LOCUS       NP_898876                497 aa            linear   ROD 07-OCT-2024
DEFINITION  ammonium transporter Rh type C [Rattus norvegicus].
ACCESSION   NP_898876 XP_214971
VERSION     NP_898876.1
DBSOURCE    REFSEQ: accession NM_183053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 497)
  AUTHORS   Han,K.H., Lee,H.W., Handlogten,M.E., Bishop,J.M., Levi,M., Kim,J.,
            Verlander,J.W. and Weiner,I.D.
  TITLE     Effect of hypokalemia on renal expression of the ammonia
            transporter family members, Rh B Glycoprotein and Rh C
            Glycoprotein, in the rat kidney
  JOURNAL   Am J Physiol Renal Physiol 301 (4), F823-F832 (2011)
   PUBMED   21753075
  REMARK    GeneRIF: Increased plasma membrane Rhcg expression in response to
            hypokalemia in the rat, particularly in the outer medullary
            collecting duct, likely contributes to the increased ammonia
            excretion and thereby to the development of metabolic alkalosis.
REFERENCE   2  (residues 1 to 497)
  AUTHORS   Izumi,Y., Hori,K., Nakayama,Y., Kimura,M., Hasuike,Y., Nanami,M.,
            Kohda,Y., Otaki,Y., Kuragano,T., Obinata,M., Kawahara,K.,
            Tanoue,A., Tomita,K., Nakanishi,T. and Nonoguchi,H.
  TITLE     Aldosterone requires vasopressin V1a receptors on intercalated
            cells to mediate acid-base homeostasis
  JOURNAL   J Am Soc Nephrol 22 (4), 673-680 (2011)
   PUBMED   21415155
REFERENCE   3  (residues 1 to 497)
  AUTHORS   Han,K.H., Lee,S.Y., Kim,W.Y., Shin,J.A., Kim,J. and Weiner,I.D.
  TITLE     Expression of ammonia transporter family members, Rh B glycoprotein
            and Rh C glycoprotein, in the developing rat kidney
  JOURNAL   Am J Physiol Renal Physiol 299 (1), F187-F198 (2010)
   PUBMED   20392801
  REMARK    GeneRIF: Expression of Rhbg and Rhcg parallels intercalated cell
            development and that immature Rhbg and Rhcg expression at birth
            contributes to incomplete ammonia excretion capacity.
REFERENCE   4  (residues 1 to 497)
  AUTHORS   Gruswitz,F., Chaudhary,S., Ho,J.D., Schlessinger,A., Pezeshki,B.,
            Ho,C.M., Sali,A., Westhoff,C.M. and Stroud,R.M.
  TITLE     Function of human Rh based on structure of RhCG at 2.1 A
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9638-9643 (2010)
   PUBMED   20457942
REFERENCE   5  (residues 1 to 497)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (residues 1 to 497)
  AUTHORS   Verlander,J.W., Miller,R.T., Frank,A.E., Royaux,I.E., Kim,Y.H. and
            Weiner,I.D.
  TITLE     Localization of the ammonium transporter proteins RhBG and RhCG in
            mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 284 (2), F323-F337 (2003)
   PUBMED   12388412
REFERENCE   7  (residues 1 to 497)
  AUTHORS   Chen,B.S., Xu,Z.X., Xu,X., Cai,Y., Han,Y.L., Wang,J., Xia,S.H.,
            Hu,H., Wei,F., Wu,M. and Wang,M.R.
  TITLE     RhCG is downregulated in oesophageal squamous cell carcinomas, but
            expressed in multiple squamous epithelia
  JOURNAL   Eur J Cancer 38 (14), 1927-1936 (2002)
   PUBMED   12204676
  REMARK    Erratum:[Eur J Cancer. 2003 Feb;39(3):405.]
REFERENCE   8  (residues 1 to 497)
  AUTHORS   Eladari,D., Cheval,L., Quentin,F., Bertrand,O., Mouro,I.,
            Cherif-Zahar,B., Cartron,J.P., Paillard,M., Doucet,A. and
            Chambrey,R.
  TITLE     Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter,
            along the rat nephron
  JOURNAL   J Am Soc Nephrol 13 (8), 1999-2008 (2002)
   PUBMED   12138130
REFERENCE   9  (residues 1 to 497)
  AUTHORS   Marini,A.M., Matassi,G., Raynal,V., Andre,B., Cartron,J.P. and
            Cherif-Zahar,B.
  TITLE     The human Rhesus-associated RhAG protein and a kidney homologue
            promote ammonium transport in yeast
  JOURNAL   Nat Genet 26 (3), 341-344 (2000)
   PUBMED   11062476
REFERENCE   10 (residues 1 to 497)
  AUTHORS   Liu,Z., Chen,Y., Mo,R., Hui,C., Cheng,J.F., Mohandas,N. and
            Huang,C.H.
  TITLE     Characterization of human RhCG and mouse Rhcg as novel nonerythroid
            Rh glycoprotein homologues predominantly expressed in kidney and
            testis
  JOURNAL   J Biol Chem 275 (33), 25641-25651 (2000)
   PUBMED   10852913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY129073.1.
            
            On Dec 17, 2003 this sequence version replaced XP_214971.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     Protein         1..497
                     /product="ammonium transporter Rh type C"
                     /note="rh family type C glycoprotein; rhesus blood group
                     family type C glycoprotein; Rhesus blood group-associated
                     C glycoprotein; Rh type C glycoprotein"
                     /calculated_mol_wt=54600
     Site            10..30
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            48
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Region          61..436
                     /region_name="Ammonium_transp"
                     /note="Ammonium Transporter Family; cl03012"
                     /db_xref="CDD:445985"
     Site            62..82
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            94..114
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            126..145
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            152..174
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            180..200
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            252..272
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            283..303
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            305..325
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            341..361
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     Site            396..416
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNN9.1)"
     CDS             1..497
                     /gene="Rhcg"
                     /coded_by="NM_183053.1:55..1548"
                     /db_xref="GeneID:293048"
                     /db_xref="RGD:727859"
ORIGIN      
        1 mawntnlrgr lpitclilqv tmvvlfgvfv rydiqadahw wlekkrknis sdvenefyyr
       61 ypsfedvham vfvgfgflmt ylqrygfsav gfnfllaafg iqwallmqgw fhffeeghil
      121 lsvenliqad fcvastcvaf gavlgkispm qllimtffqv tlftvnefil lnlieakdag
      181 gsmtihtfga yfgltvtwil yrknleqskq rqssvyhsdl famigtlflw iywpsfnsas
      241 sfhgdtqhra alntylslaa svlttvavss vihkkgkldm vhiqnatlag gvgvgtaaem
      301 mltpygaliv gffcgilstl gfaylspfle srlriqdtcg ihnlhgipgi iggivgavta
      361 aysspdvyge pgivhsfgfg gykadwtkrm qgrsqifgll lslamalvgg iivgfilklp
      421 fwgqasdenc fedaiywevp eevntvyipe dlahkhstsl vpaiplvlst psasivppvp
      481 ptppaslatv tssslvh
//
