LOCUS       NM_019224               2423 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 9 (Rgs9), mRNA.
ACCESSION   NM_019224
VERSION     NM_019224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   2  (bases 1 to 2423)
  AUTHORS   Tian,M., Zallocchi,M., Wang,W., Chen,C.K., Palczewski,K.,
            Delimont,D., Cosgrove,D. and Peng,Y.W.
  TITLE     Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod
            photoreceptors
  JOURNAL   PLoS One 8 (3), e58832 (2013)
   PUBMED   23555598
REFERENCE   3  (bases 1 to 2423)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   4  (bases 1 to 2423)
  AUTHORS   Yin,L.L., Geng,X.C. and Zhu,X.Z.
  TITLE     The involvement of RGS9 in l-3,4-dihydroxyphenylalanine-induced
            dyskinesias in unilateral 6-OHDA lesion rat model
  JOURNAL   Brain Res Bull 86 (5-6), 367-372 (2011)
   PUBMED   21963945
  REMARK    GeneRIF: RGS9 expression in striatum may involve in the abnormal
            involuntary movements induced by l-DOPA therapy
REFERENCE   5  (bases 1 to 2423)
  AUTHORS   Waugh,J.L., Celver,J., Sharma,M., Dufresne,R.L., Terzi,D.,
            Risch,S.C., Fairbrother,W.G., Neve,R.L., Kane,J.P., Malloy,M.J.,
            Pullinger,C.R., Gu,H.F., Tsatsanis,C., Hamilton,S.P., Gold,S.J.,
            Zachariou,V. and Kovoor,A.
  TITLE     Association between regulator of G protein signaling 9-2 and body
            weight
  JOURNAL   PLoS One 6 (11), e27984 (2011)
   PUBMED   22132185
  REMARK    GeneRIF: These studies with humans, rats and mice implicate RGS9-2
            as a factor in regulating body weight.
REFERENCE   6  (bases 1 to 2423)
  AUTHORS   Zachariou,V., Georgescu,D., Sanchez,N., Rahman,Z., DiLeone,R.,
            Berton,O., Neve,R.L., Sim-Selley,L.J., Selley,D.E., Gold,S.J. and
            Nestler,E.J.
  TITLE     Essential role for RGS9 in opiate action
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13656-13661 (2003)
   PUBMED   14595021
  REMARK    GeneRIF: opiate-induced changes in RGS9 levels contribute to the
            behavioral and neural plasticity associated with chronic opiate
            administration
REFERENCE   7  (bases 1 to 2423)
  AUTHORS   Rahman,Z., Schwarz,J., Gold,S.J., Zachariou,V., Wein,M.N.,
            Choi,K.H., Kovoor,A., Chen,C.K., DiLeone,R.J., Schwarz,S.C.,
            Selley,D.E., Sim-Selley,L.J., Barrot,M., Luedtke,R.R., Self,D.,
            Neve,R.L., Lester,H.A., Simon,M.I. and Nestler,E.J.
  TITLE     RGS9 modulates dopamine signaling in the basal ganglia
  JOURNAL   Neuron 38 (6), 941-952 (2003)
   PUBMED   12818179
  REMARK    GeneRIF: data demonstrate a functional interaction between RGS9-2
            and D2 receptor signaling and the behavioral actions of
            psychostimulants and suggest that psychostimulant induction of
            RGS9-2 represents a compensatory adaptation that diminishes drug
            responsiveness
REFERENCE   8  (bases 1 to 2423)
  AUTHORS   Granneman,J.G., Zhai,Y., Zhu,Z., Bannon,M.J., Burchett,S.A.,
            Schmidt,C.J., Andrade,R. and Cooper,J.
  TITLE     Molecular characterization of human and rat RGS 9L, a novel splice
            variant enriched in dopamine target regions, and chromosomal
            localization of the RGS 9 gene
  JOURNAL   Mol Pharmacol 54 (4), 687-694 (1998)
   PUBMED   9765512
REFERENCE   9  (bases 1 to 2423)
  AUTHORS   Thomas,E.A., Danielson,P.E. and Sutcliffe,J.G.
  TITLE     RGS9: a regulator of G-protein signalling with specific expression
            in rat and mouse striatum
  JOURNAL   J Neurosci Res 52 (1), 118-124 (1998)
   PUBMED   9556034
REFERENCE   10 (bases 1 to 2423)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB019145.1.
            
            On Feb 21, 2013 this sequence version replaced NM_019224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019145.1, AF071475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2423              AB019145.1         1-2423
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2423
                     /gene="Rgs9"
                     /note="regulator of G-protein signaling 9"
                     /db_xref="GeneID:29481"
                     /db_xref="RGD:3572"
     exon            1..180
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2157
                     /gene="Rgs9"
                     /codon_start=1
                     /product="regulator of G-protein signaling 9"
                     /protein_id="NP_062097.1"
                     /db_xref="GeneID:29481"
                     /db_xref="RGD:3572"
                     /translation="MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMQNQRVLVT
                     SVPHAMTGGDVLQWIIQRLWISNLEAQNLGNFIVKYGYIYPLQDPKNLVLKPDSSLYR
                     FQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYDFLNKKINYKWDFVIM
                     QAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLDYGLDRVTNPNEVKKQT
                     VTAVRKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQ
                     FWDLNAKLVEVPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACED
                     LKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHI
                     YMLMKKDSYARYLKSPIYKEMLAKAIEPQETTKRSSTLPFMRRHLRSSPSPVILRQLE
                     EEERAREAANTVDITQPGQHLAPSPHLAVYTGTCVPPSPSSPFSPSCRSPRKPFPSPS
                     RFIRRPSIAICPSPIRVALEGSSGLEGKGEASWSGANPGPPVTESIETSVDRSRPHSQ
                     PRAPLKARAALSLGRFLRRGCLASPVFARLSPKCPSVSHGKVQPLGDMGQQLPRLKPK
                     KVANFFQIKMEMPTDSGPCLMDSDDPGAGESGDQTTEKEVICPWESLAEGKAG"
     exon            181..277
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            278..328
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            329..435
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            436..487
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            488..546
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            547..623
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            624..705
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            706..768
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            769..798
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            799..860
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            861..974
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1090
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1178
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1317
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1403
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1521
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2006
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2423
                     /gene="Rgs9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctctttcc gtgcctccca gtccacgccc aggctggggc ggaccaggct ggctggtgaa
       61 cttgggggtt tccccttttc gctcccattc gtgctgtggt cgtgaattca tccagggtcc
      121 agaatgacga tccgacacca aggccagcag tacaggccga ggatggcatt tcttcaaaag
      181 attgaagcac tcgtgaagga catgcagaac ccagagacgg gagtcagaat gcagaaccag
      241 agagtcttgg tcaccagtgt ccctcatgcc atgacaggag gcgatgttct gcaatggatc
      301 atccagcgcc tttggatctc taacctcgag gcgcagaact tgggtaactt catcgtcaag
      361 tacggctaca tctacccttt gcaagacccg aagaatctcg tcctcaaacc tgacagcagc
      421 ctctatcgat ttcagacgcc gtacttctgg cccactcagc agtggccagc tgaggacacc
      481 gactatgcca tctatctagc taagcgaaat atcaagaaga aggggatttt agaagaatat
      541 gaaaaggaaa actatgattt cttgaacaag aagattaatt acaagtggga ttttgtcatc
      601 atgcaggcca aggagcagta ccggactgga aaggagagga acaaagctga caggtatgcg
      661 ctggattgcc aggagaaggc gtattggctg gtgcaccgaa gccctcctgg aatgaacaat
      721 gtgttagact acggcctgga ccgcgtgacc aatccaaacg aagttaagaa acaaacagtc
      781 actgctgtca gaaaggagat tatgtattac cagcaggcct taatgaggtc cacagtgaag
      841 tcttcggtgt cccttggagg aatcgtcaag tatagtgagc agttctcgtc caatgatgcc
      901 atcatgtctg gctgccttcc aagtaatcct tggatcacag acgacaccca gttctgggat
      961 ttaaacgcca agttggtgga ggtcccaacc aagatgcggg tggagagatg ggctttcaac
     1021 ttcagcgaac tgattcgaga ccccaagggc cggcagagct tccagtactt tctcaagaag
     1081 gaattcagtg gggagaacct gggattctgg gaagcctgtg aggatctgaa gtatggggat
     1141 cagtccaagg tcaaggagaa ggcagaggag atctacaagc tgttcctggc accgggtgca
     1201 aggcgatgga tcaacataga cggcaaaacc atggacatca ccgtgaaggg gctgagacac
     1261 ccccaccgct atgtgttgga cgcggcgcag acccacattt acatgctcat gaagaaggat
     1321 tcttatgctc gctatttgaa atctccgatc tataaagaaa tgctggccaa agctatcgag
     1381 ccacaggaaa ccaccaagag aagctccacc ctcccattta tgagacgcca cctacgctcc
     1441 agcccaagcc ctgtcattct gcggcagctg gaagaagaag agagagctcg agaagcagcc
     1501 aacaccgtgg acatcaccca gccaggtcag cacttggctc ccagccctca cctggccgtg
     1561 tacacaggga cctgcgtgcc tccctctccc tccagcccct tctcaccatc ctgccgctcg
     1621 cccaggaagc ccttcccttc cccaagtcgc ttcatccggc ggcccagcat tgccatctgc
     1681 ccctcgccca tccgagtggc cctggagggt tcttcagggc tggagggcaa gggggaagcc
     1741 agctggtctg gtgccaaccc tgggccccca gtcactgaga gcatcgagac ctctgtagac
     1801 cgctcacgac cacacagcca gcccagggcc ccgctcaagg cccgcgctgc cctgtccctt
     1861 ggcaggtttc tgagacgggg ctgtttggca tcaccagttt ttgccaggct ctcaccgaag
     1921 tgcccttctg tgtcacacgg gaaggtgcag cctctggggg acatgggtca acagctgccc
     1981 aggctgaaac ccaagaaagt agccaacttt ttccagatca aaatggaaat gcctacggac
     2041 agtgggccct gcctgatgga ctcggatgac cccggagcag gagagtctgg cgaccagacc
     2101 acggaaaagg aagtcatctg cccctgggaa agcctggcgg aagggaaggc gggctgagca
     2161 gggccgtgcg ccggaaagat ggtcctggca gacaccatca gacctggggc acacttgctc
     2221 tcaaacccaa gtgcattagg atgatattgg agaactggaa aaaaacgaat ggggtggagt
     2281 ccaatggaat gggcgtgtgc tctggttgac tcccaacggc caccttttcc ctttcactgc
     2341 ctttcccttg cttggccaga caggcatgtg ggccagaaga cgtcccttgc tgccttaaaa
     2401 tcaataaaag ggtcatctgg agg
//
