LOCUS       NM_001030034            2932 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus rhomboid 5 homolog 1 (Rhbdf1), mRNA.
ACCESSION   NM_001030034 XM_220267
VERSION     NM_001030034.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2932)
  AUTHORS   Zettl,M., Adrain,C., Strisovsky,K., Lastun,V. and Freeman,M.
  TITLE     Rhomboid family pseudoproteases use the ER quality control
            machinery to regulate intercellular signaling
  JOURNAL   Cell 145 (1), 79-91 (2011)
   PUBMED   21439629
REFERENCE   2  (bases 1 to 2932)
  AUTHORS   Zou,H., Thomas,S.M., Yan,Z.W., Grandis,J.R., Vogt,A. and Li,L.Y.
  TITLE     Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated
            transactivation of EGFR growth signals in head and neck squamous
            cancer cells
  JOURNAL   FASEB J 23 (2), 425-432 (2009)
   PUBMED   18832597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001030034.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099777.1, SRR26643287.23911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000010.1  15911311-15911420
            111-251             JAXUCZ010000010.1  15917404-15917544
            252-382             JAXUCZ010000010.1  15917622-15917752
            383-596             JAXUCZ010000010.1  15918552-15918765
            597-806             JAXUCZ010000010.1  15919006-15919215
            807-929             JAXUCZ010000010.1  15919317-15919439
            930-1087            JAXUCZ010000010.1  15919515-15919672
            1088-1345           JAXUCZ010000010.1  15920108-15920365
            1346-1457           JAXUCZ010000010.1  15920453-15920564
            1458-1532           JAXUCZ010000010.1  15920674-15920748
            1533-1694           JAXUCZ010000010.1  15920832-15920993
            1695-1795           JAXUCZ010000010.1  15921907-15922007
            1796-1859           JAXUCZ010000010.1  15922127-15922190
            1860-1954           JAXUCZ010000010.1  15922584-15922678
            1955-2030           JAXUCZ010000010.1  15922889-15922964
            2031-2131           JAXUCZ010000010.1  15923033-15923133
            2132-2285           JAXUCZ010000010.1  15923241-15923394
            2286-2932           JAXUCZ010000010.1  15923568-15924214
FEATURES             Location/Qualifiers
     source          1..2932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2932
                     /gene="Rhbdf1"
                     /note="rhomboid 5 homolog 1"
                     /db_xref="GeneID:303008"
                     /db_xref="RGD:1305075"
     exon            1..110
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..251
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2705
                     /gene="Rhbdf1"
                     /note="rhomboid family member 1; iRhom1; rhomboid family
                     1"
                     /codon_start=1
                     /product="inactive rhomboid protein 1"
                     /protein_id="NP_001025205.1"
                     /db_xref="GeneID:303008"
                     /db_xref="RGD:1305075"
                     /translation="MSEARRDSTSSLQRKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQ
                     AFLRSVSMPAETARVPSPHHEPRRLALQRQTSITQTIRRGTADWFGVSKDSDSTQKWQ
                     RKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLA
                     RGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRA
                     AAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEELSTY
                     PDEVFESPSEAALKDWEKAPDQADLTGGALDRSELERSHLMLPLERGWRKQKEGGTLA
                     PQPKVRLRQEVVSAAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSY
                     VKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRKRGVYE
                     NVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHNFILAAREREKHSACCVRNDR
                     SGCVQTSKEECSSTLAVWVKWPVHPSAPDLAGNKRQFGSVCHQDPRVCDEPSSEDPHE
                     WPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMKGYFH
                     EEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLR
                     DLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQ
                     ILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGKFDL
                     YRKRCQIIIFQAVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
                     "
     exon            252..382
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..596
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..806
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..929
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1087
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1345
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1457
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1532
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1694
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1795
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1859
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1954
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2030
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2131
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2285
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2932
                     /gene="Rhbdf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggcgga cgggccgggc cggcgcgcgg gcgcaggcag ggactaggcg cgggcgccct
       61 cccggccggc ggcggcagcc ggtgcagacc cctccgagga ccctgcggcg gcctgtctca
      121 ctgcacccgg aaccatgagc gaagcccgga gagacagtac tagcagtctg caacgcaaga
      181 aacccccgtg gctcaagttg gacatcccag ctgtggtgcc cccagcagca gaagagccca
      241 gcttcctgca gcccctgcgg cgacaggctt tcctgcggag tgtgagtatg ccggctgaga
      301 cagcccgtgt cccgtcaccc caccatgagc ctcggcggct ggcgctgcag cgtcagacat
      361 ccatcacgca gaccatccgc agggggacag ctgactggtt tggagtgagc aaggacagtg
      421 acagcaccca gaagtggcag cgtaagagca tccgtcactg cagccagcga tatgggaagc
      481 taaagccaca ggtcatccgg gagctggacc tgcccagcca ggacaatgtg tcgctgacca
      541 gcactgagac accgcctcca ctctatgtgg ggccatgcca gctgggaatg cagaagatca
      601 tagaccctct ggcccgaggc cgggccttcc gcatggccga tgacaccgcc gatggcctga
      661 gtgcccccca cactcccgtc acaccaggtg ctgcctccct ctgttccttc tccagctccc
      721 gctcaggttt caaccggctc cctcggcgtc gcaaacgtga atccgtggcc aagatgagct
      781 tccgggccgc tgcagcgctg gtgaagggtc ggtctattag ggatggcact ttacgaaggg
      841 gacagcgtcg gagctttact cctgccagct tcctggagga agacatggtg gacttccctg
      901 atgagctgga tacatctttc tttgcccggg aaggtgtcct ccatgaggag ctgtccacgt
      961 acccagatga ggtgtttgag tccccatcag aagcagcgct caaggactgg gagaaagccc
     1021 cggatcaggc agaccttacg ggtggggccc tggaccgcag cgagctcgag cgaagccact
     1081 tgatgttacc cctggaacga ggctggagga agcagaagga aggcggcacg ctagccccgc
     1141 agcccaaggt gcggcttcgc caggaggtgg tcagtgcggc tggccccagg aggggtcagc
     1201 gtatcgctgt gccagtgcgc aagctcttcg cccgggaaaa acggccgtat ggtctgggga
     1261 tggtgggacg gctcaccaac cgcacgtacc ggaaacggat tgacagctac gtcaagcggc
     1321 agatagaaga catggatgat cacaggccct tcttcactta ctggctcacc ttcgtgcact
     1381 ccctggtcac cattctggct gtgtgtatct acggcatcgc gcctgtgggc ttctcgcagc
     1441 acgagacggt ggactcggta cttcggaagc ggggtgtcta tgagaatgtc aaatacgtcc
     1501 agcaggagaa cttctggatt ggccccagct cggaggccct cattcacctg ggtgccaagt
     1561 tctccccctg catgcgccag gacccacagg tgcacaactt tatccttgct gcccgggagc
     1621 gtgaaaagca ctcagcctgc tgtgtgcgca atgaccggtc tggctgtgtg cagacgtcga
     1681 aggaggagtg ctcgtctacg ttggcagtgt gggtgaagtg gccggttcat cctagtgctc
     1741 ccgacctggc aggcaacaag aggcagtttg gttctgtctg ccaccaggac cccagggtgt
     1801 gtgatgagcc ttcctctgag gatccccacg agtggccaga agatatcacc aagtggccga
     1861 tctgcaccaa aaacagcgcg gggaaccaca ctaaccaccc tcacatggac tgtgtcataa
     1921 cgggcaggcc ctgctgcatc ggcaccaagg gcaggtgtga gatcacctcc cgggagtact
     1981 gtgacttcat gaagggctac ttccatgagg aggccacact ctgctctcag gtgcactgca
     2041 tggacgatgt ctgtggcctc ctgcctttcc tcaatcccga ggtgcctgac cagttctacc
     2101 gcctgtggct gtccctcttc ctgcacgctg ggatcctgca ctgtttggtg tccgtctgct
     2161 tccagatgac ggtcctgcgg gacctggaga agctggcagg ctggcaccgc atagccatca
     2221 tctacctgct gagcggtgtc acgggcaatc tagccagcgc catctttctg ccgtaccggg
     2281 cagaggtagg tccggccggc tcccagtttg gtatcctggc ctgtctcttt gtggagctat
     2341 tccagagctg gcagatcctg gcccgaccct ggcgtgcctt cttcaagctc ctggccgtgg
     2401 tgctcttcct ctttgccttt gggctgctgc cctggatcga caacttcgcc cacatctcag
     2461 gtttcgtcag cggcctcttc ctttcctttg ccttcctgcc ttacatcagc tttggcaagt
     2521 tcgacctgta ccgcaagcgt tgccagatca tcatcttcca ggccgtcttc ctgggcctgc
     2581 tggccggcct ggtggtcctc ttctatttct acccagtgcg ctgtgaatgg tgtgagttcc
     2641 tcacctgcat ccccttcaca gacaagttct gtgagaagta cgagctggat gctcagctcc
     2701 attgaaccag cggtggacac cccaggccac cccggcctcc tgtggccgaa cagacgggtg
     2761 cttcctgaac actgacctct cgtgcctcga gctcccgttg aaccctcaca ctgctggaca
     2821 ttatcatccg agtccccatg ataaccttct aactactccc cccacccccc ttgacaacca
     2881 cctcaggtgg tcaataaatg gactgggagc gttttagctg ccactaacgt ga
//
