LOCUS       NM_019342               2337 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 6 (Rgs6), mRNA.
ACCESSION   NM_019342 XM_001056086 XM_001063200 XM_003754220
VERSION     NM_019342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Chen,G., Zhang,F., Xue,W., Wu,R., Xu,H., Wang,K. and Zhu,J.
  TITLE     An association study revealed substantial effects of dominance,
            epistasis and substance dependence co-morbidity on alcohol
            dependence symptom count
  JOURNAL   Addict Biol 22 (6), 1475-1485 (2017)
   PUBMED   27151647
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Stewart,A., Huang,J. and Fisher,R.A.
  TITLE     RGS Proteins in Heart: Brakes on the Vagus
  JOURNAL   Front Physiol 3, 95 (2012)
   PUBMED   22685433
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Lopez-Fando,A., Rodriguez-Munoz,M., Sanchez-Blazquez,P. and
            Garzon,J.
  TITLE     Expression of neural RGS-R7 and Gbeta5 Proteins in Response to
            Acute and Chronic Morphine
  JOURNAL   Neuropsychopharmacology 30 (1), 99-110 (2005)
   PUBMED   15199376
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Liu,Z., Chatterjee,T.K. and Fisher,R.A.
  TITLE     RGS6 interacts with SCG10 and promotes neuronal differentiation.
            Role of the G gamma subunit-like (GGL) domain of RGS6
  JOURNAL   J Biol Chem 277 (40), 37832-37839 (2002)
   PUBMED   12140291
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Gold,S.J., Ni,Y.G., Dohlman,H.G. and Nestler,E.J.
  TITLE     Regulators of G-protein signaling (RGS) proteins: region-specific
            expression of nine subtypes in rat brain
  JOURNAL   J Neurosci 17 (20), 8024-8037 (1997)
   PUBMED   9315921
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XM_001063200.3, XM_001056086.3, XM_003754220.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840106,
                              SAMN12840108 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000006.1  107996495-107996558
            65-168              JAXUCZ010000006.1  108025104-108025207
            169-268             JAXUCZ010000006.1  108361319-108361418
            269-319             JAXUCZ010000006.1  108420942-108420992
            320-426             JAXUCZ010000006.1  108424674-108424780
            427-478             JAXUCZ010000006.1  108425946-108425997
            479-543             JAXUCZ010000006.1  108434854-108434918
            544-620             JAXUCZ010000006.1  108438702-108438778
            621-702             JAXUCZ010000006.1  108441392-108441473
            703-777             JAXUCZ010000006.1  108442861-108442935
            778-876             JAXUCZ010000006.1  108444907-108445005
            877-938             JAXUCZ010000006.1  108445985-108446046
            939-1049            JAXUCZ010000006.1  108463982-108464092
            1050-1175           JAXUCZ010000006.1  108473971-108474096
            1176-1362           JAXUCZ010000006.1  108482620-108482806
            1363-1452           JAXUCZ010000006.1  108500501-108500590
            1453-2337           JAXUCZ010000006.1  108523432-108524316
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24-q31"
     gene            1..2337
                     /gene="Rgs6"
                     /note="regulator of G-protein signaling 6"
                     /db_xref="GeneID:54295"
                     /db_xref="RGD:3569"
     exon            1..64
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            65..168
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1503
                     /gene="Rgs6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6"
                     /protein_id="NP_062215.1"
                     /db_xref="GeneID:54295"
                     /db_xref="RGD:3569"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTDESQSQSPVHIPSQPIRKTTKDDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKGKSLAGKRLTGLMQSS"
     exon            169..268
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            269..319
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            320..426
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            427..478
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            479..543
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            544..620
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            621..702
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            703..777
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            778..876
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            877..938
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1049
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1175
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1362
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1452
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2337
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttcagatg cgtgacaggt gcgggtgtgt gtctgcagtt tgggactgtg cacggcgagc
       61 ttactgtggg agaagacact caggatggct cagggatccg gagaccagcg agcagtgggg
      121 gttgctgatc cggaagagag ttctcccaac atgattgtct actgcaaaat cgaggacatc
      181 attacgaaga tgcaagatga caagacaggg ggtgtgccca tcagaacagt taagagcttt
      241 ctctccaaaa tccccagtgt cgtcacaggt actgacattg tgcagtggct tatgaagaac
      301 ctttccattg aagacccagt tgaagcaata cacctgggaa gccttatcgc cgcccagggc
      361 tacgtcttcc caatctcaga ccacgtcctc accatgaagg acgatggcac cttttaccgt
      421 ttccaggctc cttacttctg gccttcaaac tgctgggaac ctgaaaacac agactatgcc
      481 atctacctct gtaagaggac gatgcagaac aaggcaaggc tggaattggc cgactacgaa
      541 gcagaaaact tagcgagact ccagagggcc tttgcaagga agtgggaatt catctttatg
      601 caagcagaag cgcaagtcaa gattgaccgg aagaaagata agacggaaag gaaaatcttg
      661 gatagccaag aacgggcctt ctgggatgtc cacaggccag tgccaggctg tgtgaacaca
      721 acggaaatgg atatcagaaa atgtcggcgt ttgaagaatc cacaaaaggt taaaaagtca
      781 gtatatggtg tgacagacga gtcccagtca cagagtccgg tgcacatacc aagccagcca
      841 atcaggaaaa ctacaaaaga cgacatccga aaacagataa cgtttttgaa cgcacagatt
      901 gacagacatt gtttgaaaat gtccaaagtg gctgaaagct taatcgctta cacggagcag
      961 tatgtggaat acgacccttt cataacacca gcagagccat ctaacccttg gatcagcgat
     1021 gacatcacct tatgggacat agagatgagc aaagagccca gccagcagcg agtgaagcgt
     1081 tggggcttct cttttgatga gatactgaag gaccaggtgg ggcgggacca gttcctcaga
     1141 ttcctggagt cagaattcag ttcagaaaat ctcaggttct ggctggccgt ccaagatctc
     1201 aagaagcaac ctctacagga tgtggccaag agggtggagg aaatctggca agagttccta
     1261 gctcccggag ccccaagtgc aatcaacctg gattctcaca gctatgagat aaccagtcag
     1321 aatgtcaaag atggagggag atacacattt gaagatgccc aggagcacat ctacaagctg
     1381 atgaagagtg acagctacgc ccgcttccta cggtccaatg cttaccagga tctgttgctg
     1441 gccaagaaga agggaaagtc gctggcgggc aagcgcctta cgggcctgat gcagtcctcc
     1501 tgaccgcccc gatcccaggc tcagggcccg ggcccacaga gcacccgggc aggcgacgct
     1561 ccacatccaa cgacagagct tccttgcggg gagatttggt cactgtgaag gagaaagagt
     1621 gagggccatg gagggcactg gtgggaagct gcggtgggtg aatggggaga ccagagagaa
     1681 agaatccacg gtgctgggcc agctgggaga ggccctgctt atagcctctc tcttgtacag
     1741 ccacacacca atgctcattc tcaacaaggg tccatttcta actgggtcag agaatgtctc
     1801 atggggttcc tgtctgacta tctatcactc aagatgttgt tgaactcacc tgtccagtcg
     1861 tctggggaat ccagcaaact tcagagggac cctgggcaca cagtattaag catcacctcc
     1921 ctaccactct ctctaaagca ttggcagtgc tcactgccat ctgttccccc tccgccaccc
     1981 cactggtata ccgggtgggt gacggacgct gctttcacac aaaatgtcac atcttcagtc
     2041 ctaatgaccg ttcaagttct ctccaccctc tgtgagacca cattttaaat aagtctccac
     2101 gggtgtggtg gccagcccca gttcccatca aatgtccaaa ggtccttggc ttgaagaggc
     2161 accagtacag atagtggagt gtgttgttca gccactgaaa gttcgggtga caatctttta
     2221 aaaatattac tacttcctgt cttctgattt ttgccccttg caccttgact tgttcccttg
     2281 tgtttggctc gcaataaaca tggccatgaa ctcaggggcc attaggcttc atcccaa
//
