mediate acid-base homeostasis
  JOURNAL   J Am Soc Nephrol 22 (4), 673-680 (2011)
   PUBMED   21415155
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Han,K.H., Lee,S.Y., Kim,W.Y., Shin,J.A., Kim,J. and Weiner,I.D.
  TITLE     Expression of ammonia transporter family members, Rh B glycoprotein
            and Rh C glycoprotein, in the developing rat kidney
  JOURNAL   Am J Physiol Renal Physiol 299 (1), F187-F198 (2010)
   PUBMED   20392801
  REMARK    GeneRIF: Expression of Rhbg and Rhcg parallels intercalated cell
            development and that immature Rhbg and Rhcg expression at birth
            contributes to incomplete ammonia excretion capacity.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Gruswitz,F., Chaudhary,S., Ho,J.D., Schlessinger,A., Pezeshki,B.,
            Ho,C.M., Sali,A., Westhoff,C.M. and Stroud,R.M.
  TITLE     Function of human Rh based on structure of RhCG at 2.1 A
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9638-9643 (2010)
   PUBMED   20457942
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Verlander,J.W., Miller,R.T., Frank,A.E., Royaux,I.E., Kim,Y.H. and
            Weiner,I.D.
  TITLE     Localization of the ammonium transporter proteins RhBG and RhCG in
            mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 284 (2), F323-F337 (2003)
   PUBMED   12388412
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Chen,B.S., Xu,Z.X., Xu,X., Cai,Y., Han,Y.L., Wang,J., Xia,S.H.,
            Hu,H., Wei,F., Wu,M. and Wang,M.R.
  TITLE     RhCG is downregulated in oesophageal squamous cell carcinomas, but
            expressed in multiple squamous epithelia
  JOURNAL   Eur J Cancer 38 (14), 1927-1936 (2002)
   PUBMED   12204676
  REMARK    Erratum:[Eur J Cancer. 2003 Feb;39(3):405.]
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Eladari,D., Cheval,L., Quentin,F., Bertrand,O., Mouro,I.,
            Cherif-Zahar,B., Cartron,J.P., Paillard,M., Doucet,A. and
            Chambrey,R.
  TITLE     Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter,
            along the rat nephron
  JOURNAL   J Am Soc Nephrol 13 (8), 1999-2008 (2002)
   PUBMED   12138130
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Marini,A.M., Matassi,G., Raynal,V., Andre,B., Cartron,J.P. and
            Cherif-Zahar,B.
  TITLE     The human Rhesus-associated RhAG protein and a kidney homologue
            promote ammonium transport in yeast
  JOURNAL   Nat Genet 26 (3), 341-344 (2000)
   PUBMED   11062476
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Liu,Z., Chen,Y., Mo,R., Hui,C., Cheng,J.F., Mohandas,N. and
            Huang,C.H.
  TITLE     Characterization of human RhCG and mouse Rhcg as novel nonerythroid
            Rh glycoprotein homologues predominantly expressed in kidney and
            testis
  JOURNAL   J Biol Chem 275 (33), 25641-25651 (2000)
   PUBMED   10852913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY129073.1.
            
            On Dec 17, 2003 this sequence version replaced XM_214971.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1958
                     /gene="Rhcg"
                     /note="Rh family, C glycoprotein"
                     /db_xref="GeneID:293048"
                     /db_xref="RGD:727859"
     exon            1..241
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1548
                     /gene="Rhcg"
                     /note="rh family type C glycoprotein; rhesus blood group
                     family type C glycoprotein; Rhesus blood group-associated
                     C glycoprotein; Rh type C glycoprotein"
                     /codon_start=1
                     /product="ammonium transporter Rh type C"
                     /protein_id="NP_898876.1"
                     /db_xref="GeneID:293048"
                     /db_xref="RGD:727859"
                     /translation="MAWNTNLRGRLPITCLILQVTMVVLFGVFVRYDIQADAHWWLEK
                     KRKNISSDVENEFYYRYPSFEDVHAMVFVGFGFLMTYLQRYGFSAVGFNFLLAAFGIQ
                     WALLMQGWFHFFEEGHILLSVENLIQADFCVASTCVAFGAVLGKISPMQLLIMTFFQV
                     TLFTVNEFILLNLIEAKDAGGSMTIHTFGAYFGLTVTWILYRKNLEQSKQRQSSVYHS
                     DLFAMIGTLFLWIYWPSFNSASSFHGDTQHRAALNTYLSLAASVLTTVAVSSVIHKKG
                     KLDMVHIQNATLAGGVGVGTAAEMMLTPYGALIVGFFCGILSTLGFAYLSPFLESRLR
                     IQDTCGIHNLHGIPGIIGGIVGAVTAAYSSPDVYGEPGIVHSFGFGGYKADWTKRMQG
                     RSQIFGLLLSLAMALVGGIIVGFILKLPFWGQASDENCFEDAIYWEVPEEVNTVYIPE
                     DLAHKHSTSLVPAIPLVLSTPSASIVPPVPPTPPASLATVTSSSLVH"
     exon            242..428
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            429..579
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            580..727
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            728..894
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1032
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1169
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1294
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1368
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1572
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1938
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgtcgcc ctgtcctcgg agcccagggt actgagcgac cggcagtgca gagcatggcc
       61 tggaacacca acctccgggg gcggctgccc atcacctgcc tgatcctgca ggtgaccatg
      121 gtggttctct tcggcgtgtt cgtgcgctac gacatccagg ctgatgctca ctggtggttg
      181 gagaagaagc gcaagaacat ctccagcgat gtggagaacg aattttacta tcgctatccg
      241 agcttcgagg atgtacacgc catggtcttc gtgggcttcg gcttcctcat gacatacctg
      301 cagcgctatg ggttcagcgc tgtaggcttc aacttcctgc tggcagcttt cggcatccag
      361 tgggcgctgc tcatgcaggg atggttccat ttctttgaag aaggccacat tctcctgagc
      421 gtcgagaacc tcatccaagc cgacttctgt gtggcatcta cctgtgtggc ctttggggca
      481 gttctaggca agatcagccc aatgcaactg ctcattatga ccttcttcca agtgactctc
      541 ttcacagtga atgagttcat cctcctgaac ctgatagagg caaaggatgc agggggctct
      601 atgaccatcc acacatttgg cgcctacttt gggctcacag tgacctggat cctctaccga
      661 aaaaacctgg agcagagcaa gcagaggcag agttcagtgt accattcgga ccttttcgcc
      721 atgattggta ccctcttcct gtggatatac tggcctagct tcaactcagc cagttccttc
      781 cacggagaca cccaacaccg agcagccctc aacacctacc tctccttggc agctagtgtg
      841 ctaaccacag tggcagtgtc cagtgtcata cacaagaagg gcaagttgga tatggtgcac
      901 atccagaacg ccacacttgc aggtggggtg ggtgtgggca cagccgcgga gatgatgctc
      961 acaccttacg gcgccctcat cgtgggtttc ttctgtggca tcctctccac cctaggattt
     1021 gcctacctat cgccattcct ggagtcccgt cttcgaatcc aggacacgtg tggcattcac
     1081 aacctgcacg gcatccctgg catcataggt ggcattgtgg gtgctgtgac agcggcctac
     1141 tcctcccctg acgtgtatgg agagccgggg atagtccatt cctttggctt cgggggttac
     1201 aaggcggact ggaccaagag aatgcagggc aggtcccaga tatttggcct cctcctgagc
     1261 ttggccatgg ccctggtggg aggcatcatt gtgggattca ttttgaaatt gcccttctgg
     1321 gggcaagcct cggatgaaaa ctgcttcgag gacgccatct actgggaggt tcctgaagag
     1381 gtgaacactg tctacattcc tgaggacctc gctcacaaac attctacctc tctggtaccc
     1441 gcaatacctt tggtactttc aaccccttca gcatccatag ttcctccagt ccctccgaca
     1501 cctccagcat ccttagcaac agtaacttca tcatccttgg tacactgaac tcccagggca
     1561 ggtgagaagc aggctccaca gattgtcacc atgctctgga acgagctggg gctgacttcg
     1621 ctgggaactc tggagcaggg cagctgaaag gcccactggc ctgactctag cacctccctc
     1681 agctccttca tcccaggggg ctcgcctgag aatggaggag attcctgaca aagtgagctc
     1741 caagccaggg tcagctgtag aaggtctgcc cctgcctggg gtcatgatgc tcatatcctg
     1801 tgaaaagcac catgaagaga ggctgaggtt gggggtggga tgggggtgtg gagcgggagg
     1861 gcttggtccc ctgggttacc cctctttgga ctcttccagc ctctgcctgt tccccaacaa
     1921 tacttcccat gttcccaaaa aaaaaaaaaa aaaaaaaa
//
