LOCUS       NM_019344               5747 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), mRNA.
ACCESSION   NM_019344
VERSION     NM_019344.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5747)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   2  (bases 1 to 5747)
  AUTHORS   Soundararajan,M., Willard,F.S., Kimple,A.J., Turnbull,A.P.,
            Ball,L.J., Schoch,G.A., Gileadi,C., Fedorov,O.Y., Dowler,E.F.,
            Higman,V.A., Hutsell,S.Q., Sundstrom,M., Doyle,D.A. and
            Siderovski,D.P.
  TITLE     Structural diversity in the RGS domain and its interaction with
            heterotrimeric G protein alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 105 (17), 6457-6462 (2008)
   PUBMED   18434541
REFERENCE   3  (bases 1 to 5747)
  AUTHORS   Saitoh,O. and Odagiri,M.
  TITLE     RGS8 expression in developing cerebellar Purkinje cells
  JOURNAL   Biochem Biophys Res Commun 309 (4), 836-842 (2003)
   PUBMED   13679049
  REMARK    GeneRIF: examination of expression of mRNA in developing cerebellum
            by in situ hybridization
REFERENCE   4  (bases 1 to 5747)
  AUTHORS   Saitoh,O., Masuho,I., Itoh,M., Abe,H., Komori,K. and Odagiri,M.
  TITLE     Distribution of regulator of G protein signaling 8 (RGS8) protein
            in the cerebellum
  JOURNAL   Cerebellum 2 (2), 154-160 (2003)
   PUBMED   12880183
REFERENCE   5  (bases 1 to 5747)
  AUTHORS   Gold,S.J., Heifets,B.D., Pudiak,C.M., Potts,B.W. and Nestler,E.J.
  TITLE     Regulation of regulators of G protein signaling mRNA expression in
            rat brain by acute and chronic electroconvulsive seizures
  JOURNAL   J Neurochem 82 (4), 828-838 (2002)
   PUBMED   12358788
REFERENCE   6  (bases 1 to 5747)
  AUTHORS   Saitoh,O., Murata,Y., Odagiri,M., Itoh,M., Itoh,H., Misaka,T. and
            Kubo,Y.
  TITLE     Alternative splicing of RGS8 gene determines inhibitory function of
            receptor type-specific Gq signaling
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 10138-10143 (2002)
   PUBMED   12110731
  REMARK    GeneRIF: Alternative splicing determines inhibitory function of
            receptor type-specific Gq signaling.
REFERENCE   7  (bases 1 to 5747)
  AUTHORS   Itoh,M., Odagiri,M., Abe,H. and Saitoh,O.
  TITLE     RGS8 protein is distributed in dendrites and cell body of
            cerebellar Purkinje cell
  JOURNAL   Biochem Biophys Res Commun 287 (1), 223-228 (2001)
   PUBMED   11549278
  REMARK    GeneRIF: RGS8 protein is distributed in dendrites and cell body but
            not the nucleus nor axons of cerebellar Purkinje cells, suggesting
            protein distribution is controlled.
REFERENCE   8  (bases 1 to 5747)
  AUTHORS   Saitoh,O., Kubo,Y., Odagiri,M., Ichikawa,M., Yamagata,K. and
            Sekine,T.
  TITLE     RGS7 and RGS8 differentially accelerate G protein-mediated
            modulation of K+ currents
  JOURNAL   J Biol Chem 274 (14), 9899-9904 (1999)
   PUBMED   10092682
REFERENCE   9  (bases 1 to 5747)
  AUTHORS   Saitoh,O., Kubo,Y., Miyatani,Y., Asano,T. and Nakata,H.
  TITLE     RGS8 accelerates G-protein-mediated modulation of K+ currents
  JOURNAL   Nature 390 (6659), 525-529 (1997)
   PUBMED   9394004
REFERENCE   10 (bases 1 to 5747)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000243.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_019344.4.
            
            On Mar 15, 2021 this sequence version replaced NM_019344.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JACYVU010000243.1  673101-673328
            229-302             JACYVU010000243.1  673627-673700
            303-431             JACYVU010000243.1  675597-675725
            432-533             JACYVU010000243.1  678064-678165
            534-598             JACYVU010000243.1  679055-679119
            599-765             JACYVU010000243.1  697852-698018
            766-5747            JACYVU010000243.1  700641-705622
FEATURES             Location/Qualifiers
     source          1..5747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..5747
                     /gene="Rgs8"
                     /note="regulator of G-protein signaling 8"
                     /db_xref="GeneID:54297"
                     /db_xref="RGD:3571"
     exon            1..228
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     exon            229..302
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     exon            303..431
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..948
                     /gene="Rgs8"
                     /codon_start=1
                     /product="regulator of G-protein signaling 8"
                     /protein_id="NP_062217.1"
                     /db_xref="GeneID:54297"
                     /db_xref="RGD:3571"
                     /translation="MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKR
                     LSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLV
                     TKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYP
                     RFLRSKMYLDLLSQSQRRLS"
     exon            432..533
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     exon            534..598
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     exon            599..765
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
     exon            766..5747
                     /gene="Rgs8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtgcagc caccagcctc tcagcctccc agccagcagc agagctcatt aggaaagtac
       61 ccttccctgg atcttcagct acctggcggc ctgagaagag ttaataccta cttttggctg
      121 gggggcagag cagctgccat gggctgggga gagacttctc cctgagctgc agccaaagga
      181 gctgtaggtt agtgaggcca gaggaggaag gcgcaggatg catgccagag ctccttaacc
      241 agaagcatct ctgaccatcc acttggcaaa aacctgcagg ccatgaggac cggccaacaa
      301 cagtgagagg acgtgagagg gtaaatccct gaacccagca gtcttatttc ctaccctgac
      361 gtccctgcaa acaagcccaa ggggtaacca taagcggatg cctgtatggc tgccttactg
      421 atgccacgca ggaacaaagg catgaggact cgactgggat gcctgtcgca caaatcagac
      481 tcctgtagtg acttcacagc catccttcct gacaaaccca accgcgctct caagagactc
      541 tccacagaag aagcgacgag gtgggcagat tcctttgatg tgcttctctc tcacaagtat
      601 ggggtggcag ccttccgtgc cttcctgaag acagagttca gcgaggagaa cctggagttc
      661 tggctggcct gtgaggagtt caagaagacc aggtcgactg caaagctagt caccaaggcc
      721 cacaggatct ttgaggagtt tgtggatgtg caggctccac gggaggtgaa tatcgatttc
      781 cagacccgag aggccacgag gaagaacatg caggagccgt ccctgacttg ttttgatcaa
      841 gcccagggaa aagtccacag cctcatggag aaagactctt atcctaggtt cctgaggtcc
      901 aaaatgtact tagatctgct gtcccaaagc cagaggaggc tcagctagac ctcagatggg
      961 gactcttgaa agtcactggc tttcttttgc ccttgctgcc gagaccacat tctaacgtga
     1021 agtgtcatag atatccaaag gcgctggggt ttggggtgga aggctggggg gtgacaaggg
     1081 aatgaagggc ttttccaaag tatgacccag ctactggagc caggactctc ttccttctac
     1141 ccagacttgt gttttggtta gaggcagcac tgctgctgtc acccttctct gggtgggcca
     1201 gtaactggcc ctacataatg ccttccgtca tctctactga gaaggcagat tcactgtgcc
     1261 gggctaattt gtaaatagtg caaacacagt tcccatcacc tccacaccac accctcttca
     1321 gtaggactcc tgatttccac cttgtccttt ccccaaggga ggagtaccta gacgccacag
     1381 atcctcagtc atgatggatt gtcacacccc agtggcccaa cctgagtgag taccgggacc
     1441 tcagagttta gaagagaggt ctctttggaa ttcagttccc tagcaatgtt gacgggtaac
     1501 ctctgacaaa ggacatattc cctggagttg gctgtgtcat ccatttccac cggaccaaga
     1561 cagagtctga gatctctttt tagactttag actgaggaat tcactgaact tccgtactct
     1621 tgcaattcca gaaagtgtct tggtagattt ctcccatggc ttctgagcgg agctgtcctt
     1681 tttgaaagat aagagtcttc ttcaattcta ttaagaactt ttctagaagt ggagtgacca
     1741 gggaatgtag catcagtaga cttttgtgca atgcggctcc atataacctg tctgttgcct
     1801 aatgtattcc gtgccgtcac ctccccatgg catcacatag cactgatctc ttaggatgaa
     1861 agcggcttgg cagagggagg taaattccca tagcatgaca gctttcttag tgcctgatgc
     1921 tttccctgtc tctccacctc ctccttccat gccggccatg taactctgat gggggacact
     1981 gggtacctag gctgacactc tcattgcagc ttgcttcctg gacatacttt cttagaaagg
     2041 gtccactttt ggctgtcgag aaatagctgc cttcttggtc tctagccttt gggactgacc
     2101 ttggaagatc actgtgaata ccaggctacg gaaattctcc tgcaatgctt gtgcggtgcc
     2161 ccaggggaac tctcggaaat gcaccgcgat attctttctt agaggagtca ggaacatcat
     2221 ggaacctcta cagctgccca ggagaaagct gtccctgcca tctcctgcag ggacaggaag
     2281 atgatgaatc ttcagtacag caagcagaag atagaagacg aatctagaag ctgctggtct
     2341 ctgggtgaac cgaggatgtg gtgaagacac tgctacgaca atttacaacc agtcaacgtg
     2401 ggctcattga agggctgtga acgttcagct tgaatgaatg aaaaagtctg tggccaggct
     2461 gccctagaaa gtcggtggtg gaaggctggg ctgacactct ccttttgtgg ggtgctagcc
     2521 cttctgaagt attctagggt ttgtattctg gtcttgggga atcagttcct tccttggttg
     2581 tagccagaca aggccaagaa ggcccttgag tcctactgtg ttagtgccag ctgccctcca
     2641 agtggtacac cgtcatctgt gagtgggcgt tagtgtctgg atgtgaagag agagaacatc
     2701 tactttctag gcctcacact gaagggacct gtggcagtca catttaataa gacctctgaa
     2761 gcttcaaatg gttcctagtt atagcacata agattttttt ccccaccctg atataaaaat
     2821 attcttagct aaagctgcca gaattaatgt aatgattaaa ttctctcaca gggtattttt
     2881 taaacattgt ttacatatga aatgtgcatc tgctgccaat gctactgccc actctgtggt
     2941 gcatgacact gggcctgcag cgatgggatc gtcctagaag ggccttctca ccattggcac
     3001 tatcccgatt caaaatggct ccacccgcgc ggtgcggcac cctcacttgg ggcctagagt
     3061 tcagctcttg atgggatgaa ggctgcagaa ggtgatgtca tgcaccctgg tgactccttt
     3121 ccgcgtggga ggtatgaagg agcaagttgg agtatcctga gttctgtagc tagacgagga
     3181 catggagttt gtgtctgtgt cgaggagcag atagctctat gggactcccg tggagcatct
     3241 ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg actgtgagtc
     3301 ttgggcagta taccacagac atgctcttcc catgtaaata gcttttcaca taccgtatct
     3361 cccctgcttc tcatagaagg tgcagagctt ctagccctgg tacctcctct taggcacttt
     3421 agtcatgcta gcccagattc tgatgtgtgg tgaaacagag aaatgtttac aacatctaga
     3481 gcaatatcca agcatacctc atctccaagc ttccatgtcc cccagttccc tccccttgtc
     3541 tcttccgcta cgagcctcat ctgcctcacc aggtcttcat taaagatgcc actgcttcca
     3601 tttaatgtct tcctttgctc cagtcatgca agtgtgctga cgactggccc cggactcagg
     3661 ccagcccagg cagcaggaca cagagccgtg gctttccatc cctgaacggc ctattggtcc
     3721 cactggagtg ttgacttgct ttgggtctgg tgtgtggttt gctgttgctc tcgtggagtg
     3781 actagatctc agtcatcgac aactagagca tcctgggttg aaaggggagt gatgctctga
     3841 ggcagcattt attgttgagc gtgagcatgg atcataggga ccaccttgaa agcctctcac
     3901 aaatgctaat tcccagcttc cacacccgga ggaggtgctg atcctgtaga cctaggcaag
     3961 ggacttataa agcaacattg aacaaaagaa tgaagttcct ggatatggaa tggcctgcag
     4021 gcattggaca aaaaaggccc aagacagtgg ttctcaacct cgccactcac taggcttgcc
     4081 agggggagca gaaaaacaaa caaacaatca aacaacaaca acaaaacagt tcagtttcta
     4141 ccatagagta gctaagtcgg agaggctcag agggagtagt agttttttat aatgtcccac
     4201 tagtggcgcc aatgtgcaga tgtggactgg aagcagcagc ctaagcaacg aagaggaaca
     4261 gaactgagta aaacaggacc cgccaaccca cctggatggc aaaagcctac tattaagcca
     4321 aggatgccct gccctttctg cagctgactc tcacggtggt tgcttcgtgc ctctcggtct
     4381 cactggctcc tttgaggtca tgcctgggtt caggctaaat gaagtagttg tcagtaggta
     4441 cgtcaaagtc agggagcatc aagggcactt gactgagaac tggtttgcca ggcttccccg
     4501 gcctttacca cagtgcttcc tccaggcctg taccatgaac tctatctccc tttgtcttca
     4561 tatactcttg tgtttgacca ttgtatgtca ggctgtgccc ctgtacccaa ggtcacgcag
     4621 tagagtagct ggaacattgc tagtgagtga agagtgtctc attagtgacg gtcgtggtac
     4681 aacagcttcc aaacctctct gaggagggtg ccccttcctg gagaggatca aatctgggag
     4741 gattttccaa gactacagtg caacatggat ccctgcttca aaccctcgtt aatttttctg
     4801 accctgtgtt ggataggcag caaggaagct gcaagcgggc tctattttct ggtgctttcc
     4861 ccagaactgg ctgctctgag aaaccaaagc tgtgaacaga agaatgatct gcccagatgt
     4921 ttgtcctggc caggtctaca cgccctggac catagagaag ctctctctgc tgggagggga
     4981 aggcatgaga actgggggag gatgggcaag gtgggggaag catgaggaag aaggggcaag
     5041 gcagaagaga ccccccccag ctgccagcat gacagctgct tctctgtgtc ccagagggaa
     5101 aggtgggagg gggggcacat tcatagacag gatggtcttc tagcaagaac cccagaactc
     5161 cattgaccct gaagaggaac tgtggttttc tacccttacc ttcagtctgc caaatgttag
     5221 ctttcctgag atccatcccc ttccagttaa caacgagagg tggtaccaat attcctggcg
     5281 ctgggcgtct gtgccaccgt gtcaattggc acgagacaag gagggagaag ccaagaggag
     5341 agatggcttt ctgtccccat agcttctcaa ggaccctaca ggatgctgtg ggacacaatg
     5401 agatacatca ggacaggact acgggcctcg ccaggtttgg ggtttgggtc ctctcaataa
     5461 actgtctatt tcttgaactt aacccctcca ctccttcccc tctgccaggt taggaaaagg
     5521 cgagtaggcc ccacacgtgt cccgaccaca gtagccttag cgggtcactc acggagcaca
     5581 acagagttat agcagctcat ctgccatata aaccgcttgg ccgaccgagt cctcattgaa
     5641 ttctttcatt accatgtaaa gcgaaataca ttcaccttta ctatacacag gctgtgagaa
     5701 cataataaac aaaacctgaa cgagctgccc ttcgctctct gcccaca
//
