LOCUS       NM_019341                546 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 5 (Rgs5), mRNA.
ACCESSION   NM_019341
VERSION     NM_019341.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Hong,K., Li,M., Nourian,Z., Meininger,G.A. and Hill,M.A.
  TITLE     Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5
            (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries:
            Impaired Trafficking of RGS5 in Hypertension
  JOURNAL   Hypertension 70 (6), 1264-1272 (2017)
   PUBMED   29061726
  REMARK    GeneRIF: AT1R activation results in translocation of RGS5 toward
            the plasma membrane, limiting AT1R-mediated vasoconstriction
            through its role in Gq/11 protein-dependent signaling.
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   3  (bases 1 to 546)
  AUTHORS   Zhao,P. and Chidiac,P.
  TITLE     Regulation of RGS5 GAP activity by GPSM3
  JOURNAL   Mol Cell Biochem 405 (1-2), 33-40 (2015)
   PUBMED   25842189
  REMARK    GeneRIF: The enhancement of RGS5 activity by GPSM3 is maintained
            under these conditions.
REFERENCE   4  (bases 1 to 546)
  AUTHORS   Bokenkamp,R., van Brempt,R., van Munsteren,J.C., van den
            Wijngaert,I., de Hoogt,R., Finos,L., Goeman,J., Groot,A.C.,
            Poelmann,R.E., Blom,N.A. and DeRuiter,M.C.
  TITLE     Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes
            identified by transcriptional profiling of laser-capture
            microdissected endothelial and smooth muscle cells
  JOURNAL   PLoS One 9 (1), e86892 (2014)
   PUBMED   24489801
  REMARK    GeneRIF: Rgs5 and Dlx1 represent novel molecular targets for the
            regulation of ductus arteriosus maturation and closure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 546)
  AUTHORS   Zarzuelo,M.J., Jimenez,R., Galindo,P., Sanchez,M., Nieto,A.,
            Romero,M., Quintela,A.M., Lopez-Sepulveda,R., Gomez-Guzman,M.,
            Bailon,E., Rodriguez-Gomez,I., Zarzuelo,A., Galvez,J., Tamargo,J.,
            Perez-Vizcaino,F. and Duarte,J.
  TITLE     Antihypertensive effects of peroxisome proliferator-activated
            receptor-beta activation in spontaneously hypertensive rats
  JOURNAL   Hypertension 58 (4), 733-743 (2011)
   PUBMED   21825230
REFERENCE   6  (bases 1 to 546)
  AUTHORS   Wang,X., Adams,L.D., Pabon,L.M., Mahoney,W.M. Jr., Beaudry,D.,
            Gunaje,J., Geary,R.L., Deblois,D. and Schwartz,S.M.
  TITLE     RGS5, RGS4, and RGS2 expression and aortic contractibility are
            dynamically co-regulated during aortic banding-induced hypertrophy
  JOURNAL   J Mol Cell Cardiol 44 (3), 539-550 (2008)
   PUBMED   18207159
  REMARK    GeneRIF: After 2 days of aortic banding-induced hypertrophy,
            thoracic aorta lost expression of Rgs5, it returned to normal at 1
            week and increased many fold at 28 days, indicating that RGS
            expression and function correlate with vascular remodeling.
REFERENCE   7  (bases 1 to 546)
  AUTHORS   Grayson,T.H., Ohms,S.J., Brackenbury,T.D., Meaney,K.R., Peng,K.,
            Pittelkow,Y.E., Wilson,S.R., Sandow,S.L. and Hill,C.E.
  TITLE     Vascular microarray profiling in two models of hypertension
            identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets
  JOURNAL   BMC Genomics 8, 404 (2007)
   PUBMED   17986358
  REMARK    GeneRIF: changes in common to caveolin-1 expression and G protein
            signalling, through attenuation of Rgs2 and Rgs5, may contribute to
            hypertension through augmentation of vasoconstrictor pathways
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 546)
  AUTHORS   Lovschall,H., Mitsiadis,T.A., Poulsen,K., Jensen,K.H. and
            Kjeldsen,A.L.
  TITLE     Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth
            muscle cell axis in response to pulp injury
  JOURNAL   Int J Dev Biol 51 (8), 715-721 (2007)
   PUBMED   17939118
  REMARK    GeneRIF: Rgs5 and Notch3 are expressed in pericytes of developing
            and injured teeth and have roles along with vascular-derived stem
            cells during pulp healing
REFERENCE   9  (bases 1 to 546)
  AUTHORS   Wang,Q., Liu,M., Mullah,B., Siderovski,D.P. and Neubig,R.R.
  TITLE     Receptor-selective effects of endogenous RGS3 and RGS5 to regulate
            mitogen-activated protein kinase activation in rat vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 277 (28), 24949-24958 (2002)
   PUBMED   12006602
  REMARK    GeneRIF: role in regulating mitogen-activated protein kinase
            activation in rat vascular smooth muscle cells
REFERENCE   10 (bases 1 to 546)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF241259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF241259.1, EF568934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..546
                     /gene="Rgs5"
                     /note="regulator of G-protein signaling 5"
                     /db_xref="GeneID:54294"
                     /db_xref="RGD:3568"
     CDS             1..546
                     /gene="Rgs5"
                     /codon_start=1
                     /product="regulator of G-protein signaling 5"
                     /protein_id="NP_062214.1"
                     /db_xref="GeneID:54294"
                     /db_xref="RGD:3568"
                     /translation="MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKP
                     EKPAKAHKPSLEEVLQWRQSLDKLLQSNYGFASFKSFLKSEFSEENLEFWVACENYKK
                     IKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPHSFDLAQKRIYA
                     LMEKDSLPRFVRSEFYKELIN"
     exon            1..44
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            45..155
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..217
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            218..384
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            385..546
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgtaagg gactggcagc tctgccacac tcatgcctgg aaagggccaa agagatcaag
       61 atcaaattgg gtattcttct ccagaagcca gactctgctg ttgaccttgt cattccatat
      121 aatgagaagc cagagaagcc tgccaaggcg cacaagccct cgctggagga ggtcctgcaa
      181 tggcgccaat ccctggacaa acttctccag agcaactacg gatttgccag cttcaaaagt
      241 ttcctgaagt ctgaattcag tgaggaaaac cttgagttct gggttgcctg tgagaattac
      301 aagaagatca agtcccccat caaaatggca gagaaggcaa agcaaatcta tgaagaattc
      361 atccagacag aggcccctaa agaggtgaac attgaccact tcactaaaga catcaccatg
      421 aagaacctgg tggaaccttc ccctcacagc tttgacctgg cccagaaaag gatctacgcc
      481 ctgatggaga aggattctct gccccgcttc gtgcgctctg agttttataa ggagttaatc
      541 aactag
//
