LOCUS       NM_001107067            3480 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus rhomboid 5 homolog 2 (Rhbdf2), transcript variant
            1, mRNA.
ACCESSION   NM_001107067 XM_001081746 XM_221133
VERSION     NM_001107067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Blaydon,D.C., Etheridge,S.L., Risk,J.M., Hennies,H.C., Gay,L.J.,
            Carroll,R., Plagnol,V., McRonald,F.E., Stevens,H.P., Spurr,N.K.,
            Bishop,D.T., Ellis,A., Jankowski,J., Field,J.K., Leigh,I.M.,
            South,A.P. and Kelsell,D.P.
  TITLE     RHBDF2 mutations are associated with tylosis, a familial esophageal
            cancer syndrome
  JOURNAL   Am J Hum Genet 90 (2), 340-346 (2012)
   PUBMED   22265016
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Zettl,M., Adrain,C., Strisovsky,K., Lastun,V. and Freeman,M.
  TITLE     Rhomboid family pseudoproteases use the ER quality control
            machinery to regulate intercellular signaling
  JOURNAL   Cell 145 (1), 79-91 (2011)
   PUBMED   21439629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Aug 3, 2012 this sequence version replaced NM_001107067.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230904.1, SRR26643295.41844.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000010.1  102359075-102359117 c
            44-219              JAXUCZ010000010.1  102345289-102345464 c
            220-376             JAXUCZ010000010.1  102341126-102341282 c
            377-501             JAXUCZ010000010.1  102340030-102340154 c
            502-697             JAXUCZ010000010.1  102339204-102339399 c
            698-901             JAXUCZ010000010.1  102338922-102339125 c
            902-1027            JAXUCZ010000010.1  102338250-102338375 c
            1028-1146           JAXUCZ010000010.1  102337801-102337919 c
            1147-1344           JAXUCZ010000010.1  102337527-102337724 c
            1345-1456           JAXUCZ010000010.1  102336252-102336363 c
            1457-1531           JAXUCZ010000010.1  102335969-102336043 c
            1532-1693           JAXUCZ010000010.1  102335682-102335843 c
            1694-1800           JAXUCZ010000010.1  102335373-102335479 c
            1801-1864           JAXUCZ010000010.1  102335175-102335238 c
            1865-1959           JAXUCZ010000010.1  102334984-102335078 c
            1960-2035           JAXUCZ010000010.1  102334708-102334783 c
            2036-2136           JAXUCZ010000010.1  102334477-102334577 c
            2137-2290           JAXUCZ010000010.1  102334143-102334296 c
            2291-3480           JAXUCZ010000010.1  102331991-102333180 c
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..3480
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /note="rhomboid 5 homolog 2"
                     /db_xref="GeneID:303690"
                     /db_xref="RGD:1309699"
     exon            1..43
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            44..219
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            220..376
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2710
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /note="rhomboid, veinlet-like 6; rhomboid family member 2"
                     /codon_start=1
                     /product="inactive rhomboid protein 2"
                     /protein_id="NP_001100537.2"
                     /db_xref="GeneID:303690"
                     /db_xref="RGD:1309699"
                     /translation="MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPETQAPGEQAT
                     MLPERPKNPAFLKSVSLQEPRGRWQDGTEKRPGFRRQASLSQSIRKGTAQWFGVSGDW
                     EGKRQNWQRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPL
                     ARGRAFRHPDEVDRPHAAHAPLTPGVLSLTSFSSVRSGYSHLPRRKRISVAHMSFQAA
                     AALLKGRSVLDATGQRCRNVKRSFVYPSFLEEDAVDGADTFDSFFSKEEMSSMPDDVF
                     ESPPLSASYFRGVPSSASPVSPDGVQIPLKEYSSRAPGPGTQRGKRIASKVKHFAFDR
                     KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHILITLLVICT
                     YGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKD
                     RQIEQLIRRERNIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTEPSDKSDL
                     SQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNRTGLLHIDCKIKG
                     RPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDEVCGLLPFLNPEIPDQFY
                     RIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLP
                     YRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNI
                     AHIFGFLSGMLLAFAFLPYITFGTSDRYRKQALILVSLLVFAGLFASLVLWLYIYPIN
                     WPWIEYLTCFPFTSRFCEKYELDQVLH"
     exon            377..501
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            502..697
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..901
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1027
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1146
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1344
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1456
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1531
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1693
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1800
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1864
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1959
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2035
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2136
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2290
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..3480
                     /gene="Rhbdf2"
                     /gene_synonym="Rhbdl6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctgctcg caggcgcttc ccgggacgtg gggcctccga gaggttggcc tgctaaggca
       61 gctgccctgc ctgacccaca gacatctgtc aatctttctg ccatcctgac cccaggagac
      121 ccagagatcg aggaaaggag tggagcatgg tgtagacacc ctccggcaag cccagggagc
      181 ccaggcccgc acatctgaag gaaggaagcg ggtggccagc atcctgccca ccatggcctc
      241 agctgacaag aatggcagca acctcccatc cgtgtctggt agccgcctgc agagccggaa
      301 gccacccaac ctatccatca ctatcccgcc accagagacc caggcccccg gcgagcaggc
      361 taccatgctt cctgagaggc ccaagaaccc agccttcctg aagagcgtca gcctccagga
      421 accccgggga cgatggcagg atggcacaga gaagcgccct ggctttcgcc gccaggcctc
      481 cctgtcccag agcatccgca agggcacagc ccagtggttt ggggtcagcg gcgactggga
      541 gggcaagcga cagaactggc agcgtcgcag cctgcaccac tgcagcgtgc actacggccg
      601 cctcaaggcc tcgtgccaga gagaactgga gctgcccagc caggaggtgc catccttcca
      661 gggcactgag tctccaaaac cgtgcaagat gcccaagatt gtagacccgc tggctcgggg
      721 tcgggccttc cgccacccag atgaggtgga ccggcctcac gctgcccacg cgcctctgac
      781 cccaggggtc ctgtcgctca cgtccttctc cagcgtccgc tctggctact cccatctgcc
      841 ccgccgcaag aggatatctg ttgcccatat gagctttcag gcagccgcgg ccctcctcaa
      901 ggggcgctcc gtgctggatg caactgggca gcggtgccgg aatgtcaagc gcagcttcgt
      961 ctaccccagc ttcctggagg aggacgccgt ggacggagca gacaccttcg actccttttt
     1021 tagtaaggaa gaaatgagtt ccatgcctga tgatgtgttc gagtctcccc cactctctgc
     1081 tagctatttc cgaggtgttc catcctccgc ctcccctgtc tcccctgatg gagtgcaaat
     1141 cccactaaaa gaatacagca gccgagctcc aggtcccggg acccagcgtg gcaagcgcat
     1201 tgcctccaaa gtcaagcact ttgcgtttga ccggaagaag aggcattacg gcctgggcgt
     1261 ggtgggcaac tggctgaaca gaagctaccg gcgcagcatc agcagcaccg tgcagcggca
     1321 gctggagagc ttcgacagcc accgacccta cttcacctac tggctgacgt tcgttcacat
     1381 cctcatcacc ttgctggtga tctgcaccta cggcattgca cctgtgggct ttgcccagca
     1441 cgtcaccacc cagctggtgc tgaaaaacag aggcgtgtat gagagcgtga aatacatcca
     1501 gcaggagaac ttctggattg gccctagctc gattgacctc atccacctgg gagcaaagtt
     1561 ctcaccctgc atccggaagg accggcagat tgagcagctg atacggaggg agcgtaacat
     1621 cgagcgcacc tccggctgct gtgtccagaa tgaccgctcg ggctgcatcc agactctgaa
     1681 gaaggactgc tcggagactt tagccacgtt tgtgaagtgg cagaatgata cggagccctc
     1741 agacaagtct gacctgagcc agaagcagcc atcagcagtt gtgtgccacc aagaccccag
     1801 gacctgtgaa gagccagcct ccagtggggc ccacatctgg cctgatgaca ttaccaagtg
     1861 gccgatctgc acagagcagg cccagagcaa ccgcacaggc ttgttgcaca tagactgtaa
     1921 gatcaaaggc cgcccctgct gcatcggcac caagggcagc tgtgagatca ccacacggga
     1981 gtattgtgag ttcatgcatg gctatttcca cgaagaggca acactctgtt cccaggtgca
     2041 ctgtttggac gaggtgtgtg gccttctgcc tttcctcaac cctgagatcc ccgaccagtt
     2101 ctaccggatc tggctatctc tgttcctgca tgctggcata gtgcactgcc ttgtgtctgt
     2161 ggtcttccaa atgaccatcc tgagggactt agagaagctg gccggctggc accgcatctc
     2221 catcatcttc atcctcagtg gtattacagg caacctggcc agcgccatct tcctccccta
     2281 tcgggcagag gtgggcccag ccgggtcgca gtttggcctc ctcgcctgcc tcttcgtgga
     2341 gctattccag agctggcagc tactggagcg accatggaag gccttcttca acctgtcggc
     2401 cattgtgctt ttcctcttca tctgtggcct cctgccctgg atagacaaca tagcgcacat
     2461 cttcggtttc ctcagtggca tgctcctggc cttcgccttc ctgccctaca tcacctttgg
     2521 caccagcgat aggtaccgca agcaagccct catcctggtg tcactgctgg tcttcgccgg
     2581 gctcttcgct tccctggtgc tgtggttgta catctacccc atcaactggc cctggatcga
     2641 gtacctcacc tgctttccct tcaccagccg cttctgtgag aagtacgagc tagaccaggt
     2701 gctgcactaa cgacagacaa ggctgacccc agacgagaca ggttccccag ggagatgaca
     2761 cctccctttc tcaggtccca atgttcctga cccaagtctg ggggacatcc aggacacctg
     2821 cttctctgag gctcgggtcc caggccctgc ctgcctctct ggccccatag ggatgataac
     2881 ttttcttccc agggcttggg cctctgcagg tgctgtctcc ccactgtcac tgtgactgtg
     2941 acctcgccag acacacagct gctccctcag ttgtccccag ggttgaggtc tctaccatgc
     3001 tgctatgacc cccttttcct gtctctcctc tcctccctgt ccttcaggca cttcctggat
     3061 ttgtccatgg actcatgagc ctgctcctga ggctcctgga catagcattt gggcaaggct
     3121 ctggctgttg tctgtgggga tgacaagcat agccagacag ctatacaggg atgctaaggg
     3181 cttttgttaa gcacagcagc cagatctcct aagcctatca gctgccctag ctccagccta
     3241 tgtctgactg cacaggttgg ctctggtgcc aggctgtccc caccacctct gcgtcactcc
     3301 tgtgtggccg tgggctgagc ctccttgagg actagctccc aggggaggct tgaggctcag
     3361 ccaggccctt tgttctattt gtttttccag tttatattgt ggtcctaatt ttgtaaaata
     3421 acgctaactt tgtatggatg acgacgtctc aagtttatta aatgacattc tttatcataa
//
