LOCUS       NM_019343               2412 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 7 (Rgs7), mRNA.
ACCESSION   NM_019343
VERSION     NM_019343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Luessen,D.J., Sun,H., McGinnis,M.M., McCool,B.A. and Chen,R.
  TITLE     Chronic intermittent ethanol exposure selectively alters the
            expression of Galpha subunit isoforms and RGS subtypes in rat
            prefrontal cortex
  JOURNAL   Brain Res 1672, 106-112 (2017)
   PUBMED   28736108
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   Aguado,C., Orlandi,C., Fajardo-Serrano,A., Gil-Minguez,M.,
            Martemyanov,K.A. and Lujan,R.
  TITLE     Cellular and Subcellular Localization of the RGS7/Gbeta5/R7BP
            Complex in the Cerebellar Cortex
  JOURNAL   Front Neuroanat 10, 114 (2016)
   PUBMED   27965545
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Ostrovskaya,O., Xie,K., Masuho,I., Fajardo-Serrano,A., Lujan,R.,
            Wickman,K. and Martemyanov,K.A.
  TITLE     RGS7/Gbeta5/R7BP complex regulates synaptic plasticity and memory
            by modulating hippocampal GABABR-GIRK signaling
  JOURNAL   Elife 3, e02053 (2014)
   PUBMED   24755289
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Orlandi,C., Posokhova,E., Masuho,I., Ray,T.A., Hasan,N., Gregg,R.G.
            and Martemyanov,K.A.
  TITLE     GPR158/179 regulate G protein signaling by controlling localization
            and activity of the RGS7 complexes
  JOURNAL   J Cell Biol 197 (6), 711-719 (2012)
   PUBMED   22689652
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Witherow,D.S., Wang,Q., Levay,K., Cabrera,J.L., Chen,J.,
            Willars,G.B. and Slepak,V.Z.
  TITLE     Complexes of the G protein subunit gbeta 5 with the regulators of G
            protein signaling RGS7 and RGS9. Characterization in native tissues
            and in transfected cells
  JOURNAL   J Biol Chem 275 (32), 24872-24880 (2000)
   PUBMED   10840031
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Saitoh,O., Kubo,Y., Odagiri,M., Ichikawa,M., Yamagata,K. and
            Sekine,T.
  TITLE     RGS7 and RGS8 differentially accelerate G protein-mediated
            modulation of K+ currents
  JOURNAL   J Biol Chem 274 (14), 9899-9904 (1999)
   PUBMED   10092682
REFERENCE   9  (bases 1 to 2412)
  AUTHORS   Gold,S.J., Ni,Y.G., Dohlman,H.G. and Nestler,E.J.
  TITLE     Regulators of G-protein signaling (RGS) proteins: region-specific
            expression of nine subtypes in rat brain
  JOURNAL   J Neurosci 17 (20), 8024-8037 (1997)
   PUBMED   9315921
REFERENCE   10 (bases 1 to 2412)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 22, 2020 this sequence version replaced NM_019343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.52600.1,
                                           SRR26360194.2125219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000013.1  89940835-89941050   c
            217-340             JAXUCZ010000013.1  89939573-89939696   c
            341-437             JAXUCZ010000013.1  89711179-89711275   c
            438-488             JAXUCZ010000013.1  89637649-89637699   c
            489-595             JAXUCZ010000013.1  89600299-89600405   c
            596-647             JAXUCZ010000013.1  89596668-89596719   c
            648-712             JAXUCZ010000013.1  89575937-89576001   c
            713-789             JAXUCZ010000013.1  89574905-89574981   c
            790-871             JAXUCZ010000013.1  89574720-89574801   c
            872-946             JAXUCZ010000013.1  89545449-89545523   c
            947-1045            JAXUCZ010000013.1  89542411-89542509   c
            1046-1107           JAXUCZ010000013.1  89540964-89541025   c
            1108-1218           JAXUCZ010000013.1  89539560-89539670   c
            1219-1344           JAXUCZ010000013.1  89537471-89537596   c
            1345-1531           JAXUCZ010000013.1  89532764-89532950   c
            1532-1621           JAXUCZ010000013.1  89530978-89531067   c
            1622-1702           JAXUCZ010000013.1  89528840-89528920   c
            1703-2412           JAXUCZ010000013.1  89511492-89512201   c
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2412
                     /gene="Rgs7"
                     /note="regulator of G-protein signaling 7"
                     /db_xref="GeneID:54296"
                     /db_xref="RGD:3570"
     exon            1..216
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            217..340
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1696
                     /gene="Rgs7"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7"
                     /protein_id="NP_062216.1"
                     /db_xref="GeneID:54296"
                     /db_xref="RGD:3570"
                     /translation="MAQGNNYGQTSNGVAEESPNMLVYRKMEDVIARMQDEKNGIPIR
                     TVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLK
                     DDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAF
                     ARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSS
                     RMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHRQIKYWQIQLDRHRLKM
                     SKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGM
                     DEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQEIWQEFLAPG
                     APSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQA
                     KRKGRNIPIFPCHKNCTPTLRASTNLL"
     exon            341..437
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            438..488
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            489..595
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..647
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            648..712
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            713..789
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            790..871
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            872..946
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1045
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1107
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1218
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1344
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1531
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1621
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1702
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2412
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaagcgg aggagggaac gagcgaggcg gcccggggga gcgggcgcga gcggcggctg
       61 ccagggccgc ctgtgcaccg cgagggtggc ggtggcctga gcagcgcgag tgtgatgagg
      121 ctgccctgcc tcactgctcc gctcgcagcc agctgacagc gcctgccctc agcacgcccg
      181 gaggggaacc gcggggccgt gaccttggcc gaggagggca gactgatcat ccttgtatct
      241 gagctaccaa gttctgtgtg aaatggctca ggggaataat tatggccaga ccagcaatgg
      301 ggtggcagag gaatcaccga acatgctggt gtacagaaag atggaagatg tcatagcacg
      361 tatgcaagat gaaaaaaatg gaattcccat ccgtaccgtc aaaagcttcc tttccaagat
      421 ccccagtgtt ttctctgggt cagacattgt tcagtggtta ataaagaact taactataga
      481 agatccagtg gaggctctcc atttgggaac gctaatggct gcccatggct acttctttcc
      541 catctcagat catgtcctca cactcaagga tgacggcacc ttctaccggt ttcaaacacc
      601 ctatttttgg ccgtcaaatt gttgggagcc agaaaacaca gactatgctg tttacctctg
      661 caagagaaca atgcaaaaca aggcaaggct agagctagca gactacgaag ccgagagcct
      721 ggccaggctg cagagggcat ttgcccggaa gtgggagttc atttttatgc aagcagaagc
      781 acaagctaaa gtggacaaga agagggacaa aatcgaaagg aagatcctcg atagtcagga
      841 gagagcattc tgggatgtcc acaggcctgt gcctgggtgt gtaaatacta cagaagtgga
      901 catcaagaaa tcatcccgga tgagaaaccc acacaaaaca cgcaagtctg tctatggttt
      961 acaaaatgac atccgaagtc acagtcccac ccacacaccc acaccagaaa ccaagcctcc
     1021 aacagaagat gagttgcacc gacagataaa atactggcaa atacagttag atagacatcg
     1081 gttaaaaatg tcaaaagttg ctgatagtct actaagttat acggaacagt atgtagagta
     1141 tgacccattt cttgtaccgc ctgacccttc caacccatgg ctctcagatg atacgacatt
     1201 ctgggaactt gaagcaagca aagaaccaag tcaacagagg gtaaaacgat ggggttttgg
     1261 catggatgag gcactgaaag acccagttgg gagagagcag ttccttaagt ttctagaatc
     1321 agaattcagc tcagagaact taaggttctg gttggcagtg gaggacctga agaaaaggcc
     1381 tatccgagag gtcccctctc gagtacagga aatatggcaa gaatttctgg ctccgggggc
     1441 ccccagtgcc attaacttgg attcgaagag ttatgacaag accacacaga atgtgaagga
     1501 accaggacga tacacattcg aagatgctca ggagcacatt tacaagctga tgaagagtga
     1561 ctcatacccc cgctttataa gatctagtgc ctaccaggaa cttctacagg caaagagaaa
     1621 gggcagaaac atccctattt tcccatgcca taaaaactgt acaccaacac tgagggccag
     1681 cactaacctg ttatgaaaag aggggaaatc tctcacatcc aagaggttaa caagccttgt
     1741 tcagtcttac taaaaggatc gtctttgtca catgagagct ggacggagcc atcgcccata
     1801 ccttgtagcc catcgcgctg ttacctggag ccaaggatgt tagaccaaga tgttgcatga
     1861 atgaaggacc tgagttgttc tgtgtgcaca taaaggcatc acatttgcca agggacactg
     1921 tcatctcatt gcctccatct tcccgtgccg tttgcttccc tctctcctcg tactaagctg
     1981 gatctgtgtc cttttctttt taacgagttc aagtgaagga aaactttatt tgtcccccct
     2041 tcctctcttt ttcttaaagc ttctgctaga tgcacagttc actgaaaatt cagtcagtca
     2101 caaactggaa gaattgtaaa agaaaaaaaa gtatatatca ctaagtacac acgtggcttc
     2161 acatctatta aataataaat tggcatggaa ggaaggtgtc atttcacccg tgtatccaca
     2221 gtcttaagca agcgcccatc ttcatctgtt ctctggacat tgtctgttca tgtttcttgc
     2281 atttattttt ataccatatt taaatgagaa aacacctttt actccagatg tatcaaagtt
     2341 gacctcttct ctgtaaattt gtgtatgttt atattgttgt tttatctttc attaaaagat
     2401 gcagaatctc gt
//
