LOCUS       NM_183054               1686 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Rattus norvegicus Rh family B glycoprotein (Rhbg), mRNA.
ACCESSION   NM_183054 XM_342275
VERSION     NM_183054.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Han,K.H., Lee,H.W., Handlogten,M.E., Bishop,J.M., Levi,M., Kim,J.,
            Verlander,J.W. and Weiner,I.D.
  TITLE     Effect of hypokalemia on renal expression of the ammonia
            transporter family members, Rh B Glycoprotein and Rh C
            Glycoprotein, in the rat kidney
  JOURNAL   Am J Physiol Renal Physiol 301 (4), F823-F832 (2011)
   PUBMED   21753075
  REMARK    GeneRIF: In hypokalemia, Rhbg protein expression was decreased
            slightly in the kidney cortex and not detectably altered in the
            outer medulla.
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Han,K.H., Lee,S.Y., Kim,W.Y., Shin,J.A., Kim,J. and Weiner,I.D.
  TITLE     Expression of ammonia transporter family members, Rh B glycoprotein
            and Rh C glycoprotein, in the developing rat kidney
  JOURNAL   Am J Physiol Renal Physiol 299 (1), F187-F198 (2010)
   PUBMED   20392801
  REMARK    GeneRIF: Expression of Rhbg and Rhcg parallels intercalated cell
            development and that immature Rhbg and Rhcg expression at birth
            contributes to incomplete ammonia excretion capacity.
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Sohet,F., Colin,Y., Genetet,S., Ripoche,P., Metral,S., Le Van
            Kim,C. and Lopez,C.
  TITLE     Phosphorylation and ankyrin-G binding of the C-terminal domain
            regulate targeting and function of the ammonium transporter RhBG
  JOURNAL   J Biol Chem 283 (39), 26557-26567 (2008)
   PUBMED   18635543
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Worrell,R.T., Merk,L. and Matthews,J.B.
  TITLE     Ammonium transport in the colonic crypt cell line, T84: role for
            Rhesus glycoproteins and NKCC1
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (2), G429-G440 (2008)
   PUBMED   18032481
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Kim,H.Y., Baylis,C., Verlander,J.W., Han,K.H., Reungjui,S.,
            Handlogten,M.E. and Weiner,I.D.
  TITLE     Effect of reduced renal mass on renal ammonia transporter family,
            Rh C glycoprotein and Rh B glycoprotein, expression
  JOURNAL   Am J Physiol Renal Physiol 293 (4), F1238-F1247 (2007)
   PUBMED   17652373
  REMARK    GeneRIF: Rhbg expression was unchanged in hypertrophy of both
            intercalated cells and principal cells in the cortical and outer
            medullary collecting duct
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Handlogten,M.E., Hong,S.P., Westhoff,C.M. and Weiner,I.D.
  TITLE     Apical ammonia transport by the mouse inner medullary collecting
            duct cell (mIMCD-3)
  JOURNAL   Am J Physiol Renal Physiol 289 (2), F347-F358 (2005)
   PUBMED   15798090
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Lopez,C., Metral,S., Eladari,D., Drevensek,S., Gane,P.,
            Chambrey,R., Bennett,V., Cartron,J.P., Le Van Kim,C. and Colin,Y.
  TITLE     The ammonium transporter RhBG: requirement of a tyrosine-based
            signal and ankyrin-G for basolateral targeting and membrane
            anchorage in polarized kidney epithelial cells
  JOURNAL   J Biol Chem 280 (9), 8221-8228 (2005)
   PUBMED   15611082
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Quentin,F., Eladari,D., Cheval,L., Lopez,C., Goossens,D., Colin,Y.,
            Cartron,J.P., Paillard,M. and Chambrey,R.
  TITLE     RhBG and RhCG, the putative ammonia transporters, are expressed in
            the same cells in the distal nephron
  JOURNAL   J Am Soc Nephrol 14 (3), 545-554 (2003)
   PUBMED   12595489
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Verlander,J.W., Miller,R.T., Frank,A.E., Royaux,I.E., Kim,Y.H. and
            Weiner,I.D.
  TITLE     Localization of the ammonium transporter proteins RhBG and RhCG in
            mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 284 (2), F323-F337 (2003)
   PUBMED   12388412
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Liu,Z., Peng,J., Mo,R., Hui,C. and Huang,C.H.
  TITLE     Rh type B glycoprotein is a new member of the Rh superfamily and a
            putative ammonia transporter in mammals
  JOURNAL   J Biol Chem 276 (2), 1424-1433 (2001)
   PUBMED   11024028
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY129072.1.
            
            On Jan 12, 2005 this sequence version replaced XM_342275.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129072.1, BC079365.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1686
                     /gene="Rhbg"
                     /note="Rh family B glycoprotein"
                     /db_xref="GeneID:310625"
                     /db_xref="RGD:727813"
     exon            1..208
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1398
                     /gene="Rhbg"
                     /note="rh family type B glycoprotein; rhesus blood group
                     family type B glycoprotein; Rhesus blood group-associated
                     B glycoprotein; Rh type B glycoprotein"
                     /codon_start=1
                     /product="ammonium transporter Rh type B"
                     /protein_id="NP_898877.1"
                     /db_xref="GeneID:310625"
                     /db_xref="RGD:727813"
                     /translation="MARIPRHRRLVLPLLCLLFQGATSLLFAIFVRYNHETDAALWHW
                     GNHSNVDNEFYFRYPSFQDVHVMVFVGFGFLMVFLQRYGFSSVGFTFLVATFTLQWAT
                     LLQGFLHSFHGGHIHIGVESLINADFCAGAVLISFGAVLGKTGPAQLLLMALLEAVLF
                     SVNEFILLSLLGVRDAGGSMTIHTFGAYFGLFLSRVLYRSQLEKSRHRQTSVYNSDLF
                     AMIGTIFLWVFWPSFNSAPTALGDGQHRTVVNTYYSLTASTLSTFALSALVSGDGRLD
                     MVHIQNAALAGGVVVGTASEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESRFKLQD
                     TCGVHNLHGMPGVLGAILGVVVAALATHEAYGDGLQTVFPLIAKGQRSATSQAMYQLF
                     GMFVTLVFASVGGSLGGLLLRLPFLDSPPDSQCFEDQVYWEVPGEQEAETQRPLRTEE
                     PDTQA"
     exon            209..395
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            396..546
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            547..694
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            695..861
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            862..999
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1133
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1255
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1329
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1667
                     /gene="Rhbg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtccggg atagcacagt caccgcgttc atggcccgca ttccccgcca ccggcgcctg
       61 gtcctgccgc tgctgtgtct gctcttccaa ggcgccacct ccctcctctt tgcgatcttt
      121 gtccgctaca accacgaaac cgacgctgcc ctgtggcact ggggcaacca cagtaacgtg
      181 gacaacgagt tttactttcg ctacccaagc ttccaggatg tgcatgtcat ggtcttcgtg
      241 ggctttggct tcctcatggt ctttctacag cggtacggct tcagcagtgt gggctttacc
      301 ttcctcgtgg ccaccttcac cctgcagtgg gccacactac tccaaggctt cctccactct
      361 ttccatggtg gccacatcca cattggcgtg gagagtttga tcaacgctga cttctgtgcg
      421 ggcgctgtgc tcatctcttt cggggctgtt ctgggcaaga ctgggccagc ccagctgctg
      481 ctaatggccc tactggaggc agtgctgttt agtgtcaatg agtttatact gctcagtctc
      541 ctgggggtga gagatgctgg agggtccatg accattcaca catttggggc ctacttcggg
      601 ctgttcctct cacgggtcct ctacagatcc cagctggaga agagcaggca ccgacagacc
      661 tctgtctaca actctgacct ctttgccatg atcgggacca tcttcctgtg ggttttctgg
      721 cccagcttca actccgctcc gacagcgctg ggggatgggc agcatcggac agtggtcaac
      781 acgtactatt cactcaccgc gagcaccctc agtactttcg ccttgtcagc ccttgtcagt
      841 ggggatggac gactggacat ggtccacatc cagaatgcag cactggctgg aggggttgtg
      901 gtggggacag caagtgagat gatgttgaca ccctttgggg ctctggcagc tggctttctg
      961 gctgggaccg tctccaccct ggggtataag ttctttacgc ctatccttga atccagattt
     1021 aaactgcaag acacatgtgg tgttcacaac ctccatggga tgccaggggt cctgggggcc
     1081 atcctgggag tcgtagtggc tgcactggcc acccacgaag cttatggaga tggcctgcag
     1141 actgtgttcc cactcatagc caagggtcag cgcagtgcta catctcaggc catgtatcag
     1201 ctctttggaa tgtttgtcac actggtgttt gcctctgtgg gtggcagcct tggagggctc
     1261 ctgctgcggc tcccctttct ggactcccct ccagactccc aatgcttcga ggaccaggtt
     1321 tactgggagg tacctgggga gcaggaggct gagacccaga ggcctctgag aactgaggaa
     1381 ccagacaccc aggcctaatt gctgccagca tgactgatgg acgctgtcct cagagaagac
     1441 aatggctcct gccattggtt actcctgctt ttgttactat tgtgtgagga agtcttccac
     1501 ccccaggagg atccccatta gcttgtgcct gtggccagaa aaggccaaag ccagccctag
     1561 gtgactgcca ccccattgac cagtgttacc ctattccagt gacacccaag ccaggtccac
     1621 tctgggtggg aagctgggtg ataaacaagt atcaccaagg actctgaaaa aaaaaaaaaa
     1681 aaaaaa
//
