LOCUS       NM_001024891            1352 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus rhomboid domain containing 1 (Rhbdd1), mRNA.
ACCESSION   NM_001024891 XM_237331
VERSION     NM_001024891.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Fleig,L., Bergbold,N., Sahasrabudhe,P., Geiger,B., Kaltak,L. and
            Lemberg,M.K.
  TITLE     Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD
            of membrane proteins
  JOURNAL   Mol Cell 47 (4), 558-569 (2012)
   PUBMED   22795130
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Wan,C., Fu,J., Wang,Y., Miao,S., Song,W. and Wang,L.
  TITLE     Exosome-related multi-pass transmembrane protein TSAP6 is a target
            of rhomboid protease RHBDD1-induced proteolysis
  JOURNAL   PLoS One 7 (5), e37452 (2012)
   PUBMED   22624035
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Wang,Y., Song,W., Li,S., Guan,X., Miao,S., Zong,S., Koide,S.S. and
            Wang,L.
  TITLE     GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic
            capacity in mouse seminiferous tubules
  JOURNAL   BMC Cell Biol 10, 25 (2009)
   PUBMED   19358743
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Wang,Y., Guan,X., Fok,K.L., Li,S., Zhang,X., Miao,S., Zong,S.,
            Koide,S.S., Chan,H.C. and Wang,L.
  TITLE     A novel member of the Rhomboid family, RHBDD1, regulates
            BIK-mediated apoptosis
  JOURNAL   Cell Mol Life Sci 65 (23), 3822-3829 (2008)
   PUBMED   18953687
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097416.1.
            
            [WARNING] On Jul 24, 2024 this sequence was replaced by
            NM_001024891.2.
            
            On Jun 17, 2005 this sequence version replaced XM_237331.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..1352
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /note="rhomboid domain containing 1"
                     /db_xref="GeneID:316557"
                     /db_xref="RGD:1306477"
     exon            1..188
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            189..694
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1212
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /EC_number="3.4.21.105"
                     /note="rhomboid domain-containing protein 1; rhomboid-like
                     protein 4"
                     /codon_start=1
                     /product="rhomboid-related protein 4"
                     /protein_id="NP_001020062.1"
                     /db_xref="GeneID:316557"
                     /db_xref="RGD:1306477"
                     /translation="MQRRTRGIDTGLLLLLSQVFHIGINNIPPVTLATLAVNVWFFLN
                     PWKPLYHSCISVEKCYQQNDWQRLLLSPVHHGDDWHLYFNMVSMLWKGVKLEKRLGSR
                     WFAYIIATFSLLTGVVYLLLQFASAELMNQPDFKRNCAVGFSGVLFALKVLSNHYCPG
                     GFVNILGFPVPNRFACWAELAAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDACA
                     GIFISNAGSSGQQYHFNNAGPSGYQNRYTDGRPVNYEATYRNYDIYTAGLSEEEQLER
                     ALRASIWDRGNTRNGPIPYGFRLPPEEEMRRQRLHRFDGQ"
     exon            695..827
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            828..916
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            917..973
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1117
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1319
                     /gene="Rhbdd1"
                     /gene_synonym="RGD1306477; rRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgttccttg tcactaactc aaatgagctc tgtaagacag tagtcctgtc accaccttct
       61 gtgcccatgg tcttgggttt cttctctgtg cgtacaacat cctgagccag tggttggttt
      121 agttcctggt gacaagtgag cgtaaaaaca agaactgcat tttttccagt gtaggatttg
      181 gcacattcgt gctgctctcc gtgtgcctct ctgggatcct aatctagtac agttccttag
      241 ccacgctcct catatccagt catgcagcgg agaacaagag ggatcgacac tggcctcctt
      301 ctgctcctct ctcaagtgtt ccacatcggg atcaacaaca ttccacctgt taccctcgca
      361 accttggctg tcaacgtctg gttcttcctg aatccttgga agcccctgta ccattcctgc
      421 atcagtgtgg aaaagtgtta ccagcagaac gactggcagc gtttactgct ttctcccgtg
      481 caccacggag atgactggca tctgtatttc aacatggtgt ccatgctctg gaaaggagtg
      541 aagctggaga aaaggctggg gagtcggtgg tttgcctaca tcattgccac gttctccctg
      601 cttacggggg tggtgtattt gctcttgcag tttgcttctg cagaactcat gaatcagcct
      661 gacttcaaaa ggaactgtgc cgtcggcttc tcaggcgttt tgtttgcctt gaaagttctt
      721 agcaaccact actgccccgg aggctttgtc aacattttgg gctttcctgt ccccaacaga
      781 tttgcttgtt gggcagagct ggcggccatt cacttctgca ccccagggac ttcctttgct
      841 gggcatctgg ccggcattct cgttggactg atgtacactc aggggcctct gaagaaaatc
      901 atggatgcat gtgcaggcat ttttatctcc aacgctgggt cttcaggaca gcagtaccac
      961 tttaataatg cgggcccctc cggatatcag aatcgctata cagatggccg accagtgaac
     1021 tatgaagcaa cttacaggaa ctatgacatc tacacagcag gcctgagcga ggaggagcag
     1081 ctggaacgag cgttaagagc cagcatctgg gaccgaggaa ataccagaaa tggcccaata
     1141 ccgtatgggt tccggctccc gccagaagaa gaaatgagga gacagcgtct tcacagattt
     1201 gatggccagt gatgtggtac cacgcagggg aaggcgcgtt ccagctgtgt gattggagcc
     1261 cattcacttt acccctcaac cccctgattg gttttaaaca aaagaagagc gcaccgttaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
