LOCUS       NM_001106684            1360 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus rhomboid like 2 (Rhbdl2), mRNA.
ACCESSION   NM_001106684 XM_216520
VERSION     NM_001106684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Zettl,M., Adrain,C., Strisovsky,K., Lastun,V. and Freeman,M.
  TITLE     Rhomboid family pseudoproteases use the ER quality control
            machinery to regulate intercellular signaling
  JOURNAL   Cell 145 (1), 79-91 (2011)
   PUBMED   21439629
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Lei,X. and Li,Y.M.
  TITLE     The processing of human rhomboid intramembrane serine protease
            RHBDL2 is required for its proteolytic activity
  JOURNAL   J Mol Biol 394 (5), 815-825 (2009)
   PUBMED   19850051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 7, 2022 this sequence version replaced NM_001106684.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.23610.1,
                                           SRR26360186.589799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16093047
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000005.1  141322354-141322476
            124-386             JAXUCZ010000005.1  141346413-141346675
            387-535             JAXUCZ010000005.1  141350056-141350204
            536-648             JAXUCZ010000005.1  141353499-141353611
            649-749             JAXUCZ010000005.1  141359485-141359585
            750-810             JAXUCZ010000005.1  141361129-141361189
            811-872             JAXUCZ010000005.1  141363173-141363234
            873-1360            JAXUCZ010000005.1  141366260-141366747
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1360
                     /gene="Rhbdl2"
                     /note="rhomboid like 2"
                     /db_xref="GeneID:298512"
                     /db_xref="RGD:1308295"
     exon            1..123
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            124..386
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1052
                     /gene="Rhbdl2"
                     /EC_number="3.4.21.105"
                     /note="rhomboid protease 2; rhomboid, veinlet-like 2"
                     /codon_start=1
                     /product="rhomboid-related protein 2"
                     /protein_id="NP_001100154.2"
                     /db_xref="GeneID:298512"
                     /db_xref="RGD:1308295"
                     /translation="MAAAHEMEMESVNLNMEREGKEELEEEKMRGDGEGKDFPRGRKV
                     HRIVSKWMLPEPVRRTYLERANCLPPPLFIVLISLAELAVFIYYAVWKPQKQWITLDT
                     GILESPLTYRPEKREEAWRFISYMLVHAGVQHIVGNLFMQLVLGIPLEMVHKGLRVGL
                     VYLAGVLAGSLASSIFDPLKSLVGASGGVYALMGGYFMNVIVNFREMIPALGIVRLLV
                     IILIVASDMGFALYRRFFVPANGSPVSFAAHIAGGFAGMSVGYTVFSCFDKTLLKDPR
                     FWISIAAYVACLLFAVFFNIFLSPAN"
     exon            387..535
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..648
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..749
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..810
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..872
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1360
                     /gene="Rhbdl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctggga gggcgggaga ggagcctggc aggctgtggc tggagcctcc aggcagctcc
       61 gttggcccct tgacgtgcaa gatccgactg cagaggggga ccgctgtgac tcggcctccc
      121 cgggcggagg gaggaccagg acgatggctg ctgctcacga gatggagatg gagagtgtga
      181 acctgaatat ggagagagag ggaaaggaag aactggagga ggagaaaatg agaggggatg
      241 gggaaggtaa agactttccc aggggtcgaa aggtccacag gattgtctcc aagtggatgc
      301 ttcctgagcc agtccgaaga acatacttgg agagagccaa ctgcctccca ccgcccctgt
      361 tcatcgttct catcagtctg gctgagctgg ctgtgtttat ttattatgcg gtgtggaagc
      421 ctcagaagca gtggattacc ctggacacgg ggatcttgga aagtcccttg acataccgcc
      481 ctgagaagag ggaggaagcc tggaggttta tctcatacat gctggtccat gctggagtcc
      541 agcacatcgt ggggaatctt tttatgcagc tcgtcctggg tattcccttg gagatggtcc
      601 acaaaggcct ccgagtgggg ctggtgtacc tggcaggcgt gcttgcaggt tccctggcca
      661 gctccatttt tgaccccctt aagtctctcg tgggtgcttc aggaggagtc tatgccttga
      721 tgggtggcta ttttatgaat gttatagtga attttcgaga aatgattcct gcccttggaa
      781 tcgtcaggct actcgttatc attctgatag ttgcctcaga catgggcttt gctctctaca
      841 gaagattctt tgtccctgca aatgggtctc cggtgtcctt cgctgctcac attgcaggcg
      901 gatttgctgg gatgtccgta ggttacactg tgttcagctg cttcgacaag accctgctca
      961 aagaccccag gttctggatc tcgatcgcgg cctatgtagc ttgtctctta tttgctgtgt
     1021 tttttaacat ctttctgtcc ccagcaaact gacttgcctc tgttataagc cacttaataa
     1081 aagtgtcaca tgggaggaag tggcaaactt tgtaaagaaa cacagatatc ccagcctatg
     1141 ctaagaatgt tattaaaaaa aagaaagaag acaggacagc agctgagctt ccagcgcgaa
     1201 gcaagaagat aaaaagcaaa gactgggcct ttcatgcaca gagcatgcgt gtgtgaccct
     1261 gtgaaggagc cttgatatcc ttgggggatg taatttggag cttgtttata ggctccacga
     1321 gagctgcact atcctgataa taaacatttt tcatatctgg
//
